Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ64_LEIDO

TriTrypDb:

LdBPK_080440.1 , LdCL_080009300 , LDHU3_08.0500

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQ64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.651
CLV_NRD_NRD_1	143	145	PF00675	0.586
CLV_NRD_NRD_1	343	345	PF00675	0.507
CLV_NRD_NRD_1	400	402	PF00675	0.403
CLV_NRD_NRD_1	423	425	PF00675	0.510
CLV_NRD_NRD_1	428	430	PF00675	0.538
CLV_NRD_NRD_1	460	462	PF00675	0.525
CLV_NRD_NRD_1	467	469	PF00675	0.522
CLV_NRD_NRD_1	605	607	PF00675	0.548
CLV_NRD_NRD_1	701	703	PF00675	0.629
CLV_NRD_NRD_1	706	708	PF00675	0.638
CLV_NRD_NRD_1	750	752	PF00675	0.650
CLV_NRD_NRD_1	794	796	PF00675	0.547
CLV_PCSK_FUR_1	421	425	PF00082	0.505
CLV_PCSK_FUR_1	699	703	PF00082	0.625
CLV_PCSK_FUR_1	704	708	PF00082	0.636
CLV_PCSK_KEX2_1	145	147	PF00082	0.605
CLV_PCSK_KEX2_1	163	165	PF00082	0.502
CLV_PCSK_KEX2_1	342	344	PF00082	0.566
CLV_PCSK_KEX2_1	400	402	PF00082	0.413
CLV_PCSK_KEX2_1	423	425	PF00082	0.684
CLV_PCSK_KEX2_1	428	430	PF00082	0.538
CLV_PCSK_KEX2_1	467	469	PF00082	0.544
CLV_PCSK_KEX2_1	496	498	PF00082	0.532
CLV_PCSK_KEX2_1	605	607	PF00082	0.547
CLV_PCSK_KEX2_1	701	703	PF00082	0.629
CLV_PCSK_KEX2_1	706	708	PF00082	0.638
CLV_PCSK_KEX2_1	750	752	PF00082	0.650
CLV_PCSK_KEX2_1	783	785	PF00082	0.427
CLV_PCSK_KEX2_1	794	796	PF00082	0.484
CLV_PCSK_KEX2_1	849	851	PF00082	0.629
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.520
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.468
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.545
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.427
CLV_PCSK_PC1ET2_1	849	851	PF00082	0.492
CLV_PCSK_PC7_1	159	165	PF00082	0.624
CLV_PCSK_PC7_1	424	430	PF00082	0.522
CLV_PCSK_PC7_1	702	708	PF00082	0.695
CLV_PCSK_PC7_1	779	785	PF00082	0.429
CLV_PCSK_SKI1_1	149	153	PF00082	0.519
CLV_PCSK_SKI1_1	478	482	PF00082	0.679
CLV_PCSK_SKI1_1	606	610	PF00082	0.524
CLV_PCSK_SKI1_1	814	818	PF00082	0.420
CLV_PCSK_SKI1_1	849	853	PF00082	0.490
CLV_PCSK_SKI1_1	871	875	PF00082	0.546
CLV_Separin_Metazoa	332	336	PF03568	0.470
CLV_Separin_Metazoa	458	462	PF03568	0.500
DEG_APCC_DBOX_1	347	355	PF00400	0.461
DEG_COP1_1	45	53	PF00400	0.418
DEG_SCF_FBW7_2	921	928	PF00400	0.579
DEG_SPOP_SBC_1	559	563	PF00917	0.639
DEG_SPOP_SBC_1	567	571	PF00917	0.647
DOC_CYCLIN_RxL_1	810	818	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.398
DOC_MAPK_gen_1	342	351	PF00069	0.470
DOC_MAPK_gen_1	494	504	PF00069	0.505
DOC_MAPK_MEF2A_6	496	505	PF00069	0.568
DOC_MAPK_MEF2A_6	827	834	PF00069	0.515
DOC_MAPK_NFAT4_5	827	835	PF00069	0.570
DOC_PP1_RVXF_1	4	10	PF00149	0.408
DOC_PP2B_LxvP_1	20	23	PF13499	0.484
DOC_PP2B_LxvP_1	389	392	PF13499	0.492
DOC_PP4_FxxP_1	552	555	PF00568	0.562
DOC_USP7_MATH_1	133	137	PF00917	0.694
DOC_USP7_MATH_1	212	216	PF00917	0.759
DOC_USP7_MATH_1	559	563	PF00917	0.639
DOC_USP7_MATH_1	567	571	PF00917	0.652
DOC_USP7_MATH_1	635	639	PF00917	0.640
DOC_USP7_MATH_1	64	68	PF00917	0.546
DOC_USP7_MATH_1	685	689	PF00917	0.652
DOC_USP7_MATH_1	782	786	PF00917	0.414
DOC_USP7_MATH_1	833	837	PF00917	0.557
DOC_USP7_MATH_1	872	876	PF00917	0.588
DOC_USP7_UBL2_3	141	145	PF12436	0.512
DOC_USP7_UBL2_3	148	152	PF12436	0.500
DOC_USP7_UBL2_3	219	223	PF12436	0.684
DOC_USP7_UBL2_3	490	494	PF12436	0.512
DOC_USP7_UBL2_3	845	849	PF12436	0.506
DOC_WW_Pin1_4	448	453	PF00397	0.598
DOC_WW_Pin1_4	53	58	PF00397	0.514
DOC_WW_Pin1_4	568	573	PF00397	0.616
DOC_WW_Pin1_4	714	719	PF00397	0.610
DOC_WW_Pin1_4	921	926	PF00397	0.581
LIG_14-3-3_CanoR_1	428	434	PF00244	0.543
LIG_14-3-3_CanoR_1	515	520	PF00244	0.624
LIG_14-3-3_CanoR_1	657	662	PF00244	0.768
LIG_14-3-3_CanoR_1	704	713	PF00244	0.644
LIG_14-3-3_CanoR_1	729	734	PF00244	0.633
LIG_14-3-3_CanoR_1	827	833	PF00244	0.550
LIG_14-3-3_CanoR_1	850	856	PF00244	0.419
LIG_Actin_WH2_2	839	854	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BIR_III_4	258	262	PF00653	0.634
LIG_BRCT_BRCA1_1	561	565	PF00533	0.648
LIG_Clathr_ClatBox_1	305	309	PF01394	0.455
LIG_Clathr_ClatBox_1	41	45	PF01394	0.399
LIG_eIF4E_1	300	306	PF01652	0.418
LIG_eIF4E_1	36	42	PF01652	0.439
LIG_FHA_1	112	118	PF00498	0.692
LIG_FHA_1	2	8	PF00498	0.450
LIG_FHA_1	26	32	PF00498	0.562
LIG_FHA_1	434	440	PF00498	0.574
LIG_FHA_1	45	51	PF00498	0.421
LIG_FHA_1	515	521	PF00498	0.559
LIG_FHA_1	561	567	PF00498	0.559
LIG_FHA_2	325	331	PF00498	0.491
LIG_FHA_2	430	436	PF00498	0.536
LIG_FHA_2	438	444	PF00498	0.502
LIG_FHA_2	449	455	PF00498	0.527
LIG_FHA_2	524	530	PF00498	0.599
LIG_FHA_2	910	916	PF00498	0.640
LIG_GBD_Chelix_1	333	341	PF00786	0.397
LIG_LIR_Apic_2	297	303	PF02991	0.432
LIG_LIR_Apic_2	483	489	PF02991	0.521
LIG_LIR_Apic_2	551	555	PF02991	0.561
LIG_LIR_Gen_1	228	239	PF02991	0.576
LIG_LIR_Gen_1	521	531	PF02991	0.603
LIG_LIR_Gen_1	536	546	PF02991	0.552
LIG_LIR_Gen_1	83	93	PF02991	0.586
LIG_LIR_Nem_3	228	234	PF02991	0.591
LIG_LIR_Nem_3	309	315	PF02991	0.396
LIG_LIR_Nem_3	411	417	PF02991	0.489
LIG_LIR_Nem_3	483	488	PF02991	0.578
LIG_LIR_Nem_3	607	612	PF02991	0.547
LIG_LIR_Nem_3	688	693	PF02991	0.622
LIG_LIR_Nem_3	83	88	PF02991	0.558
LIG_LYPXL_yS_3	302	305	PF13949	0.481
LIG_LYPXL_yS_3	690	693	PF13949	0.602
LIG_SH2_CRK	12	16	PF00017	0.489
LIG_SH2_CRK	300	304	PF00017	0.419
LIG_SH2_CRK	312	316	PF00017	0.391
LIG_SH2_CRK	36	40	PF00017	0.446
LIG_SH2_CRK	486	490	PF00017	0.530
LIG_SH2_NCK_1	36	40	PF00017	0.446
LIG_SH2_SRC	16	19	PF00017	0.373
LIG_SH2_SRC	300	303	PF00017	0.486
LIG_SH2_SRC	58	61	PF00017	0.544
LIG_SH2_STAP1	36	40	PF00017	0.446
LIG_SH2_STAT3	463	466	PF00017	0.506
LIG_SH2_STAT3	519	522	PF00017	0.552
LIG_SH2_STAT5	304	307	PF00017	0.481
LIG_SH2_STAT5	350	353	PF00017	0.458
LIG_SH2_STAT5	40	43	PF00017	0.377
LIG_SH2_STAT5	463	466	PF00017	0.506
LIG_SH2_STAT5	519	522	PF00017	0.569
LIG_SH2_STAT5	692	695	PF00017	0.799
LIG_SH2_STAT5	858	861	PF00017	0.425
LIG_SH3_1	286	292	PF00018	0.608
LIG_SH3_3	12	18	PF00018	0.476
LIG_SH3_3	286	292	PF00018	0.671
LIG_SH3_3	45	51	PF00018	0.544
LIG_SH3_3	485	491	PF00018	0.520
LIG_SH3_3	54	60	PF00018	0.593
LIG_SH3_3	890	896	PF00018	0.613
LIG_SH3_4	490	497	PF00018	0.508
LIG_SUMO_SIM_anti_2	435	443	PF11976	0.505
LIG_SUMO_SIM_par_1	112	123	PF11976	0.626
LIG_SUMO_SIM_par_1	390	397	PF11976	0.449
LIG_SUMO_SIM_par_1	435	443	PF11976	0.513
LIG_SUMO_SIM_par_1	45	52	PF11976	0.485
LIG_SUMO_SIM_par_1	618	627	PF11976	0.573
LIG_TRAF2_1	23	26	PF00917	0.483
LIG_TRAF2_1	240	243	PF00917	0.632
LIG_TRAF2_1	327	330	PF00917	0.485
LIG_UBA3_1	187	196	PF00899	0.497
MOD_CDK_SPK_2	448	453	PF00069	0.598
MOD_CK1_1	131	137	PF00069	0.634
MOD_CK1_1	171	177	PF00069	0.652
MOD_CK1_1	2	8	PF00069	0.582
MOD_CK1_1	408	414	PF00069	0.590
MOD_CK1_1	437	443	PF00069	0.562
MOD_CK1_1	518	524	PF00069	0.550
MOD_CK1_1	568	574	PF00069	0.607
MOD_CK1_1	669	675	PF00069	0.616
MOD_CK1_1	679	685	PF00069	0.612
MOD_CK1_1	709	715	PF00069	0.626
MOD_CK1_1	724	730	PF00069	0.665
MOD_CK1_1	732	738	PF00069	0.710
MOD_CK1_1	867	873	PF00069	0.636
MOD_CK2_1	133	139	PF00069	0.622
MOD_CK2_1	180	186	PF00069	0.601
MOD_CK2_1	202	208	PF00069	0.611
MOD_CK2_1	219	225	PF00069	0.652
MOD_CK2_1	237	243	PF00069	0.475
MOD_CK2_1	324	330	PF00069	0.494
MOD_CK2_1	350	356	PF00069	0.463
MOD_CK2_1	437	443	PF00069	0.562
MOD_CK2_1	448	454	PF00069	0.493
MOD_CK2_1	523	529	PF00069	0.598
MOD_CK2_1	644	650	PF00069	0.652
MOD_CK2_1	782	788	PF00069	0.442
MOD_CK2_1	909	915	PF00069	0.640
MOD_Cter_Amidation	216	219	PF01082	0.761
MOD_GlcNHglycan	1	4	PF01048	0.564
MOD_GlcNHglycan	131	134	PF01048	0.764
MOD_GlcNHglycan	170	173	PF01048	0.611
MOD_GlcNHglycan	204	207	PF01048	0.579
MOD_GlcNHglycan	215	218	PF01048	0.718
MOD_GlcNHglycan	279	282	PF01048	0.618
MOD_GlcNHglycan	36	39	PF01048	0.408
MOD_GlcNHglycan	407	410	PF01048	0.595
MOD_GlcNHglycan	577	580	PF01048	0.655
MOD_GlcNHglycan	683	686	PF01048	0.672
MOD_GlcNHglycan	713	716	PF01048	0.623
MOD_GlcNHglycan	734	737	PF01048	0.787
MOD_GlcNHglycan	754	757	PF01048	0.712
MOD_GlcNHglycan	874	877	PF01048	0.660
MOD_GlcNHglycan	882	885	PF01048	0.628
MOD_GlcNHglycan	89	94	PF01048	0.565
MOD_GSK3_1	129	136	PF00069	0.645
MOD_GSK3_1	167	174	PF00069	0.587
MOD_GSK3_1	213	220	PF00069	0.694
MOD_GSK3_1	369	376	PF00069	0.650
MOD_GSK3_1	401	408	PF00069	0.615
MOD_GSK3_1	429	436	PF00069	0.601
MOD_GSK3_1	514	521	PF00069	0.557
MOD_GSK3_1	554	561	PF00069	0.601
MOD_GSK3_1	60	67	PF00069	0.496
MOD_GSK3_1	644	651	PF00069	0.702
MOD_GSK3_1	653	660	PF00069	0.690
MOD_GSK3_1	669	676	PF00069	0.559
MOD_GSK3_1	681	688	PF00069	0.561
MOD_GSK3_1	705	712	PF00069	0.654
MOD_GSK3_1	721	728	PF00069	0.538
MOD_GSK3_1	759	766	PF00069	0.677
MOD_GSK3_1	867	874	PF00069	0.591
MOD_GSK3_1	89	96	PF00069	0.635
MOD_N-GLC_1	725	730	PF02516	0.669
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	294	299	PF00069	0.577
MOD_NEK2_1	324	329	PF00069	0.441
MOD_NEK2_1	433	438	PF00069	0.586
MOD_NEK2_1	44	49	PF00069	0.551
MOD_NEK2_1	480	485	PF00069	0.524
MOD_NEK2_1	558	563	PF00069	0.709
MOD_NEK2_1	644	649	PF00069	0.640
MOD_NEK2_1	678	683	PF00069	0.674
MOD_NEK2_1	880	885	PF00069	0.636
MOD_NEK2_2	523	528	PF00069	0.500
MOD_PIKK_1	518	524	PF00454	0.550
MOD_PIKK_1	763	769	PF00454	0.644
MOD_PIKK_1	93	99	PF00454	0.671
MOD_PK_1	729	735	PF00069	0.612
MOD_PKA_1	706	712	PF00069	0.693
MOD_PKA_2	129	135	PF00069	0.685
MOD_PKA_2	202	208	PF00069	0.565
MOD_PKA_2	427	433	PF00069	0.617
MOD_PKA_2	514	520	PF00069	0.622
MOD_PKA_2	705	711	PF00069	0.641
MOD_PKA_2	728	734	PF00069	0.645
MOD_PKA_2	841	847	PF00069	0.521
MOD_PKB_1	704	712	PF00069	0.596
MOD_Plk_1	434	440	PF00069	0.511
MOD_Plk_1	44	50	PF00069	0.482
MOD_Plk_1	666	672	PF00069	0.684
MOD_Plk_2-3	180	186	PF00069	0.611
MOD_Plk_2-3	237	243	PF00069	0.585
MOD_Plk_2-3	548	554	PF00069	0.558
MOD_Plk_4	111	117	PF00069	0.690
MOD_Plk_4	27	33	PF00069	0.482
MOD_Plk_4	350	356	PF00069	0.460
MOD_Plk_4	434	440	PF00069	0.511
MOD_Plk_4	44	50	PF00069	0.478
MOD_Plk_4	515	521	PF00069	0.559
MOD_Plk_4	548	554	PF00069	0.558
MOD_Plk_4	788	794	PF00069	0.431
MOD_Plk_4	864	870	PF00069	0.572
MOD_ProDKin_1	448	454	PF00069	0.593
MOD_ProDKin_1	53	59	PF00069	0.518
MOD_ProDKin_1	568	574	PF00069	0.612
MOD_ProDKin_1	714	720	PF00069	0.608
MOD_ProDKin_1	921	927	PF00069	0.582
MOD_SUMO_for_1	162	165	PF00179	0.568
MOD_SUMO_rev_2	147	157	PF00179	0.587
MOD_SUMO_rev_2	471	475	PF00179	0.513
MOD_SUMO_rev_2	738	746	PF00179	0.642
TRG_AP2beta_CARGO_1	607	616	PF09066	0.530
TRG_DiLeu_BaEn_1	811	816	PF01217	0.479
TRG_DiLeu_LyEn_5	811	816	PF01217	0.479
TRG_ENDOCYTIC_2	12	15	PF00928	0.493
TRG_ENDOCYTIC_2	302	305	PF00928	0.477
TRG_ENDOCYTIC_2	312	315	PF00928	0.340
TRG_ENDOCYTIC_2	36	39	PF00928	0.443
TRG_ENDOCYTIC_2	524	527	PF00928	0.593
TRG_ENDOCYTIC_2	690	693	PF00928	0.602
TRG_ER_diArg_1	341	344	PF00400	0.405
TRG_ER_diArg_1	399	401	PF00400	0.400
TRG_ER_diArg_1	421	424	PF00400	0.510
TRG_ER_diArg_1	428	431	PF00400	0.548
TRG_ER_diArg_1	698	701	PF00400	0.618
TRG_ER_diArg_1	703	706	PF00400	0.631
TRG_ER_diArg_1	793	795	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	814	818	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP1	Leptomonas seymouri	53%	100%
A4HTJ2	Leishmania infantum	99%	100%
E9AMC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4QIC6	Leishmania major	93%	100%