Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPU0_LEIDO

TriTrypDb:

LdBPK_070160.1 , LdCL_070009800 , LDHU3_07.0580

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPU0

PDB structure(s): 7ane_h

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.523
CLV_NRD_NRD_1	68	70	PF00675	0.365
CLV_PCSK_KEX2_1	19	21	PF00082	0.412
CLV_PCSK_SKI1_1	158	162	PF00082	0.416
CLV_PCSK_SKI1_1	5	9	PF00082	0.534
CLV_PCSK_SKI1_1	69	73	PF00082	0.391
DEG_MDM2_SWIB_1	36	44	PF02201	0.369
DEG_Nend_Nbox_1	1	3	PF02207	0.514
DOC_MAPK_gen_1	120	129	PF00069	0.371
DOC_PP4_FxxP_1	82	85	PF00568	0.385
DOC_USP7_MATH_1	111	115	PF00917	0.337
LIG_14-3-3_CanoR_1	19	26	PF00244	0.450
LIG_14-3-3_CanoR_1	69	76	PF00244	0.400
LIG_eIF4E_1	76	82	PF01652	0.376
LIG_FHA_1	20	26	PF00498	0.382
LIG_LIR_Gen_1	149	160	PF02991	0.414
LIG_LIR_Gen_1	75	84	PF02991	0.469
LIG_LIR_Nem_3	104	110	PF02991	0.389
LIG_LIR_Nem_3	149	155	PF02991	0.420
LIG_LIR_Nem_3	75	79	PF02991	0.420
LIG_LIR_Nem_3	93	98	PF02991	0.245
LIG_Pex14_2	36	40	PF04695	0.392
LIG_SH2_CRK	110	114	PF00017	0.498
LIG_SH2_GRB2like	110	113	PF00017	0.381
LIG_SH2_NCK_1	110	114	PF00017	0.395
LIG_SH2_SRC	110	113	PF00017	0.378
LIG_SH2_STAP1	32	36	PF00017	0.363
LIG_SH2_STAT3	96	99	PF00017	0.380
LIG_SH3_3	48	54	PF00018	0.459
LIG_TYR_ITIM	108	113	PF00017	0.380
LIG_TYR_ITIM	161	166	PF00017	0.406
LIG_TYR_ITIM	84	89	PF00017	0.400
MOD_CK1_1	114	120	PF00069	0.345
MOD_GlcNHglycan	123	126	PF01048	0.407
MOD_GlcNHglycan	59	62	PF01048	0.470
MOD_N-GLC_1	111	116	PF02516	0.346
MOD_NEK2_1	121	126	PF00069	0.438
MOD_NEK2_1	55	60	PF00069	0.444
MOD_NEK2_2	32	37	PF00069	0.367
MOD_PKA_1	19	25	PF00069	0.402
MOD_PKA_1	69	75	PF00069	0.431
MOD_PKA_2	19	25	PF00069	0.448
MOD_Plk_1	111	117	PF00069	0.340
MOD_Plk_1	139	145	PF00069	0.460
MOD_Plk_1	32	38	PF00069	0.361
TRG_ENDOCYTIC_2	110	113	PF00928	0.381
TRG_ENDOCYTIC_2	163	166	PF00928	0.415
TRG_ENDOCYTIC_2	76	79	PF00928	0.434
TRG_ENDOCYTIC_2	86	89	PF00928	0.401
TRG_ENDOCYTIC_2	95	98	PF00928	0.351
TRG_ER_diArg_1	18	20	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E2	Leptomonas seymouri	87%	100%
A0A0S4JA27	Bodo saltans	62%	100%
A0A1X0NPB0	Trypanosomatidae	78%	100%
A0A422NAP1	Trypanosoma rangeli	78%	100%
A4H4Z1	Leishmania braziliensis	95%	100%
A4HT67	Leishmania infantum	100%	100%
C9ZUR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9AL56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QIP8	Leishmania major	98%	100%