RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WPX7_LEIDO

TriTrypDb:

LdBPK_070800.1 , LdCL_070012800 , LDHU3_07.0970

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.675
CLV_C14_Caspase3-7	336	340	PF00656	0.572
CLV_C14_Caspase3-7	407	411	PF00656	0.534
CLV_NRD_NRD_1	13	15	PF00675	0.522
CLV_NRD_NRD_1	20	22	PF00675	0.564
CLV_NRD_NRD_1	223	225	PF00675	0.668
CLV_NRD_NRD_1	369	371	PF00675	0.569
CLV_NRD_NRD_1	396	398	PF00675	0.613
CLV_NRD_NRD_1	430	432	PF00675	0.460
CLV_NRD_NRD_1	449	451	PF00675	0.626
CLV_NRD_NRD_1	569	571	PF00675	0.557
CLV_PCSK_KEX2_1	13	15	PF00082	0.522
CLV_PCSK_KEX2_1	20	22	PF00082	0.564
CLV_PCSK_KEX2_1	223	225	PF00082	0.668
CLV_PCSK_KEX2_1	369	371	PF00082	0.569
CLV_PCSK_KEX2_1	396	398	PF00082	0.609
CLV_PCSK_KEX2_1	432	434	PF00082	0.484
CLV_PCSK_KEX2_1	449	451	PF00082	0.568
CLV_PCSK_KEX2_1	569	571	PF00082	0.537
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.614
CLV_PCSK_PC7_1	428	434	PF00082	0.560
CLV_PCSK_PC7_1	9	15	PF00082	0.629
CLV_PCSK_SKI1_1	266	270	PF00082	0.639
CLV_PCSK_SKI1_1	335	339	PF00082	0.672
CLV_PCSK_SKI1_1	359	363	PF00082	0.648
CLV_PCSK_SKI1_1	369	373	PF00082	0.424
DEG_APCC_DBOX_1	126	134	PF00400	0.667
DEG_APCC_DBOX_1	368	376	PF00400	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.724
DEG_SCF_FBW7_1	35	41	PF00400	0.691
DOC_CKS1_1	35	40	PF01111	0.691
DOC_CYCLIN_yClb5_NLxxxL_5	397	405	PF00134	0.485
DOC_MAPK_gen_1	369	377	PF00069	0.557
DOC_MAPK_gen_1	431	440	PF00069	0.575
DOC_PP1_RVXF_1	18	25	PF00149	0.650
DOC_PP2B_LxvP_1	287	290	PF13499	0.583
DOC_PP2B_LxvP_1	308	311	PF13499	0.728
DOC_PP2B_LxvP_1	416	419	PF13499	0.597
DOC_USP7_MATH_1	177	181	PF00917	0.709
DOC_USP7_MATH_1	185	189	PF00917	0.634
DOC_USP7_MATH_1	260	264	PF00917	0.669
DOC_USP7_MATH_1	268	272	PF00917	0.614
DOC_USP7_MATH_1	275	279	PF00917	0.579
DOC_USP7_MATH_1	346	350	PF00917	0.714
DOC_USP7_MATH_1	38	42	PF00917	0.664
DOC_USP7_MATH_1	417	421	PF00917	0.574
DOC_WW_Pin1_4	111	116	PF00397	0.626
DOC_WW_Pin1_4	266	271	PF00397	0.739
DOC_WW_Pin1_4	34	39	PF00397	0.756
DOC_WW_Pin1_4	459	464	PF00397	0.665
DOC_WW_Pin1_4	49	54	PF00397	0.636
DOC_WW_Pin1_4	536	541	PF00397	0.663
DOC_WW_Pin1_4	74	79	PF00397	0.692
LIG_14-3-3_CanoR_1	178	186	PF00244	0.658
LIG_14-3-3_CanoR_1	223	230	PF00244	0.601
LIG_14-3-3_CanoR_1	314	319	PF00244	0.594
LIG_14-3-3_CanoR_1	343	353	PF00244	0.647
LIG_14-3-3_CanoR_1	421	430	PF00244	0.454
LIG_14-3-3_CanoR_1	449	459	PF00244	0.759
LIG_14-3-3_CanoR_1	484	490	PF00244	0.601
LIG_APCC_ABBA_1	546	551	PF00400	0.668
LIG_CaM_IQ_9	12	28	PF13499	0.522
LIG_FHA_1	282	288	PF00498	0.786
LIG_FHA_1	303	309	PF00498	0.755
LIG_FHA_1	310	316	PF00498	0.640
LIG_FHA_1	393	399	PF00498	0.559
LIG_FHA_1	464	470	PF00498	0.680
LIG_FHA_1	486	492	PF00498	0.664
LIG_FHA_2	327	333	PF00498	0.669
LIG_FHA_2	35	41	PF00498	0.618
LIG_FHA_2	405	411	PF00498	0.522
LIG_FHA_2	60	66	PF00498	0.595
LIG_LIR_Gen_1	156	161	PF02991	0.720
LIG_LIR_Gen_1	196	205	PF02991	0.549
LIG_LIR_Nem_3	156	160	PF02991	0.723
LIG_LIR_Nem_3	196	201	PF02991	0.549
LIG_MYND_1	534	538	PF01753	0.637
LIG_SH2_STAT5	549	552	PF00017	0.647
LIG_SH3_1	352	358	PF00018	0.571
LIG_SH3_2	354	359	PF14604	0.564
LIG_SH3_3	254	260	PF00018	0.749
LIG_SH3_3	350	356	PF00018	0.628
LIG_SH3_3	42	48	PF00018	0.689
LIG_SH3_3	455	461	PF00018	0.753
LIG_SH3_3	501	507	PF00018	0.625
LIG_SH3_3	526	532	PF00018	0.741
LIG_SH3_3	534	540	PF00018	0.624
LIG_SH3_3	72	78	PF00018	0.631
LIG_SH3_CIN85_PxpxPR_1	354	359	PF14604	0.637
LIG_SUMO_SIM_par_1	414	420	PF11976	0.617
LIG_WW_1	146	149	PF00397	0.574
LIG_WW_3	356	360	PF00397	0.557
LIG_WW_3	462	466	PF00397	0.588
MOD_CDC14_SPxK_1	462	465	PF00782	0.655
MOD_CDC14_SPxK_1	77	80	PF00782	0.690
MOD_CDK_SPxK_1	459	465	PF00069	0.661
MOD_CDK_SPxK_1	74	80	PF00069	0.694
MOD_CK1_1	180	186	PF00069	0.597
MOD_CK1_1	271	277	PF00069	0.776
MOD_CK1_1	302	308	PF00069	0.740
MOD_CK1_1	325	331	PF00069	0.729
MOD_CK1_1	420	426	PF00069	0.614
MOD_CK1_1	451	457	PF00069	0.781
MOD_CK1_1	485	491	PF00069	0.713
MOD_CK1_1	509	515	PF00069	0.708
MOD_CK1_1	518	524	PF00069	0.612
MOD_CK1_1	59	65	PF00069	0.573
MOD_CK2_1	59	65	PF00069	0.593
MOD_Cter_Amidation	221	224	PF01082	0.610
MOD_DYRK1A_RPxSP_1	266	270	PF00069	0.661
MOD_GlcNHglycan	124	127	PF01048	0.640
MOD_GlcNHglycan	138	142	PF01048	0.630
MOD_GlcNHglycan	167	170	PF01048	0.671
MOD_GlcNHglycan	187	190	PF01048	0.487
MOD_GlcNHglycan	2	5	PF01048	0.592
MOD_GlcNHglycan	231	234	PF01048	0.702
MOD_GlcNHglycan	270	273	PF01048	0.641
MOD_GlcNHglycan	344	347	PF01048	0.729
MOD_GlcNHglycan	389	392	PF01048	0.580
MOD_GlcNHglycan	423	426	PF01048	0.460
MOD_GlcNHglycan	484	487	PF01048	0.756
MOD_GlcNHglycan	543	546	PF01048	0.667
MOD_GlcNHglycan	58	61	PF01048	0.688
MOD_GlcNHglycan	88	91	PF01048	0.780
MOD_GSK3_1	180	187	PF00069	0.678
MOD_GSK3_1	225	232	PF00069	0.748
MOD_GSK3_1	271	278	PF00069	0.716
MOD_GSK3_1	299	306	PF00069	0.738
MOD_GSK3_1	30	37	PF00069	0.697
MOD_GSK3_1	310	317	PF00069	0.502
MOD_GSK3_1	322	329	PF00069	0.609
MOD_GSK3_1	342	349	PF00069	0.606
MOD_GSK3_1	382	389	PF00069	0.658
MOD_GSK3_1	39	46	PF00069	0.685
MOD_GSK3_1	404	411	PF00069	0.517
MOD_GSK3_1	417	424	PF00069	0.489
MOD_GSK3_1	448	455	PF00069	0.698
MOD_GSK3_1	459	466	PF00069	0.602
MOD_GSK3_1	49	56	PF00069	0.541
MOD_GSK3_1	506	513	PF00069	0.621
MOD_GSK3_1	536	543	PF00069	0.646
MOD_GSK3_1	74	81	PF00069	0.647
MOD_N-GLC_2	109	111	PF02516	0.611
MOD_NEK2_1	211	216	PF00069	0.608
MOD_NEK2_1	283	288	PF00069	0.689
MOD_NEK2_1	362	367	PF00069	0.614
MOD_NEK2_1	408	413	PF00069	0.553
MOD_NEK2_1	448	453	PF00069	0.753
MOD_NEK2_2	515	520	PF00069	0.465
MOD_PIKK_1	289	295	PF00454	0.629
MOD_PIKK_1	549	555	PF00454	0.577
MOD_PKA_1	223	229	PF00069	0.607
MOD_PKA_1	449	455	PF00069	0.700
MOD_PKA_2	165	171	PF00069	0.687
MOD_PKA_2	177	183	PF00069	0.620
MOD_PKA_2	222	228	PF00069	0.609
MOD_PKA_2	30	36	PF00069	0.583
MOD_PKA_2	303	309	PF00069	0.704
MOD_PKA_2	342	348	PF00069	0.647
MOD_PKA_2	420	426	PF00069	0.614
MOD_PKA_2	448	454	PF00069	0.755
MOD_PKB_1	307	315	PF00069	0.570
MOD_Plk_1	39	45	PF00069	0.588
MOD_Plk_4	153	159	PF00069	0.686
MOD_Plk_4	276	282	PF00069	0.667
MOD_Plk_4	30	36	PF00069	0.583
MOD_Plk_4	314	320	PF00069	0.727
MOD_ProDKin_1	111	117	PF00069	0.626
MOD_ProDKin_1	266	272	PF00069	0.736
MOD_ProDKin_1	34	40	PF00069	0.757
MOD_ProDKin_1	459	465	PF00069	0.665
MOD_ProDKin_1	49	55	PF00069	0.632
MOD_ProDKin_1	536	542	PF00069	0.665
MOD_ProDKin_1	74	80	PF00069	0.694
TRG_DiLeu_BaEn_2	152	158	PF01217	0.638
TRG_ER_diArg_1	12	14	PF00400	0.520
TRG_ER_diArg_1	19	21	PF00400	0.551
TRG_ER_diArg_1	369	371	PF00400	0.523
TRG_ER_diArg_1	396	398	PF00400	0.609
TRG_ER_diArg_1	430	433	PF00400	0.465
TRG_ER_diArg_1	448	450	PF00400	0.529
TRG_ER_diArg_1	464	467	PF00400	0.571
TRG_ER_diArg_1	569	571	PF00400	0.573
TRG_NLS_MonoExtN_4	428	435	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4N4	Leptomonas seymouri	28%	100%
A4H523	Leishmania braziliensis	59%	100%
A4HT96	Leishmania infantum	99%	100%
E9ACQ2	Leishmania major	84%	100%
E9AL85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%