Radial_spokehead-like_protein_putative/Pfam:PF047 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQ16_LEIDO

TriTrypDb:

LdBPK_071080.1 , LdCL_070015600 , LDHU3_07.1290

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0001534	radial spoke	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

A0A3S7WQ16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQ16

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0003341	cilium movement	4	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0030030	cell projection organization	4	3
GO:0030031	cell projection assembly	5	3
GO:0035082	axoneme assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	3
GO:0060271	cilium assembly	6	3
GO:0060294	cilium movement involved in cell motility	5	3
GO:0070925	organelle assembly	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0120031	plasma membrane bounded cell projection assembly	6	3
GO:0120036	plasma membrane bounded cell projection organization	5	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.634
CLV_PCSK_KEX2_1	181	183	PF00082	0.534
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.534
CLV_PCSK_SKI1_1	182	186	PF00082	0.650
CLV_PCSK_SKI1_1	298	302	PF00082	0.403
DOC_CKS1_1	125	130	PF01111	0.532
DOC_MAPK_gen_1	180	191	PF00069	0.458
DOC_MAPK_gen_1	34	42	PF00069	0.434
DOC_PP1_SILK_1	129	134	PF00149	0.395
DOC_USP7_MATH_1	152	156	PF00917	0.617
DOC_USP7_MATH_1	226	230	PF00917	0.407
DOC_USP7_MATH_1	66	70	PF00917	0.457
DOC_USP7_UBL2_3	181	185	PF12436	0.508
DOC_USP7_UBL2_3	41	45	PF12436	0.420
DOC_WW_Pin1_4	124	129	PF00397	0.568
DOC_WW_Pin1_4	35	40	PF00397	0.456
LIG_14-3-3_CanoR_1	187	192	PF00244	0.511
LIG_14-3-3_CanoR_1	209	213	PF00244	0.365
LIG_14-3-3_CanoR_1	227	232	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.360
LIG_FHA_1	267	273	PF00498	0.403
LIG_FHA_1	289	295	PF00498	0.401
LIG_FHA_2	15	21	PF00498	0.497
LIG_LIR_Apic_2	269	274	PF02991	0.473
LIG_LIR_Apic_2	305	311	PF02991	0.322
LIG_LIR_Gen_1	105	114	PF02991	0.447
LIG_LIR_Gen_1	243	251	PF02991	0.357
LIG_LIR_Gen_1	78	85	PF02991	0.518
LIG_LIR_Nem_3	69	73	PF02991	0.382
LIG_LIR_Nem_3	78	82	PF02991	0.406
LIG_PDZ_Class_2	329	334	PF00595	0.379
LIG_Pex14_1	284	288	PF04695	0.325
LIG_Pex14_2	328	332	PF04695	0.421
LIG_PTB_Apo_2	2	9	PF02174	0.427
LIG_PTB_Apo_2	296	303	PF02174	0.326
LIG_PTB_Apo_2	58	65	PF02174	0.507
LIG_PTB_Phospho_1	2	8	PF10480	0.433
LIG_PTB_Phospho_1	296	302	PF10480	0.364
LIG_SH2_CRK	100	104	PF00017	0.415
LIG_SH2_CRK	320	324	PF00017	0.408
LIG_SH2_STAP1	106	110	PF00017	0.470
LIG_SH2_STAT3	216	219	PF00017	0.438
LIG_SH2_STAT5	216	219	PF00017	0.408
LIG_SH2_STAT5	245	248	PF00017	0.335
LIG_SH2_STAT5	271	274	PF00017	0.489
LIG_SH2_STAT5	320	323	PF00017	0.349
LIG_SH2_STAT5	8	11	PF00017	0.483
LIG_SH3_3	120	126	PF00018	0.575
LIG_SH3_3	173	179	PF00018	0.604
LIG_SH3_5	267	271	PF00018	0.494
LIG_SUMO_SIM_par_1	187	193	PF11976	0.405
MOD_CAAXbox	331	334	PF01239	0.422
MOD_CDK_SPxK_1	35	41	PF00069	0.448
MOD_CK1_1	14	20	PF00069	0.492
MOD_CK1_1	69	75	PF00069	0.401
MOD_CK1_1	83	89	PF00069	0.477
MOD_CK2_1	14	20	PF00069	0.344
MOD_CK2_1	187	193	PF00069	0.463
MOD_GSK3_1	143	150	PF00069	0.546
MOD_N-GLC_1	227	232	PF02516	0.537
MOD_N-GLC_1	288	293	PF02516	0.427
MOD_NEK2_1	11	16	PF00069	0.446
MOD_NEK2_1	24	29	PF00069	0.284
MOD_NEK2_2	208	213	PF00069	0.439
MOD_NEK2_2	282	287	PF00069	0.477
MOD_NEK2_2	302	307	PF00069	0.398
MOD_NEK2_2	66	71	PF00069	0.452
MOD_PIKK_1	29	35	PF00454	0.511
MOD_PK_1	187	193	PF00069	0.508
MOD_PKA_1	240	246	PF00069	0.483
MOD_PKA_2	208	214	PF00069	0.371
MOD_PKA_2	226	232	PF00069	0.562
MOD_Plk_1	19	25	PF00069	0.441
MOD_Plk_1	227	233	PF00069	0.567
MOD_Plk_2-3	147	153	PF00069	0.605
MOD_Plk_4	302	308	PF00069	0.314
MOD_Plk_4	66	72	PF00069	0.419
MOD_ProDKin_1	124	130	PF00069	0.562
MOD_ProDKin_1	35	41	PF00069	0.453
TRG_DiLeu_BaEn_3	254	260	PF01217	0.512
TRG_DiLeu_BaEn_4	87	93	PF01217	0.455
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.356
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.368
TRG_ENDOCYTIC_2	100	103	PF00928	0.474
TRG_ENDOCYTIC_2	106	109	PF00928	0.480
TRG_ENDOCYTIC_2	245	248	PF00928	0.323
TRG_ENDOCYTIC_2	8	11	PF00928	0.495
TRG_ER_diArg_1	179	182	PF00400	0.567
TRG_ER_diArg_1	256	259	PF00400	0.422
TRG_NLS_MonoExtN_4	177	184	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL99	Leptomonas seymouri	72%	98%
A0A0S4J8G1	Bodo saltans	39%	100%
A0A1X0NQ76	Trypanosomatidae	49%	100%
A0A3R7MSU5	Trypanosoma rangeli	49%	99%
A4H541	Leishmania braziliensis	86%	100%
A4HTB7	Leishmania infantum	97%	100%
C9ZUK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ALB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
E9B489	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q2KIU7	Bos taurus	24%	100%
Q4Q3T7	Leishmania major	24%	100%
Q4QIJ4	Leishmania major	98%	100%
Q5TYW6	Danio rerio	26%	100%
Q9D9V4	Mus musculus	24%	100%
Q9H1X1	Homo sapiens	24%	100%
V5B8M6	Trypanosoma cruzi	28%	100%