Radial_spokehead-like_protein_putative/Pfam:PF047 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ16_LEIDO

TriTrypDb:

LdBPK_071080.1 , LdCL_070015600 , LDHU3_07.1290

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	2
GO:0005930	axoneme	2	1
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WQ16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ16

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0003341	cilium movement	4	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.634
CLV_PCSK_KEX2_1	181	183	PF00082	0.534
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.534
CLV_PCSK_SKI1_1	182	186	PF00082	0.650
CLV_PCSK_SKI1_1	298	302	PF00082	0.403
DOC_CKS1_1	125	130	PF01111	0.532
DOC_MAPK_gen_1	180	191	PF00069	0.458
DOC_MAPK_gen_1	34	42	PF00069	0.434
DOC_PP1_SILK_1	129	134	PF00149	0.395
DOC_USP7_MATH_1	152	156	PF00917	0.617

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL99	Leptomonas seymouri	72%	98%
A0A0S4J8G1	Bodo saltans	39%	100%
A0A1X0NQ76	Trypanosomatidae	49%	100%
A0A3R7MSU5	Trypanosoma rangeli	49%	99%
A4H541	Leishmania braziliensis	86%	100%
A4HTB7	Leishmania infantum	97%	100%
C9ZUK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ALB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
E9B489	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%

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