Abscisic acid G-protein coupled receptor family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3735)/Abscisic acid G-protein coupled receptor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPT2_LEIDO

TriTrypDb:

LdBPK_070490.1 , LdCL_070008400 , LDHU3_07.0410

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WPT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.506
CLV_NRD_NRD_1	155	157	PF00675	0.448
CLV_NRD_NRD_1	246	248	PF00675	0.677
CLV_NRD_NRD_1	333	335	PF00675	0.745
CLV_NRD_NRD_1	400	402	PF00675	0.275
CLV_NRD_NRD_1	671	673	PF00675	0.475
CLV_PCSK_KEX2_1	144	146	PF00082	0.512
CLV_PCSK_KEX2_1	149	151	PF00082	0.509
CLV_PCSK_KEX2_1	155	157	PF00082	0.443
CLV_PCSK_KEX2_1	246	248	PF00082	0.677
CLV_PCSK_KEX2_1	333	335	PF00082	0.747
CLV_PCSK_KEX2_1	670	672	PF00082	0.475
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.469
CLV_PCSK_PC7_1	140	146	PF00082	0.447
CLV_PCSK_SKI1_1	108	112	PF00082	0.484
CLV_PCSK_SKI1_1	207	211	PF00082	0.361
CLV_PCSK_SKI1_1	362	366	PF00082	0.492
CLV_PCSK_SKI1_1	614	618	PF00082	0.329
CLV_PCSK_SKI1_1	709	713	PF00082	0.312
DEG_APCC_DBOX_1	181	189	PF00400	0.615
DEG_APCC_DBOX_1	206	214	PF00400	0.564
DEG_APCC_DBOX_1	708	716	PF00400	0.312
DEG_APCC_DBOX_1	814	822	PF00400	0.579
DEG_SPOP_SBC_1	67	71	PF00917	0.385
DEG_SPOP_SBC_1	822	826	PF00917	0.540
DOC_ANK_TNKS_1	289	296	PF00023	0.450
DOC_ANK_TNKS_1	670	677	PF00023	0.329
DOC_CYCLIN_RxL_1	589	597	PF00134	0.605
DOC_MAPK_gen_1	205	213	PF00069	0.487
DOC_MAPK_HePTP_8	105	117	PF00069	0.260
DOC_MAPK_MEF2A_6	108	117	PF00069	0.264
DOC_MAPK_MEF2A_6	205	213	PF00069	0.505
DOC_MAPK_MEF2A_6	362	370	PF00069	0.275
DOC_MAPK_MEF2A_6	621	630	PF00069	0.475
DOC_MAPK_MEF2A_6	729	737	PF00069	0.475
DOC_PP1_RVXF_1	203	209	PF00149	0.649
DOC_PP2B_LxvP_1	259	262	PF13499	0.482
DOC_PP4_FxxP_1	386	389	PF00568	0.312
DOC_USP7_MATH_1	278	282	PF00917	0.538
DOC_USP7_MATH_1	344	348	PF00917	0.502
DOC_USP7_MATH_1	358	362	PF00917	0.216
DOC_USP7_MATH_1	58	62	PF00917	0.421
DOC_USP7_MATH_1	66	70	PF00917	0.433
DOC_WW_Pin1_4	379	384	PF00397	0.312
DOC_WW_Pin1_4	436	441	PF00397	0.679
DOC_WW_Pin1_4	443	448	PF00397	0.666
DOC_WW_Pin1_4	458	463	PF00397	0.664
DOC_WW_Pin1_4	490	495	PF00397	0.723
DOC_WW_Pin1_4	526	531	PF00397	0.828
DOC_WW_Pin1_4	550	555	PF00397	0.683
DOC_WW_Pin1_4	559	564	PF00397	0.681
DOC_WW_Pin1_4	760	765	PF00397	0.317
LIG_14-3-3_CanoR_1	104	112	PF00244	0.387
LIG_14-3-3_CanoR_1	144	151	PF00244	0.699
LIG_14-3-3_CanoR_1	156	165	PF00244	0.587
LIG_14-3-3_CanoR_1	180	189	PF00244	0.705
LIG_14-3-3_CanoR_1	238	245	PF00244	0.478
LIG_14-3-3_CanoR_1	255	259	PF00244	0.425
LIG_14-3-3_CanoR_1	362	367	PF00244	0.292
LIG_14-3-3_CanoR_1	451	458	PF00244	0.760
LIG_14-3-3_CanoR_1	523	530	PF00244	0.681
LIG_14-3-3_CanoR_1	580	585	PF00244	0.590
LIG_14-3-3_CanoR_1	592	597	PF00244	0.541
LIG_14-3-3_CanoR_1	614	619	PF00244	0.529
LIG_14-3-3_CanoR_1	753	757	PF00244	0.329
LIG_14-3-3_CanoR_1	793	801	PF00244	0.295
LIG_Actin_WH2_2	595	612	PF00022	0.561
LIG_Actin_WH2_2	739	755	PF00022	0.388
LIG_BIR_II_1	1	5	PF00653	0.377
LIG_BIR_III_4	321	325	PF00653	0.519
LIG_BRCT_BRCA1_1	173	177	PF00533	0.715
LIG_BRCT_BRCA1_1	185	189	PF00533	0.657
LIG_BRCT_BRCA1_1	438	442	PF00533	0.696
LIG_BRCT_BRCA1_1	95	99	PF00533	0.360
LIG_deltaCOP1_diTrp_1	435	442	PF00928	0.642
LIG_deltaCOP1_diTrp_1	796	799	PF00928	0.312
LIG_EH1_1	602	610	PF00400	0.562
LIG_EH1_1	743	751	PF00400	0.312
LIG_eIF4E_1	15	21	PF01652	0.316
LIG_eIF4E_1	744	750	PF01652	0.312
LIG_FHA_1	109	115	PF00498	0.312
LIG_FHA_1	118	124	PF00498	0.312
LIG_FHA_1	224	230	PF00498	0.476
LIG_FHA_1	254	260	PF00498	0.470
LIG_FHA_1	358	364	PF00498	0.275
LIG_FHA_1	40	46	PF00498	0.312
LIG_FHA_1	562	568	PF00498	0.789
LIG_FHA_1	655	661	PF00498	0.275
LIG_FHA_1	664	670	PF00498	0.275
LIG_FHA_1	687	693	PF00498	0.295
LIG_FHA_1	730	736	PF00498	0.460
LIG_FHA_1	93	99	PF00498	0.409
LIG_FHA_2	659	665	PF00498	0.260
LIG_FHA_2	681	687	PF00498	0.329
LIG_IBAR_NPY_1	475	477	PF08397	0.697
LIG_LIR_Apic_2	435	440	PF02991	0.631
LIG_LIR_Gen_1	109	118	PF02991	0.312
LIG_LIR_Gen_1	375	385	PF02991	0.388
LIG_LIR_Gen_1	48	58	PF02991	0.312
LIG_LIR_Gen_1	591	600	PF02991	0.570
LIG_LIR_Gen_1	795	801	PF02991	0.315
LIG_LIR_Gen_1	9	16	PF02991	0.302
LIG_LIR_Gen_1	90	99	PF02991	0.475
LIG_LIR_Nem_3	109	115	PF02991	0.312
LIG_LIR_Nem_3	375	380	PF02991	0.470
LIG_LIR_Nem_3	48	53	PF02991	0.312
LIG_LIR_Nem_3	591	596	PF02991	0.571
LIG_LIR_Nem_3	597	602	PF02991	0.527
LIG_LIR_Nem_3	785	791	PF02991	0.324
LIG_LIR_Nem_3	795	800	PF02991	0.265
LIG_LIR_Nem_3	9	13	PF02991	0.296
LIG_LIR_Nem_3	96	102	PF02991	0.355
LIG_NRBOX	112	118	PF00104	0.354
LIG_NRBOX	209	215	PF00104	0.388
LIG_Pex14_2	39	43	PF04695	0.312
LIG_RPA_C_Fungi	666	678	PF08784	0.255
LIG_SH2_CRK	249	253	PF00017	0.580
LIG_SH2_CRK	377	381	PF00017	0.312
LIG_SH2_CRK	430	434	PF00017	0.451
LIG_SH2_CRK	477	481	PF00017	0.660
LIG_SH2_CRK	623	627	PF00017	0.312
LIG_SH2_CRK	633	637	PF00017	0.312
LIG_SH2_CRK	791	795	PF00017	0.312
LIG_SH2_NCK_1	377	381	PF00017	0.312
LIG_SH2_STAP1	10	14	PF00017	0.312
LIG_SH2_STAP1	173	177	PF00017	0.515
LIG_SH2_STAT3	789	792	PF00017	0.312
LIG_SH2_STAT5	15	18	PF00017	0.340
LIG_SH2_STAT5	249	252	PF00017	0.603
LIG_SH2_STAT5	390	393	PF00017	0.346
LIG_SH2_STAT5	413	416	PF00017	0.409
LIG_SH2_STAT5	5	8	PF00017	0.334
LIG_SH2_STAT5	599	602	PF00017	0.436
LIG_SH2_STAT5	744	747	PF00017	0.312
LIG_SH2_STAT5	823	826	PF00017	0.563
LIG_SH3_1	557	563	PF00018	0.618
LIG_SH3_2	329	334	PF14604	0.691
LIG_SH3_3	120	126	PF00018	0.340
LIG_SH3_3	22	28	PF00018	0.472
LIG_SH3_3	310	316	PF00018	0.588
LIG_SH3_3	326	332	PF00018	0.570
LIG_SH3_3	377	383	PF00018	0.340
LIG_SH3_3	470	476	PF00018	0.637
LIG_SH3_3	557	563	PF00018	0.617
LIG_SH3_3	564	570	PF00018	0.610
LIG_Sin3_3	50	57	PF02671	0.307
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.345
LIG_SUMO_SIM_anti_2	816	826	PF11976	0.409
LIG_SUMO_SIM_par_1	113	120	PF11976	0.340
LIG_SUMO_SIM_par_1	748	755	PF11976	0.312
LIG_TRAF2_1	282	285	PF00917	0.642
LIG_TYR_ITIM	428	433	PF00017	0.435
MOD_CDC14_SPxK_1	448	451	PF00782	0.686
MOD_CDK_SPxK_1	445	451	PF00069	0.680
MOD_CDK_SPxxK_3	550	557	PF00069	0.542
MOD_CK1_1	106	112	PF00069	0.340
MOD_CK1_1	154	160	PF00069	0.558
MOD_CK1_1	167	173	PF00069	0.579
MOD_CK1_1	175	181	PF00069	0.524
MOD_CK1_1	183	189	PF00069	0.557
MOD_CK1_1	241	247	PF00069	0.511
MOD_CK1_1	30	36	PF00069	0.472
MOD_CK1_1	48	54	PF00069	0.278
MOD_CK1_1	515	521	PF00069	0.738
MOD_CK1_1	562	568	PF00069	0.583
MOD_CK1_1	588	594	PF00069	0.492
MOD_CK1_1	90	96	PF00069	0.555
MOD_CK2_1	279	285	PF00069	0.650
MOD_CK2_1	288	294	PF00069	0.520
MOD_CK2_1	658	664	PF00069	0.291
MOD_CK2_1	680	686	PF00069	0.388
MOD_CK2_1	823	829	PF00069	0.497
MOD_CMANNOS	88	91	PF00535	0.581
MOD_Cter_Amidation	142	145	PF01082	0.602
MOD_Cter_Amidation	147	150	PF01082	0.626
MOD_GlcNHglycan	105	108	PF01048	0.472
MOD_GlcNHglycan	141	144	PF01048	0.620
MOD_GlcNHglycan	159	162	PF01048	0.570
MOD_GlcNHglycan	166	169	PF01048	0.566
MOD_GlcNHglycan	270	273	PF01048	0.704
MOD_GlcNHglycan	281	284	PF01048	0.580
MOD_GlcNHglycan	31	35	PF01048	0.621
MOD_GlcNHglycan	346	349	PF01048	0.634
MOD_GlcNHglycan	374	377	PF01048	0.388
MOD_GlcNHglycan	485	489	PF01048	0.630
MOD_GlcNHglycan	50	53	PF01048	0.277
MOD_GlcNHglycan	514	517	PF01048	0.740
MOD_GlcNHglycan	530	533	PF01048	0.535
MOD_GlcNHglycan	564	567	PF01048	0.736
MOD_GlcNHglycan	587	590	PF01048	0.439
MOD_GlcNHglycan	633	636	PF01048	0.272
MOD_GlcNHglycan	64	67	PF01048	0.604
MOD_GlcNHglycan	722	725	PF01048	0.321
MOD_GlcNHglycan	78	81	PF01048	0.487
MOD_GlcNHglycan	825	828	PF01048	0.484
MOD_GSK3_1	139	146	PF00069	0.639
MOD_GSK3_1	150	157	PF00069	0.592
MOD_GSK3_1	167	174	PF00069	0.630
MOD_GSK3_1	176	183	PF00069	0.615
MOD_GSK3_1	237	244	PF00069	0.532
MOD_GSK3_1	247	254	PF00069	0.554
MOD_GSK3_1	274	281	PF00069	0.660
MOD_GSK3_1	358	365	PF00069	0.347
MOD_GSK3_1	39	46	PF00069	0.328
MOD_GSK3_1	484	491	PF00069	0.629
MOD_GSK3_1	522	529	PF00069	0.784
MOD_GSK3_1	561	568	PF00069	0.622
MOD_GSK3_1	579	586	PF00069	0.515
MOD_GSK3_1	58	65	PF00069	0.643
MOD_GSK3_1	588	595	PF00069	0.530
MOD_GSK3_1	654	661	PF00069	0.283
MOD_GSK3_1	676	683	PF00069	0.388
MOD_GSK3_1	716	723	PF00069	0.312
MOD_GSK3_1	731	738	PF00069	0.312
MOD_GSK3_1	752	759	PF00069	0.364
MOD_GSK3_1	817	824	PF00069	0.452
MOD_N-GLC_1	512	517	PF02516	0.598
MOD_N-GLC_1	526	531	PF02516	0.533
MOD_NEK2_1	103	108	PF00069	0.388
MOD_NEK2_1	116	121	PF00069	0.316
MOD_NEK2_1	129	134	PF00069	0.262
MOD_NEK2_1	151	156	PF00069	0.585
MOD_NEK2_1	164	169	PF00069	0.461
MOD_NEK2_1	172	177	PF00069	0.573
MOD_NEK2_1	39	44	PF00069	0.312
MOD_NEK2_1	428	433	PF00069	0.539
MOD_NEK2_1	45	50	PF00069	0.319
MOD_NEK2_1	484	489	PF00069	0.602
MOD_NEK2_1	505	510	PF00069	0.618
MOD_NEK2_1	594	599	PF00069	0.410
MOD_NEK2_1	648	653	PF00069	0.311
MOD_NEK2_1	663	668	PF00069	0.306
MOD_NEK2_1	680	685	PF00069	0.213
MOD_NEK2_1	704	709	PF00069	0.304
MOD_NEK2_1	716	721	PF00069	0.349
MOD_NEK2_1	722	727	PF00069	0.441
MOD_NEK2_1	751	756	PF00069	0.312
MOD_NEK2_1	814	819	PF00069	0.529
MOD_NEK2_1	92	97	PF00069	0.476
MOD_PIKK_1	247	253	PF00454	0.578
MOD_PIKK_1	522	528	PF00454	0.678
MOD_PIKK_1	649	655	PF00454	0.291
MOD_PK_1	238	244	PF00069	0.570
MOD_PKA_1	155	161	PF00069	0.559
MOD_PKA_2	103	109	PF00069	0.477
MOD_PKA_2	139	145	PF00069	0.696
MOD_PKA_2	154	160	PF00069	0.470
MOD_PKA_2	175	181	PF00069	0.535
MOD_PKA_2	237	243	PF00069	0.560
MOD_PKA_2	254	260	PF00069	0.481
MOD_PKA_2	279	285	PF00069	0.650
MOD_PKA_2	505	511	PF00069	0.652
MOD_PKA_2	522	528	PF00069	0.609
MOD_PKA_2	579	585	PF00069	0.433
MOD_PKA_2	752	758	PF00069	0.388
MOD_PKA_2	792	798	PF00069	0.340
MOD_PKA_2	814	820	PF00069	0.480
MOD_Plk_1	183	189	PF00069	0.571
MOD_Plk_1	30	36	PF00069	0.440
MOD_Plk_1	58	64	PF00069	0.546
MOD_Plk_1	663	669	PF00069	0.388
MOD_Plk_4	117	123	PF00069	0.323
MOD_Plk_4	184	190	PF00069	0.574
MOD_Plk_4	254	260	PF00069	0.646
MOD_Plk_4	388	394	PF00069	0.388
MOD_Plk_4	428	434	PF00069	0.530
MOD_Plk_4	45	51	PF00069	0.428
MOD_Plk_4	58	64	PF00069	0.470
MOD_Plk_4	594	600	PF00069	0.410
MOD_Plk_4	614	620	PF00069	0.183
MOD_Plk_4	641	647	PF00069	0.288
MOD_Plk_4	658	664	PF00069	0.307
MOD_Plk_4	735	741	PF00069	0.312
MOD_Plk_4	814	820	PF00069	0.423
MOD_Plk_4	87	93	PF00069	0.659
MOD_ProDKin_1	379	385	PF00069	0.312
MOD_ProDKin_1	436	442	PF00069	0.604
MOD_ProDKin_1	443	449	PF00069	0.577
MOD_ProDKin_1	458	464	PF00069	0.579
MOD_ProDKin_1	490	496	PF00069	0.661
MOD_ProDKin_1	526	532	PF00069	0.798
MOD_ProDKin_1	550	556	PF00069	0.606
MOD_ProDKin_1	559	565	PF00069	0.596
MOD_ProDKin_1	760	766	PF00069	0.371
MOD_SUMO_for_1	311	314	PF00179	0.667
MOD_SUMO_rev_2	264	270	PF00179	0.650
MOD_SUMO_rev_2	306	313	PF00179	0.579
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.573
TRG_ENDOCYTIC_2	10	13	PF00928	0.312
TRG_ENDOCYTIC_2	249	252	PF00928	0.534
TRG_ENDOCYTIC_2	377	380	PF00928	0.312
TRG_ENDOCYTIC_2	430	433	PF00928	0.443
TRG_ENDOCYTIC_2	481	484	PF00928	0.592
TRG_ENDOCYTIC_2	599	602	PF00928	0.407
TRG_ENDOCYTIC_2	623	626	PF00928	0.312
TRG_ENDOCYTIC_2	633	636	PF00928	0.312
TRG_ENDOCYTIC_2	791	794	PF00928	0.312
TRG_ER_diArg_1	205	208	PF00400	0.504
TRG_ER_diArg_1	245	247	PF00400	0.550
TRG_ER_diArg_1	332	334	PF00400	0.737
TRG_ER_diArg_1	393	396	PF00400	0.312
TRG_ER_diArg_1	669	672	PF00400	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R5	Leptomonas seymouri	48%	100%
A4H4X8	Leishmania braziliensis	70%	100%
A4HT51	Leishmania infantum	99%	100%
E9AL43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QIR1	Leishmania major	91%	100%