Ring finger domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPU3_LEIDO

TriTrypDb:

LdBPK_070100.1 , LdCL_070009000 , LDHU3_07.0480

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WPU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	493	497	PF00656	0.612
CLV_NRD_NRD_1	249	251	PF00675	0.780
CLV_NRD_NRD_1	266	268	PF00675	0.537
CLV_NRD_NRD_1	420	422	PF00675	0.470
CLV_NRD_NRD_1	507	509	PF00675	0.563
CLV_NRD_NRD_1	58	60	PF00675	0.807
CLV_NRD_NRD_1	714	716	PF00675	0.769
CLV_PCSK_FUR_1	247	251	PF00082	0.725
CLV_PCSK_FUR_1	505	509	PF00082	0.543
CLV_PCSK_KEX2_1	247	249	PF00082	0.784
CLV_PCSK_KEX2_1	266	268	PF00082	0.513
CLV_PCSK_KEX2_1	420	422	PF00082	0.470
CLV_PCSK_KEX2_1	507	509	PF00082	0.563
CLV_PCSK_KEX2_1	540	542	PF00082	0.475
CLV_PCSK_KEX2_1	58	60	PF00082	0.807
CLV_PCSK_KEX2_1	714	716	PF00082	0.772
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.452
CLV_PCSK_SKI1_1	249	253	PF00082	0.784
CLV_PCSK_SKI1_1	275	279	PF00082	0.710
CLV_PCSK_SKI1_1	431	435	PF00082	0.406
CLV_PCSK_SKI1_1	61	65	PF00082	0.661
CLV_PCSK_SKI1_1	823	827	PF00082	0.500
CLV_PCSK_SKI1_1	861	865	PF00082	0.529
CLV_Separin_Metazoa	546	550	PF03568	0.544
CLV_Separin_Metazoa	586	590	PF03568	0.603
DEG_Nend_UBRbox_1	1	4	PF02207	0.737
DEG_SPOP_SBC_1	124	128	PF00917	0.796
DEG_SPOP_SBC_1	141	145	PF00917	0.585
DEG_SPOP_SBC_1	147	151	PF00917	0.544
DEG_SPOP_SBC_1	351	355	PF00917	0.736
DEG_SPOP_SBC_1	39	43	PF00917	0.700
DOC_CYCLIN_yClb3_PxF_3	331	337	PF00134	0.581
DOC_MAPK_MEF2A_6	439	446	PF00069	0.614
DOC_MAPK_MEF2A_6	527	534	PF00069	0.474
DOC_PP1_RVXF_1	855	861	PF00149	0.572
DOC_PP2B_LxvP_1	251	254	PF13499	0.778
DOC_PP2B_PxIxI_1	529	535	PF00149	0.531
DOC_PP4_FxxP_1	753	756	PF00568	0.658
DOC_PP4_FxxP_1	772	775	PF00568	0.566
DOC_USP7_MATH_1	10	14	PF00917	0.718
DOC_USP7_MATH_1	104	108	PF00917	0.736
DOC_USP7_MATH_1	124	128	PF00917	0.621
DOC_USP7_MATH_1	140	144	PF00917	0.613
DOC_USP7_MATH_1	148	152	PF00917	0.565
DOC_USP7_MATH_1	169	173	PF00917	0.601
DOC_USP7_MATH_1	216	220	PF00917	0.690
DOC_USP7_MATH_1	228	232	PF00917	0.600
DOC_USP7_MATH_1	255	259	PF00917	0.782
DOC_USP7_MATH_1	261	265	PF00917	0.694
DOC_USP7_MATH_1	319	323	PF00917	0.670
DOC_USP7_MATH_1	350	354	PF00917	0.736
DOC_USP7_MATH_1	366	370	PF00917	0.658
DOC_USP7_MATH_1	614	618	PF00917	0.710
DOC_WW_Pin1_4	126	131	PF00397	0.726
DOC_WW_Pin1_4	177	182	PF00397	0.639
DOC_WW_Pin1_4	199	204	PF00397	0.697
DOC_WW_Pin1_4	217	222	PF00397	0.608
DOC_WW_Pin1_4	284	289	PF00397	0.716
DOC_WW_Pin1_4	295	300	PF00397	0.610
DOC_WW_Pin1_4	314	319	PF00397	0.614
DOC_WW_Pin1_4	343	348	PF00397	0.694
DOC_WW_Pin1_4	390	395	PF00397	0.562
DOC_WW_Pin1_4	437	442	PF00397	0.589
DOC_WW_Pin1_4	6	11	PF00397	0.735
DOC_WW_Pin1_4	647	652	PF00397	0.747
DOC_WW_Pin1_4	659	664	PF00397	0.622
DOC_WW_Pin1_4	747	752	PF00397	0.777
LIG_14-3-3_CanoR_1	266	272	PF00244	0.765
LIG_14-3-3_CanoR_1	275	284	PF00244	0.658
LIG_14-3-3_CanoR_1	310	318	PF00244	0.722
LIG_14-3-3_CanoR_1	38	46	PF00244	0.735
LIG_14-3-3_CanoR_1	421	427	PF00244	0.406
LIG_14-3-3_CanoR_1	431	436	PF00244	0.303
LIG_14-3-3_CanoR_1	463	469	PF00244	0.520
LIG_14-3-3_CanoR_1	470	476	PF00244	0.545
LIG_14-3-3_CanoR_1	512	516	PF00244	0.546
LIG_14-3-3_CanoR_1	541	550	PF00244	0.432
LIG_14-3-3_CanoR_1	715	725	PF00244	0.775
LIG_14-3-3_CanoR_1	823	833	PF00244	0.563
LIG_14-3-3_CanoR_1	897	901	PF00244	0.559
LIG_APCC_ABBA_1	847	852	PF00400	0.538
LIG_APCC_ABBA_1	862	867	PF00400	0.285
LIG_APCC_ABBAyCdc20_2	861	867	PF00400	0.470
LIG_BIR_III_4	499	503	PF00653	0.668
LIG_BRCT_BRCA1_1	749	753	PF00533	0.581
LIG_BRCT_BRCA1_1	821	825	PF00533	0.559
LIG_BRCT_MDC1_1	918	922	PF00533	0.588
LIG_FHA_1	289	295	PF00498	0.684
LIG_FHA_1	356	362	PF00498	0.729
LIG_FHA_1	432	438	PF00498	0.441
LIG_FHA_1	667	673	PF00498	0.716
LIG_FHA_1	742	748	PF00498	0.765
LIG_FHA_1	769	775	PF00498	0.749
LIG_FHA_2	276	282	PF00498	0.695
LIG_FHA_2	355	361	PF00498	0.824
LIG_FHA_2	391	397	PF00498	0.514
LIG_Integrin_RGD_1	501	503	PF01839	0.730
LIG_LIR_Apic_2	684	688	PF02991	0.738
LIG_LIR_Apic_2	750	756	PF02991	0.573
LIG_LIR_Apic_2	771	775	PF02991	0.731
LIG_LIR_Gen_1	291	299	PF02991	0.662
LIG_LIR_Gen_1	804	814	PF02991	0.555
LIG_LIR_Nem_3	291	295	PF02991	0.703
LIG_LIR_Nem_3	336	340	PF02991	0.791
LIG_LIR_Nem_3	575	581	PF02991	0.460
LIG_LIR_Nem_3	684	690	PF02991	0.681
LIG_LIR_Nem_3	804	809	PF02991	0.558
LIG_LIR_Nem_3	831	836	PF02991	0.348
LIG_LIR_Nem_3	859	863	PF02991	0.534
LIG_Pex14_1	880	884	PF04695	0.643
LIG_Pex14_2	894	898	PF04695	0.550
LIG_SH2_CRK	292	296	PF00017	0.698
LIG_SH2_CRK	578	582	PF00017	0.456
LIG_SH2_NCK_1	292	296	PF00017	0.666
LIG_SH2_PTP2	531	534	PF00017	0.462
LIG_SH2_PTP2	833	836	PF00017	0.373
LIG_SH2_SRC	531	534	PF00017	0.462
LIG_SH2_STAP1	292	296	PF00017	0.666
LIG_SH2_STAP1	619	623	PF00017	0.670
LIG_SH2_STAP1	821	825	PF00017	0.495
LIG_SH2_STAT5	292	295	PF00017	0.698
LIG_SH2_STAT5	531	534	PF00017	0.462
LIG_SH2_STAT5	833	836	PF00017	0.517
LIG_SH2_STAT5	848	851	PF00017	0.308
LIG_SH2_STAT5	884	887	PF00017	0.635
LIG_SH3_3	117	123	PF00018	0.721
LIG_SH3_3	302	308	PF00018	0.744
LIG_SH3_3	315	321	PF00018	0.649
LIG_SH3_3	323	329	PF00018	0.716
LIG_SH3_3	595	601	PF00018	0.718
LIG_SH3_3	668	674	PF00018	0.713
LIG_SH3_3	680	686	PF00018	0.636
LIG_SH3_3	692	698	PF00018	0.606
LIG_SH3_3	915	921	PF00018	0.448
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.623
LIG_SUMO_SIM_anti_2	584	589	PF11976	0.597
LIG_SUMO_SIM_par_1	384	389	PF11976	0.533
LIG_SUMO_SIM_par_1	562	568	PF11976	0.616
LIG_SUMO_SIM_par_1	596	602	PF11976	0.635
LIG_SUMO_SIM_par_1	650	655	PF11976	0.665
LIG_TRAF2_2	390	395	PF00917	0.591
LIG_WRC_WIRS_1	112	117	PF05994	0.608
LIG_WW_3	789	793	PF00397	0.621
MOD_CDC14_SPxK_1	667	670	PF00782	0.716
MOD_CDK_SPK_2	295	300	PF00069	0.664
MOD_CDK_SPxK_1	437	443	PF00069	0.483
MOD_CDK_SPxK_1	664	670	PF00069	0.720
MOD_CK1_1	107	113	PF00069	0.707
MOD_CK1_1	129	135	PF00069	0.734
MOD_CK1_1	177	183	PF00069	0.639
MOD_CK1_1	209	215	PF00069	0.688
MOD_CK1_1	219	225	PF00069	0.667
MOD_CK1_1	231	237	PF00069	0.625
MOD_CK1_1	24	30	PF00069	0.727
MOD_CK1_1	270	276	PF00069	0.720
MOD_CK1_1	314	320	PF00069	0.772
MOD_CK1_1	346	352	PF00069	0.722
MOD_CK1_1	355	361	PF00069	0.654
MOD_CK1_1	364	370	PF00069	0.623
MOD_CK1_1	375	381	PF00069	0.333
MOD_CK1_1	469	475	PF00069	0.599
MOD_CK1_1	617	623	PF00069	0.720
MOD_CK1_1	647	653	PF00069	0.666
MOD_CK1_1	662	668	PF00069	0.724
MOD_CK1_1	73	79	PF00069	0.752
MOD_CK1_1	824	830	PF00069	0.516
MOD_CK2_1	275	281	PF00069	0.665
MOD_CK2_1	354	360	PF00069	0.765
MOD_CK2_1	517	523	PF00069	0.417
MOD_Cter_Amidation	264	267	PF01082	0.713
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.735
MOD_GlcNHglycan	144	147	PF01048	0.692
MOD_GlcNHglycan	160	163	PF01048	0.607
MOD_GlcNHglycan	166	169	PF01048	0.679
MOD_GlcNHglycan	171	174	PF01048	0.637
MOD_GlcNHglycan	197	200	PF01048	0.772
MOD_GlcNHglycan	211	215	PF01048	0.577
MOD_GlcNHglycan	261	264	PF01048	0.711
MOD_GlcNHglycan	275	278	PF01048	0.601
MOD_GlcNHglycan	29	32	PF01048	0.761
MOD_GlcNHglycan	313	316	PF01048	0.731
MOD_GlcNHglycan	348	351	PF01048	0.743
MOD_GlcNHglycan	354	357	PF01048	0.600
MOD_GlcNHglycan	368	371	PF01048	0.521
MOD_GlcNHglycan	480	483	PF01048	0.697
MOD_GlcNHglycan	543	546	PF01048	0.557
MOD_GlcNHglycan	557	560	PF01048	0.372
MOD_GlcNHglycan	646	649	PF01048	0.731
MOD_GlcNHglycan	664	667	PF01048	0.623
MOD_GlcNHglycan	679	682	PF01048	0.500
MOD_GlcNHglycan	731	734	PF01048	0.751
MOD_GlcNHglycan	760	763	PF01048	0.593
MOD_GlcNHglycan	787	790	PF01048	0.761
MOD_GlcNHglycan	798	801	PF01048	0.607
MOD_GlcNHglycan	907	910	PF01048	0.512
MOD_GlcNHglycan	918	921	PF01048	0.476
MOD_GSK3_1	104	111	PF00069	0.700
MOD_GSK3_1	124	131	PF00069	0.590
MOD_GSK3_1	142	149	PF00069	0.666
MOD_GSK3_1	177	184	PF00069	0.713
MOD_GSK3_1	195	202	PF00069	0.617
MOD_GSK3_1	206	213	PF00069	0.610
MOD_GSK3_1	216	223	PF00069	0.672
MOD_GSK3_1	229	236	PF00069	0.654
MOD_GSK3_1	255	262	PF00069	0.743
MOD_GSK3_1	267	274	PF00069	0.639
MOD_GSK3_1	280	287	PF00069	0.582
MOD_GSK3_1	342	349	PF00069	0.751
MOD_GSK3_1	350	357	PF00069	0.692
MOD_GSK3_1	362	369	PF00069	0.542
MOD_GSK3_1	6	13	PF00069	0.728
MOD_GSK3_1	643	650	PF00069	0.663
MOD_GSK3_1	662	669	PF00069	0.607
MOD_GSK3_1	70	77	PF00069	0.754
MOD_GSK3_1	702	709	PF00069	0.744
MOD_GSK3_1	742	749	PF00069	0.768
MOD_GSK3_1	758	765	PF00069	0.724
MOD_GSK3_1	808	815	PF00069	0.615
MOD_GSK3_1	819	826	PF00069	0.434
MOD_N-GLC_1	104	109	PF02516	0.709
MOD_N-GLC_1	39	44	PF02516	0.735
MOD_N-GLC_1	429	434	PF02516	0.327
MOD_N-GLC_2	26	28	PF02516	0.722
MOD_NEK2_1	1	6	PF00069	0.737
MOD_NEK2_1	226	231	PF00069	0.756
MOD_NEK2_1	342	347	PF00069	0.735
MOD_NEK2_1	361	366	PF00069	0.772
MOD_NEK2_1	565	570	PF00069	0.553
MOD_NEK2_1	690	695	PF00069	0.760
MOD_NEK2_1	905	910	PF00069	0.501
MOD_NEK2_2	308	313	PF00069	0.722
MOD_NEK2_2	614	619	PF00069	0.674
MOD_PIKK_1	129	135	PF00454	0.734
MOD_PIKK_1	171	177	PF00454	0.718
MOD_PIKK_1	469	475	PF00454	0.570
MOD_PIKK_1	565	571	PF00454	0.571
MOD_PIKK_1	63	69	PF00454	0.659
MOD_PIKK_1	690	696	PF00454	0.718
MOD_PIKK_1	706	712	PF00454	0.559
MOD_PKA_2	1	7	PF00069	0.735
MOD_PKA_2	141	147	PF00069	0.668
MOD_PKA_2	209	215	PF00069	0.727
MOD_PKA_2	265	271	PF00069	0.708
MOD_PKA_2	469	475	PF00069	0.570
MOD_PKA_2	511	517	PF00069	0.547
MOD_PKA_2	728	734	PF00069	0.613
MOD_PKA_2	74	80	PF00069	0.741
MOD_PKA_2	896	902	PF00069	0.568
MOD_PKB_1	59	67	PF00069	0.658
MOD_Plk_1	280	286	PF00069	0.695
MOD_Plk_1	734	740	PF00069	0.709
MOD_Plk_1	742	748	PF00069	0.538
MOD_Plk_4	290	296	PF00069	0.661
MOD_Plk_4	372	378	PF00069	0.609
MOD_Plk_4	422	428	PF00069	0.406
MOD_Plk_4	614	620	PF00069	0.723
MOD_Plk_4	828	834	PF00069	0.377
MOD_ProDKin_1	126	132	PF00069	0.726
MOD_ProDKin_1	177	183	PF00069	0.639
MOD_ProDKin_1	199	205	PF00069	0.697
MOD_ProDKin_1	217	223	PF00069	0.607
MOD_ProDKin_1	284	290	PF00069	0.715
MOD_ProDKin_1	295	301	PF00069	0.610
MOD_ProDKin_1	314	320	PF00069	0.615
MOD_ProDKin_1	343	349	PF00069	0.694
MOD_ProDKin_1	390	396	PF00069	0.559
MOD_ProDKin_1	437	443	PF00069	0.594
MOD_ProDKin_1	6	12	PF00069	0.729
MOD_ProDKin_1	647	653	PF00069	0.749
MOD_ProDKin_1	659	665	PF00069	0.624
MOD_ProDKin_1	747	753	PF00069	0.778
MOD_SUMO_rev_2	355	364	PF00179	0.590
TRG_DiLeu_BaEn_2	900	906	PF01217	0.552
TRG_ENDOCYTIC_2	292	295	PF00928	0.698
TRG_ENDOCYTIC_2	531	534	PF00928	0.519
TRG_ENDOCYTIC_2	578	581	PF00928	0.456
TRG_ENDOCYTIC_2	833	836	PF00928	0.517
TRG_ER_diArg_1	247	250	PF00400	0.723
TRG_ER_diArg_1	46	49	PF00400	0.737
TRG_ER_diArg_1	460	463	PF00400	0.398
TRG_ER_diArg_1	505	508	PF00400	0.553
TRG_ER_diArg_1	57	59	PF00400	0.589
TRG_ER_diArg_1	588	591	PF00400	0.619
TRG_ER_diArg_1	713	715	PF00400	0.776
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H4Y3	Leishmania braziliensis	65%	100%
A4HT31	Leishmania infantum	100%	100%
E9AL48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QIQ6	Leishmania major	91%	100%