Flavoprotein subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein subunit-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WPX2_LEIDO

TriTrypDb:

LdBPK_070910.1 , LdCL_070013900 , LDHU3_07.1080

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPX2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0020037	heme binding	4	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046906	tetrapyrrole binding	3	6
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0000166	nucleotide binding	3	2
GO:0010181	FMN binding	4	2
GO:0032553	ribonucleotide binding	3	2
GO:0036094	small molecule binding	2	2
GO:0043168	anion binding	3	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.333
CLV_C14_Caspase3-7	585	589	PF00656	0.484
CLV_NRD_NRD_1	312	314	PF00675	0.314
CLV_PCSK_KEX2_1	312	314	PF00082	0.317
CLV_PCSK_KEX2_1	355	357	PF00082	0.387
CLV_PCSK_KEX2_1	403	405	PF00082	0.387
CLV_PCSK_KEX2_1	416	418	PF00082	0.286
CLV_PCSK_KEX2_1	595	597	PF00082	0.413
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.338
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.275
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.202
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.413
CLV_PCSK_PC7_1	351	357	PF00082	0.389
CLV_PCSK_SKI1_1	170	174	PF00082	0.292
CLV_PCSK_SKI1_1	404	408	PF00082	0.328
CLV_PCSK_SKI1_1	43	47	PF00082	0.234
CLV_PCSK_SKI1_1	438	442	PF00082	0.273
CLV_PCSK_SKI1_1	526	530	PF00082	0.414
CLV_PCSK_SKI1_1	592	596	PF00082	0.524
CLV_PCSK_SKI1_1	76	80	PF00082	0.254
DEG_ODPH_VHL_1	458	471	PF01847	0.292
DOC_CYCLIN_RxL_1	523	531	PF00134	0.401
DOC_CYCLIN_RxL_1	613	624	PF00134	0.292
DOC_MAPK_gen_1	142	150	PF00069	0.333
DOC_PP1_RVXF_1	124	130	PF00149	0.292
DOC_USP7_MATH_1	100	104	PF00917	0.341
DOC_USP7_MATH_1	27	31	PF00917	0.255
DOC_USP7_MATH_1	425	429	PF00917	0.267
DOC_USP7_MATH_1	569	573	PF00917	0.638
DOC_WW_Pin1_4	324	329	PF00397	0.337
DOC_WW_Pin1_4	429	434	PF00397	0.401
DOC_WW_Pin1_4	579	584	PF00397	0.734
DOC_WW_Pin1_4	58	63	PF00397	0.224
DOC_WW_Pin1_4	658	663	PF00397	0.333
DOC_WW_Pin1_4	96	101	PF00397	0.310
LIG_14-3-3_CanoR_1	404	413	PF00244	0.292
LIG_APCC_ABBA_1	75	80	PF00400	0.254
LIG_BIR_III_2	580	584	PF00653	0.579
LIG_BRCT_BRCA1_1	407	411	PF00533	0.229
LIG_Clathr_ClatBox_1	260	264	PF01394	0.333
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.273
LIG_eIF4E_1	348	354	PF01652	0.302
LIG_FHA_1	149	155	PF00498	0.306
LIG_FHA_1	188	194	PF00498	0.314
LIG_FHA_1	369	375	PF00498	0.204
LIG_FHA_1	523	529	PF00498	0.386
LIG_FHA_1	621	627	PF00498	0.333
LIG_FHA_2	238	244	PF00498	0.273
LIG_FHA_2	583	589	PF00498	0.610
LIG_FHA_2	596	602	PF00498	0.241
LIG_GBD_Chelix_1	614	622	PF00786	0.292
LIG_LIR_Apic_2	531	535	PF02991	0.496
LIG_LIR_Gen_1	151	160	PF02991	0.352
LIG_LIR_Gen_1	327	338	PF02991	0.292
LIG_LIR_Gen_1	543	553	PF02991	0.527
LIG_LIR_Gen_1	609	620	PF02991	0.337
LIG_LIR_Gen_1	645	656	PF02991	0.333
LIG_LIR_Nem_3	151	155	PF02991	0.292
LIG_LIR_Nem_3	327	333	PF02991	0.378
LIG_LIR_Nem_3	377	381	PF02991	0.281
LIG_LIR_Nem_3	439	444	PF02991	0.333
LIG_LIR_Nem_3	543	548	PF02991	0.461
LIG_LIR_Nem_3	609	615	PF02991	0.337
LIG_LIR_Nem_3	645	651	PF02991	0.333
LIG_LIR_Nem_3	85	89	PF02991	0.310
LIG_MAD2	176	184	PF02301	0.347
LIG_PCNA_yPIPBox_3	502	515	PF02747	0.246
LIG_Pex14_1	115	119	PF04695	0.292
LIG_Pex14_2	215	219	PF04695	0.333
LIG_Pex14_2	407	411	PF04695	0.204
LIG_SH2_CRK	152	156	PF00017	0.292
LIG_SH2_CRK	516	520	PF00017	0.316
LIG_SH2_CRK	532	536	PF00017	0.457
LIG_SH2_GRB2like	119	122	PF00017	0.267
LIG_SH2_NCK_1	152	156	PF00017	0.292
LIG_SH2_NCK_1	597	601	PF00017	0.292
LIG_SH2_STAP1	545	549	PF00017	0.460
LIG_SH2_STAT5	119	122	PF00017	0.292
LIG_SH2_STAT5	330	333	PF00017	0.357
LIG_SH2_STAT5	348	351	PF00017	0.277
LIG_SH2_STAT5	454	457	PF00017	0.254
LIG_SH2_STAT5	464	467	PF00017	0.220
LIG_SH2_STAT5	490	493	PF00017	0.292
LIG_SH2_STAT5	527	530	PF00017	0.352
LIG_SH2_STAT5	597	600	PF00017	0.292
LIG_SH2_STAT5	660	663	PF00017	0.333
LIG_SH3_1	94	100	PF00018	0.254
LIG_SH3_3	178	184	PF00018	0.368
LIG_SH3_3	273	279	PF00018	0.273
LIG_SH3_3	551	557	PF00018	0.524
LIG_SH3_3	559	565	PF00018	0.537
LIG_SH3_3	624	630	PF00018	0.333
LIG_SH3_3	648	654	PF00018	0.292
LIG_SH3_3	94	100	PF00018	0.254
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.251
LIG_SUMO_SIM_par_1	37	42	PF11976	0.251
LIG_TYR_ITIM	150	155	PF00017	0.292
LIG_TYR_ITIM	514	519	PF00017	0.318
LIG_UBA3_1	154	163	PF00899	0.273
LIG_UBA3_1	410	416	PF00899	0.204
MOD_CK1_1	109	115	PF00069	0.244
MOD_CK1_1	429	435	PF00069	0.435
MOD_CK1_1	576	582	PF00069	0.688
MOD_CK1_1	642	648	PF00069	0.229
MOD_CK2_1	153	159	PF00069	0.456
MOD_CK2_1	334	340	PF00069	0.292
MOD_CK2_1	356	362	PF00069	0.254
MOD_CK2_1	595	601	PF00069	0.295
MOD_GlcNHglycan	108	111	PF01048	0.279
MOD_GlcNHglycan	155	158	PF01048	0.328
MOD_GlcNHglycan	316	319	PF01048	0.317
MOD_GlcNHglycan	335	339	PF01048	0.365
MOD_GlcNHglycan	358	361	PF01048	0.329
MOD_GlcNHglycan	395	398	PF01048	0.292
MOD_GlcNHglycan	42	46	PF01048	0.275
MOD_GlcNHglycan	55	58	PF01048	0.221
MOD_GlcNHglycan	574	578	PF01048	0.512
MOD_GlcNHglycan	68	71	PF01048	0.241
MOD_GSK3_1	131	138	PF00069	0.296
MOD_GSK3_1	232	239	PF00069	0.337
MOD_GSK3_1	364	371	PF00069	0.261
MOD_GSK3_1	425	432	PF00069	0.428
MOD_GSK3_1	48	55	PF00069	0.222
MOD_GSK3_1	569	576	PF00069	0.579
MOD_GSK3_1	96	103	PF00069	0.293
MOD_LATS_1	133	139	PF00433	0.333
MOD_N-GLC_1	49	54	PF02516	0.261
MOD_N-GLC_1	620	625	PF02516	0.292
MOD_N-GLC_1	82	87	PF02516	0.257
MOD_NEK2_1	148	153	PF00069	0.273
MOD_NEK2_1	237	242	PF00069	0.325
MOD_NEK2_1	374	379	PF00069	0.330
MOD_NEK2_1	406	411	PF00069	0.392
MOD_NEK2_1	41	46	PF00069	0.424
MOD_NEK2_1	436	441	PF00069	0.292
MOD_NEK2_1	528	533	PF00069	0.389
MOD_PIKK_1	1	7	PF00454	0.548
MOD_PIKK_1	60	66	PF00454	0.251
MOD_PKA_1	595	601	PF00069	0.273
MOD_PKA_2	106	112	PF00069	0.273
MOD_PKA_2	595	601	PF00069	0.292
MOD_PKB_1	168	176	PF00069	0.267
MOD_Plk_1	221	227	PF00069	0.287
MOD_Plk_1	41	47	PF00069	0.227
MOD_Plk_1	82	88	PF00069	0.251
MOD_Plk_2-3	445	451	PF00069	0.292
MOD_Plk_4	222	228	PF00069	0.251
MOD_Plk_4	27	33	PF00069	0.213
MOD_Plk_4	34	40	PF00069	0.236
MOD_Plk_4	406	412	PF00069	0.229
MOD_Plk_4	436	442	PF00069	0.333
MOD_Plk_4	506	512	PF00069	0.240
MOD_Plk_4	528	534	PF00069	0.405
MOD_Plk_4	540	546	PF00069	0.479
MOD_Plk_4	632	638	PF00069	0.333
MOD_ProDKin_1	324	330	PF00069	0.337
MOD_ProDKin_1	429	435	PF00069	0.401
MOD_ProDKin_1	579	585	PF00069	0.734
MOD_ProDKin_1	58	64	PF00069	0.224
MOD_ProDKin_1	658	664	PF00069	0.333
MOD_ProDKin_1	96	102	PF00069	0.310
MOD_SUMO_for_1	369	372	PF00179	0.245
MOD_SUMO_rev_2	473	482	PF00179	0.292
MOD_SUMO_rev_2	567	575	PF00179	0.511
MOD_SUMO_rev_2	588	594	PF00179	0.456
TRG_ENDOCYTIC_2	152	155	PF00928	0.333
TRG_ENDOCYTIC_2	330	333	PF00928	0.349
TRG_ENDOCYTIC_2	516	519	PF00928	0.320
TRG_ENDOCYTIC_2	545	548	PF00928	0.462
TRG_ER_diArg_1	168	171	PF00400	0.267
TRG_NES_CRM1_1	66	81	PF08389	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C0	Leptomonas seymouri	37%	100%
A0A0S4IHN0	Bodo saltans	39%	100%
A0A0S4KND3	Bodo saltans	53%	100%
A0A1X0NPF8	Trypanosomatidae	57%	99%
A0A3S7X915	Leishmania donovani	36%	100%
A0A422MX37	Trypanosoma rangeli	34%	100%
A4HME0	Leishmania braziliensis	36%	94%
A4HME1	Leishmania braziliensis	35%	100%
A4HTA6	Leishmania infantum	100%	100%
A4IB13	Leishmania infantum	35%	92%
B2GCE0	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	27%	100%
B5XRB0	Klebsiella pneumoniae (strain 342)	30%	73%
C8WLE3	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	27%	100%
C9ZQ34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	74%
E9AEU2	Leishmania major	36%	92%
E9AL95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B5Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	92%
O13755	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P0C278	Shewanella frigidimarina	33%	100%
P21375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P32614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P83223	Shewanella oneidensis (strain MR-1)	34%	100%
Q07WU7	Shewanella frigidimarina (strain NCIMB 400)	33%	100%
Q4QIK9	Leishmania major	95%	100%
Q8CVD0	Shewanella oneidensis (strain MR-1)	30%	100%
Q9Z4P0	Shewanella frigidimarina (strain NCIMB 400)	31%	100%