Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ81_LEIDO

TriTrypDb:

LdBPK_080370.1 , LdCL_080008600 , LDHU3_08.0430

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQ81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.578
CLV_C14_Caspase3-7	468	472	PF00656	0.752
CLV_NRD_NRD_1	241	243	PF00675	0.521
CLV_NRD_NRD_1	562	564	PF00675	0.458
CLV_PCSK_KEX2_1	241	243	PF00082	0.521
CLV_PCSK_KEX2_1	329	331	PF00082	0.643
CLV_PCSK_KEX2_1	562	564	PF00082	0.375
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.643
CLV_PCSK_SKI1_1	354	358	PF00082	0.611
CLV_PCSK_SKI1_1	448	452	PF00082	0.567
DEG_COP1_1	460	473	PF00400	0.587
DEG_SCF_FBW7_1	105	111	PF00400	0.610
DEG_SPOP_SBC_1	355	359	PF00917	0.697
DEG_SPOP_SBC_1	453	457	PF00917	0.633
DEG_SPOP_SBC_1	67	71	PF00917	0.584
DOC_CKS1_1	105	110	PF01111	0.608
DOC_CYCLIN_RxL_1	442	456	PF00134	0.539
DOC_MAPK_gen_1	562	568	PF00069	0.383
DOC_PP2B_LxvP_1	450	453	PF13499	0.761
DOC_PP2B_LxvP_1	482	485	PF13499	0.625
DOC_USP7_MATH_1	119	123	PF00917	0.682
DOC_USP7_MATH_1	125	129	PF00917	0.692
DOC_USP7_MATH_1	132	136	PF00917	0.587
DOC_USP7_MATH_1	181	185	PF00917	0.572
DOC_USP7_MATH_1	308	312	PF00917	0.640
DOC_USP7_MATH_1	355	359	PF00917	0.713
DOC_USP7_MATH_1	382	386	PF00917	0.596
DOC_WW_Pin1_4	104	109	PF00397	0.706
DOC_WW_Pin1_4	136	141	PF00397	0.626
DOC_WW_Pin1_4	203	208	PF00397	0.505
DOC_WW_Pin1_4	276	281	PF00397	0.634
DOC_WW_Pin1_4	337	342	PF00397	0.629
DOC_WW_Pin1_4	358	363	PF00397	0.665
DOC_WW_Pin1_4	365	370	PF00397	0.583
DOC_WW_Pin1_4	372	377	PF00397	0.558
DOC_WW_Pin1_4	411	416	PF00397	0.532
DOC_WW_Pin1_4	517	522	PF00397	0.604
LIG_14-3-3_CanoR_1	169	178	PF00244	0.427
LIG_14-3-3_CanoR_1	232	240	PF00244	0.425
LIG_14-3-3_CanoR_1	354	364	PF00244	0.642
LIG_14-3-3_CanoR_1	448	453	PF00244	0.619
LIG_14-3-3_CanoR_1	500	506	PF00244	0.531
LIG_14-3-3_CanoR_1	513	519	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_4	301	305	PF00653	0.608
LIG_BIR_III_4	318	322	PF00653	0.505
LIG_EH1_1	34	42	PF00400	0.391
LIG_eIF4E_1	35	41	PF01652	0.426
LIG_EVH1_1	104	108	PF00568	0.535
LIG_EVH1_1	141	145	PF00568	0.635
LIG_FHA_1	337	343	PF00498	0.686
LIG_FHA_1	355	361	PF00498	0.479
LIG_FHA_1	412	418	PF00498	0.538
LIG_FHA_1	525	531	PF00498	0.579
LIG_FHA_2	312	318	PF00498	0.553
LIG_FHA_2	507	513	PF00498	0.527
LIG_HP1_1	285	289	PF01393	0.638
LIG_LIR_Gen_1	23	33	PF02991	0.664
LIG_LIR_Nem_3	23	29	PF02991	0.675
LIG_MYND_1	481	485	PF01753	0.591
LIG_RPA_C_Fungi	229	241	PF08784	0.418
LIG_RPA_C_Fungi	558	570	PF08784	0.314
LIG_SH2_STAT3	416	419	PF00017	0.613
LIG_SH2_STAT5	247	250	PF00017	0.467
LIG_SH2_STAT5	416	419	PF00017	0.540
LIG_SH2_STAT5	9	12	PF00017	0.494
LIG_SH2_STAT5	98	101	PF00017	0.531
LIG_SH3_3	102	108	PF00018	0.586
LIG_SH3_3	110	116	PF00018	0.644
LIG_SH3_3	134	140	PF00018	0.679
LIG_SH3_3	279	285	PF00018	0.598
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.505
LIG_SUMO_SIM_anti_2	564	570	PF11976	0.386
LIG_SUMO_SIM_par_1	448	457	PF11976	0.644
LIG_TRAF2_1	172	175	PF00917	0.445
LIG_UBA3_1	373	378	PF00899	0.676
LIG_WRC_WIRS_1	26	31	PF05994	0.693
LIG_WW_2	142	145	PF00397	0.658
MOD_CDC14_SPxK_1	375	378	PF00782	0.603
MOD_CDK_SPxK_1	372	378	PF00069	0.602
MOD_CK1_1	2	8	PF00069	0.614
MOD_CK1_1	25	31	PF00069	0.500
MOD_CK1_1	265	271	PF00069	0.732
MOD_CK1_1	311	317	PF00069	0.668
MOD_CK1_1	320	326	PF00069	0.646
MOD_CK1_1	358	364	PF00069	0.725
MOD_CK1_1	385	391	PF00069	0.638
MOD_CK1_1	397	403	PF00069	0.628
MOD_CK1_1	409	415	PF00069	0.737
MOD_CK1_1	457	463	PF00069	0.653
MOD_CK1_1	517	523	PF00069	0.630
MOD_CK1_1	72	78	PF00069	0.742
MOD_CK2_1	169	175	PF00069	0.448
MOD_CK2_1	176	182	PF00069	0.493
MOD_CK2_1	311	317	PF00069	0.552
MOD_CK2_1	456	462	PF00069	0.661
MOD_CK2_1	47	53	PF00069	0.548
MOD_CK2_1	77	83	PF00069	0.619
MOD_GlcNHglycan	11	14	PF01048	0.452
MOD_GlcNHglycan	121	124	PF01048	0.677
MOD_GlcNHglycan	126	130	PF01048	0.801
MOD_GlcNHglycan	134	137	PF01048	0.545
MOD_GlcNHglycan	152	155	PF01048	0.558
MOD_GlcNHglycan	171	174	PF01048	0.326
MOD_GlcNHglycan	188	191	PF01048	0.767
MOD_GlcNHglycan	213	216	PF01048	0.489
MOD_GlcNHglycan	235	238	PF01048	0.451
MOD_GlcNHglycan	268	271	PF01048	0.648
MOD_GlcNHglycan	317	322	PF01048	0.682
MOD_GlcNHglycan	384	387	PF01048	0.613
MOD_GlcNHglycan	389	394	PF01048	0.647
MOD_GlcNHglycan	456	459	PF01048	0.763
MOD_GlcNHglycan	464	467	PF01048	0.619
MOD_GlcNHglycan	72	75	PF01048	0.615
MOD_GlcNHglycan	79	82	PF01048	0.614
MOD_GSK3_1	104	111	PF00069	0.663
MOD_GSK3_1	132	139	PF00069	0.608
MOD_GSK3_1	181	188	PF00069	0.534
MOD_GSK3_1	21	28	PF00069	0.390
MOD_GSK3_1	262	269	PF00069	0.733
MOD_GSK3_1	272	279	PF00069	0.678
MOD_GSK3_1	3	10	PF00069	0.567
MOD_GSK3_1	332	339	PF00069	0.753
MOD_GSK3_1	350	357	PF00069	0.751
MOD_GSK3_1	385	392	PF00069	0.642
MOD_GSK3_1	394	401	PF00069	0.635
MOD_GSK3_1	448	455	PF00069	0.674
MOD_GSK3_1	457	464	PF00069	0.621
MOD_GSK3_1	47	54	PF00069	0.553
MOD_GSK3_1	513	520	PF00069	0.739
MOD_GSK3_1	66	73	PF00069	0.664
MOD_N-GLC_2	488	490	PF02516	0.504
MOD_N-GLC_2	529	531	PF02516	0.422
MOD_NEK2_1	1	6	PF00069	0.667
MOD_NEK2_1	167	172	PF00069	0.434
MOD_NEK2_1	211	216	PF00069	0.451
MOD_NEK2_1	22	27	PF00069	0.512
MOD_NEK2_1	363	368	PF00069	0.607
MOD_NEK2_1	396	401	PF00069	0.652
MOD_NEK2_1	493	498	PF00069	0.517
MOD_NEK2_1	501	506	PF00069	0.537
MOD_NEK2_1	59	64	PF00069	0.627
MOD_OFUCOSY	490	497	PF10250	0.504
MOD_PIKK_1	262	268	PF00454	0.695
MOD_PIKK_1	322	328	PF00454	0.627
MOD_PIKK_1	4	10	PF00454	0.619
MOD_PK_1	562	568	PF00069	0.403
MOD_PKA_1	562	568	PF00069	0.453
MOD_PKA_2	233	239	PF00069	0.460
MOD_PKA_2	462	468	PF00069	0.696
MOD_PKA_2	562	568	PF00069	0.365
MOD_PKB_1	330	338	PF00069	0.579
MOD_Plk_1	22	28	PF00069	0.553
MOD_Plk_4	193	199	PF00069	0.560
MOD_Plk_4	514	520	PF00069	0.546
MOD_Plk_4	530	536	PF00069	0.551
MOD_ProDKin_1	104	110	PF00069	0.710
MOD_ProDKin_1	136	142	PF00069	0.624
MOD_ProDKin_1	203	209	PF00069	0.501
MOD_ProDKin_1	276	282	PF00069	0.628
MOD_ProDKin_1	337	343	PF00069	0.626
MOD_ProDKin_1	358	364	PF00069	0.666
MOD_ProDKin_1	365	371	PF00069	0.584
MOD_ProDKin_1	372	378	PF00069	0.559
MOD_ProDKin_1	411	417	PF00069	0.530
MOD_ProDKin_1	517	523	PF00069	0.599
MOD_SUMO_rev_2	214	222	PF00179	0.404
MOD_SUMO_rev_2	322	331	PF00179	0.633
TRG_DiLeu_BaEn_1	36	41	PF01217	0.454
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.606
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.596
TRG_ENDOCYTIC_2	26	29	PF00928	0.627
TRG_ENDOCYTIC_2	42	45	PF00928	0.301
TRG_ENDOCYTIC_2	98	101	PF00928	0.531
TRG_ER_diArg_1	240	242	PF00400	0.508
TRG_ER_diArg_1	330	333	PF00400	0.633
TRG_ER_diArg_1	498	501	PF00400	0.463
TRG_ER_diArg_1	552	555	PF00400	0.557
TRG_ER_diArg_1	561	563	PF00400	0.401
TRG_NES_CRM1_1	290	301	PF08389	0.641
TRG_NLS_MonoExtC_3	328	333	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML5	Leptomonas seymouri	41%	100%
A4H5A8	Leishmania braziliensis	66%	100%
A4HTI7	Leishmania infantum	99%	100%
E9AMB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QID3	Leishmania major	88%	100%