Amastin surface glycoprotein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQ88_LEIDO

TriTrypDb:

LdBPK_080650.1 , LdCL_080011500 , LDHU3_08.0720

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WQ88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.650
CLV_NRD_NRD_1	277	279	PF00675	0.519
CLV_PCSK_KEX2_1	277	279	PF00082	0.519
CLV_PCSK_SKI1_1	68	72	PF00082	0.575
DEG_SCF_FBW7_2	55	61	PF00400	0.374
DOC_CKS1_1	192	197	PF01111	0.424
DOC_CKS1_1	210	215	PF01111	0.353
DOC_CKS1_1	55	60	PF01111	0.375
DOC_CYCLIN_RxL_1	175	186	PF00134	0.478
DOC_MAPK_gen_1	67	78	PF00069	0.323
DOC_MAPK_MEF2A_6	71	80	PF00069	0.377
DOC_PP4_FxxP_1	192	195	PF00568	0.435
DOC_PP4_FxxP_1	210	213	PF00568	0.421
DOC_USP7_MATH_1	161	165	PF00917	0.468
DOC_USP7_MATH_1	219	223	PF00917	0.487
DOC_USP7_MATH_1	41	45	PF00917	0.354
DOC_USP7_UBL2_3	67	71	PF12436	0.452
DOC_WW_Pin1_4	191	196	PF00397	0.527
DOC_WW_Pin1_4	209	214	PF00397	0.399
DOC_WW_Pin1_4	54	59	PF00397	0.369
LIG_14-3-3_CanoR_1	111	115	PF00244	0.659
LIG_14-3-3_CanoR_1	12	16	PF00244	0.462
LIG_14-3-3_CanoR_1	277	284	PF00244	0.657
LIG_BRCT_BRCA1_1	105	109	PF00533	0.599
LIG_deltaCOP1_diTrp_1	249	255	PF00928	0.408
LIG_EH_1	230	234	PF12763	0.377
LIG_FHA_1	127	133	PF00498	0.453
LIG_FHA_1	192	198	PF00498	0.481
LIG_FHA_1	221	227	PF00498	0.546
LIG_FHA_1	267	273	PF00498	0.505
LIG_FHA_1	27	33	PF00498	0.461
LIG_FHA_1	45	51	PF00498	0.253
LIG_FHA_2	244	250	PF00498	0.416
LIG_LIR_Apic_2	191	195	PF02991	0.408
LIG_LIR_Apic_2	208	213	PF02991	0.398
LIG_LIR_Gen_1	238	248	PF02991	0.438
LIG_LIR_Gen_1	253	262	PF02991	0.302
LIG_LIR_LC3C_4	268	272	PF02991	0.388
LIG_LIR_Nem_3	253	258	PF02991	0.328
LIG_PTB_Apo_2	239	246	PF02174	0.356
LIG_SH2_GRB2like	146	149	PF00017	0.382
LIG_SH2_NCK_1	56	60	PF00017	0.364
LIG_SH2_STAP1	146	150	PF00017	0.469
LIG_SH2_STAT5	140	143	PF00017	0.359
LIG_SH2_STAT5	56	59	PF00017	0.382
LIG_SUMO_SIM_anti_2	268	275	PF11976	0.452
LIG_SUMO_SIM_anti_2	286	293	PF11976	0.549
LIG_SUMO_SIM_anti_2	6	14	PF11976	0.585
LIG_WRC_WIRS_1	237	242	PF05994	0.472
MOD_CDK_SPxxK_3	209	216	PF00069	0.444
MOD_CK1_1	107	113	PF00069	0.679
MOD_CK1_1	191	197	PF00069	0.480
MOD_CK1_1	3	9	PF00069	0.729
MOD_CK1_1	44	50	PF00069	0.354
MOD_CK2_1	243	249	PF00069	0.413
MOD_Cter_Amidation	275	278	PF01082	0.412
MOD_GlcNHglycan	163	166	PF01048	0.677
MOD_GlcNHglycan	2	5	PF01048	0.429
MOD_GlcNHglycan	286	289	PF01048	0.525
MOD_GSK3_1	103	110	PF00069	0.592
MOD_GSK3_1	42	49	PF00069	0.364
MOD_GSK3_1	50	57	PF00069	0.386
MOD_GSK3_1	6	13	PF00069	0.525
MOD_N-GLC_1	153	158	PF02516	0.674
MOD_N-GLC_1	42	47	PF02516	0.640
MOD_N-GLC_2	149	151	PF02516	0.627
MOD_NEK2_1	10	15	PF00069	0.635
MOD_NEK2_1	105	110	PF00069	0.568
MOD_NEK2_1	126	131	PF00069	0.464
MOD_NEK2_1	159	164	PF00069	0.479
MOD_NEK2_1	243	248	PF00069	0.460
MOD_NEK2_1	258	263	PF00069	0.232
MOD_NEK2_1	26	31	PF00069	0.262
MOD_NEK2_1	266	271	PF00069	0.339
MOD_NEK2_1	284	289	PF00069	0.551
MOD_NEK2_1	42	47	PF00069	0.323
MOD_NEK2_1	98	103	PF00069	0.448
MOD_NEK2_2	236	241	PF00069	0.463
MOD_PIKK_1	159	165	PF00454	0.462
MOD_PIKK_1	44	50	PF00454	0.332
MOD_PKA_1	183	189	PF00069	0.423
MOD_PKA_1	277	283	PF00069	0.676
MOD_PKA_2	11	17	PF00069	0.530
MOD_PKA_2	110	116	PF00069	0.615
MOD_PKA_2	170	176	PF00069	0.448
MOD_PKA_2	276	282	PF00069	0.665
MOD_Plk_1	42	48	PF00069	0.435
MOD_Plk_4	170	176	PF00069	0.505
MOD_Plk_4	188	194	PF00069	0.372
MOD_Plk_4	266	272	PF00069	0.356
MOD_Plk_4	46	52	PF00069	0.321
MOD_Plk_4	6	12	PF00069	0.585
MOD_Plk_4	84	90	PF00069	0.290
MOD_Plk_4	98	104	PF00069	0.314
MOD_ProDKin_1	191	197	PF00069	0.527
MOD_ProDKin_1	209	215	PF00069	0.400
MOD_ProDKin_1	54	60	PF00069	0.370
TRG_DiLeu_BaEn_1	295	300	PF01217	0.685
TRG_DiLeu_LyEn_5	295	300	PF01217	0.738
TRG_ER_diArg_1	114	117	PF00400	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I287	Leptomonas seymouri	40%	100%
A4H5G2	Leishmania braziliensis	58%	98%
A4HTL2	Leishmania infantum	100%	100%
E9AME3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QIA5	Leishmania major	82%	100%