DNAJ-domain transmembrane-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain transmembrane-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WPX9_LEIDO

TriTrypDb:

LdBPK_070880.1 , LdCL_070013600 , LDHU3_07.1050

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WPX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.753
CLV_C14_Caspase3-7	215	219	PF00656	0.637
CLV_C14_Caspase3-7	394	398	PF00656	0.621
CLV_C14_Caspase3-7	42	46	PF00656	0.688
CLV_NRD_NRD_1	410	412	PF00675	0.474
CLV_NRD_NRD_1	64	66	PF00675	0.600
CLV_PCSK_KEX2_1	409	411	PF00082	0.478
CLV_PCSK_KEX2_1	64	66	PF00082	0.503
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.478
CLV_PCSK_SKI1_1	367	371	PF00082	0.313
DEG_COP1_1	138	148	PF00400	0.673
DEG_Nend_UBRbox_1	1	4	PF02207	0.674
DEG_SCF_FBW7_1	53	59	PF00400	0.681
DEG_SPOP_SBC_1	120	124	PF00917	0.774
DEG_SPOP_SBC_1	44	48	PF00917	0.792
DOC_CKS1_1	53	58	PF01111	0.683
DOC_CYCLIN_RxL_1	153	164	PF00134	0.546
DOC_MAPK_MEF2A_6	367	376	PF00069	0.313
DOC_PP2B_LxvP_1	320	323	PF13499	0.522
DOC_PP2B_LxvP_1	347	350	PF13499	0.526
DOC_USP7_MATH_1	105	109	PF00917	0.756
DOC_USP7_MATH_1	119	123	PF00917	0.723
DOC_USP7_MATH_1	144	148	PF00917	0.645
DOC_USP7_MATH_1	23	27	PF00917	0.733
DOC_USP7_MATH_1	31	35	PF00917	0.782
DOC_USP7_MATH_1	327	331	PF00917	0.480
DOC_USP7_MATH_1	40	44	PF00917	0.699
DOC_USP7_MATH_1	56	60	PF00917	0.784
DOC_USP7_MATH_1	81	85	PF00917	0.755
DOC_USP7_MATH_1	97	101	PF00917	0.696
DOC_WW_Pin1_4	12	17	PF00397	0.740
DOC_WW_Pin1_4	21	26	PF00397	0.659
DOC_WW_Pin1_4	278	283	PF00397	0.474
DOC_WW_Pin1_4	52	57	PF00397	0.767
DOC_WW_Pin1_4	83	88	PF00397	0.753
LIG_14-3-3_CanoR_1	247	253	PF00244	0.725
LIG_14-3-3_CanoR_1	319	323	PF00244	0.574
LIG_14-3-3_CanoR_1	324	330	PF00244	0.509
LIG_Actin_WH2_2	209	227	PF00022	0.517
LIG_CSL_BTD_1	347	350	PF09270	0.526
LIG_EH1_1	354	362	PF00400	0.458
LIG_FHA_1	13	19	PF00498	0.792
LIG_FHA_1	140	146	PF00498	0.715
LIG_FHA_1	155	161	PF00498	0.506
LIG_FHA_1	278	284	PF00498	0.554
LIG_FHA_1	288	294	PF00498	0.475
LIG_FHA_1	380	386	PF00498	0.335
LIG_FHA_1	84	90	PF00498	0.709
LIG_FHA_2	129	135	PF00498	0.761
LIG_FHA_2	202	208	PF00498	0.609
LIG_FHA_2	224	230	PF00498	0.558
LIG_FHA_2	247	253	PF00498	0.709
LIG_FHA_2	40	46	PF00498	0.688
LIG_GBD_Chelix_1	372	380	PF00786	0.453
LIG_LIR_Apic_2	345	351	PF02991	0.527
LIG_LIR_Gen_1	147	155	PF02991	0.537
LIG_LIR_Gen_1	15	25	PF02991	0.655
LIG_LIR_Gen_1	204	214	PF02991	0.643
LIG_LIR_Gen_1	354	361	PF02991	0.503
LIG_LIR_Nem_3	147	151	PF02991	0.545
LIG_LIR_Nem_3	15	20	PF02991	0.660
LIG_LIR_Nem_3	204	209	PF02991	0.638
LIG_LIR_Nem_3	266	271	PF02991	0.321
LIG_LIR_Nem_3	354	358	PF02991	0.457
LIG_Pex14_1	274	278	PF04695	0.471
LIG_SH2_CRK	180	184	PF00017	0.563
LIG_SH2_CRK	206	210	PF00017	0.555
LIG_SH2_CRK	337	341	PF00017	0.452
LIG_SH2_NCK_1	67	71	PF00017	0.736
LIG_SH2_STAP1	206	210	PF00017	0.639
LIG_SH2_STAP1	368	372	PF00017	0.453
LIG_SH2_STAP1	67	71	PF00017	0.736
LIG_SH3_3	50	56	PF00018	0.749
LIG_TRAF2_1	131	134	PF00917	0.799
LIG_TYR_ITIM	335	340	PF00017	0.453
LIG_WRC_WIRS_1	145	150	PF05994	0.602
MOD_CK1_1	122	128	PF00069	0.764
MOD_CK1_1	246	252	PF00069	0.718
MOD_CK1_1	296	302	PF00069	0.473
MOD_CK1_1	34	40	PF00069	0.745
MOD_CK1_1	43	49	PF00069	0.704
MOD_CK1_1	59	65	PF00069	0.822
MOD_CK1_1	69	75	PF00069	0.725
MOD_CK2_1	122	128	PF00069	0.770
MOD_CK2_1	144	150	PF00069	0.631
MOD_CK2_1	223	229	PF00069	0.554
MOD_CK2_1	246	252	PF00069	0.714
MOD_Cter_Amidation	407	410	PF01082	0.478
MOD_GlcNHglycan	116	120	PF01048	0.465
MOD_GlcNHglycan	124	127	PF01048	0.482
MOD_GlcNHglycan	21	24	PF01048	0.464
MOD_GlcNHglycan	212	215	PF01048	0.448
MOD_GlcNHglycan	265	268	PF01048	0.453
MOD_GlcNHglycan	295	298	PF01048	0.761
MOD_GlcNHglycan	344	347	PF01048	0.678
MOD_GlcNHglycan	36	39	PF01048	0.494
MOD_GlcNHglycan	393	396	PF01048	0.446
MOD_GlcNHglycan	42	45	PF01048	0.612
MOD_GlcNHglycan	68	71	PF01048	0.516
MOD_GlcNHglycan	83	86	PF01048	0.628
MOD_GlcNHglycan	99	102	PF01048	0.460
MOD_GSK3_1	115	122	PF00069	0.757
MOD_GSK3_1	19	26	PF00069	0.749
MOD_GSK3_1	243	250	PF00069	0.684
MOD_GSK3_1	283	290	PF00069	0.485
MOD_GSK3_1	338	345	PF00069	0.463
MOD_GSK3_1	36	43	PF00069	0.628
MOD_GSK3_1	52	59	PF00069	0.827
MOD_GSK3_1	65	72	PF00069	0.699
MOD_GSK3_1	77	84	PF00069	0.710
MOD_N-GLC_1	202	207	PF02516	0.441
MOD_NEK2_1	19	24	PF00069	0.771
MOD_NEK2_1	243	248	PF00069	0.732
MOD_NEK2_1	277	282	PF00069	0.518
MOD_NEK2_1	360	365	PF00069	0.475
MOD_NEK2_2	56	61	PF00069	0.677
MOD_PIKK_1	299	305	PF00454	0.427
MOD_PIKK_1	7	13	PF00454	0.731
MOD_PKA_2	128	134	PF00069	0.695
MOD_PKA_2	246	252	PF00069	0.734
MOD_PKA_2	318	324	PF00069	0.578
MOD_PKA_2	402	408	PF00069	0.673
MOD_Plk_1	202	208	PF00069	0.641
MOD_Plk_2-3	128	134	PF00069	0.713
MOD_Plk_4	31	37	PF00069	0.678
MOD_Plk_4	379	385	PF00069	0.335
MOD_ProDKin_1	12	18	PF00069	0.740
MOD_ProDKin_1	21	27	PF00069	0.660
MOD_ProDKin_1	278	284	PF00069	0.477
MOD_ProDKin_1	52	58	PF00069	0.766
MOD_ProDKin_1	83	89	PF00069	0.753
MOD_SUMO_rev_2	128	136	PF00179	0.795
TRG_DiLeu_BaEn_1	252	257	PF01217	0.655
TRG_ENDOCYTIC_2	152	155	PF00928	0.529
TRG_ENDOCYTIC_2	180	183	PF00928	0.565
TRG_ENDOCYTIC_2	206	209	PF00928	0.552
TRG_ENDOCYTIC_2	337	340	PF00928	0.452
TRG_NES_CRM1_1	150	164	PF08389	0.639
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA2	Leptomonas seymouri	48%	90%
A4H529	Leishmania braziliensis	72%	100%
A4HTA3	Leishmania infantum	100%	100%
E9AL92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIL2	Leishmania major	90%	100%