Uncharacterized_protein_family_(UPF0172)_putative /Pfam:PF03665

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0172), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPT3_LEIDO

TriTrypDb:

LdBPK_070450.1 , LdCL_070008000 , LDHU3_07.0370

Length:

254

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0072546	EMC complex	3	10
GO:0098796	membrane protein complex	2	10
GO:0140534	endoplasmic reticulum protein-containing complex	2	10
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WPT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.607
CLV_PCSK_KEX2_1	37	39	PF00082	0.235
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.235
CLV_PCSK_SKI1_1	130	134	PF00082	0.369
CLV_PCSK_SKI1_1	17	21	PF00082	0.235
DEG_SPOP_SBC_1	3	7	PF00917	0.482
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.352
DOC_MAPK_RevD_3	238	254	PF00069	0.341
DOC_PP1_RVXF_1	143	150	PF00149	0.352
DOC_USP7_MATH_1	164	168	PF00917	0.310
DOC_USP7_MATH_1	205	209	PF00917	0.284
DOC_USP7_MATH_1	46	50	PF00917	0.328
DOC_USP7_MATH_1	56	60	PF00917	0.292
DOC_WW_Pin1_4	123	128	PF00397	0.260
DOC_WW_Pin1_4	155	160	PF00397	0.304
DOC_WW_Pin1_4	49	54	PF00397	0.355
DOC_WW_Pin1_4	8	13	PF00397	0.337
LIG_14-3-3_CanoR_1	119	127	PF00244	0.321
LIG_14-3-3_CanoR_1	139	149	PF00244	0.367
LIG_14-3-3_CanoR_1	172	179	PF00244	0.325
LIG_14-3-3_CanoR_1	190	194	PF00244	0.262
LIG_14-3-3_CanoR_1	195	203	PF00244	0.359
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_BIR_III_2	75	79	PF00653	0.235
LIG_eIF4E_1	242	248	PF01652	0.308
LIG_FHA_1	14	20	PF00498	0.226
LIG_FHA_1	142	148	PF00498	0.306
LIG_FHA_1	176	182	PF00498	0.296
LIG_FHA_1	4	10	PF00498	0.634
LIG_FHA_1	68	74	PF00498	0.363
LIG_FHA_2	239	245	PF00498	0.286
LIG_LIR_Gen_1	93	103	PF02991	0.245
LIG_LIR_Nem_3	221	226	PF02991	0.334
LIG_LIR_Nem_3	93	99	PF02991	0.245
LIG_SH2_CRK	23	27	PF00017	0.377
LIG_SH2_NCK_1	96	100	PF00017	0.235
LIG_SH2_SRC	96	99	PF00017	0.308
LIG_SH2_STAP1	15	19	PF00017	0.295
LIG_SH2_STAT3	242	245	PF00017	0.235
LIG_SH2_STAT3	25	28	PF00017	0.243
LIG_SH2_STAT5	114	117	PF00017	0.277
LIG_SH2_STAT5	15	18	PF00017	0.260
LIG_SH2_STAT5	242	245	PF00017	0.258
LIG_SH2_STAT5	72	75	PF00017	0.308
LIG_SH3_1	23	29	PF00018	0.352
LIG_SH3_3	23	29	PF00018	0.417
LIG_SH3_3	50	56	PF00018	0.264
LIG_SH3_3	6	12	PF00018	0.374
LIG_SUMO_SIM_par_1	177	183	PF11976	0.376
LIG_TYR_ITIM	94	99	PF00017	0.235
LIG_UBA3_1	247	254	PF00899	0.520
MOD_CDK_SPxxK_3	123	130	PF00069	0.352
MOD_CK1_1	126	132	PF00069	0.254
MOD_CK1_1	158	164	PF00069	0.294
MOD_CK1_1	180	186	PF00069	0.302
MOD_CK1_1	2	8	PF00069	0.479
MOD_CK1_1	208	214	PF00069	0.271
MOD_CK1_1	49	55	PF00069	0.275
MOD_CK1_1	64	70	PF00069	0.387
MOD_CK2_1	183	189	PF00069	0.361
MOD_CK2_1	208	214	PF00069	0.339
MOD_CK2_1	238	244	PF00069	0.286
MOD_Cter_Amidation	35	38	PF01082	0.235
MOD_GlcNHglycan	1	4	PF01048	0.519
MOD_GlcNHglycan	185	188	PF01048	0.395
MOD_GlcNHglycan	207	210	PF01048	0.246
MOD_GlcNHglycan	49	52	PF01048	0.335
MOD_GlcNHglycan	63	66	PF01048	0.337
MOD_GSK3_1	102	109	PF00069	0.282
MOD_GSK3_1	154	161	PF00069	0.343
MOD_GSK3_1	171	178	PF00069	0.309
MOD_GSK3_1	208	215	PF00069	0.441
MOD_GSK3_1	4	11	PF00069	0.477
MOD_GSK3_1	47	54	PF00069	0.272
MOD_GSK3_1	61	68	PF00069	0.319
MOD_GSK3_1	79	86	PF00069	0.221
MOD_N-GLC_1	175	180	PF02516	0.208
MOD_N-GLC_2	153	155	PF02516	0.336
MOD_NEK2_1	163	168	PF00069	0.389
MOD_NEK2_1	4	9	PF00069	0.582
MOD_NEK2_1	79	84	PF00069	0.235
MOD_PIKK_1	180	186	PF00454	0.322
MOD_PKA_1	37	43	PF00069	0.219
MOD_PKA_2	118	124	PF00069	0.271
MOD_PKA_2	171	177	PF00069	0.325
MOD_PKA_2	189	195	PF00069	0.159
MOD_PKA_2	37	43	PF00069	0.250
MOD_Plk_1	175	181	PF00069	0.272
MOD_Plk_1	203	209	PF00069	0.395
MOD_Plk_4	106	112	PF00069	0.380
MOD_Plk_4	208	214	PF00069	0.271
MOD_Plk_4	4	10	PF00069	0.486
MOD_ProDKin_1	123	129	PF00069	0.260
MOD_ProDKin_1	155	161	PF00069	0.304
MOD_ProDKin_1	49	55	PF00069	0.355
MOD_ProDKin_1	8	14	PF00069	0.337
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.246
TRG_ENDOCYTIC_2	96	99	PF00928	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U5	Leptomonas seymouri	76%	100%
A0A1X0NP88	Trypanosomatidae	39%	95%
A0A422NDI1	Trypanosoma rangeli	46%	100%
A4H4X4	Leishmania braziliensis	85%	100%
A4HT47	Leishmania infantum	100%	100%
C9ZUT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	93%
E9AL39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QIR5	Leishmania major	98%	100%