LeishMANIAdb
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EamA-like transporter family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EamA-like transporter family, putative
Gene product:
EamA-like transporter family, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WPT7_LEIDO
TriTrypDb:
LdBPK_070070.1 , LdCL_070009300 , LDHU3_07.0510
Length:
610

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S7WPT7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPT7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0022857 transmembrane transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 274 278 PF00656 0.775
CLV_C14_Caspase3-7 328 332 PF00656 0.700
CLV_C14_Caspase3-7 454 458 PF00656 0.427
CLV_NRD_NRD_1 123 125 PF00675 0.433
CLV_NRD_NRD_1 340 342 PF00675 0.511
CLV_NRD_NRD_1 361 363 PF00675 0.547
CLV_NRD_NRD_1 368 370 PF00675 0.508
CLV_NRD_NRD_1 373 375 PF00675 0.346
CLV_NRD_NRD_1 378 380 PF00675 0.346
CLV_PCSK_FUR_1 121 125 PF00082 0.429
CLV_PCSK_FUR_1 366 370 PF00082 0.517
CLV_PCSK_FUR_1 371 375 PF00082 0.346
CLV_PCSK_KEX2_1 123 125 PF00082 0.433
CLV_PCSK_KEX2_1 340 342 PF00082 0.511
CLV_PCSK_KEX2_1 360 362 PF00082 0.545
CLV_PCSK_KEX2_1 368 370 PF00082 0.508
CLV_PCSK_KEX2_1 373 375 PF00082 0.346
CLV_PCSK_KEX2_1 378 380 PF00082 0.346
CLV_PCSK_PC7_1 364 370 PF00082 0.554
CLV_PCSK_PC7_1 374 380 PF00082 0.312
CLV_PCSK_SKI1_1 267 271 PF00082 0.633
CLV_PCSK_SKI1_1 382 386 PF00082 0.511
CLV_PCSK_SKI1_1 97 101 PF00082 0.546
DEG_APCC_DBOX_1 34 42 PF00400 0.665
DEG_APCC_DBOX_1 373 381 PF00400 0.546
DOC_CKS1_1 248 253 PF01111 0.784
DOC_CKS1_1 571 576 PF01111 0.411
DOC_CYCLIN_RxL_1 263 274 PF00134 0.766
DOC_CYCLIN_yClb5_NLxxxL_5 543 552 PF00134 0.411
DOC_CYCLIN_yCln2_LP_2 199 205 PF00134 0.632
DOC_CYCLIN_yCln2_LP_2 429 435 PF00134 0.523
DOC_CYCLIN_yCln2_LP_2 559 565 PF00134 0.411
DOC_CYCLIN_yCln2_LP_2 571 577 PF00134 0.411
DOC_MAPK_gen_1 378 387 PF00069 0.617
DOC_MAPK_MEF2A_6 290 297 PF00069 0.766
DOC_MAPK_MEF2A_6 315 323 PF00069 0.743
DOC_MAPK_MEF2A_6 437 445 PF00069 0.384
DOC_MAPK_MEF2A_6 51 60 PF00069 0.650
DOC_MAPK_MEF2A_6 64 73 PF00069 0.581
DOC_PP2B_LxvP_1 58 61 PF13499 0.616
DOC_PP4_FxxP_1 487 490 PF00568 0.600
DOC_PP4_FxxP_1 511 514 PF00568 0.391
DOC_PP4_FxxP_1 527 530 PF00568 0.460
DOC_PP4_FxxP_1 95 98 PF00568 0.487
DOC_USP7_MATH_1 171 175 PF00917 0.753
DOC_USP7_MATH_1 288 292 PF00917 0.708
DOC_USP7_MATH_1 307 311 PF00917 0.675
DOC_USP7_MATH_1 33 37 PF00917 0.658
DOC_USP7_MATH_1 480 484 PF00917 0.411
DOC_USP7_MATH_1 528 532 PF00917 0.335
DOC_WW_Pin1_4 122 127 PF00397 0.626
DOC_WW_Pin1_4 178 183 PF00397 0.770
DOC_WW_Pin1_4 204 209 PF00397 0.802
DOC_WW_Pin1_4 243 248 PF00397 0.805
DOC_WW_Pin1_4 3 8 PF00397 0.745
DOC_WW_Pin1_4 558 563 PF00397 0.411
DOC_WW_Pin1_4 570 575 PF00397 0.411
LIG_14-3-3_CanoR_1 290 294 PF00244 0.769
LIG_14-3-3_CanoR_1 373 378 PF00244 0.549
LIG_14-3-3_CanoR_1 44 53 PF00244 0.598
LIG_BIR_III_4 24 28 PF00653 0.770
LIG_BIR_III_4 457 461 PF00653 0.454
LIG_BRCT_BRCA1_1 473 477 PF00533 0.411
LIG_BRCT_BRCA1_1 91 95 PF00533 0.433
LIG_BRCT_BRCA1_2 91 97 PF00533 0.432
LIG_FHA_1 131 137 PF00498 0.776
LIG_FHA_1 17 23 PF00498 0.798
LIG_FHA_1 248 254 PF00498 0.782
LIG_FHA_1 290 296 PF00498 0.800
LIG_FHA_1 414 420 PF00498 0.411
LIG_FHA_1 446 452 PF00498 0.411
LIG_FHA_1 480 486 PF00498 0.411
LIG_FHA_1 558 564 PF00498 0.411
LIG_FHA_1 570 576 PF00498 0.411
LIG_FHA_2 123 129 PF00498 0.637
LIG_FHA_2 337 343 PF00498 0.738
LIG_FHA_2 520 526 PF00498 0.501
LIG_GBD_Chelix_1 563 571 PF00786 0.411
LIG_GSK3_LRP6_1 247 252 PF00069 0.685
LIG_LIR_Apic_2 303 307 PF02991 0.701
LIG_LIR_Apic_2 525 530 PF02991 0.425
LIG_LIR_Apic_2 92 98 PF02991 0.428
LIG_LIR_Gen_1 417 428 PF02991 0.387
LIG_LIR_Gen_1 531 540 PF02991 0.417
LIG_LIR_Nem_3 417 423 PF02991 0.387
LIG_LIR_Nem_3 531 535 PF02991 0.483
LIG_LIR_Nem_3 82 88 PF02991 0.510
LIG_MLH1_MIPbox_1 473 477 PF16413 0.411
LIG_MYND_1 251 255 PF01753 0.779
LIG_PDZ_Class_2 605 610 PF00595 0.432
LIG_Pex14_1 112 116 PF04695 0.411
LIG_Pex14_2 100 104 PF04695 0.387
LIG_Pex14_2 118 122 PF04695 0.521
LIG_Pex14_2 387 391 PF04695 0.411
LIG_Pex14_2 95 99 PF04695 0.434
LIG_PTB_Apo_2 110 117 PF02174 0.411
LIG_PTB_Apo_2 392 399 PF02174 0.411
LIG_PTB_Apo_2 505 512 PF02174 0.385
LIG_REV1ctd_RIR_1 115 125 PF16727 0.355
LIG_SH2_CRK 304 308 PF00017 0.667
LIG_SH2_CRK 481 485 PF00017 0.411
LIG_SH2_GRB2like 103 106 PF00017 0.411
LIG_SH2_NCK_1 304 308 PF00017 0.733
LIG_SH2_STAP1 46 50 PF00017 0.563
LIG_SH2_STAP1 481 485 PF00017 0.411
LIG_SH2_STAT5 103 106 PF00017 0.343
LIG_SH2_STAT5 396 399 PF00017 0.411
LIG_SH2_STAT5 481 484 PF00017 0.411
LIG_SH2_STAT5 592 595 PF00017 0.511
LIG_SH2_STAT5 88 91 PF00017 0.464
LIG_SH3_3 245 251 PF00018 0.780
LIG_SH3_3 383 389 PF00018 0.423
LIG_SH3_CIN85_PxpxPR_1 247 252 PF14604 0.685
LIG_SUMO_SIM_anti_2 316 323 PF11976 0.743
LIG_SUMO_SIM_par_1 441 446 PF11976 0.423
LIG_SUMO_SIM_par_1 468 474 PF11976 0.385
LIG_SUMO_SIM_par_1 515 520 PF11976 0.511
LIG_TRAF2_1 150 153 PF00917 0.849
LIG_TRAF2_1 314 317 PF00917 0.741
LIG_UBA3_1 58 64 PF00899 0.541
LIG_UBA3_1 89 97 PF00899 0.510
LIG_WW_1 223 226 PF00397 0.796
LIG_WW_3 357 361 PF00397 0.782
MOD_CDK_SPK_2 247 252 PF00069 0.693
MOD_CDK_SPxxK_3 3 10 PF00069 0.692
MOD_CK1_1 178 184 PF00069 0.812
MOD_CK1_1 207 213 PF00069 0.708
MOD_CK1_1 234 240 PF00069 0.725
MOD_CK1_1 3 9 PF00069 0.634
MOD_CK1_1 305 311 PF00069 0.700
MOD_CK1_1 403 409 PF00069 0.411
MOD_CK1_1 414 420 PF00069 0.411
MOD_CK1_1 570 576 PF00069 0.411
MOD_CK2_1 146 152 PF00069 0.821
MOD_CK2_1 190 196 PF00069 0.709
MOD_CK2_1 265 271 PF00069 0.682
MOD_CK2_1 310 316 PF00069 0.690
MOD_CK2_1 336 342 PF00069 0.681
MOD_CK2_1 519 525 PF00069 0.518
MOD_CMANNOS 529 532 PF00535 0.610
MOD_GlcNHglycan 11 14 PF01048 0.739
MOD_GlcNHglycan 118 121 PF01048 0.587
MOD_GlcNHglycan 177 180 PF01048 0.818
MOD_GlcNHglycan 233 236 PF01048 0.753
MOD_GlcNHglycan 239 242 PF01048 0.689
MOD_GlcNHglycan 283 286 PF01048 0.708
MOD_GlcNHglycan 309 312 PF01048 0.673
MOD_GlcNHglycan 445 448 PF01048 0.469
MOD_GlcNHglycan 473 476 PF01048 0.515
MOD_GlcNHglycan 588 591 PF01048 0.424
MOD_GSK3_1 142 149 PF00069 0.683
MOD_GSK3_1 171 178 PF00069 0.777
MOD_GSK3_1 180 187 PF00069 0.690
MOD_GSK3_1 207 214 PF00069 0.722
MOD_GSK3_1 243 250 PF00069 0.782
MOD_GSK3_1 258 265 PF00069 0.534
MOD_GSK3_1 277 284 PF00069 0.703
MOD_GSK3_1 302 309 PF00069 0.697
MOD_GSK3_1 398 405 PF00069 0.411
MOD_GSK3_1 408 415 PF00069 0.411
MOD_GSK3_1 441 448 PF00069 0.511
MOD_GSK3_1 539 546 PF00069 0.485
MOD_GSK3_1 553 560 PF00069 0.308
MOD_GSK3_1 563 570 PF00069 0.411
MOD_GSK3_1 99 106 PF00069 0.411
MOD_LATS_1 173 179 PF00433 0.681
MOD_N-GLC_1 104 109 PF02516 0.411
MOD_N-GLC_1 352 357 PF02516 0.787
MOD_N-GLC_1 398 403 PF02516 0.411
MOD_N-GLC_1 546 551 PF02516 0.411
MOD_N-GLC_2 204 206 PF02516 0.585
MOD_NEK2_1 116 121 PF00069 0.523
MOD_NEK2_1 184 189 PF00069 0.742
MOD_NEK2_1 231 236 PF00069 0.703
MOD_NEK2_1 398 403 PF00069 0.411
MOD_NEK2_1 413 418 PF00069 0.411
MOD_NEK2_1 422 427 PF00069 0.411
MOD_NEK2_1 443 448 PF00069 0.511
MOD_NEK2_1 519 524 PF00069 0.523
MOD_NEK2_1 539 544 PF00069 0.183
MOD_NEK2_1 567 572 PF00069 0.411
MOD_NEK2_1 73 78 PF00069 0.359
MOD_NEK2_1 99 104 PF00069 0.411
MOD_PIKK_1 130 136 PF00454 0.717
MOD_PIKK_1 218 224 PF00454 0.808
MOD_PKA_1 373 379 PF00069 0.511
MOD_PKA_2 289 295 PF00069 0.722
MOD_PKA_2 373 379 PF00069 0.411
MOD_PKA_2 9 15 PF00069 0.668
MOD_PKB_1 371 379 PF00069 0.511
MOD_Plk_1 160 166 PF00069 0.685
MOD_Plk_1 302 308 PF00069 0.697
MOD_Plk_1 330 336 PF00069 0.552
MOD_Plk_1 398 404 PF00069 0.411
MOD_Plk_4 26 32 PF00069 0.611
MOD_Plk_4 317 323 PF00069 0.686
MOD_Plk_4 330 336 PF00069 0.671
MOD_Plk_4 408 414 PF00069 0.411
MOD_Plk_4 415 421 PF00069 0.411
MOD_Plk_4 445 451 PF00069 0.399
MOD_Plk_4 480 486 PF00069 0.411
MOD_Plk_4 539 545 PF00069 0.511
MOD_Plk_4 73 79 PF00069 0.408
MOD_Plk_4 80 86 PF00069 0.406
MOD_Plk_4 99 105 PF00069 0.213
MOD_ProDKin_1 122 128 PF00069 0.525
MOD_ProDKin_1 178 184 PF00069 0.724
MOD_ProDKin_1 204 210 PF00069 0.770
MOD_ProDKin_1 243 249 PF00069 0.772
MOD_ProDKin_1 3 9 PF00069 0.691
MOD_ProDKin_1 558 564 PF00069 0.411
MOD_ProDKin_1 570 576 PF00069 0.411
TRG_DiLeu_BaLyEn_6 534 539 PF01217 0.411
TRG_DiLeu_BaLyEn_6 54 59 PF01217 0.556
TRG_ENDOCYTIC_2 481 484 PF00928 0.411
TRG_ER_diArg_1 122 124 PF00400 0.531
TRG_ER_diArg_1 35 38 PF00400 0.631
TRG_ER_diArg_1 359 362 PF00400 0.689
TRG_ER_diArg_1 363 366 PF00400 0.677
TRG_ER_diArg_1 368 371 PF00400 0.627
TRG_ER_diArg_1 372 374 PF00400 0.400
TRG_ER_diArg_1 377 379 PF00400 0.377
TRG_Pf-PMV_PEXEL_1 192 196 PF00026 0.709
TRG_Pf-PMV_PEXEL_1 267 271 PF00026 0.725
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.654

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM12 Leptomonas seymouri 59% 94%
A4H4Y6 Leishmania braziliensis 69% 100%
A4HT28 Leishmania infantum 99% 100%
E9AL51 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QIQ3 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS