Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 54, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPV8_LEIDO

TriTrypDb:

LdBPK_070620.1 , LdCL_070011200 , LDHU3_07.0770

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WPV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.728
CLV_NRD_NRD_1	104	106	PF00675	0.657
CLV_NRD_NRD_1	23	25	PF00675	0.339
CLV_NRD_NRD_1	31	33	PF00675	0.466
CLV_NRD_NRD_1	310	312	PF00675	0.689
CLV_NRD_NRD_1	39	41	PF00675	0.479
CLV_NRD_NRD_1	412	414	PF00675	0.505
CLV_NRD_NRD_1	415	417	PF00675	0.508
CLV_NRD_NRD_1	6	8	PF00675	0.552
CLV_NRD_NRD_1	61	63	PF00675	0.609
CLV_NRD_NRD_1	96	98	PF00675	0.768
CLV_PCSK_FUR_1	37	41	PF00082	0.653
CLV_PCSK_KEX2_1	312	314	PF00082	0.677
CLV_PCSK_KEX2_1	39	41	PF00082	0.545
CLV_PCSK_KEX2_1	433	435	PF00082	0.568
CLV_PCSK_KEX2_1	63	65	PF00082	0.523
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.677
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.483
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.533
CLV_PCSK_PC7_1	35	41	PF00082	0.617
CLV_PCSK_SKI1_1	145	149	PF00082	0.409
CLV_PCSK_SKI1_1	184	188	PF00082	0.447
CLV_PCSK_SKI1_1	256	260	PF00082	0.495
CLV_PCSK_SKI1_1	297	301	PF00082	0.713
CLV_PCSK_SKI1_1	335	339	PF00082	0.633
CLV_PCSK_SKI1_1	394	398	PF00082	0.556
CLV_PCSK_SKI1_1	40	44	PF00082	0.455
CLV_PCSK_SKI1_1	434	438	PF00082	0.506
DEG_COP1_1	128	137	PF00400	0.577
DEG_SCF_FBW7_1	445	450	PF00400	0.507
DEG_SPOP_SBC_1	126	130	PF00917	0.688
DOC_CKS1_1	444	449	PF01111	0.500
DOC_CYCLIN_RxL_1	234	246	PF00134	0.463
DOC_CYCLIN_RxL_1	431	441	PF00134	0.547
DOC_MAPK_gen_1	144	152	PF00069	0.360
DOC_MAPK_gen_1	181	187	PF00069	0.376
DOC_MAPK_gen_1	234	243	PF00069	0.482
DOC_MAPK_gen_1	244	253	PF00069	0.497
DOC_MAPK_gen_1	62	69	PF00069	0.570
DOC_MAPK_MEF2A_6	145	154	PF00069	0.385
DOC_PP1_RVXF_1	237	244	PF00149	0.439
DOC_PP1_RVXF_1	456	463	PF00149	0.563
DOC_PP2B_LxvP_1	185	188	PF13499	0.383
DOC_SPAK_OSR1_1	242	246	PF12202	0.494
DOC_USP7_MATH_1	112	116	PF00917	0.657
DOC_USP7_MATH_1	119	123	PF00917	0.665
DOC_USP7_MATH_1	126	130	PF00917	0.554
DOC_USP7_MATH_1	352	356	PF00917	0.659
DOC_USP7_MATH_1	438	442	PF00917	0.612
DOC_USP7_MATH_1	453	457	PF00917	0.638
DOC_USP7_MATH_1	56	60	PF00917	0.688
DOC_USP7_MATH_1	85	89	PF00917	0.725
DOC_USP7_UBL2_3	300	304	PF12436	0.703
DOC_USP7_UBL2_3	356	360	PF12436	0.717
DOC_USP7_UBL2_3	417	421	PF12436	0.484
DOC_WW_Pin1_4	107	112	PF00397	0.704
DOC_WW_Pin1_4	260	265	PF00397	0.607
DOC_WW_Pin1_4	304	309	PF00397	0.778
DOC_WW_Pin1_4	322	327	PF00397	0.661
DOC_WW_Pin1_4	344	349	PF00397	0.651
DOC_WW_Pin1_4	443	448	PF00397	0.582
DOC_WW_Pin1_4	91	96	PF00397	0.656
LIG_14-3-3_CanoR_1	439	443	PF00244	0.694
LIG_14-3-3_CanoR_1	452	462	PF00244	0.621
LIG_APCC_ABBA_1	186	191	PF00400	0.340
LIG_FHA_1	167	173	PF00498	0.433
LIG_FHA_1	261	267	PF00498	0.525
LIG_FHA_1	327	333	PF00498	0.743
LIG_FHA_1	407	413	PF00498	0.542
LIG_FHA_2	283	289	PF00498	0.731
LIG_Integrin_RGD_1	281	283	PF01839	0.619
LIG_LIR_Gen_1	424	429	PF02991	0.470
LIG_LIR_LC3C_4	169	174	PF02991	0.414
LIG_LIR_Nem_3	180	186	PF02991	0.459
LIG_LIR_Nem_3	424	428	PF02991	0.474
LIG_SH2_CRK	183	187	PF00017	0.435
LIG_SH3_4	356	363	PF00018	0.646
LIG_TRAF2_1	402	405	PF00917	0.561
LIG_TRAF2_2	158	163	PF00917	0.484
LIG_UBA3_1	231	239	PF00899	0.423
MOD_CDC14_SPxK_1	110	113	PF00782	0.599
MOD_CDC14_SPxK_1	94	97	PF00782	0.618
MOD_CDK_SPK_2	344	349	PF00069	0.560
MOD_CDK_SPK_2	443	448	PF00069	0.527
MOD_CDK_SPxK_1	107	113	PF00069	0.605
MOD_CDK_SPxK_1	91	97	PF00069	0.620
MOD_CDK_SPxxK_3	107	114	PF00069	0.617
MOD_CDK_SPxxK_3	304	311	PF00069	0.676
MOD_CDK_SPxxK_3	91	98	PF00069	0.619
MOD_CK1_1	122	128	PF00069	0.664
MOD_CK1_1	129	135	PF00069	0.474
MOD_CK1_1	307	313	PF00069	0.708
MOD_CK1_1	359	365	PF00069	0.561
MOD_CK1_1	87	93	PF00069	0.679
MOD_CK2_1	284	290	PF00069	0.726
MOD_CK2_1	344	350	PF00069	0.676
MOD_CK2_1	359	365	PF00069	0.621
MOD_CK2_1	385	391	PF00069	0.532
MOD_CK2_1	399	405	PF00069	0.510
MOD_GlcNHglycan	114	117	PF01048	0.673
MOD_GlcNHglycan	124	127	PF01048	0.775
MOD_GlcNHglycan	332	335	PF01048	0.817
MOD_GlcNHglycan	455	458	PF01048	0.673
MOD_GlcNHglycan	58	61	PF01048	0.644
MOD_GlcNHglycan	87	90	PF01048	0.689
MOD_GSK3_1	122	129	PF00069	0.592
MOD_GSK3_1	162	169	PF00069	0.480
MOD_GSK3_1	173	180	PF00069	0.358
MOD_GSK3_1	307	314	PF00069	0.745
MOD_GSK3_1	322	329	PF00069	0.787
MOD_GSK3_1	352	359	PF00069	0.634
MOD_GSK3_1	443	450	PF00069	0.504
MOD_GSK3_1	52	59	PF00069	0.646
MOD_GSK3_1	87	94	PF00069	0.796
MOD_N-GLC_1	122	127	PF02516	0.729
MOD_N-GLC_1	344	349	PF02516	0.560
MOD_N-GLC_1	453	458	PF02516	0.567
MOD_NEK2_2	249	254	PF00069	0.571
MOD_PIKK_1	258	264	PF00454	0.600
MOD_PKA_1	311	317	PF00069	0.734
MOD_PKA_2	243	249	PF00069	0.479
MOD_PKA_2	438	444	PF00069	0.687
MOD_PKA_2	447	453	PF00069	0.749
MOD_PKA_2	96	102	PF00069	0.757
MOD_Plk_1	249	255	PF00069	0.574
MOD_Plk_2-3	284	290	PF00069	0.601
MOD_Plk_4	129	135	PF00069	0.623
MOD_ProDKin_1	107	113	PF00069	0.704
MOD_ProDKin_1	260	266	PF00069	0.607
MOD_ProDKin_1	304	310	PF00069	0.776
MOD_ProDKin_1	322	328	PF00069	0.662
MOD_ProDKin_1	344	350	PF00069	0.652
MOD_ProDKin_1	443	449	PF00069	0.585
MOD_ProDKin_1	91	97	PF00069	0.659
MOD_SUMO_for_1	367	370	PF00179	0.455
MOD_SUMO_rev_2	316	325	PF00179	0.804
MOD_SUMO_rev_2	362	369	PF00179	0.502
MOD_SUMO_rev_2	90	99	PF00179	0.560
TRG_ENDOCYTIC_2	183	186	PF00928	0.407
TRG_ER_diArg_1	253	256	PF00400	0.469
TRG_ER_diArg_1	61	64	PF00400	0.617
TRG_ER_diArg_1	76	79	PF00400	0.430
TRG_NLS_MonoExtC_3	310	315	PF00514	0.768
TRG_NLS_MonoExtC_3	359	364	PF00514	0.702
TRG_NLS_MonoExtN_4	308	315	PF00514	0.732
TRG_NLS_MonoExtN_4	357	364	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB51	Leptomonas seymouri	61%	100%
A0A0S4IW25	Bodo saltans	31%	100%
A0A3R7ME95	Trypanosoma rangeli	39%	100%
A4H507	Leishmania braziliensis	72%	100%
A4HT71	Leishmania infantum	98%	100%
C9ZUP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	83%
E9AL69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QIN5	Leishmania major	91%	100%
V5BY30	Trypanosoma cruzi	41%	97%