QA-SNARE_protein_putative/GeneDB:LmjF.07.0520

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPV3_LEIDO

TriTrypDb:

LdBPK_070570.1 , LdCL_070010700 , LDHU3_07.0700

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005794	Golgi apparatus	5	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0012507	ER to Golgi transport vesicle membrane	6	1
GO:0030658	transport vesicle membrane	5	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031201	SNARE complex	3	1
GO:0031902	late endosome membrane	6	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A0A3S7WPV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPV3

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.641
CLV_NRD_NRD_1	60	62	PF00675	0.408
CLV_PCSK_KEX2_1	230	232	PF00082	0.583
CLV_PCSK_KEX2_1	60	62	PF00082	0.408
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.583
CLV_PCSK_PC7_1	56	62	PF00082	0.401
CLV_PCSK_SKI1_1	129	133	PF00082	0.396
CLV_PCSK_SKI1_1	140	144	PF00082	0.379
CLV_PCSK_SKI1_1	206	210	PF00082	0.399
DEG_APCC_DBOX_1	48	56	PF00400	0.665
DEG_Nend_UBRbox_2	1	3	PF02207	0.691
DOC_CYCLIN_RxL_1	56	66	PF00134	0.623
DOC_MAPK_gen_1	19	27	PF00069	0.651
DOC_MAPK_gen_1	204	211	PF00069	0.562
DOC_MAPK_RevD_3	20	35	PF00069	0.627
DOC_MAPK_RevD_3	217	231	PF00069	0.366
DOC_PP1_RVXF_1	191	198	PF00149	0.587
DOC_USP7_MATH_1	142	146	PF00917	0.636
DOC_USP7_MATH_1	95	99	PF00917	0.744
LIG_14-3-3_CanoR_1	117	125	PF00244	0.700
LIG_14-3-3_CanoR_1	60	64	PF00244	0.641
LIG_14-3-3_CanoR_1	96	106	PF00244	0.694
LIG_FHA_1	147	153	PF00498	0.673
LIG_FHA_1	160	166	PF00498	0.608
LIG_FHA_1	26	32	PF00498	0.631
LIG_FHA_1	60	66	PF00498	0.682
LIG_FHA_2	103	109	PF00498	0.636
LIG_FHA_2	161	167	PF00498	0.627
LIG_FHA_2	28	34	PF00498	0.581
LIG_LIR_Gen_1	205	216	PF02991	0.476
LIG_LIR_Nem_3	205	211	PF02991	0.476
LIG_Pex14_2	208	212	PF04695	0.326
LIG_Pex14_2	224	228	PF04695	0.397
LIG_PTB_Apo_2	88	95	PF02174	0.604
LIG_PTB_Phospho_1	88	94	PF10480	0.599
LIG_SH2_CRK	199	203	PF00017	0.609
LIG_SH2_STAP1	85	89	PF00017	0.649
LIG_SH2_STAT3	106	109	PF00017	0.713
LIG_SUMO_SIM_par_1	23	30	PF11976	0.628
LIG_SUMO_SIM_par_1	61	66	PF11976	0.719
LIG_TRAF2_1	105	108	PF00917	0.707
LIG_WRC_WIRS_1	1	6	PF05994	0.690
MOD_CK1_1	226	232	PF00069	0.541
MOD_CK2_1	102	108	PF00069	0.629
MOD_CK2_1	160	166	PF00069	0.623
MOD_CK2_1	27	33	PF00069	0.598
MOD_GlcNHglycan	99	102	PF01048	0.545
MOD_GSK3_1	142	149	PF00069	0.620
MOD_N-GLC_1	153	158	PF02516	0.491
MOD_NEK2_1	11	16	PF00069	0.610
MOD_NEK2_1	125	130	PF00069	0.642
MOD_NEK2_2	207	212	PF00069	0.340
MOD_PKA_2	59	65	PF00069	0.617
MOD_PKA_2	95	101	PF00069	0.758
MOD_Plk_1	11	17	PF00069	0.620
MOD_Plk_1	78	84	PF00069	0.682
MOD_Plk_4	160	166	PF00069	0.657
MOD_Plk_4	207	213	PF00069	0.336
MOD_Plk_4	223	229	PF00069	0.298
MOD_SUMO_for_1	20	23	PF00179	0.575
MOD_SUMO_rev_2	121	131	PF00179	0.617
MOD_SUMO_rev_2	29	37	PF00179	0.573
TRG_DiLeu_BaEn_4	179	185	PF01217	0.673
TRG_ENDOCYTIC_2	199	202	PF00928	0.596
TRG_NES_CRM1_1	9	23	PF08389	0.599
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF5	Leptomonas seymouri	75%	100%
A0A0S4IUP1	Bodo saltans	45%	100%
A0A1X0NPE9	Trypanosomatidae	60%	100%
A0A3R7MA41	Trypanosoma rangeli	57%	100%
A4H502	Leishmania braziliensis	83%	100%
A4HT76	Leishmania infantum	100%	100%
C9ZUP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9AL64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QIP0	Leishmania major	96%	100%
V5B8J0	Trypanosoma cruzi	56%	100%