Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ18_LEIDO

TriTrypDb:

LdBPK_071290.1 , LdCL_070017900 , LDHU3_07.1520

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7WQ18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.568
CLV_NRD_NRD_1	229	231	PF00675	0.563
CLV_NRD_NRD_1	252	254	PF00675	0.546
CLV_NRD_NRD_1	260	262	PF00675	0.508
CLV_NRD_NRD_1	27	29	PF00675	0.489
CLV_NRD_NRD_1	302	304	PF00675	0.592
CLV_NRD_NRD_1	32	34	PF00675	0.463
CLV_PCSK_FUR_1	25	29	PF00082	0.468
CLV_PCSK_KEX2_1	251	253	PF00082	0.549
CLV_PCSK_KEX2_1	260	262	PF00082	0.480
CLV_PCSK_KEX2_1	27	29	PF00082	0.489
CLV_PCSK_KEX2_1	292	294	PF00082	0.693
CLV_PCSK_KEX2_1	32	34	PF00082	0.463
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.510
CLV_PCSK_PC7_1	28	34	PF00082	0.496
CLV_PCSK_SKI1_1	273	277	PF00082	0.541
CLV_PCSK_SKI1_1	42	46	PF00082	0.584
DEG_APCC_DBOX_1	251	259	PF00400	0.502
DOC_CYCLIN_yClb5_NLxxxL_5	133	141	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.571
DOC_MAPK_gen_1	292	300	PF00069	0.722
DOC_MAPK_gen_1	318	326	PF00069	0.490
DOC_MAPK_MEF2A_6	133	141	PF00069	0.523
DOC_MAPK_MEF2A_6	292	300	PF00069	0.509
DOC_MAPK_NFAT4_5	293	301	PF00069	0.501
DOC_PP2B_LxvP_1	174	177	PF13499	0.551
DOC_PP2B_LxvP_1	298	301	PF13499	0.487
DOC_USP7_MATH_1	180	184	PF00917	0.566
DOC_USP7_MATH_1	186	190	PF00917	0.502
DOC_USP7_MATH_1	310	314	PF00917	0.514
DOC_WW_Pin1_4	218	223	PF00397	0.621
LIG_14-3-3_CanoR_1	115	124	PF00244	0.510
LIG_14-3-3_CanoR_1	264	272	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	188	192	PF00533	0.418
LIG_FHA_1	169	175	PF00498	0.582
LIG_FHA_1	219	225	PF00498	0.718
LIG_FHA_1	277	283	PF00498	0.538
LIG_FHA_1	292	298	PF00498	0.695
LIG_FHA_1	330	336	PF00498	0.510
LIG_FHA_1	72	78	PF00498	0.510
LIG_FHA_2	234	240	PF00498	0.621
LIG_FHA_2	266	272	PF00498	0.450
LIG_FHA_2	47	53	PF00498	0.583
LIG_LIR_Gen_1	38	47	PF02991	0.487
LIG_LIR_Nem_3	24	29	PF02991	0.512
LIG_LIR_Nem_3	38	43	PF02991	0.492
LIG_LIR_Nem_3	8	12	PF02991	0.622
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.456
LIG_SH2_CRK	40	44	PF00017	0.535
LIG_SH2_NCK_1	86	90	PF00017	0.574
LIG_SH2_SRC	86	89	PF00017	0.361
LIG_SH2_STAP1	210	214	PF00017	0.635
LIG_SH2_STAP1	278	282	PF00017	0.560
LIG_SH2_STAP1	40	44	PF00017	0.462
LIG_SH2_STAT5	278	281	PF00017	0.451
LIG_SH2_STAT5	348	351	PF00017	0.491
LIG_SH2_STAT5	40	43	PF00017	0.532
LIG_SH2_STAT5	96	99	PF00017	0.463
LIG_SH3_3	174	180	PF00018	0.524
LIG_SUMO_SIM_anti_2	73	81	PF11976	0.552
LIG_SUMO_SIM_par_1	294	302	PF11976	0.495
LIG_TRAF2_1	155	158	PF00917	0.428
LIG_TRAF2_1	213	216	PF00917	0.627
LIG_UBA3_1	296	304	PF00899	0.479
LIG_WRC_WIRS_1	47	52	PF05994	0.582
LIG_WRC_WIRS_1	6	11	PF05994	0.623
MOD_CK1_1	299	305	PF00069	0.607
MOD_CK1_1	330	336	PF00069	0.551
MOD_CK2_1	310	316	PF00069	0.554
MOD_CK2_1	46	52	PF00069	0.532
MOD_GlcNHglycan	188	191	PF01048	0.509
MOD_GlcNHglycan	329	332	PF01048	0.464
MOD_GSK3_1	165	172	PF00069	0.397
MOD_GSK3_1	186	193	PF00069	0.481
MOD_GSK3_1	233	240	PF00069	0.689
MOD_GSK3_1	38	45	PF00069	0.466
MOD_LATS_1	113	119	PF00433	0.578
MOD_N-GLC_1	218	223	PF02516	0.684
MOD_NEK2_1	165	170	PF00069	0.375
MOD_NEK2_1	21	26	PF00069	0.484
MOD_NEK2_1	225	230	PF00069	0.689
MOD_NEK2_1	296	301	PF00069	0.641
MOD_NEK2_1	351	356	PF00069	0.414
MOD_PKA_2	327	333	PF00069	0.418
MOD_PKA_2	53	59	PF00069	0.603
MOD_Plk_2-3	46	52	PF00069	0.502
MOD_Plk_4	13	19	PF00069	0.581
MOD_Plk_4	169	175	PF00069	0.480
MOD_Plk_4	330	336	PF00069	0.501
MOD_ProDKin_1	218	224	PF00069	0.621
MOD_SUMO_rev_2	313	320	PF00179	0.579
MOD_SUMO_rev_2	65	71	PF00179	0.600
TRG_DiLeu_BaEn_1	39	44	PF01217	0.606
TRG_DiLeu_BaEn_3	119	125	PF01217	0.553
TRG_ENDOCYTIC_2	114	117	PF00928	0.501
TRG_ENDOCYTIC_2	347	350	PF00928	0.418
TRG_ENDOCYTIC_2	40	43	PF00928	0.485
TRG_ENDOCYTIC_2	86	89	PF00928	0.560
TRG_ER_diArg_1	251	253	PF00400	0.636
TRG_ER_diArg_1	259	261	PF00400	0.604
TRG_ER_diArg_1	26	28	PF00400	0.494
TRG_ER_diArg_1	31	33	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I2	Leptomonas seymouri	68%	99%
A0A1X0NRB2	Trypanosomatidae	42%	100%
A0A3R7MAC7	Trypanosoma rangeli	47%	100%
A4H560	Leishmania braziliensis	85%	100%
A4HTD7	Leishmania infantum	99%	100%
C9ZUH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ALD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QIH5	Leishmania major	93%	100%
V5B8H7	Trypanosoma cruzi	45%	100%