Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ50_LEIDO

TriTrypDb:

LdBPK_080120.1 , LdCL_080006100 , LDHU3_08.0150

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQ50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ50

PDB structure(s): 7ane_as

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.496
CLV_NRD_NRD_1	125	127	PF00675	0.467
CLV_NRD_NRD_1	223	225	PF00675	0.631
CLV_NRD_NRD_1	261	263	PF00675	0.446
CLV_PCSK_KEX2_1	125	127	PF00082	0.467
CLV_PCSK_KEX2_1	223	225	PF00082	0.521
CLV_PCSK_KEX2_1	261	263	PF00082	0.446
DEG_APCC_DBOX_1	194	202	PF00400	0.578
DOC_PP1_RVXF_1	260	267	PF00149	0.440
DOC_PP2B_LxvP_1	219	222	PF13499	0.498
DOC_PP2B_LxvP_1	70	73	PF13499	0.507
DOC_PP4_FxxP_1	174	177	PF00568	0.418
DOC_USP7_MATH_1	65	69	PF00917	0.511
DOC_USP7_MATH_2	30	36	PF00917	0.440
DOC_WW_Pin1_4	205	210	PF00397	0.645
DOC_WW_Pin1_4	213	218	PF00397	0.549
DOC_WW_Pin1_4	229	234	PF00397	0.423
LIG_14-3-3_CanoR_1	223	231	PF00244	0.654
LIG_14-3-3_CanoR_1	261	265	PF00244	0.423
LIG_APCC_ABBA_1	140	145	PF00400	0.479
LIG_FHA_1	214	220	PF00498	0.637
LIG_FHA_2	129	135	PF00498	0.490
LIG_FHA_2	230	236	PF00498	0.626
LIG_LIR_Apic_2	235	240	PF02991	0.578
LIG_LIR_Gen_1	166	177	PF02991	0.404
LIG_LIR_Gen_1	185	196	PF02991	0.370
LIG_LIR_Gen_1	25	34	PF02991	0.402
LIG_LIR_Nem_3	166	172	PF02991	0.388
LIG_LIR_Nem_3	185	191	PF02991	0.378
LIG_LIR_Nem_3	213	218	PF02991	0.630
LIG_LIR_Nem_3	25	29	PF02991	0.425
LIG_LIR_Nem_3	98	103	PF02991	0.595
LIG_LYPXL_yS_3	20	23	PF13949	0.481
LIG_PDZ_Class_1	265	270	PF00595	0.537
LIG_Pex14_1	266	270	PF04695	0.423
LIG_REV1ctd_RIR_1	172	176	PF16727	0.442
LIG_SH2_CRK	114	118	PF00017	0.451
LIG_SH2_CRK	237	241	PF00017	0.479
LIG_SH2_CRK	26	30	PF00017	0.420
LIG_SH2_STAP1	49	53	PF00017	0.373
LIG_SH2_STAT5	173	176	PF00017	0.426
LIG_SH2_STAT5	243	246	PF00017	0.466
LIG_SH2_STAT5	86	89	PF00017	0.405
LIG_SH3_1	230	236	PF00018	0.602
LIG_SH3_2	233	238	PF14604	0.579
LIG_SH3_3	174	180	PF00018	0.386
LIG_SH3_3	230	236	PF00018	0.588
LIG_TRAF2_1	163	166	PF00917	0.618
LIG_TYR_ITIM	18	23	PF00017	0.475
LIG_TYR_ITIM	24	29	PF00017	0.389
MOD_CDC14_SPxK_1	208	211	PF00782	0.580
MOD_CDK_SPxK_1	205	211	PF00069	0.580
MOD_CK1_1	152	158	PF00069	0.470
MOD_CK1_1	197	203	PF00069	0.565
MOD_CK1_1	22	28	PF00069	0.455
MOD_CK1_1	35	41	PF00069	0.445
MOD_CK1_1	98	104	PF00069	0.582
MOD_CK2_1	229	235	PF00069	0.633
MOD_CMANNOS	266	269	PF00535	0.417
MOD_Cter_Amidation	259	262	PF01082	0.435
MOD_GlcNHglycan	131	134	PF01048	0.504
MOD_GlcNHglycan	151	154	PF01048	0.274
MOD_GSK3_1	148	155	PF00069	0.512
MOD_GSK3_1	32	39	PF00069	0.560
MOD_N-GLC_1	149	154	PF02516	0.575
MOD_NEK2_1	10	15	PF00069	0.504
MOD_NEK2_1	148	153	PF00069	0.558
MOD_NEK2_1	265	270	PF00069	0.537
MOD_NEK2_1	3	8	PF00069	0.544
MOD_NEK2_2	167	172	PF00069	0.428
MOD_PIKK_1	161	167	PF00454	0.601
MOD_PIKK_1	182	188	PF00454	0.565
MOD_PKA_2	194	200	PF00069	0.522
MOD_PKA_2	222	228	PF00069	0.668
MOD_PKA_2	260	266	PF00069	0.423
MOD_PKA_2	3	9	PF00069	0.620
MOD_Plk_4	19	25	PF00069	0.473
MOD_ProDKin_1	205	211	PF00069	0.645
MOD_ProDKin_1	213	219	PF00069	0.548
MOD_ProDKin_1	229	235	PF00069	0.419
TRG_AP2beta_CARGO_1	166	176	PF09066	0.467
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.426
TRG_ENDOCYTIC_2	114	117	PF00928	0.390
TRG_ENDOCYTIC_2	20	23	PF00928	0.455
TRG_ENDOCYTIC_2	26	29	PF00928	0.403
TRG_ENDOCYTIC_2	49	52	PF00928	0.361
TRG_ER_diArg_1	124	126	PF00400	0.474
TRG_ER_diArg_1	222	224	PF00400	0.640
TRG_ER_diArg_1	77	80	PF00400	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B2	Leptomonas seymouri	68%	100%
A0A0S4IR07	Bodo saltans	38%	100%
A0A1X0NNZ6	Trypanosomatidae	50%	100%
A0A3R7NMZ5	Trypanosoma rangeli	49%	100%
A4H579	Leishmania braziliensis	85%	100%
A4HTG2	Leishmania infantum	100%	100%
C9ZPP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AM90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QIF7	Leishmania major	98%	100%
V5DDB9	Trypanosoma cruzi	49%	100%