Splicing factor ptsr1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor ptsr1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WPZ1_LEIDO

TriTrypDb:

LdBPK_071020.1 , LdCL_070014900 , LDHU3_07.1200

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WPZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.635
CLV_NRD_NRD_1	218	220	PF00675	0.531
CLV_NRD_NRD_1	234	236	PF00675	0.393
CLV_NRD_NRD_1	258	260	PF00675	0.723
CLV_NRD_NRD_1	273	275	PF00675	0.790
CLV_NRD_NRD_1	288	290	PF00675	0.558
CLV_NRD_NRD_1	297	299	PF00675	0.632
CLV_NRD_NRD_1	303	305	PF00675	0.575
CLV_NRD_NRD_1	327	329	PF00675	0.733
CLV_NRD_NRD_1	340	342	PF00675	0.559
CLV_NRD_NRD_1	343	345	PF00675	0.535
CLV_NRD_NRD_1	353	355	PF00675	0.647
CLV_NRD_NRD_1	363	365	PF00675	0.720
CLV_NRD_NRD_1	366	368	PF00675	0.691
CLV_NRD_NRD_1	371	373	PF00675	0.582
CLV_PCSK_FUR_1	301	305	PF00082	0.735
CLV_PCSK_FUR_1	325	329	PF00082	0.731
CLV_PCSK_FUR_1	338	342	PF00082	0.569
CLV_PCSK_FUR_1	364	368	PF00082	0.814
CLV_PCSK_KEX2_1	163	165	PF00082	0.635
CLV_PCSK_KEX2_1	218	220	PF00082	0.531
CLV_PCSK_KEX2_1	234	236	PF00082	0.393
CLV_PCSK_KEX2_1	260	262	PF00082	0.783
CLV_PCSK_KEX2_1	273	275	PF00082	0.790
CLV_PCSK_KEX2_1	287	289	PF00082	0.573
CLV_PCSK_KEX2_1	296	298	PF00082	0.631
CLV_PCSK_KEX2_1	303	305	PF00082	0.565
CLV_PCSK_KEX2_1	327	329	PF00082	0.733
CLV_PCSK_KEX2_1	340	342	PF00082	0.559
CLV_PCSK_KEX2_1	343	345	PF00082	0.535
CLV_PCSK_KEX2_1	352	354	PF00082	0.656
CLV_PCSK_KEX2_1	363	365	PF00082	0.711
CLV_PCSK_KEX2_1	366	368	PF00082	0.685
CLV_PCSK_KEX2_1	371	373	PF00082	0.670
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.635
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.704
CLV_PCSK_PC7_1	269	275	PF00082	0.780
CLV_PCSK_PC7_1	293	299	PF00082	0.705
CLV_PCSK_PC7_1	359	365	PF00082	0.776
CLV_PCSK_PC7_1	367	373	PF00082	0.719
CLV_PCSK_SKI1_1	117	121	PF00082	0.510
CLV_PCSK_SKI1_1	185	189	PF00082	0.508
CLV_PCSK_SKI1_1	88	92	PF00082	0.559
DEG_APCC_KENBOX_2	159	163	PF00400	0.619
DEG_SPOP_SBC_1	121	125	PF00917	0.503
DOC_MAPK_gen_1	142	149	PF00069	0.540
DOC_MAPK_MEF2A_6	142	151	PF00069	0.541
DOC_MAPK_MEF2A_6	74	83	PF00069	0.556
DOC_MAPK_RevD_3	248	261	PF00069	0.511
DOC_USP7_MATH_1	15	19	PF00917	0.787
DOC_USP7_MATH_1	202	206	PF00917	0.468
DOC_USP7_MATH_1	23	27	PF00917	0.603
DOC_WW_Pin1_4	261	266	PF00397	0.705
DOC_WW_Pin1_4	304	309	PF00397	0.798
DOC_WW_Pin1_4	328	333	PF00397	0.766
DOC_WW_Pin1_4	58	63	PF00397	0.746
LIG_14-3-3_CanoR_1	301	307	PF00244	0.696
LIG_14-3-3_CanoR_1	31	39	PF00244	0.729
LIG_14-3-3_CanoR_1	311	317	PF00244	0.642
LIG_14-3-3_CanoR_1	325	331	PF00244	0.686
LIG_14-3-3_CanoR_1	88	93	PF00244	0.562
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_FHA_1	121	127	PF00498	0.564
LIG_FHA_1	231	237	PF00498	0.619
LIG_FHA_1	87	93	PF00498	0.529
LIG_FHA_1	94	100	PF00498	0.556
LIG_FHA_2	122	128	PF00498	0.516
LIG_FHA_2	153	159	PF00498	0.601
LIG_FHA_2	227	233	PF00498	0.495
LIG_FHA_2	46	52	PF00498	0.712
LIG_FHA_2	59	65	PF00498	0.532
LIG_FHA_2	89	95	PF00498	0.543
LIG_GBD_Chelix_1	236	244	PF00786	0.545
LIG_Integrin_RGD_1	367	369	PF01839	0.671
LIG_NRP_CendR_1	372	375	PF00754	0.708
LIG_Pex14_2	141	145	PF04695	0.475
LIG_PTB_Apo_2	135	142	PF02174	0.531
LIG_SH2_GRB2like	180	183	PF00017	0.587
LIG_SH2_NCK_1	224	228	PF00017	0.391
LIG_SH2_SRC	224	227	PF00017	0.492
LIG_SH2_STAT5	180	183	PF00017	0.593
LIG_SH2_STAT5	221	224	PF00017	0.592
LIG_SH2_STAT5	306	309	PF00017	0.723
LIG_SH2_STAT5	98	101	PF00017	0.531
LIG_SH3_2	69	74	PF14604	0.698
LIG_SH3_3	46	52	PF00018	0.640
LIG_SH3_3	66	72	PF00018	0.815
LIG_SUMO_SIM_par_1	88	94	PF11976	0.532
LIG_TRAF2_1	125	128	PF00917	0.509
MOD_CDC14_SPxK_1	264	267	PF00782	0.713
MOD_CDK_SPxK_1	261	267	PF00069	0.707
MOD_CDK_SPxxK_3	304	311	PF00069	0.729
MOD_CK1_1	152	158	PF00069	0.590
MOD_CK1_1	30	36	PF00069	0.732
MOD_CK1_1	302	308	PF00069	0.807
MOD_CK1_1	309	315	PF00069	0.779
MOD_CK1_1	317	323	PF00069	0.655
MOD_CK1_1	331	337	PF00069	0.605
MOD_CK2_1	121	127	PF00069	0.514
MOD_CK2_1	152	158	PF00069	0.590
MOD_CK2_1	202	208	PF00069	0.521
MOD_CK2_1	45	51	PF00069	0.671
MOD_CK2_1	88	94	PF00069	0.556
MOD_Cter_Amidation	294	297	PF01082	0.652
MOD_Cter_Amidation	325	328	PF01082	0.732
MOD_DYRK1A_RPxSP_1	304	308	PF00069	0.727
MOD_DYRK1A_RPxSP_1	328	332	PF00069	0.727
MOD_GlcNHglycan	17	20	PF01048	0.611
MOD_GlcNHglycan	21	24	PF01048	0.555
MOD_GlcNHglycan	27	30	PF01048	0.621
MOD_GlcNHglycan	45	48	PF01048	0.691
MOD_GlcNHglycan	7	10	PF01048	0.739
MOD_GSK3_1	1	8	PF00069	0.735
MOD_GSK3_1	13	20	PF00069	0.641
MOD_GSK3_1	21	28	PF00069	0.631
MOD_GSK3_1	226	233	PF00069	0.598
MOD_GSK3_1	29	36	PF00069	0.642
MOD_GSK3_1	302	309	PF00069	0.793
MOD_GSK3_1	310	317	PF00069	0.701
MOD_GSK3_1	86	93	PF00069	0.469
MOD_LATS_1	285	291	PF00433	0.731
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	120	125	PF00069	0.539
MOD_PIKK_1	7	13	PF00454	0.776
MOD_PKA_1	287	293	PF00069	0.734
MOD_PKA_2	169	175	PF00069	0.681
MOD_PKA_2	280	286	PF00069	0.711
MOD_PKA_2	287	293	PF00069	0.671
MOD_PKA_2	30	36	PF00069	0.803
MOD_PKA_2	302	308	PF00069	0.564
MOD_PKA_2	310	316	PF00069	0.662
MOD_PKA_2	326	332	PF00069	0.664
MOD_PKA_2	339	345	PF00069	0.578
MOD_PKB_1	287	295	PF00069	0.733
MOD_PKB_1	319	327	PF00069	0.735
MOD_PKB_1	352	360	PF00069	0.601
MOD_Plk_1	121	127	PF00069	0.516
MOD_Plk_2-3	122	128	PF00069	0.518
MOD_Plk_4	253	259	PF00069	0.551
MOD_Plk_4	75	81	PF00069	0.557
MOD_ProDKin_1	261	267	PF00069	0.707
MOD_ProDKin_1	304	310	PF00069	0.798
MOD_ProDKin_1	328	334	PF00069	0.766
MOD_ProDKin_1	58	64	PF00069	0.748
TRG_DiLeu_BaEn_1	128	133	PF01217	0.519
TRG_DiLeu_BaEn_1	247	252	PF01217	0.490
TRG_ENDOCYTIC_2	224	227	PF00928	0.492
TRG_ER_diArg_1	112	115	PF00400	0.538
TRG_ER_diArg_1	234	236	PF00400	0.484
TRG_ER_diArg_1	258	261	PF00400	0.758
TRG_ER_diArg_1	272	274	PF00400	0.812
TRG_ER_diArg_1	287	289	PF00400	0.554
TRG_ER_diArg_1	296	298	PF00400	0.629
TRG_ER_diArg_1	301	304	PF00400	0.577
TRG_ER_diArg_1	325	328	PF00400	0.732
TRG_ER_diArg_1	340	343	PF00400	0.735
TRG_ER_diArg_1	352	354	PF00400	0.647
TRG_ER_diArg_1	371	374	PF00400	0.787
TRG_NLS_MonoCore_2	162	167	PF00514	0.631
TRG_NLS_MonoExtC_3	162	168	PF00514	0.633
TRG_NLS_MonoExtN_4	160	167	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H537	Leishmania braziliensis	80%	100%
A4HTB3	Leishmania infantum	99%	100%
E9ALA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QIK0	Leishmania major	95%	100%