Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ84_LEIDO

TriTrypDb:

LdBPK_080550.1 , LdCL_080010400 , LDHU3_08.0610

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQ84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.769
CLV_NRD_NRD_1	133	135	PF00675	0.701
CLV_NRD_NRD_1	177	179	PF00675	0.509
CLV_NRD_NRD_1	214	216	PF00675	0.479
CLV_NRD_NRD_1	227	229	PF00675	0.465
CLV_NRD_NRD_1	245	247	PF00675	0.443
CLV_NRD_NRD_1	91	93	PF00675	0.584
CLV_PCSK_KEX2_1	133	135	PF00082	0.701
CLV_PCSK_KEX2_1	179	181	PF00082	0.492
CLV_PCSK_KEX2_1	213	215	PF00082	0.483
CLV_PCSK_KEX2_1	226	228	PF00082	0.468
CLV_PCSK_KEX2_1	245	247	PF00082	0.443
CLV_PCSK_KEX2_1	91	93	PF00082	0.584
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.466
CLV_PCSK_PC7_1	222	228	PF00082	0.454
CLV_PCSK_SKI1_1	16	20	PF00082	0.548
CLV_PCSK_SKI1_1	200	204	PF00082	0.409
DEG_APCC_DBOX_1	199	207	PF00400	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.669
DOC_CYCLIN_RxL_1	13	22	PF00134	0.590
DOC_PP1_RVXF_1	14	21	PF00149	0.551
DOC_PP2B_LxvP_1	342	345	PF13499	0.639
DOC_USP7_MATH_1	288	292	PF00917	0.703
DOC_WW_Pin1_4	183	188	PF00397	0.506
DOC_WW_Pin1_4	2	7	PF00397	0.570
LIG_14-3-3_CanoR_1	133	139	PF00244	0.541
LIG_14-3-3_CanoR_1	178	184	PF00244	0.524
LIG_14-3-3_CanoR_1	213	218	PF00244	0.462
LIG_14-3-3_CanoR_1	228	237	PF00244	0.453
LIG_BRCT_BRCA1_1	181	185	PF00533	0.502
LIG_BRCT_BRCA1_1	327	331	PF00533	0.589
LIG_Clathr_ClatBox_1	161	165	PF01394	0.608
LIG_DCNL_PONY_1	1	4	PF03556	0.729
LIG_FHA_1	230	236	PF00498	0.453
LIG_FHA_2	272	278	PF00498	0.578
LIG_LIR_Gen_1	262	271	PF02991	0.571
LIG_NRBOX	193	199	PF00104	0.438
LIG_Pex14_2	19	23	PF04695	0.533
LIG_SH2_CRK	199	203	PF00017	0.408
LIG_SH2_CRK	209	213	PF00017	0.490
LIG_SH2_STAP1	138	142	PF00017	0.526
LIG_SH2_STAT5	160	163	PF00017	0.579
LIG_SH2_STAT5	249	252	PF00017	0.476
LIG_SH3_2	173	178	PF14604	0.675
LIG_SH3_3	110	116	PF00018	0.671
LIG_SH3_3	167	173	PF00018	0.544
LIG_SH3_3	282	288	PF00018	0.547
LIG_SH3_3	341	347	PF00018	0.641
LIG_SH3_3	56	62	PF00018	0.755
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.556
LIG_TRAF2_1	156	159	PF00917	0.570
LIG_TRAF2_2	113	118	PF00917	0.578
LIG_TYR_ITIM	197	202	PF00017	0.412
LIG_WW_3	5	9	PF00397	0.536
MOD_CDC14_SPxK_1	5	8	PF00782	0.500
MOD_CDK_SPxK_1	2	8	PF00069	0.539
MOD_CDK_SPxxK_3	185	192	PF00069	0.482
MOD_CK1_1	129	135	PF00069	0.494
MOD_CK1_1	77	83	PF00069	0.748
MOD_CK2_1	277	283	PF00069	0.548
MOD_GlcNHglycan	128	131	PF01048	0.523
MOD_GlcNHglycan	27	30	PF01048	0.744
MOD_GlcNHglycan	316	319	PF01048	0.598
MOD_GlcNHglycan	32	35	PF01048	0.744
MOD_GSK3_1	179	186	PF00069	0.536
MOD_GSK3_1	255	262	PF00069	0.555
MOD_GSK3_1	30	37	PF00069	0.611
MOD_GSK3_1	73	80	PF00069	0.752
MOD_N-GLC_1	255	260	PF02516	0.541
MOD_N-GLC_1	296	301	PF02516	0.722
MOD_N-GLC_1	86	91	PF02516	0.570
MOD_NEK2_1	12	17	PF00069	0.561
MOD_NEK2_1	19	24	PF00069	0.613
MOD_NEK2_1	257	262	PF00069	0.569
MOD_NEK2_1	86	91	PF00069	0.613
MOD_NEK2_2	244	249	PF00069	0.557
MOD_PIKK_1	154	160	PF00454	0.630
MOD_PKA_1	179	185	PF00069	0.443
MOD_PKA_1	213	219	PF00069	0.463
MOD_PKA_2	179	185	PF00069	0.521
MOD_PKA_2	213	219	PF00069	0.463
MOD_PKA_2	24	30	PF00069	0.704
MOD_PKA_2	244	250	PF00069	0.565
MOD_Plk_1	288	294	PF00069	0.675
MOD_Plk_2-3	277	283	PF00069	0.548
MOD_Plk_4	190	196	PF00069	0.579
MOD_Plk_4	277	283	PF00069	0.549
MOD_Plk_4	42	48	PF00069	0.703
MOD_ProDKin_1	183	189	PF00069	0.508
MOD_ProDKin_1	2	8	PF00069	0.574
MOD_SUMO_for_1	331	334	PF00179	0.702
MOD_SUMO_rev_2	184	194	PF00179	0.476
MOD_SUMO_rev_2	273	280	PF00179	0.569
MOD_SUMO_rev_2	319	328	PF00179	0.678
MOD_SUMO_rev_2	66	76	PF00179	0.591
TRG_DiLeu_BaEn_1	190	195	PF01217	0.459
TRG_ENDOCYTIC_2	199	202	PF00928	0.412
TRG_ENDOCYTIC_2	209	212	PF00928	0.489
TRG_ENDOCYTIC_2	220	223	PF00928	0.452
TRG_ER_diArg_1	133	135	PF00400	0.701
TRG_ER_diArg_1	212	215	PF00400	0.494
TRG_ER_diArg_1	225	228	PF00400	0.455
TRG_ER_diArg_1	90	92	PF00400	0.584
TRG_NLS_MonoExtN_4	176	182	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I921	Leptomonas seymouri	73%	97%
A4H5C2	Leishmania braziliensis	86%	100%
A4HTK2	Leishmania infantum	99%	100%
E9AMD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIB5	Leishmania major	94%	100%