Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WQ53_LEIDO

TriTrypDb:

LdBPK_080110.1 , LdCL_080006000 , LDHU3_08.0130

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQ53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.641
CLV_MEL_PAP_1	156	162	PF00089	0.747
CLV_NRD_NRD_1	246	248	PF00675	0.715
CLV_NRD_NRD_1	254	256	PF00675	0.720
CLV_NRD_NRD_1	316	318	PF00675	0.570
CLV_NRD_NRD_1	545	547	PF00675	0.613
CLV_NRD_NRD_1	570	572	PF00675	0.553
CLV_NRD_NRD_1	582	584	PF00675	0.672
CLV_NRD_NRD_1	91	93	PF00675	0.782
CLV_PCSK_FUR_1	568	572	PF00082	0.552
CLV_PCSK_FUR_1	89	93	PF00082	0.610
CLV_PCSK_KEX2_1	246	248	PF00082	0.715
CLV_PCSK_KEX2_1	254	256	PF00082	0.720
CLV_PCSK_KEX2_1	316	318	PF00082	0.576
CLV_PCSK_KEX2_1	365	367	PF00082	0.586
CLV_PCSK_KEX2_1	568	570	PF00082	0.558
CLV_PCSK_KEX2_1	582	584	PF00082	0.649
CLV_PCSK_KEX2_1	91	93	PF00082	0.830
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.586
CLV_PCSK_PC7_1	312	318	PF00082	0.627
CLV_PCSK_SKI1_1	402	406	PF00082	0.685
CLV_PCSK_SKI1_1	446	450	PF00082	0.649
CLV_PCSK_SKI1_1	547	551	PF00082	0.537
CLV_PCSK_SKI1_1	553	557	PF00082	0.516
CLV_PCSK_SKI1_1	587	591	PF00082	0.811
CLV_PCSK_SKI1_1	91	95	PF00082	0.613
CLV_Separin_Metazoa	515	519	PF03568	0.658
DEG_APCC_DBOX_1	531	539	PF00400	0.649
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DEG_SCF_FBW7_1	93	98	PF00400	0.622
DEG_SPOP_SBC_1	170	174	PF00917	0.621
DEG_SPOP_SBC_1	612	616	PF00917	0.678
DOC_MAPK_gen_1	126	135	PF00069	0.708
DOC_MAPK_gen_1	468	476	PF00069	0.567
DOC_MAPK_gen_1	546	552	PF00069	0.539
DOC_MAPK_gen_1	558	565	PF00069	0.530
DOC_MAPK_MEF2A_6	126	135	PF00069	0.815
DOC_MAPK_MEF2A_6	27	34	PF00069	0.589
DOC_PP2B_LxvP_1	266	269	PF13499	0.690
DOC_PP4_FxxP_1	594	597	PF00568	0.551
DOC_PP4_FxxP_1	636	639	PF00568	0.598
DOC_USP7_MATH_1	151	155	PF00917	0.720
DOC_USP7_MATH_1	169	173	PF00917	0.694
DOC_USP7_MATH_1	325	329	PF00917	0.687
DOC_USP7_MATH_1	39	43	PF00917	0.819
DOC_USP7_MATH_1	411	415	PF00917	0.792
DOC_USP7_MATH_1	485	489	PF00917	0.629
DOC_USP7_MATH_1	578	582	PF00917	0.641
DOC_USP7_MATH_1	613	617	PF00917	0.690
DOC_WW_Pin1_4	103	108	PF00397	0.698
DOC_WW_Pin1_4	146	151	PF00397	0.728
DOC_WW_Pin1_4	210	215	PF00397	0.756
DOC_WW_Pin1_4	238	243	PF00397	0.773
DOC_WW_Pin1_4	261	266	PF00397	0.781
DOC_WW_Pin1_4	277	282	PF00397	0.517
DOC_WW_Pin1_4	37	42	PF00397	0.673
DOC_WW_Pin1_4	588	593	PF00397	0.721
DOC_WW_Pin1_4	616	621	PF00397	0.738
DOC_WW_Pin1_4	637	642	PF00397	0.693
DOC_WW_Pin1_4	7	12	PF00397	0.733
DOC_WW_Pin1_4	91	96	PF00397	0.786
LIG_14-3-3_CanoR_1	205	214	PF00244	0.769
LIG_14-3-3_CanoR_1	233	239	PF00244	0.696
LIG_14-3-3_CanoR_1	247	253	PF00244	0.580
LIG_14-3-3_CanoR_1	298	305	PF00244	0.494
LIG_14-3-3_CanoR_1	338	346	PF00244	0.625
LIG_14-3-3_CanoR_1	348	357	PF00244	0.510
LIG_14-3-3_CanoR_1	489	497	PF00244	0.575
LIG_14-3-3_CanoR_1	523	527	PF00244	0.538
LIG_Actin_WH2_2	487	504	PF00022	0.545
LIG_Actin_WH2_2	514	531	PF00022	0.548
LIG_BIR_III_4	631	635	PF00653	0.806
LIG_BRCT_BRCA1_1	590	594	PF00533	0.581
LIG_FHA_1	115	121	PF00498	0.762
LIG_FHA_1	130	136	PF00498	0.656
LIG_FHA_1	233	239	PF00498	0.734
LIG_FHA_1	277	283	PF00498	0.698
LIG_FHA_1	29	35	PF00498	0.779
LIG_FHA_1	338	344	PF00498	0.586
LIG_FHA_1	352	358	PF00498	0.486
LIG_FHA_1	432	438	PF00498	0.540
LIG_FHA_1	445	451	PF00498	0.549
LIG_FHA_1	489	495	PF00498	0.546
LIG_FHA_1	523	529	PF00498	0.543
LIG_FHA_2	359	365	PF00498	0.685
LIG_FHA_2	378	384	PF00498	0.492
LIG_FHA_2	403	409	PF00498	0.755
LIG_FHA_2	434	440	PF00498	0.650
LIG_FHA_2	50	56	PF00498	0.657
LIG_Integrin_RGD_1	219	221	PF01839	0.808
LIG_LIR_Apic_2	221	225	PF02991	0.718
LIG_LIR_Apic_2	591	597	PF02991	0.561
LIG_LIR_Apic_2	635	639	PF02991	0.599
LIG_LIR_Gen_1	172	182	PF02991	0.646
LIG_LIR_Nem_3	172	178	PF02991	0.664
LIG_MYND_1	261	265	PF01753	0.816
LIG_NRBOX	184	190	PF00104	0.632
LIG_NRBOX	342	348	PF00104	0.496
LIG_NRBOX	79	85	PF00104	0.614
LIG_PCNA_yPIPBox_3	468	480	PF02747	0.565
LIG_RPA_C_Fungi	578	590	PF08784	0.600
LIG_SH2_CRK	175	179	PF00017	0.626
LIG_SH2_CRK	222	226	PF00017	0.722
LIG_SH2_GRB2like	19	22	PF00017	0.793
LIG_SH2_NCK_1	20	24	PF00017	0.683
LIG_SH2_STAP1	175	179	PF00017	0.626
LIG_SH2_STAT3	479	482	PF00017	0.566
LIG_SH2_STAT5	293	296	PF00017	0.611
LIG_SH2_STAT5	479	482	PF00017	0.644
LIG_SH3_1	222	228	PF00018	0.717
LIG_SH3_1	27	33	PF00018	0.585
LIG_SH3_3	104	110	PF00018	0.661
LIG_SH3_3	128	134	PF00018	0.775
LIG_SH3_3	147	153	PF00018	0.556
LIG_SH3_3	222	228	PF00018	0.724
LIG_SH3_3	27	33	PF00018	0.675
LIG_SH3_3	272	278	PF00018	0.699
LIG_SH3_3	636	642	PF00018	0.599
LIG_SH3_3	8	14	PF00018	0.687
LIG_SH3_3	90	96	PF00018	0.681
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.539
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.614
LIG_SUMO_SIM_par_1	433	439	PF11976	0.537
LIG_SUMO_SIM_par_1	561	567	PF11976	0.634
LIG_SUMO_SIM_par_1	58	64	PF11976	0.735
LIG_TRAF2_1	145	148	PF00917	0.672
LIG_TRAF2_1	381	384	PF00917	0.544
LIG_TRAF2_1	512	515	PF00917	0.671
LIG_UBA3_1	437	446	PF00899	0.489
MOD_CDC14_SPxK_1	40	43	PF00782	0.695
MOD_CDC14_SPxK_1	640	643	PF00782	0.704
MOD_CDK_SPK_2	588	593	PF00069	0.724
MOD_CDK_SPxK_1	238	244	PF00069	0.708
MOD_CDK_SPxK_1	37	43	PF00069	0.674
MOD_CDK_SPxK_1	637	643	PF00069	0.698
MOD_CDK_SPxxK_3	106	113	PF00069	0.626
MOD_CK1_1	109	115	PF00069	0.644
MOD_CK1_1	141	147	PF00069	0.786
MOD_CK1_1	149	155	PF00069	0.798
MOD_CK1_1	201	207	PF00069	0.806
MOD_CK1_1	328	334	PF00069	0.633
MOD_CK1_1	349	355	PF00069	0.674
MOD_CK1_1	421	427	PF00069	0.667
MOD_CK1_1	488	494	PF00069	0.646
MOD_CK1_1	581	587	PF00069	0.683
MOD_CK1_1	614	620	PF00069	0.663
MOD_CK1_1	637	643	PF00069	0.632
MOD_CK2_1	141	147	PF00069	0.769
MOD_CK2_1	358	364	PF00069	0.559
MOD_CK2_1	377	383	PF00069	0.489
MOD_CK2_1	402	408	PF00069	0.749
MOD_CK2_1	49	55	PF00069	0.703
MOD_CK2_1	492	498	PF00069	0.528
MOD_CK2_1	509	515	PF00069	0.526
MOD_Cter_Amidation	314	317	PF01082	0.656
MOD_GlcNHglycan	144	147	PF01048	0.786
MOD_GlcNHglycan	2	5	PF01048	0.793
MOD_GlcNHglycan	200	203	PF01048	0.763
MOD_GlcNHglycan	299	302	PF01048	0.573
MOD_GlcNHglycan	327	330	PF01048	0.674
MOD_GlcNHglycan	334	337	PF01048	0.575
MOD_GlcNHglycan	408	412	PF01048	0.703
MOD_GlcNHglycan	413	416	PF01048	0.690
MOD_GlcNHglycan	420	423	PF01048	0.681
MOD_GlcNHglycan	469	473	PF01048	0.462
MOD_GlcNHglycan	493	497	PF01048	0.431
MOD_GlcNHglycan	583	586	PF01048	0.781
MOD_GlcNHglycan	606	609	PF01048	0.654
MOD_GlcNHglycan	621	624	PF01048	0.710
MOD_GlcNHglycan	635	639	PF01048	0.527
MOD_GlcNHglycan	98	101	PF01048	0.679
MOD_GSK3_1	109	116	PF00069	0.697
MOD_GSK3_1	138	145	PF00069	0.768
MOD_GSK3_1	201	208	PF00069	0.840
MOD_GSK3_1	234	241	PF00069	0.773
MOD_GSK3_1	255	262	PF00069	0.783
MOD_GSK3_1	28	35	PF00069	0.675
MOD_GSK3_1	328	335	PF00069	0.678
MOD_GSK3_1	407	414	PF00069	0.745
MOD_GSK3_1	417	424	PF00069	0.561
MOD_GSK3_1	488	495	PF00069	0.536
MOD_GSK3_1	541	548	PF00069	0.565
MOD_GSK3_1	55	62	PF00069	0.791
MOD_GSK3_1	611	618	PF00069	0.703
MOD_GSK3_1	91	98	PF00069	0.620
MOD_LATS_1	253	259	PF00433	0.658
MOD_N-GLC_1	444	449	PF02516	0.564
MOD_N-GLC_1	84	89	PF02516	0.775
MOD_N-GLC_2	69	71	PF02516	0.646
MOD_NEK2_1	346	351	PF00069	0.516
MOD_NEK2_1	431	436	PF00069	0.537
MOD_NEK2_1	545	550	PF00069	0.539
MOD_NEK2_1	84	89	PF00069	0.775
MOD_PIKK_1	101	107	PF00454	0.734
MOD_PIKK_1	255	261	PF00454	0.749
MOD_PIKK_1	439	445	PF00454	0.597
MOD_PIKK_1	509	515	PF00454	0.616
MOD_PIKK_1	61	67	PF00454	0.751
MOD_PKA_2	232	238	PF00069	0.763
MOD_PKA_2	297	303	PF00069	0.583
MOD_PKA_2	337	343	PF00069	0.550
MOD_PKA_2	488	494	PF00069	0.576
MOD_PKA_2	522	528	PF00069	0.541
MOD_PKA_2	545	551	PF00069	0.540
MOD_PKA_2	581	587	PF00069	0.682
MOD_Plk_1	444	450	PF00069	0.567
MOD_Plk_1	485	491	PF00069	0.634
MOD_Plk_2-3	22	28	PF00069	0.699
MOD_Plk_2-3	358	364	PF00069	0.475
MOD_Plk_2-3	433	439	PF00069	0.564
MOD_Plk_4	151	157	PF00069	0.776
MOD_Plk_4	433	439	PF00069	0.642
MOD_Plk_4	545	551	PF00069	0.552
MOD_Plk_4	76	82	PF00069	0.623
MOD_ProDKin_1	103	109	PF00069	0.700
MOD_ProDKin_1	146	152	PF00069	0.729
MOD_ProDKin_1	210	216	PF00069	0.757
MOD_ProDKin_1	238	244	PF00069	0.774
MOD_ProDKin_1	261	267	PF00069	0.775
MOD_ProDKin_1	277	283	PF00069	0.507
MOD_ProDKin_1	37	43	PF00069	0.674
MOD_ProDKin_1	588	594	PF00069	0.720
MOD_ProDKin_1	616	622	PF00069	0.738
MOD_ProDKin_1	637	643	PF00069	0.698
MOD_ProDKin_1	7	13	PF00069	0.733
MOD_ProDKin_1	91	97	PF00069	0.788
MOD_SUMO_for_1	538	541	PF00179	0.533
MOD_SUMO_rev_2	439	448	PF00179	0.596
MOD_SUMO_rev_2	493	501	PF00179	0.646
TRG_DiLeu_BaEn_1	76	81	PF01217	0.622
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.724
TRG_ENDOCYTIC_2	175	178	PF00928	0.660
TRG_ENDOCYTIC_2	20	23	PF00928	0.630
TRG_ER_diArg_1	557	560	PF00400	0.572
TRG_ER_diArg_1	568	571	PF00400	0.564
TRG_ER_diArg_1	89	92	PF00400	0.811
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P938	Leptomonas seymouri	42%	78%
A4H578	Leishmania braziliensis	68%	100%
A4HTG1	Leishmania infantum	100%	100%
E9AM89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIF8	Leishmania major	90%	100%