NUDIX family hydrolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX family hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPU2_LEIDO

TriTrypDb:

LdBPK_070500.1 , LdCL_070008500 , LDHU3_07.0420

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7WPU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPU2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015938	coenzyme A catabolic process	7	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033869	nucleoside bisphosphate catabolic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034031	ribonucleoside bisphosphate catabolic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034034	purine nucleoside bisphosphate catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0010945	CoA pyrophosphatase activity	6	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0003986	acetyl-CoA hydrolase activity	6	1
GO:0016289	CoA hydrolase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.575
CLV_C14_Caspase3-7	136	140	PF00656	0.618
CLV_C14_Caspase3-7	582	586	PF00656	0.664
CLV_C14_Caspase3-7	592	596	PF00656	0.670
CLV_C14_Caspase3-7	676	680	PF00656	0.643
CLV_MEL_PAP_1	39	45	PF00089	0.336
CLV_NRD_NRD_1	159	161	PF00675	0.304
CLV_NRD_NRD_1	171	173	PF00675	0.227
CLV_NRD_NRD_1	23	25	PF00675	0.396
CLV_NRD_NRD_1	33	35	PF00675	0.302
CLV_NRD_NRD_1	472	474	PF00675	0.402
CLV_NRD_NRD_1	541	543	PF00675	0.389
CLV_NRD_NRD_1	557	559	PF00675	0.502
CLV_NRD_NRD_1	64	66	PF00675	0.418
CLV_NRD_NRD_1	650	652	PF00675	0.505
CLV_NRD_NRD_1	771	773	PF00675	0.455
CLV_PCSK_FUR_1	555	559	PF00082	0.471
CLV_PCSK_KEX2_1	152	154	PF00082	0.251
CLV_PCSK_KEX2_1	159	161	PF00082	0.266
CLV_PCSK_KEX2_1	171	173	PF00082	0.326
CLV_PCSK_KEX2_1	23	25	PF00082	0.396
CLV_PCSK_KEX2_1	33	35	PF00082	0.302
CLV_PCSK_KEX2_1	472	474	PF00082	0.402
CLV_PCSK_KEX2_1	540	542	PF00082	0.395
CLV_PCSK_KEX2_1	557	559	PF00082	0.502
CLV_PCSK_KEX2_1	64	66	PF00082	0.418
CLV_PCSK_KEX2_1	649	651	PF00082	0.507
CLV_PCSK_KEX2_1	771	773	PF00082	0.455
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.239
CLV_PCSK_PC7_1	29	35	PF00082	0.346
CLV_PCSK_SKI1_1	226	230	PF00082	0.280
CLV_PCSK_SKI1_1	255	259	PF00082	0.286
CLV_PCSK_SKI1_1	462	466	PF00082	0.368
CLV_PCSK_SKI1_1	49	53	PF00082	0.365
CLV_PCSK_SKI1_1	59	63	PF00082	0.338
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DEG_SCF_FBW7_2	489	495	PF00400	0.470
DEG_SPOP_SBC_1	101	105	PF00917	0.606
DEG_SPOP_SBC_1	307	311	PF00917	0.711
DOC_ANK_TNKS_1	107	114	PF00023	0.637
DOC_CKS1_1	489	494	PF01111	0.474
DOC_MAPK_gen_1	159	167	PF00069	0.472
DOC_MAPK_gen_1	33	41	PF00069	0.571
DOC_MAPK_MEF2A_6	34	43	PF00069	0.498
DOC_MAPK_RevD_3	8	24	PF00069	0.547
DOC_PP2B_LxvP_1	300	303	PF13499	0.540
DOC_PP4_FxxP_1	274	277	PF00568	0.604
DOC_PP4_FxxP_1	370	373	PF00568	0.596
DOC_USP7_MATH_1	102	106	PF00917	0.584
DOC_USP7_MATH_1	107	111	PF00917	0.580
DOC_USP7_MATH_1	245	249	PF00917	0.433
DOC_USP7_MATH_1	270	274	PF00917	0.603
DOC_USP7_MATH_1	306	310	PF00917	0.700
DOC_USP7_MATH_1	517	521	PF00917	0.236
DOC_USP7_MATH_1	561	565	PF00917	0.737
DOC_USP7_MATH_1	675	679	PF00917	0.744
DOC_USP7_MATH_1	75	79	PF00917	0.701
DOC_USP7_MATH_1	84	88	PF00917	0.715
DOC_USP7_MATH_1	97	101	PF00917	0.606
DOC_WW_Pin1_4	233	238	PF00397	0.457
DOC_WW_Pin1_4	328	333	PF00397	0.639
DOC_WW_Pin1_4	336	341	PF00397	0.691
DOC_WW_Pin1_4	342	347	PF00397	0.639
DOC_WW_Pin1_4	488	493	PF00397	0.469
DOC_WW_Pin1_4	687	692	PF00397	0.708
LIG_14-3-3_CanoR_1	255	262	PF00244	0.503
LIG_14-3-3_CanoR_1	33	41	PF00244	0.498
LIG_14-3-3_CanoR_1	404	413	PF00244	0.538
LIG_14-3-3_CanoR_1	446	450	PF00244	0.685
LIG_14-3-3_CanoR_1	59	67	PF00244	0.629
LIG_14-3-3_CanoR_1	613	621	PF00244	0.663
LIG_14-3-3_CanoR_1	626	632	PF00244	0.649
LIG_14-3-3_CanoR_1	651	661	PF00244	0.758
LIG_14-3-3_CanoR_1	674	684	PF00244	0.720
LIG_Actin_WH2_2	753	769	PF00022	0.615
LIG_BIR_III_2	337	341	PF00653	0.648
LIG_BRCT_BRCA1_1	218	222	PF00533	0.488
LIG_BRCT_BRCA1_1	90	94	PF00533	0.699
LIG_Clathr_ClatBox_1	361	365	PF01394	0.504
LIG_deltaCOP1_diTrp_1	112	122	PF00928	0.560
LIG_deltaCOP1_diTrp_1	371	374	PF00928	0.568
LIG_FHA_1	114	120	PF00498	0.570
LIG_FHA_1	15	21	PF00498	0.553
LIG_FHA_1	234	240	PF00498	0.514
LIG_FHA_1	50	56	PF00498	0.629
LIG_FHA_1	626	632	PF00498	0.813
LIG_FHA_1	696	702	PF00498	0.755
LIG_FHA_1	707	713	PF00498	0.632
LIG_FHA_2	152	158	PF00498	0.472
LIG_FHA_2	185	191	PF00498	0.471
LIG_FHA_2	332	338	PF00498	0.742
LIG_FHA_2	355	361	PF00498	0.547
LIG_FHA_2	613	619	PF00498	0.685
LIG_FHA_2	652	658	PF00498	0.694
LIG_FHA_2	674	680	PF00498	0.797
LIG_FXI_DFP_1	177	181	PF00024	0.304
LIG_Integrin_RGD_1	731	733	PF01839	0.436
LIG_LIR_Apic_2	112	118	PF02991	0.583
LIG_LIR_Apic_2	273	277	PF02991	0.609
LIG_LIR_Gen_1	120	126	PF02991	0.470
LIG_LIR_Gen_1	178	188	PF02991	0.471
LIG_LIR_Gen_1	200	208	PF02991	0.488
LIG_LIR_Gen_1	293	302	PF02991	0.553
LIG_LIR_Gen_1	471	481	PF02991	0.500
LIG_LIR_Nem_3	120	125	PF02991	0.539
LIG_LIR_Nem_3	178	183	PF02991	0.464
LIG_LIR_Nem_3	186	191	PF02991	0.449
LIG_LIR_Nem_3	200	204	PF02991	0.433
LIG_LIR_Nem_3	248	254	PF02991	0.500
LIG_LIR_Nem_3	293	297	PF02991	0.537
LIG_LIR_Nem_3	371	375	PF02991	0.586
LIG_LIR_Nem_3	395	401	PF02991	0.515
LIG_LIR_Nem_3	471	477	PF02991	0.476
LIG_PCNA_PIPBox_1	658	667	PF02747	0.683
LIG_Pex14_2	370	374	PF04695	0.566
LIG_SH2_CRK	384	388	PF00017	0.523
LIG_SH2_CRK	474	478	PF00017	0.351
LIG_SH2_NCK_1	188	192	PF00017	0.504
LIG_SH2_NCK_1	512	516	PF00017	0.357
LIG_SH2_NCK_1	67	71	PF00017	0.666
LIG_SH2_SRC	188	191	PF00017	0.472
LIG_SH2_SRC	67	70	PF00017	0.664
LIG_SH2_STAP1	134	138	PF00017	0.566
LIG_SH2_STAP1	394	398	PF00017	0.491
LIG_SH2_STAP1	512	516	PF00017	0.357
LIG_SH2_STAP1	545	549	PF00017	0.566
LIG_SH2_STAT3	773	776	PF00017	0.663
LIG_SH2_STAT5	124	127	PF00017	0.562
LIG_SH2_STAT5	294	297	PF00017	0.493
LIG_SH2_STAT5	512	515	PF00017	0.351
LIG_SH3_1	486	492	PF00018	0.291
LIG_SH3_3	24	30	PF00018	0.604
LIG_SH3_3	264	270	PF00018	0.549
LIG_SH3_3	300	306	PF00018	0.630
LIG_SH3_3	337	343	PF00018	0.758
LIG_SH3_3	383	389	PF00018	0.533
LIG_SH3_3	486	492	PF00018	0.351
LIG_SH3_3	680	686	PF00018	0.665
LIG_SH3_3	738	744	PF00018	0.741
LIG_Sin3_3	481	488	PF02671	0.313
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.559
LIG_SUMO_SIM_par_1	360	366	PF11976	0.517
LIG_SUMO_SIM_par_1	685	690	PF11976	0.643
LIG_SUMO_SIM_par_1	708	713	PF11976	0.664
LIG_TRAF2_1	187	190	PF00917	0.472
LIG_TYR_ITIM	382	387	PF00017	0.381
LIG_UBA3_1	148	152	PF00899	0.351
LIG_WRC_WIRS_1	271	276	PF05994	0.499
LIG_WRC_WIRS_1	55	60	PF05994	0.427
MOD_CDC14_SPxK_1	690	693	PF00782	0.569
MOD_CDK_SPK_2	328	333	PF00069	0.545
MOD_CDK_SPxK_1	687	693	PF00069	0.573
MOD_CDK_SPxxK_3	328	335	PF00069	0.546
MOD_CDK_SPxxK_3	342	349	PF00069	0.511
MOD_CK1_1	100	106	PF00069	0.514
MOD_CK1_1	296	302	PF00069	0.424
MOD_CK1_1	309	315	PF00069	0.658
MOD_CK1_1	32	38	PF00069	0.443
MOD_CK1_1	339	345	PF00069	0.668
MOD_CK1_1	363	369	PF00069	0.537
MOD_CK1_1	440	446	PF00069	0.744
MOD_CK1_1	452	458	PF00069	0.459
MOD_CK1_1	590	596	PF00069	0.647
MOD_CK1_1	692	698	PF00069	0.671
MOD_CK1_1	705	711	PF00069	0.530
MOD_CK1_1	87	93	PF00069	0.788
MOD_CK2_1	151	157	PF00069	0.313
MOD_CK2_1	184	190	PF00069	0.311
MOD_CK2_1	354	360	PF00069	0.359
MOD_CK2_1	465	471	PF00069	0.473
MOD_CK2_1	612	618	PF00069	0.615
MOD_CK2_1	624	630	PF00069	0.628
MOD_CK2_1	651	657	PF00069	0.681
MOD_CMANNOS	348	351	PF00535	0.384
MOD_CMANNOS	403	406	PF00535	0.429
MOD_Cter_Amidation	169	172	PF01082	0.283
MOD_GlcNHglycan	109	112	PF01048	0.454
MOD_GlcNHglycan	161	164	PF01048	0.351
MOD_GlcNHglycan	2	5	PF01048	0.438
MOD_GlcNHglycan	311	314	PF01048	0.699
MOD_GlcNHglycan	34	37	PF01048	0.347
MOD_GlcNHglycan	442	445	PF01048	0.700
MOD_GlcNHglycan	447	450	PF01048	0.612
MOD_GlcNHglycan	479	482	PF01048	0.351
MOD_GlcNHglycan	563	566	PF01048	0.578
MOD_GlcNHglycan	581	584	PF01048	0.641
MOD_GlcNHglycan	621	624	PF01048	0.720
MOD_GlcNHglycan	641	644	PF01048	0.722
MOD_GlcNHglycan	669	672	PF01048	0.620
MOD_GlcNHglycan	704	707	PF01048	0.654
MOD_GlcNHglycan	719	722	PF01048	0.507
MOD_GlcNHglycan	77	80	PF01048	0.658
MOD_GlcNHglycan	86	89	PF01048	0.788
MOD_GlcNHglycan	95	98	PF01048	0.496
MOD_GlcNHglycan	99	102	PF01048	0.513
MOD_GSK3_1	307	314	PF00069	0.779
MOD_GSK3_1	433	440	PF00069	0.641
MOD_GSK3_1	445	452	PF00069	0.534
MOD_GSK3_1	49	56	PF00069	0.437
MOD_GSK3_1	587	594	PF00069	0.748
MOD_GSK3_1	663	670	PF00069	0.695
MOD_GSK3_1	685	692	PF00069	0.663
MOD_GSK3_1	695	702	PF00069	0.567
MOD_GSK3_1	75	82	PF00069	0.673
MOD_GSK3_1	84	91	PF00069	0.783
MOD_GSK3_1	93	100	PF00069	0.727
MOD_N-GLC_1	571	576	PF02516	0.575
MOD_NEK2_1	151	156	PF00069	0.313
MOD_NEK2_1	374	379	PF00069	0.395
MOD_NEK2_1	438	443	PF00069	0.615
MOD_NEK2_1	465	470	PF00069	0.435
MOD_NEK2_1	604	609	PF00069	0.584
MOD_NEK2_1	701	706	PF00069	0.653
MOD_NEK2_2	245	250	PF00069	0.258
MOD_NEK2_2	351	356	PF00069	0.447
MOD_NEK2_2	54	59	PF00069	0.425
MOD_PIKK_1	11	17	PF00454	0.429
MOD_PIKK_1	44	50	PF00454	0.459
MOD_PKA_1	159	165	PF00069	0.341
MOD_PKA_2	107	113	PF00069	0.553
MOD_PKA_2	159	165	PF00069	0.285
MOD_PKA_2	184	190	PF00069	0.357
MOD_PKA_2	32	38	PF00069	0.515
MOD_PKA_2	445	451	PF00069	0.583
MOD_PKA_2	590	596	PF00069	0.569
MOD_PKA_2	604	610	PF00069	0.564
MOD_PKA_2	612	618	PF00069	0.537
MOD_PKA_2	625	631	PF00069	0.559
MOD_PKA_2	673	679	PF00069	0.672
MOD_PKA_2	88	94	PF00069	0.630
MOD_PKB_1	649	657	PF00069	0.614
MOD_PKB_1	772	780	PF00069	0.581
MOD_Plk_2-3	360	366	PF00069	0.425
MOD_Plk_2-3	566	572	PF00069	0.608
MOD_Plk_4	290	296	PF00069	0.371
MOD_Plk_4	576	582	PF00069	0.601
MOD_ProDKin_1	233	239	PF00069	0.292
MOD_ProDKin_1	328	334	PF00069	0.546
MOD_ProDKin_1	336	342	PF00069	0.615
MOD_ProDKin_1	488	494	PF00069	0.470
MOD_ProDKin_1	687	693	PF00069	0.645
MOD_SUMO_rev_2	69	78	PF00179	0.563
MOD_SUMO_rev_2	763	769	PF00179	0.536
TRG_AP2beta_CARGO_1	120	129	PF09066	0.319
TRG_DiLeu_BaEn_3	764	770	PF01217	0.578
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.444
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.543
TRG_ENDOCYTIC_2	134	137	PF00928	0.443
TRG_ENDOCYTIC_2	188	191	PF00928	0.351
TRG_ENDOCYTIC_2	294	297	PF00928	0.342
TRG_ENDOCYTIC_2	384	387	PF00928	0.435
TRG_ENDOCYTIC_2	393	396	PF00928	0.303
TRG_ENDOCYTIC_2	474	477	PF00928	0.292
TRG_ER_diArg_1	159	161	PF00400	0.310
TRG_ER_diArg_1	23	25	PF00400	0.486
TRG_ER_diArg_1	264	267	PF00400	0.514
TRG_ER_diArg_1	332	335	PF00400	0.604
TRG_ER_diArg_1	411	414	PF00400	0.503
TRG_ER_diArg_1	458	461	PF00400	0.488
TRG_ER_diArg_1	472	474	PF00400	0.449
TRG_ER_diArg_1	540	542	PF00400	0.537
TRG_ER_diArg_1	554	557	PF00400	0.622
TRG_ER_diArg_1	649	651	PF00400	0.754
TRG_ER_diArg_1	770	772	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6E0	Leptomonas seymouri	39%	100%
A0A1X0NPA0	Trypanosomatidae	31%	100%
A4H4X9	Leishmania braziliensis	64%	100%
A4HT52	Leishmania infantum	99%	100%
E9AL44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QIR0	Leishmania major	88%	100%