Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPX5_LEIDO

TriTrypDb:

LdBPK_070890.1 , LdCL_070013700 , LDHU3_07.1060

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7WPX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.446
CLV_NRD_NRD_1	206	208	PF00675	0.560
CLV_NRD_NRD_1	213	215	PF00675	0.537
CLV_NRD_NRD_1	220	222	PF00675	0.462
CLV_NRD_NRD_1	299	301	PF00675	0.580
CLV_PCSK_FUR_1	158	162	PF00082	0.458
CLV_PCSK_KEX2_1	160	162	PF00082	0.446
CLV_PCSK_KEX2_1	193	195	PF00082	0.581
CLV_PCSK_KEX2_1	212	214	PF00082	0.594
CLV_PCSK_KEX2_1	220	222	PF00082	0.506
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.581
CLV_PCSK_SKI1_1	190	194	PF00082	0.572
CLV_PCSK_SKI1_1	293	297	PF00082	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_ANK_TNKS_1	58	65	PF00023	0.465
DOC_PP4_FxxP_1	203	206	PF00568	0.725
DOC_PP4_FxxP_1	60	63	PF00568	0.470
DOC_USP7_MATH_1	255	259	PF00917	0.809
DOC_USP7_MATH_1	261	265	PF00917	0.779
DOC_USP7_MATH_1	272	276	PF00917	0.659
DOC_USP7_MATH_1	281	285	PF00917	0.564
DOC_USP7_MATH_1	42	46	PF00917	0.575
DOC_USP7_MATH_1	84	88	PF00917	0.637
DOC_WW_Pin1_4	145	150	PF00397	0.782
DOC_WW_Pin1_4	230	235	PF00397	0.820
DOC_WW_Pin1_4	44	49	PF00397	0.500
LIG_14-3-3_CanoR_1	227	235	PF00244	0.765
LIG_14-3-3_CanoR_1	46	52	PF00244	0.526
LIG_14-3-3_CterR_2	300	304	PF00244	0.787
LIG_BRCT_BRCA1_1	34	38	PF00533	0.593
LIG_BRCT_BRCA1_1	77	81	PF00533	0.518
LIG_deltaCOP1_diTrp_1	90	97	PF00928	0.743
LIG_EH_1	40	44	PF12763	0.580
LIG_FHA_1	77	83	PF00498	0.518
LIG_LIR_Nem_3	47	52	PF02991	0.491
LIG_SH2_GRB2like	25	28	PF00017	0.589
LIG_SH2_NCK_1	52	56	PF00017	0.549
LIG_SH2_SRC	154	157	PF00017	0.690
LIG_SH2_STAT3	156	159	PF00017	0.756
LIG_SH2_STAT3	5	8	PF00017	0.573
LIG_SH2_STAT5	144	147	PF00017	0.801
LIG_SH2_STAT5	74	77	PF00017	0.518
LIG_SH3_3	264	270	PF00018	0.824
LIG_SH3_3	275	281	PF00018	0.690
LIG_TRAF2_1	284	287	PF00917	0.673
LIG_TYR_ITIM	72	77	PF00017	0.518
LIG_UBA3_1	295	301	PF00899	0.773
MOD_CDK_SPxxK_3	145	152	PF00069	0.777
MOD_CK1_1	138	144	PF00069	0.744
MOD_CK1_1	223	229	PF00069	0.760
MOD_CK1_1	230	236	PF00069	0.796
MOD_CK1_1	47	53	PF00069	0.507
MOD_CK2_1	226	232	PF00069	0.832
MOD_CK2_1	281	287	PF00069	0.785
MOD_GlcNHglycan	197	201	PF01048	0.534
MOD_GlcNHglycan	222	225	PF01048	0.506
MOD_GlcNHglycan	263	267	PF01048	0.531
MOD_GlcNHglycan	34	37	PF01048	0.779
MOD_GSK3_1	223	230	PF00069	0.804
MOD_LATS_1	30	36	PF00433	0.595
MOD_N-GLC_1	230	235	PF02516	0.475
MOD_N-GLC_1	272	277	PF02516	0.625
MOD_NEK2_1	75	80	PF00069	0.446
MOD_NEK2_1	99	104	PF00069	0.753
MOD_PKA_1	220	226	PF00069	0.693
MOD_PKA_2	220	226	PF00069	0.738
MOD_PKA_2	97	103	PF00069	0.760
MOD_Plk_1	272	278	PF00069	0.772
MOD_Plk_4	273	279	PF00069	0.730
MOD_Plk_4	62	68	PF00069	0.427
MOD_Plk_4	76	82	PF00069	0.295
MOD_ProDKin_1	145	151	PF00069	0.778
MOD_ProDKin_1	230	236	PF00069	0.821
MOD_ProDKin_1	44	50	PF00069	0.494
TRG_ENDOCYTIC_2	74	77	PF00928	0.518
TRG_ER_diArg_1	139	142	PF00400	0.758
TRG_ER_diArg_1	158	161	PF00400	0.594
TRG_ER_diArg_1	212	214	PF00400	0.794
TRG_ER_diArg_1	57	60	PF00400	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H530	Leishmania braziliensis	75%	100%
E9AL93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QIL1	Leishmania major	91%	98%