GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPV9_LEIDO

TriTrypDb:

LdBPK_070690.1 , LdCL_070011800 , LDHU3_07.0830

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	478	480	PF00675	0.482
CLV_NRD_NRD_1	523	525	PF00675	0.682
CLV_NRD_NRD_1	604	606	PF00675	0.539
CLV_PCSK_KEX2_1	386	388	PF00082	0.463
CLV_PCSK_KEX2_1	478	480	PF00082	0.482
CLV_PCSK_KEX2_1	604	606	PF00082	0.539
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.463
CLV_PCSK_PC7_1	382	388	PF00082	0.461
CLV_PCSK_SKI1_1	382	386	PF00082	0.463
CLV_PCSK_SKI1_1	387	391	PF00082	0.419
CLV_PCSK_SKI1_1	410	414	PF00082	0.484
CLV_PCSK_SKI1_1	454	458	PF00082	0.459
CLV_PCSK_SKI1_1	478	482	PF00082	0.595
CLV_Separin_Metazoa	619	623	PF03568	0.504
DEG_APCC_DBOX_1	15	23	PF00400	0.526
DEG_APCC_DBOX_1	231	239	PF00400	0.559
DEG_COP1_1	570	578	PF00400	0.530
DEG_SCF_FBW7_2	262	269	PF00400	0.594
DEG_SPOP_SBC_1	517	521	PF00917	0.666
DEG_SPOP_SBC_1	62	66	PF00917	0.660
DOC_CKS1_1	263	268	PF01111	0.595
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	238	241	PF00134	0.544
DOC_MAPK_gen_1	138	146	PF00069	0.461
DOC_MAPK_gen_1	315	323	PF00069	0.521
DOC_MAPK_MEF2A_6	138	146	PF00069	0.422
DOC_MAPK_MEF2A_6	317	325	PF00069	0.393
DOC_PP2B_LxvP_1	176	179	PF13499	0.565
DOC_PP2B_LxvP_1	202	205	PF13499	0.530
DOC_PP2B_LxvP_1	238	241	PF13499	0.667
DOC_PP2B_LxvP_1	259	262	PF13499	0.704
DOC_PP2B_LxvP_1	275	278	PF13499	0.559
DOC_USP7_MATH_1	163	167	PF00917	0.639
DOC_USP7_MATH_1	190	194	PF00917	0.637
DOC_USP7_MATH_1	313	317	PF00917	0.423
DOC_USP7_MATH_1	373	377	PF00917	0.481
DOC_USP7_MATH_1	449	453	PF00917	0.516
DOC_USP7_MATH_1	501	505	PF00917	0.582
DOC_USP7_MATH_1	518	522	PF00917	0.597
DOC_USP7_MATH_1	52	56	PF00917	0.587
DOC_USP7_MATH_1	535	539	PF00917	0.716
DOC_USP7_MATH_1	62	66	PF00917	0.622
DOC_USP7_MATH_1	68	72	PF00917	0.567
DOC_USP7_MATH_1	88	92	PF00917	0.476
DOC_WW_Pin1_4	184	189	PF00397	0.699
DOC_WW_Pin1_4	262	267	PF00397	0.622
DOC_WW_Pin1_4	574	579	PF00397	0.651
DOC_WW_Pin1_4	63	68	PF00397	0.650
DOC_WW_Pin1_4	72	77	PF00397	0.602
DOC_WW_Pin1_4	83	88	PF00397	0.479
LIG_14-3-3_CanoR_1	112	120	PF00244	0.461
LIG_14-3-3_CanoR_1	232	236	PF00244	0.477
LIG_14-3-3_CanoR_1	36	44	PF00244	0.525
LIG_14-3-3_CanoR_1	387	396	PF00244	0.455
LIG_14-3-3_CanoR_1	410	415	PF00244	0.394
LIG_Actin_WH2_2	385	402	PF00022	0.464
LIG_EVH1_1	275	279	PF00568	0.643
LIG_FHA_1	108	114	PF00498	0.496
LIG_FHA_1	194	200	PF00498	0.574
LIG_FHA_1	246	252	PF00498	0.664
LIG_FHA_1	272	278	PF00498	0.706
LIG_FHA_1	307	313	PF00498	0.420
LIG_FHA_1	4	10	PF00498	0.627
LIG_FHA_1	423	429	PF00498	0.414
LIG_FHA_1	587	593	PF00498	0.587
LIG_FHA_2	163	169	PF00498	0.530
LIG_FHA_2	263	269	PF00498	0.687
LIG_FHA_2	281	287	PF00498	0.483
LIG_FHA_2	330	336	PF00498	0.495
LIG_FHA_2	48	54	PF00498	0.553
LIG_FHA_2	518	524	PF00498	0.655
LIG_FHA_2	99	105	PF00498	0.494
LIG_LIR_Gen_1	126	134	PF02991	0.505
LIG_LIR_Nem_3	126	130	PF02991	0.514
LIG_PCNA_yPIPBox_3	598	610	PF02747	0.458
LIG_PTAP_UEV_1	630	635	PF05743	0.608
LIG_SH2_CRK	127	131	PF00017	0.511
LIG_SH3_1	260	266	PF00018	0.590
LIG_SH3_1	273	279	PF00018	0.530
LIG_SH3_3	203	209	PF00018	0.587
LIG_SH3_3	260	266	PF00018	0.648
LIG_SH3_3	273	279	PF00018	0.622
LIG_SH3_3	572	578	PF00018	0.657
LIG_SH3_3	624	630	PF00018	0.603
LIG_SUMO_SIM_anti_2	570	577	PF11976	0.479
LIG_SUMO_SIM_par_1	577	583	PF11976	0.643
LIG_TRAF2_1	101	104	PF00917	0.483
LIG_TRAF2_1	147	150	PF00917	0.511
LIG_TRAF2_1	209	212	PF00917	0.581
LIG_TRAF2_1	266	269	PF00917	0.663
LIG_TRAF2_1	51	54	PF00917	0.576
LIG_UBA3_1	19	25	PF00899	0.529
MOD_CK1_1	166	172	PF00069	0.747
MOD_CK1_1	193	199	PF00069	0.647
MOD_CK1_1	264	270	PF00069	0.687
MOD_CK1_1	3	9	PF00069	0.635
MOD_CK1_1	538	544	PF00069	0.683
MOD_CK1_1	559	565	PF00069	0.616
MOD_CK1_1	72	78	PF00069	0.671
MOD_CK1_1	79	85	PF00069	0.621
MOD_CK2_1	111	117	PF00069	0.425
MOD_CK2_1	162	168	PF00069	0.514
MOD_CK2_1	262	268	PF00069	0.684
MOD_CK2_1	299	305	PF00069	0.489
MOD_CK2_1	35	41	PF00069	0.524
MOD_CK2_1	373	379	PF00069	0.479
MOD_CK2_1	466	472	PF00069	0.439
MOD_CK2_1	47	53	PF00069	0.461
MOD_CK2_1	499	505	PF00069	0.784
MOD_CK2_1	98	104	PF00069	0.498
MOD_GlcNHglycan	172	175	PF01048	0.727
MOD_GlcNHglycan	206	209	PF01048	0.620
MOD_GlcNHglycan	252	255	PF01048	0.628
MOD_GlcNHglycan	37	40	PF01048	0.522
MOD_GlcNHglycan	414	417	PF01048	0.487
MOD_GlcNHglycan	494	497	PF01048	0.482
MOD_GlcNHglycan	50	53	PF01048	0.453
MOD_GlcNHglycan	511	517	PF01048	0.597
MOD_GlcNHglycan	631	634	PF01048	0.673
MOD_GlcNHglycan	78	81	PF01048	0.630
MOD_GlcNHglycan	90	93	PF01048	0.520
MOD_GSK3_1	107	114	PF00069	0.496
MOD_GSK3_1	162	169	PF00069	0.693
MOD_GSK3_1	180	187	PF00069	0.678
MOD_GSK3_1	190	197	PF00069	0.639
MOD_GSK3_1	373	380	PF00069	0.478
MOD_GSK3_1	43	50	PF00069	0.531
MOD_GSK3_1	512	519	PF00069	0.654
MOD_GSK3_1	535	542	PF00069	0.763
MOD_GSK3_1	555	562	PF00069	0.578
MOD_GSK3_1	629	636	PF00069	0.685
MOD_GSK3_1	68	75	PF00069	0.668
MOD_GSK3_1	79	86	PF00069	0.582
MOD_N-GLC_1	62	67	PF02516	0.678
MOD_N-GLC_1	69	74	PF02516	0.657
MOD_NEK2_1	107	112	PF00069	0.501
MOD_NEK2_1	180	185	PF00069	0.610
MOD_NEK2_1	43	48	PF00069	0.540
MOD_NEK2_1	586	591	PF00069	0.474
MOD_NEK2_2	449	454	PF00069	0.519
MOD_PIKK_1	194	200	PF00454	0.600
MOD_PIKK_1	222	228	PF00454	0.612
MOD_PIKK_1	526	532	PF00454	0.658
MOD_PIKK_1	54	60	PF00454	0.586
MOD_PIKK_1	586	592	PF00454	0.471
MOD_PIKK_1	90	96	PF00454	0.579
MOD_PIKK_1	98	104	PF00454	0.461
MOD_PK_1	466	472	PF00069	0.460
MOD_PKA_2	111	117	PF00069	0.529
MOD_PKA_2	231	237	PF00069	0.507
MOD_PKA_2	35	41	PF00069	0.524
MOD_Plk_1	313	319	PF00069	0.420
MOD_Plk_1	52	58	PF00069	0.609
MOD_Plk_1	539	545	PF00069	0.626
MOD_Plk_4	190	196	PF00069	0.754
MOD_ProDKin_1	184	190	PF00069	0.694
MOD_ProDKin_1	262	268	PF00069	0.624
MOD_ProDKin_1	574	580	PF00069	0.649
MOD_ProDKin_1	63	69	PF00069	0.651
MOD_ProDKin_1	72	78	PF00069	0.602
MOD_ProDKin_1	83	89	PF00069	0.475
MOD_SUMO_rev_2	461	465	PF00179	0.479
MOD_SUMO_rev_2	519	527	PF00179	0.717
TRG_ENDOCYTIC_2	127	130	PF00928	0.516
TRG_ER_diArg_1	151	154	PF00400	0.404
TRG_ER_diArg_1	604	606	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H513	Leishmania braziliensis	61%	100%
A4HT87	Leishmania infantum	99%	100%
E9AL75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIM9	Leishmania major	87%	99%