Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPV5_LEIDO

TriTrypDb:

LdBPK_070540.1 , LdCL_070010400 , LDHU3_07.0670

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7WPV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.690
CLV_C14_Caspase3-7	181	185	PF00656	0.655
CLV_NRD_NRD_1	100	102	PF00675	0.392
CLV_NRD_NRD_1	103	105	PF00675	0.409
CLV_NRD_NRD_1	149	151	PF00675	0.452
CLV_NRD_NRD_1	213	215	PF00675	0.413
CLV_NRD_NRD_1	301	303	PF00675	0.421
CLV_PCSK_KEX2_1	149	151	PF00082	0.452
CLV_PCSK_KEX2_1	213	215	PF00082	0.405
CLV_PCSK_KEX2_1	226	228	PF00082	0.344
CLV_PCSK_KEX2_1	301	303	PF00082	0.401
CLV_PCSK_KEX2_1	99	101	PF00082	0.401
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.433
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.444
CLV_PCSK_PC7_1	95	101	PF00082	0.400
CLV_PCSK_SKI1_1	113	117	PF00082	0.505
CLV_PCSK_SKI1_1	301	305	PF00082	0.410
CLV_PCSK_SKI1_1	59	63	PF00082	0.599
CLV_PCSK_SKI1_1	88	92	PF00082	0.417
DEG_MDM2_SWIB_1	41	48	PF02201	0.325
DEG_SCF_FBW7_1	7	14	PF00400	0.401
DEG_SPOP_SBC_1	27	31	PF00917	0.518
DEG_SPOP_SBC_1	32	36	PF00917	0.479
DEG_SPOP_SBC_1	384	388	PF00917	0.688
DOC_MAPK_DCC_7	59	69	PF00069	0.430
DOC_MAPK_FxFP_2	207	210	PF00069	0.653
DOC_MAPK_gen_1	162	172	PF00069	0.582
DOC_MAPK_gen_1	313	321	PF00069	0.670
DOC_MAPK_MEF2A_6	156	163	PF00069	0.594
DOC_MAPK_RevD_3	85	100	PF00069	0.573
DOC_PP1_RVXF_1	57	63	PF00149	0.428
DOC_PP2B_LxvP_1	67	70	PF13499	0.356
DOC_PP4_FxxP_1	207	210	PF00568	0.562
DOC_USP7_MATH_1	231	235	PF00917	0.701
DOC_USP7_MATH_1	252	256	PF00917	0.751
DOC_USP7_MATH_1	26	30	PF00917	0.566
DOC_USP7_MATH_1	32	36	PF00917	0.536
DOC_USP7_MATH_1	322	326	PF00917	0.728
DOC_USP7_MATH_1	336	340	PF00917	0.733
DOC_USP7_MATH_1	370	374	PF00917	0.789
DOC_USP7_UBL2_3	213	217	PF12436	0.643
DOC_WW_Pin1_4	248	253	PF00397	0.773
DOC_WW_Pin1_4	276	281	PF00397	0.772
DOC_WW_Pin1_4	28	33	PF00397	0.440
DOC_WW_Pin1_4	5	10	PF00397	0.565
LIG_14-3-3_CanoR_1	156	160	PF00244	0.577
LIG_14-3-3_CanoR_1	175	183	PF00244	0.531
LIG_14-3-3_CanoR_1	190	198	PF00244	0.479
LIG_14-3-3_CanoR_1	235	241	PF00244	0.708
LIG_14-3-3_CanoR_1	301	307	PF00244	0.700
LIG_14-3-3_CanoR_1	375	381	PF00244	0.732
LIG_14-3-3_CanoR_1	383	390	PF00244	0.648
LIG_14-3-3_CanoR_1	47	54	PF00244	0.430
LIG_BRCT_BRCA1_1	296	300	PF00533	0.716
LIG_BRCT_BRCA1_1	338	342	PF00533	0.742
LIG_BRCT_BRCA1_1	37	41	PF00533	0.433
LIG_CaM_NSCaTE_8	44	51	PF13499	0.439
LIG_CSL_BTD_1	67	70	PF09270	0.328
LIG_FHA_1	201	207	PF00498	0.561
LIG_FHA_1	379	385	PF00498	0.694
LIG_FHA_1	78	84	PF00498	0.337
LIG_FHA_2	12	18	PF00498	0.406
LIG_FHA_2	179	185	PF00498	0.656
LIG_FHA_2	51	57	PF00498	0.364
LIG_LIR_Apic_2	205	211	PF02991	0.567
LIG_LIR_Gen_1	103	112	PF02991	0.635
LIG_LIR_Gen_1	42	51	PF02991	0.444
LIG_LIR_Gen_1	80	90	PF02991	0.440
LIG_LIR_Nem_3	103	109	PF02991	0.603
LIG_LIR_Nem_3	184	189	PF02991	0.556
LIG_LIR_Nem_3	297	303	PF02991	0.598
LIG_LIR_Nem_3	379	385	PF02991	0.696
LIG_LIR_Nem_3	42	48	PF02991	0.446
LIG_LIR_Nem_3	80	85	PF02991	0.440
LIG_Pex14_1	45	49	PF04695	0.436
LIG_Pex14_2	300	304	PF04695	0.609
LIG_Pex14_2	41	45	PF04695	0.399
LIG_Pex14_2	90	94	PF04695	0.564
LIG_SH2_CRK	382	386	PF00017	0.688
LIG_SH2_STAT5	306	309	PF00017	0.609
LIG_SH2_STAT5	82	85	PF00017	0.331
LIG_UBA3_1	108	116	PF00899	0.625
LIG_WRC_WIRS_1	82	87	PF05994	0.370
MOD_CDC14_SPxK_1	251	254	PF00782	0.807
MOD_CDK_SPxK_1	248	254	PF00069	0.801
MOD_CK1_1	248	254	PF00069	0.764
MOD_CK1_1	263	269	PF00069	0.685
MOD_CK1_1	30	36	PF00069	0.501
MOD_CK1_1	373	379	PF00069	0.786
MOD_CK1_1	386	392	PF00069	0.645
MOD_CK1_1	50	56	PF00069	0.333
MOD_CK2_1	11	17	PF00069	0.503
MOD_CK2_1	263	269	PF00069	0.811
MOD_CK2_1	321	327	PF00069	0.728
MOD_CK2_1	50	56	PF00069	0.407
MOD_GlcNHglycan	191	194	PF01048	0.383
MOD_GlcNHglycan	20	23	PF01048	0.710
MOD_GlcNHglycan	265	268	PF01048	0.601
MOD_GlcNHglycan	3	6	PF01048	0.791
MOD_GlcNHglycan	334	337	PF01048	0.548
MOD_GlcNHglycan	339	342	PF01048	0.533
MOD_GlcNHglycan	347	350	PF01048	0.459
MOD_GlcNHglycan	351	354	PF01048	0.423
MOD_GlcNHglycan	359	362	PF01048	0.426
MOD_GlcNHglycan	37	40	PF01048	0.731
MOD_GlcNHglycan	376	379	PF01048	0.451
MOD_GlcNHglycan	394	397	PF01048	0.394
MOD_GlcNHglycan	49	52	PF01048	0.699
MOD_GSK3_1	1	8	PF00069	0.558
MOD_GSK3_1	244	251	PF00069	0.719
MOD_GSK3_1	259	266	PF00069	0.700
MOD_GSK3_1	26	33	PF00069	0.559
MOD_GSK3_1	322	329	PF00069	0.705
MOD_GSK3_1	332	339	PF00069	0.714
MOD_GSK3_1	345	352	PF00069	0.695
MOD_GSK3_1	35	42	PF00069	0.418
MOD_GSK3_1	370	377	PF00069	0.773
MOD_GSK3_1	73	80	PF00069	0.408
MOD_N-GLC_1	236	241	PF02516	0.517
MOD_N-GLC_1	245	250	PF02516	0.351
MOD_N-GLC_1	276	281	PF02516	0.551
MOD_NEK2_1	155	160	PF00069	0.550
MOD_NEK2_1	178	183	PF00069	0.610
MOD_NEK2_1	188	193	PF00069	0.513
MOD_NEK2_1	245	250	PF00069	0.761
MOD_NEK2_1	260	265	PF00069	0.708
MOD_NEK2_1	296	301	PF00069	0.668
MOD_NEK2_1	321	326	PF00069	0.729
MOD_NEK2_1	343	348	PF00069	0.652
MOD_NEK2_2	81	86	PF00069	0.327
MOD_PIKK_1	200	206	PF00454	0.575
MOD_PIKK_1	254	260	PF00454	0.749
MOD_PK_1	326	332	PF00069	0.755
MOD_PKA_2	155	161	PF00069	0.568
MOD_PKA_2	189	195	PF00069	0.560
MOD_PKA_2	322	328	PF00069	0.702
MOD_PKA_2	374	380	PF00069	0.777
MOD_Plk_1	142	148	PF00069	0.645
MOD_Plk_1	236	242	PF00069	0.727
MOD_Plk_1	245	251	PF00069	0.554
MOD_Plk_4	326	332	PF00069	0.736
MOD_Plk_4	77	83	PF00069	0.382
MOD_ProDKin_1	248	254	PF00069	0.774
MOD_ProDKin_1	276	282	PF00069	0.772
MOD_ProDKin_1	28	34	PF00069	0.438
MOD_ProDKin_1	5	11	PF00069	0.564
MOD_SUMO_rev_2	305	315	PF00179	0.639
TRG_ENDOCYTIC_2	106	109	PF00928	0.616
TRG_ENDOCYTIC_2	382	385	PF00928	0.692
TRG_ENDOCYTIC_2	82	85	PF00928	0.403
TRG_ER_diArg_1	300	302	PF00400	0.637
TRG_ER_diArg_1	85	88	PF00400	0.432
TRG_ER_diArg_1	99	101	PF00400	0.590
TRG_NES_CRM1_1	167	180	PF08389	0.556
TRG_NLS_Bipartite_1	213	229	PF00514	0.637
TRG_NLS_MonoExtC_3	224	229	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSU4	Leptomonas seymouri	74%	100%
A0A0S4IXL3	Bodo saltans	33%	100%
A0A1X0NPE0	Trypanosomatidae	39%	100%
A0A3R7NBC4	Trypanosoma rangeli	46%	100%
A4H4Z9	Leishmania braziliensis	86%	99%
A4HT79	Leishmania infantum	100%	100%
C9ZUQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AL61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
Q4QIP3	Leishmania major	96%	100%
V5B859	Trypanosoma cruzi	43%	100%