Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WQA9_LEIDO

TriTrypDb:

LdBPK_080610.1 , LdCL_080011000 , LDHU3_08.0670

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7WQA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.746
CLV_NRD_NRD_1	134	136	PF00675	0.446
CLV_NRD_NRD_1	14	16	PF00675	0.638
CLV_NRD_NRD_1	195	197	PF00675	0.503
CLV_NRD_NRD_1	238	240	PF00675	0.622
CLV_NRD_NRD_1	276	278	PF00675	0.563
CLV_NRD_NRD_1	284	286	PF00675	0.528
CLV_NRD_NRD_1	66	68	PF00675	0.446
CLV_NRD_NRD_1	70	72	PF00675	0.465
CLV_NRD_NRD_1	75	77	PF00675	0.452
CLV_PCSK_FUR_1	12	16	PF00082	0.631
CLV_PCSK_KEX2_1	14	16	PF00082	0.638
CLV_PCSK_KEX2_1	194	196	PF00082	0.507
CLV_PCSK_KEX2_1	276	278	PF00082	0.569
CLV_PCSK_KEX2_1	283	285	PF00082	0.528
CLV_PCSK_KEX2_1	65	67	PF00082	0.415
CLV_PCSK_KEX2_1	70	72	PF00082	0.432
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.507
CLV_PCSK_PC7_1	279	285	PF00082	0.512
CLV_PCSK_PC7_1	66	72	PF00082	0.467
CLV_PCSK_SKI1_1	239	243	PF00082	0.561
DOC_CKS1_1	453	458	PF01111	0.706
DOC_CYCLIN_RxL_1	210	224	PF00134	0.737
DOC_CYCLIN_RxL_1	247	255	PF00134	0.752
DOC_MAPK_gen_1	21	29	PF00069	0.517
DOC_MAPK_gen_1	483	491	PF00069	0.750
DOC_MAPK_MEF2A_6	21	29	PF00069	0.517
DOC_PP2B_LxvP_1	79	82	PF13499	0.718
DOC_USP7_MATH_1	120	124	PF00917	0.741
DOC_USP7_MATH_1	248	252	PF00917	0.754
DOC_USP7_MATH_1	256	260	PF00917	0.681
DOC_USP7_MATH_1	429	433	PF00917	0.750
DOC_USP7_MATH_1	497	501	PF00917	0.744
DOC_USP7_MATH_1	88	92	PF00917	0.725
DOC_USP7_MATH_1	96	100	PF00917	0.688
DOC_WW_Pin1_4	102	107	PF00397	0.752
DOC_WW_Pin1_4	113	118	PF00397	0.681
DOC_WW_Pin1_4	168	173	PF00397	0.735
DOC_WW_Pin1_4	252	257	PF00397	0.744
DOC_WW_Pin1_4	30	35	PF00397	0.484
DOC_WW_Pin1_4	353	358	PF00397	0.740
DOC_WW_Pin1_4	368	373	PF00397	0.645
DOC_WW_Pin1_4	412	417	PF00397	0.760
DOC_WW_Pin1_4	452	457	PF00397	0.706
DOC_WW_Pin1_4	501	506	PF00397	0.679
DOC_WW_Pin1_4	77	82	PF00397	0.655
LIG_14-3-3_CanoR_1	247	253	PF00244	0.744
LIG_14-3-3_CanoR_1	352	357	PF00244	0.679
LIG_14-3-3_CanoR_1	366	372	PF00244	0.634
LIG_14-3-3_CanoR_1	414	420	PF00244	0.706
LIG_14-3-3_CanoR_1	450	456	PF00244	0.709
LIG_14-3-3_CanoR_1	469	478	PF00244	0.635
LIG_14-3-3_CanoR_1	70	79	PF00244	0.644
LIG_Actin_WH2_2	194	212	PF00022	0.684
LIG_BIR_III_4	459	463	PF00653	0.706
LIG_BRCT_BRCA1_1	48	52	PF00533	0.392
LIG_EVH1_2	81	85	PF00568	0.661
LIG_FHA_1	30	36	PF00498	0.476
LIG_FHA_1	342	348	PF00498	0.762
LIG_FHA_1	353	359	PF00498	0.666
LIG_FHA_1	371	377	PF00498	0.624
LIG_FHA_2	383	389	PF00498	0.725
LIG_FHA_2	453	459	PF00498	0.708
LIG_LIR_Apic_2	310	316	PF02991	0.744
LIG_LIR_Apic_2	475	481	PF02991	0.708
LIG_LIR_Gen_1	399	409	PF02991	0.742
LIG_LIR_Gen_1	43	52	PF02991	0.392
LIG_LIR_Nem_3	361	365	PF02991	0.689
LIG_LIR_Nem_3	399	404	PF02991	0.678
LIG_LIR_Nem_3	43	47	PF02991	0.392
LIG_LIR_Nem_3	49	55	PF02991	0.334
LIG_LYPXL_yS_3	379	382	PF13949	0.684
LIG_MAD2	17	25	PF02301	0.503
LIG_MLH1_MIPbox_1	48	52	PF16413	0.392
LIG_Pex14_2	48	52	PF04695	0.476
LIG_RPA_C_Fungi	60	72	PF08784	0.415
LIG_SH2_NCK_1	478	482	PF00017	0.630
LIG_SH2_PTP2	362	365	PF00017	0.692
LIG_SH2_PTP2	44	47	PF00017	0.392
LIG_SH2_SRC	44	47	PF00017	0.392
LIG_SH2_STAP1	389	393	PF00017	0.671
LIG_SH2_STAT5	362	365	PF00017	0.692
LIG_SH2_STAT5	44	47	PF00017	0.392
LIG_SH2_STAT5	51	54	PF00017	0.324
LIG_SH3_1	487	493	PF00018	0.681
LIG_SH3_3	269	275	PF00018	0.606
LIG_SH3_3	371	377	PF00018	0.617
LIG_SH3_3	407	413	PF00018	0.687
LIG_SH3_3	487	493	PF00018	0.681
LIG_SH3_3	499	505	PF00018	0.564
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.681
LIG_SUMO_SIM_anti_2	36	43	PF11976	0.502
LIG_SUMO_SIM_par_1	25	30	PF11976	0.652
LIG_SUMO_SIM_par_1	354	361	PF11976	0.592
LIG_SUMO_SIM_par_1	435	443	PF11976	0.687
LIG_TYR_ITIM	360	365	PF00017	0.690
LIG_TYR_ITIM	42	47	PF00017	0.392
LIG_WRC_WIRS_1	492	497	PF05994	0.680
MOD_CDC14_SPxK_1	105	108	PF00782	0.701
MOD_CDK_SPxK_1	102	108	PF00069	0.698
MOD_CDK_SPxK_1	168	174	PF00069	0.671
MOD_CK1_1	113	119	PF00069	0.582
MOD_CK1_1	127	133	PF00069	0.494
MOD_CK1_1	185	191	PF00069	0.702
MOD_CK1_1	200	206	PF00069	0.538
MOD_CK1_1	233	239	PF00069	0.698
MOD_CK1_1	30	36	PF00069	0.594
MOD_CK1_1	317	323	PF00069	0.691
MOD_CK1_1	325	331	PF00069	0.635
MOD_CK1_1	370	376	PF00069	0.688
MOD_CK1_1	415	421	PF00069	0.716
MOD_CK1_1	432	438	PF00069	0.521
MOD_CK1_1	449	455	PF00069	0.558
MOD_CK1_1	474	480	PF00069	0.632
MOD_CK1_1	99	105	PF00069	0.677
MOD_CK2_1	382	388	PF00069	0.657
MOD_GlcNHglycan	184	187	PF01048	0.699
MOD_GlcNHglycan	189	192	PF01048	0.658
MOD_GlcNHglycan	211	214	PF01048	0.583
MOD_GlcNHglycan	29	32	PF01048	0.545
MOD_GlcNHglycan	317	320	PF01048	0.646
MOD_GlcNHglycan	329	332	PF01048	0.643
MOD_GlcNHglycan	426	429	PF01048	0.576
MOD_GlcNHglycan	458	463	PF01048	0.629
MOD_GlcNHglycan	499	502	PF01048	0.594
MOD_GSK3_1	109	116	PF00069	0.571
MOD_GSK3_1	120	127	PF00069	0.559
MOD_GSK3_1	181	188	PF00069	0.698
MOD_GSK3_1	197	204	PF00069	0.532
MOD_GSK3_1	248	255	PF00069	0.691
MOD_GSK3_1	25	32	PF00069	0.624
MOD_GSK3_1	314	321	PF00069	0.687
MOD_GSK3_1	322	329	PF00069	0.629
MOD_GSK3_1	33	40	PF00069	0.474
MOD_GSK3_1	348	355	PF00069	0.692
MOD_GSK3_1	378	385	PF00069	0.600
MOD_GSK3_1	429	436	PF00069	0.685
MOD_GSK3_1	470	477	PF00069	0.628
MOD_GSK3_1	497	504	PF00069	0.594
MOD_GSK3_1	95	102	PF00069	0.682
MOD_N-GLC_1	102	107	PF02516	0.606
MOD_N-GLC_1	471	476	PF02516	0.629
MOD_NEK2_1	209	214	PF00069	0.583
MOD_NEK2_1	235	240	PF00069	0.614
MOD_NEK2_1	27	32	PF00069	0.642
MOD_NEK2_1	35	40	PF00069	0.492
MOD_OFUCOSY	288	295	PF10250	0.693
MOD_PIKK_1	449	455	PF00454	0.634
MOD_PIKK_1	71	77	PF00454	0.541
MOD_PKA_1	195	201	PF00069	0.610
MOD_PKA_2	120	126	PF00069	0.671
MOD_PKA_2	195	201	PF00069	0.698
MOD_PKA_2	286	292	PF00069	0.708
MOD_PKA_2	351	357	PF00069	0.593
MOD_PKA_2	449	455	PF00069	0.722
MOD_PKA_2	470	476	PF00069	0.628
MOD_PKB_1	469	477	PF00069	0.627
MOD_Plk_1	127	133	PF00069	0.629
MOD_Plk_1	201	207	PF00069	0.680
MOD_Plk_1	233	239	PF00069	0.698
MOD_Plk_1	296	302	PF00069	0.626
MOD_Plk_1	474	480	PF00069	0.632
MOD_Plk_2-3	388	394	PF00069	0.675
MOD_Plk_4	127	133	PF00069	0.629
MOD_Plk_4	163	169	PF00069	0.681
MOD_Plk_4	309	315	PF00069	0.681
MOD_Plk_4	358	364	PF00069	0.601
MOD_Plk_4	37	43	PF00069	0.442
MOD_Plk_4	378	384	PF00069	0.583
MOD_Plk_4	433	439	PF00069	0.597
MOD_Plk_4	491	497	PF00069	0.681
MOD_Plk_4	96	102	PF00069	0.587
MOD_ProDKin_1	102	108	PF00069	0.698
MOD_ProDKin_1	113	119	PF00069	0.593
MOD_ProDKin_1	168	174	PF00069	0.671
MOD_ProDKin_1	252	258	PF00069	0.679
MOD_ProDKin_1	30	36	PF00069	0.587
MOD_ProDKin_1	353	359	PF00069	0.679
MOD_ProDKin_1	368	374	PF00069	0.543
MOD_ProDKin_1	412	418	PF00069	0.707
MOD_ProDKin_1	452	458	PF00069	0.629
MOD_ProDKin_1	501	507	PF00069	0.590
MOD_ProDKin_1	77	83	PF00069	0.557
MOD_SUMO_rev_2	224	233	PF00179	0.602
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.683
TRG_ENDOCYTIC_2	362	365	PF00928	0.692
TRG_ENDOCYTIC_2	379	382	PF00928	0.522
TRG_ENDOCYTIC_2	44	47	PF00928	0.392
TRG_ENDOCYTIC_2	465	468	PF00928	0.614
TRG_ER_diArg_1	12	15	PF00400	0.597
TRG_ER_diArg_1	132	135	PF00400	0.547
TRG_ER_diArg_1	195	197	PF00400	0.624
TRG_ER_diArg_1	275	277	PF00400	0.712
TRG_ER_diArg_1	283	285	PF00400	0.650
TRG_ER_diArg_1	468	471	PF00400	0.621
TRG_ER_diArg_1	65	67	PF00400	0.488
TRG_ER_diArg_1	69	71	PF00400	0.530
TRG_NLS_MonoExtC_3	193	199	PF00514	0.620
TRG_NLS_MonoExtC_3	238	244	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HTK8	Leishmania infantum	99%	100%
Q4QIB0	Leishmania major	79%	98%