DUF1279 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ61_LEIDO

TriTrypDb:

LdBPK_080170.1 , LdCL_080006600 , LDHU3_08.0200

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WQ61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.493
CLV_PCSK_KEX2_1	220	222	PF00082	0.612
CLV_PCSK_KEX2_1	26	28	PF00082	0.491
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.612
CLV_PCSK_SKI1_1	175	179	PF00082	0.521
CLV_PCSK_SKI1_1	220	224	PF00082	0.690
DEG_APCC_DBOX_1	174	182	PF00400	0.325
DEG_Nend_Nbox_1	1	3	PF02207	0.714
DOC_CDC14_PxL_1	199	207	PF14671	0.365
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.414
DOC_MAPK_gen_1	105	115	PF00069	0.496
DOC_MAPK_MEF2A_6	105	113	PF00069	0.478
DOC_PP2B_LxvP_1	205	208	PF13499	0.366
DOC_USP7_MATH_1	44	48	PF00917	0.745
DOC_USP7_MATH_1	54	58	PF00917	0.641
DOC_USP7_MATH_1	81	85	PF00917	0.690
DOC_USP7_MATH_1	93	97	PF00917	0.624
DOC_WW_Pin1_4	170	175	PF00397	0.387
DOC_WW_Pin1_4	228	233	PF00397	0.503
DOC_WW_Pin1_4	52	57	PF00397	0.726
DOC_WW_Pin1_4	75	80	PF00397	0.727
LIG_14-3-3_CanoR_1	221	225	PF00244	0.390
LIG_14-3-3_CanoR_1	39	44	PF00244	0.635
LIG_FHA_1	131	137	PF00498	0.404
LIG_FHA_1	199	205	PF00498	0.352
LIG_Integrin_RGD_1	60	62	PF01839	0.506
LIG_LIR_Gen_1	118	128	PF02991	0.332
LIG_LIR_Gen_1	158	167	PF02991	0.496
LIG_LIR_Nem_3	118	123	PF02991	0.332
LIG_LIR_Nem_3	158	163	PF02991	0.430
LIG_LYPXL_S_1	187	191	PF13949	0.586
LIG_LYPXL_yS_3	188	191	PF13949	0.384
LIG_NRBOX	131	137	PF00104	0.383
LIG_Pex14_2	6	10	PF04695	0.595
LIG_SH2_CRK	120	124	PF00017	0.323
LIG_SH2_STAT5	122	125	PF00017	0.348
LIG_SH2_STAT5	134	137	PF00017	0.366
LIG_SH2_STAT5	180	183	PF00017	0.361
LIG_SH3_3	150	156	PF00018	0.358
LIG_SH3_3	186	192	PF00018	0.380
LIG_SH3_3	222	228	PF00018	0.440
LIG_SUMO_SIM_par_1	16	21	PF11976	0.688
LIG_TYR_ITIM	178	183	PF00017	0.367
LIG_TYR_ITSM	116	123	PF00017	0.332
MOD_CDK_SPK_2	170	175	PF00069	0.387
MOD_CK1_1	42	48	PF00069	0.680
MOD_CK1_1	52	58	PF00069	0.649
MOD_CK1_1	77	83	PF00069	0.746
MOD_CK1_1	84	90	PF00069	0.710
MOD_CK1_1	92	98	PF00069	0.630
MOD_GlcNHglycan	228	231	PF01048	0.686
MOD_GlcNHglycan	46	49	PF01048	0.527
MOD_GlcNHglycan	56	59	PF01048	0.494
MOD_GlcNHglycan	79	82	PF01048	0.504
MOD_GlcNHglycan	83	86	PF01048	0.500
MOD_GlcNHglycan	91	94	PF01048	0.458
MOD_GlcNHglycan	95	98	PF01048	0.408
MOD_GSK3_1	216	223	PF00069	0.433
MOD_GSK3_1	226	233	PF00069	0.538
MOD_GSK3_1	38	45	PF00069	0.682
MOD_GSK3_1	48	55	PF00069	0.652
MOD_GSK3_1	71	78	PF00069	0.730
MOD_GSK3_1	89	96	PF00069	0.703
MOD_N-GLC_2	184	186	PF02516	0.574
MOD_NEK2_1	124	129	PF00069	0.388
MOD_NEK2_1	130	135	PF00069	0.408
MOD_NEK2_1	18	23	PF00069	0.690
MOD_NEK2_1	216	221	PF00069	0.452
MOD_PK_1	16	22	PF00069	0.652
MOD_PKA_1	220	226	PF00069	0.428
MOD_PKA_2	220	226	PF00069	0.393
MOD_PKA_2	38	44	PF00069	0.692
MOD_PKA_2	71	77	PF00069	0.716
MOD_Plk_4	115	121	PF00069	0.321
MOD_Plk_4	130	136	PF00069	0.356
MOD_Plk_4	145	151	PF00069	0.293
MOD_ProDKin_1	170	176	PF00069	0.384
MOD_ProDKin_1	52	58	PF00069	0.726
MOD_ProDKin_1	75	81	PF00069	0.729
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.570
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.426
TRG_ENDOCYTIC_2	120	123	PF00928	0.277
TRG_ENDOCYTIC_2	180	183	PF00928	0.392
TRG_ENDOCYTIC_2	188	191	PF00928	0.353
TRG_ER_diArg_1	2	5	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.215

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL2	Leptomonas seymouri	47%	100%
A4H583	Leishmania braziliensis	71%	100%
A4HTG7	Leishmania infantum	100%	100%
C9ZPP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AM95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QIF3	Leishmania major	91%	100%