von Willebrand factor type A domain family protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQ17_LEIDO

TriTrypDb:

LdBPK_071300.1 , LdCL_070018000 , LDHU3_07.1530

Length:

345

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008540	proteasome regulatory particle, base subcomplex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote/Amastigote: 344, 345

Expansion

Sequence features

A0A3S7WQ17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ17

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.331
CLV_NRD_NRD_1	132	134	PF00675	0.504
CLV_NRD_NRD_1	285	287	PF00675	0.473
CLV_PCSK_KEX2_1	108	110	PF00082	0.547
CLV_PCSK_KEX2_1	285	287	PF00082	0.473
CLV_PCSK_KEX2_1	83	85	PF00082	0.586
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.561
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.586
CLV_Separin_Metazoa	282	286	PF03568	0.512
DEG_APCC_KENBOX_2	162	166	PF00400	0.645
DEG_SPOP_SBC_1	311	315	PF00917	0.889
DOC_CYCLIN_yClb1_LxF_4	45	51	PF00134	0.427
DOC_CYCLIN_yClb5_NLxxxL_5	174	181	PF00134	0.644
DOC_MAPK_gen_1	105	113	PF00069	0.347
DOC_MAPK_gen_1	130	141	PF00069	0.482
DOC_MAPK_gen_1	285	292	PF00069	0.473
DOC_MAPK_MEF2A_6	133	141	PF00069	0.470
DOC_MAPK_MEF2A_6	285	292	PF00069	0.473
DOC_MAPK_NFAT4_5	285	293	PF00069	0.473
DOC_PP1_RVXF_1	107	114	PF00149	0.347
DOC_USP7_MATH_1	201	205	PF00917	0.765
DOC_USP7_MATH_1	237	241	PF00917	0.665
DOC_USP7_MATH_1	249	253	PF00917	0.743
DOC_USP7_MATH_1	312	316	PF00917	0.823
DOC_USP7_UBL2_3	130	134	PF12436	0.537
DOC_USP7_UBL2_3	158	162	PF12436	0.624
DOC_WW_Pin1_4	113	118	PF00397	0.401
DOC_WW_Pin1_4	252	257	PF00397	0.839
DOC_WW_Pin1_4	301	306	PF00397	0.841
LIG_14-3-3_CanoR_1	221	225	PF00244	0.420
LIG_14-3-3_CanoR_1	84	93	PF00244	0.380
LIG_CaM_IQ_9	150	165	PF13499	0.654
LIG_FHA_1	176	182	PF00498	0.543
LIG_FHA_1	63	69	PF00498	0.364
LIG_FHA_2	119	125	PF00498	0.505
LIG_FHA_2	311	317	PF00498	0.779
LIG_FHA_2	57	63	PF00498	0.361
LIG_GBD_Chelix_1	216	224	PF00786	0.420
LIG_LIR_Gen_1	166	173	PF02991	0.515
LIG_LIR_Gen_1	272	283	PF02991	0.744
LIG_LIR_Gen_1	3	14	PF02991	0.400
LIG_LIR_Gen_1	59	68	PF02991	0.399
LIG_LIR_Nem_3	166	171	PF02991	0.505
LIG_LIR_Nem_3	3	9	PF02991	0.426
LIG_LIR_Nem_3	59	64	PF02991	0.409
LIG_MAD2	109	117	PF02301	0.347
LIG_PTAP_UEV_1	305	310	PF05743	0.707
LIG_SH2_GRB2like	275	278	PF00017	0.765
LIG_SH3_3	111	117	PF00018	0.427
LIG_SH3_3	253	259	PF00018	0.765
LIG_SH3_3	303	309	PF00018	0.872
LIG_SUMO_SIM_anti_2	147	154	PF11976	0.583
LIG_TRAF2_1	279	282	PF00917	0.418
MOD_CK1_1	252	258	PF00069	0.841
MOD_CK1_1	300	306	PF00069	0.822
MOD_CK1_1	74	80	PF00069	0.402
MOD_CK1_1	99	105	PF00069	0.347
MOD_CK2_1	101	107	PF00069	0.403
MOD_CK2_1	118	124	PF00069	0.390
MOD_CK2_1	145	151	PF00069	0.615
MOD_CK2_1	158	164	PF00069	0.625
MOD_CK2_1	276	282	PF00069	0.400
MOD_CK2_1	310	316	PF00069	0.799
MOD_CK2_1	56	62	PF00069	0.361
MOD_Cter_Amidation	81	84	PF01082	0.586
MOD_GlcNHglycan	203	206	PF01048	0.751
MOD_GlcNHglycan	240	243	PF01048	0.761
MOD_GlcNHglycan	245	248	PF01048	0.784
MOD_GlcNHglycan	249	252	PF01048	0.799
MOD_GlcNHglycan	294	297	PF01048	0.610
MOD_GlcNHglycan	306	309	PF01048	0.638
MOD_GlcNHglycan	88	91	PF01048	0.596
MOD_GSK3_1	243	250	PF00069	0.787
MOD_GSK3_1	288	295	PF00069	0.509
MOD_GSK3_1	297	304	PF00069	0.748
MOD_GSK3_1	310	317	PF00069	0.734
MOD_GSK3_1	56	63	PF00069	0.361
MOD_GSK3_1	70	77	PF00069	0.361
MOD_GSK3_1	92	99	PF00069	0.370
MOD_N-GLC_1	175	180	PF02516	0.552
MOD_N-GLC_1	201	206	PF02516	0.734
MOD_N-GLC_1	276	281	PF02516	0.631
MOD_N-GLC_1	85	90	PF02516	0.597
MOD_N-GLC_2	56	58	PF02516	0.547
MOD_NEK2_1	292	297	PF00069	0.510
MOD_NEK2_1	50	55	PF00069	0.451
MOD_NEK2_1	96	101	PF00069	0.347
MOD_PKA_1	158	164	PF00069	0.594
MOD_PKA_2	220	226	PF00069	0.420
MOD_Plk_1	163	169	PF00069	0.593
MOD_Plk_1	271	277	PF00069	0.758
MOD_Plk_1	44	50	PF00069	0.347
MOD_Plk_2-3	271	277	PF00069	0.705
MOD_Plk_4	56	62	PF00069	0.361
MOD_ProDKin_1	113	119	PF00069	0.410
MOD_ProDKin_1	252	258	PF00069	0.837
MOD_ProDKin_1	301	307	PF00069	0.841
TRG_DiLeu_BaEn_2	163	169	PF01217	0.630
TRG_ENDOCYTIC_2	275	278	PF00928	0.779
TRG_ENDOCYTIC_2	61	64	PF00928	0.451
TRG_ER_diArg_1	284	286	PF00400	0.473
TRG_NLS_MonoExtC_3	129	134	PF00514	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L9	Leptomonas seymouri	72%	100%
A0A1X0NPW3	Trypanosomatidae	55%	100%
A0A3R7NGB6	Trypanosoma rangeli	59%	99%
A4H561	Leishmania braziliensis	86%	99%
A4HTD8	Leishmania infantum	100%	100%
C9ZUH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ALD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O17453	Schistosoma mansoni	35%	82%
O61742	Caenorhabditis elegans	40%	100%
O82143	Oryza sativa subsp. japonica	37%	86%
O94444	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P38886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P55034	Arabidopsis thaliana	38%	89%
P55035	Drosophila melanogaster	37%	87%
Q4QIH4	Leishmania major	97%	100%
V5DQ49	Trypanosoma cruzi	60%	100%