Paraflagellar_rod_protein_putative/Pfam:PF05149

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPT1_LEIDO

TriTrypDb:

LdBPK_070470.1 , LdCL_070008200 , LDHU3_07.0390

Length:

809

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0031514	motile cilium	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A0A3S7WPT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPT1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005516	calmodulin binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.673
CLV_C14_Caspase3-7	549	553	PF00656	0.455
CLV_C14_Caspase3-7	687	691	PF00656	0.829
CLV_NRD_NRD_1	210	212	PF00675	0.581
CLV_NRD_NRD_1	265	267	PF00675	0.761
CLV_NRD_NRD_1	386	388	PF00675	0.641
CLV_NRD_NRD_1	5	7	PF00675	0.668
CLV_NRD_NRD_1	640	642	PF00675	0.397
CLV_PCSK_FUR_1	578	582	PF00082	0.495
CLV_PCSK_KEX2_1	210	212	PF00082	0.579
CLV_PCSK_KEX2_1	335	337	PF00082	0.646
CLV_PCSK_KEX2_1	386	388	PF00082	0.655
CLV_PCSK_KEX2_1	5	7	PF00082	0.668
CLV_PCSK_KEX2_1	580	582	PF00082	0.457
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.710
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.495
CLV_PCSK_SKI1_1	210	214	PF00082	0.595
CLV_PCSK_SKI1_1	28	32	PF00082	0.705
CLV_PCSK_SKI1_1	315	319	PF00082	0.655
CLV_PCSK_SKI1_1	371	375	PF00082	0.582
CLV_PCSK_SKI1_1	408	412	PF00082	0.555
CLV_PCSK_SKI1_1	419	423	PF00082	0.540
CLV_PCSK_SKI1_1	540	544	PF00082	0.422
CLV_PCSK_SKI1_1	650	654	PF00082	0.473
CLV_PCSK_SKI1_1	801	805	PF00082	0.644
CLV_Separin_Metazoa	423	427	PF03568	0.322
DEG_APCC_DBOX_1	209	217	PF00400	0.521
DEG_APCC_DBOX_1	370	378	PF00400	0.488
DEG_APCC_DBOX_1	407	415	PF00400	0.406
DEG_APCC_DBOX_1	446	454	PF00400	0.502
DEG_APCC_DBOX_1	783	791	PF00400	0.655
DEG_ODPH_VHL_1	223	235	PF01847	0.657
DEG_SCF_FBW7_2	188	194	PF00400	0.680
DEG_SPOP_SBC_1	70	74	PF00917	0.588
DEG_SPOP_SBC_1	723	727	PF00917	0.816
DOC_CKS1_1	176	181	PF01111	0.638
DOC_CKS1_1	188	193	PF01111	0.682
DOC_CKS1_1	674	679	PF01111	0.778
DOC_CYCLIN_RxL_1	78	89	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.694
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.692
DOC_MAPK_DCC_7	189	197	PF00069	0.622
DOC_MAPK_gen_1	369	377	PF00069	0.492
DOC_MAPK_gen_1	383	392	PF00069	0.535
DOC_MAPK_MEF2A_6	189	197	PF00069	0.622
DOC_MAPK_MEF2A_6	622	631	PF00069	0.510
DOC_PP1_RVXF_1	456	462	PF00149	0.382
DOC_PP2B_LxvP_1	222	225	PF13499	0.673
DOC_PP2B_LxvP_1	99	102	PF13499	0.695
DOC_PP2B_PxIxI_1	192	198	PF00149	0.568
DOC_USP7_MATH_1	148	152	PF00917	0.653
DOC_USP7_MATH_1	373	377	PF00917	0.555
DOC_USP7_MATH_1	410	414	PF00917	0.539
DOC_USP7_MATH_1	65	69	PF00917	0.807
DOC_USP7_MATH_1	684	688	PF00917	0.846
DOC_USP7_MATH_1	696	700	PF00917	0.855
DOC_USP7_MATH_1	70	74	PF00917	0.822
DOC_USP7_MATH_1	704	708	PF00917	0.712
DOC_USP7_MATH_1	753	757	PF00917	0.613
DOC_USP7_MATH_2	102	108	PF00917	0.689
DOC_WW_Pin1_4	175	180	PF00397	0.655
DOC_WW_Pin1_4	187	192	PF00397	0.588
DOC_WW_Pin1_4	216	221	PF00397	0.688
DOC_WW_Pin1_4	673	678	PF00397	0.814
DOC_WW_Pin1_4	691	696	PF00397	0.664
LIG_14-3-3_CanoR_1	170	177	PF00244	0.615
LIG_14-3-3_CanoR_1	426	433	PF00244	0.382
LIG_14-3-3_CanoR_1	581	588	PF00244	0.461
LIG_14-3-3_CanoR_1	593	597	PF00244	0.450
LIG_14-3-3_CanoR_1	601	608	PF00244	0.364
LIG_14-3-3_CanoR_1	655	662	PF00244	0.657
LIG_14-3-3_CanoR_1	88	94	PF00244	0.655
LIG_Actin_WH2_2	617	634	PF00022	0.346
LIG_Actin_WH2_2	766	783	PF00022	0.676
LIG_APCC_ABBA_1	375	380	PF00400	0.559
LIG_BIR_III_2	690	694	PF00653	0.848
LIG_Clathr_ClatBox_1	803	807	PF01394	0.692
LIG_CtBP_PxDLS_1	733	737	PF00389	0.705
LIG_FHA_1	154	160	PF00498	0.671
LIG_FHA_1	275	281	PF00498	0.757
LIG_FHA_1	420	426	PF00498	0.455
LIG_FHA_1	744	750	PF00498	0.600
LIG_FHA_2	176	182	PF00498	0.631
LIG_FHA_2	268	274	PF00498	0.801
LIG_FHA_2	581	587	PF00498	0.510
LIG_FHA_2	661	667	PF00498	0.772
LIG_FHA_2	698	704	PF00498	0.927
LIG_LIR_Nem_3	528	533	PF02991	0.371
LIG_LIR_Nem_3	561	566	PF02991	0.471
LIG_LIR_Nem_3	774	780	PF02991	0.668
LIG_NRBOX	139	145	PF00104	0.594
LIG_NRBOX	212	218	PF00104	0.544
LIG_SH2_SRC	533	536	PF00017	0.392
LIG_SH2_STAP1	406	410	PF00017	0.510
LIG_SH2_STAP1	567	571	PF00017	0.455
LIG_SH2_STAP1	8	12	PF00017	0.672
LIG_SH2_STAT3	566	569	PF00017	0.370
LIG_SH2_STAT3	758	761	PF00017	0.622
LIG_SH2_STAT5	165	168	PF00017	0.576
LIG_SH2_STAT5	221	224	PF00017	0.622
LIG_SH2_STAT5	533	536	PF00017	0.354
LIG_SH2_STAT5	563	566	PF00017	0.379
LIG_SH2_STAT5	63	66	PF00017	0.766
LIG_SH2_STAT5	630	633	PF00017	0.397
LIG_SH2_STAT5	758	761	PF00017	0.678
LIG_SH3_1	18	24	PF00018	0.800
LIG_SH3_1	692	698	PF00018	0.675
LIG_SH3_3	18	24	PF00018	0.668
LIG_SH3_3	199	205	PF00018	0.700
LIG_SH3_3	247	253	PF00018	0.885
LIG_SH3_3	692	698	PF00018	0.675
LIG_SH3_3	737	743	PF00018	0.645
LIG_SH3_3	803	809	PF00018	0.594
LIG_SH3_4	257	264	PF00018	0.779
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.616
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.461
LIG_SUMO_SIM_anti_2	388	396	PF11976	0.583
LIG_SUMO_SIM_par_1	373	382	PF11976	0.568
LIG_SUMO_SIM_par_1	388	396	PF11976	0.612
LIG_TRAF2_1	287	290	PF00917	0.860
LIG_TRAF2_1	547	550	PF00917	0.455
LIG_TRAF2_1	573	576	PF00917	0.379
LIG_TRAF2_1	664	667	PF00917	0.698
LIG_TRAF2_1	783	786	PF00917	0.659
LIG_TRAF2_1	789	792	PF00917	0.717
LIG_TRFH_1	221	225	PF08558	0.691
LIG_TYR_ITIM	38	43	PF00017	0.784
MOD_CK1_1	274	280	PF00069	0.707
MOD_CK1_1	376	382	PF00069	0.564
MOD_CK1_1	396	402	PF00069	0.406
MOD_CK1_1	45	51	PF00069	0.744
MOD_CK1_1	69	75	PF00069	0.789
MOD_CK1_1	694	700	PF00069	0.860
MOD_CK1_1	702	708	PF00069	0.800
MOD_CK2_1	175	181	PF00069	0.744
MOD_CK2_1	267	273	PF00069	0.721
MOD_CK2_1	484	490	PF00069	0.510
MOD_CK2_1	632	638	PF00069	0.540
MOD_CK2_1	660	666	PF00069	0.776
MOD_CK2_1	697	703	PF00069	0.847
MOD_CK2_1	780	786	PF00069	0.718
MOD_GlcNHglycan	133	136	PF01048	0.688
MOD_GlcNHglycan	14	17	PF01048	0.721
MOD_GlcNHglycan	150	153	PF01048	0.737
MOD_GlcNHglycan	244	247	PF01048	0.777
MOD_GlcNHglycan	44	47	PF01048	0.709
MOD_GlcNHglycan	506	509	PF01048	0.497
MOD_GlcNHglycan	56	59	PF01048	0.669
MOD_GlcNHglycan	68	71	PF01048	0.675
MOD_GlcNHglycan	686	689	PF01048	0.786
MOD_GSK3_1	142	149	PF00069	0.659
MOD_GSK3_1	248	255	PF00069	0.805
MOD_GSK3_1	267	274	PF00069	0.715
MOD_GSK3_1	50	57	PF00069	0.742
MOD_GSK3_1	65	72	PF00069	0.588
MOD_GSK3_1	723	730	PF00069	0.781
MOD_GSK3_1	732	739	PF00069	0.648
MOD_GSK3_1	753	760	PF00069	0.640
MOD_GSK3_1	8	15	PF00069	0.680
MOD_GSK3_1	83	90	PF00069	0.579
MOD_LATS_1	129	135	PF00433	0.658
MOD_N-GLC_1	271	276	PF02516	0.684
MOD_NEK2_1	153	158	PF00069	0.687
MOD_NEK2_1	33	38	PF00069	0.672
MOD_NEK2_1	54	59	PF00069	0.745
MOD_NEK2_1	591	596	PF00069	0.399
MOD_NEK2_1	71	76	PF00069	0.604
MOD_NEK2_1	736	741	PF00069	0.687
MOD_NEK2_2	205	210	PF00069	0.566
MOD_NEK2_2	373	378	PF00069	0.551
MOD_PIKK_1	196	202	PF00454	0.679
MOD_PIKK_1	425	431	PF00454	0.433
MOD_PIKK_1	580	586	PF00454	0.528
MOD_PIKK_1	654	660	PF00454	0.631
MOD_PIKK_1	71	77	PF00454	0.743
MOD_PIKK_1	757	763	PF00454	0.623
MOD_PIKK_1	87	93	PF00454	0.767
MOD_PKA_1	580	586	PF00069	0.510
MOD_PKA_2	169	175	PF00069	0.592
MOD_PKA_2	425	431	PF00069	0.448
MOD_PKA_2	580	586	PF00069	0.413
MOD_PKA_2	592	598	PF00069	0.478
MOD_PKA_2	600	606	PF00069	0.304
MOD_PKA_2	654	660	PF00069	0.743
MOD_PKA_2	780	786	PF00069	0.662
MOD_PKA_2	87	93	PF00069	0.815
MOD_Plk_1	248	254	PF00069	0.625
MOD_Plk_1	267	273	PF00069	0.712
MOD_Plk_4	104	110	PF00069	0.785
MOD_Plk_4	161	167	PF00069	0.651
MOD_Plk_4	231	237	PF00069	0.639
MOD_Plk_4	50	56	PF00069	0.740
MOD_Plk_4	592	598	PF00069	0.455
MOD_ProDKin_1	175	181	PF00069	0.656
MOD_ProDKin_1	187	193	PF00069	0.592
MOD_ProDKin_1	216	222	PF00069	0.685
MOD_ProDKin_1	673	679	PF00069	0.815
MOD_ProDKin_1	691	697	PF00069	0.665
MOD_SUMO_rev_2	311	320	PF00179	0.657
MOD_SUMO_rev_2	635	643	PF00179	0.430
MOD_SUMO_rev_2	687	694	PF00179	0.844
MOD_SUMO_rev_2	769	778	PF00179	0.605
TRG_DiLeu_BaEn_1	139	144	PF01217	0.593
TRG_DiLeu_BaEn_1	463	468	PF01217	0.456
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.510
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.595
TRG_ENDOCYTIC_2	40	43	PF00928	0.783
TRG_ENDOCYTIC_2	567	570	PF00928	0.382
TRG_ER_diArg_1	209	211	PF00400	0.583
TRG_ER_diArg_1	368	371	PF00400	0.470
TRG_ER_diArg_1	385	387	PF00400	0.491
TRG_ER_diArg_1	478	481	PF00400	0.406
TRG_ER_diArg_1	5	7	PF00400	0.668
TRG_ER_diArg_1	587	590	PF00400	0.510
TRG_NLS_MonoCore_2	255	260	PF00514	0.728
TRG_NLS_MonoExtN_4	253	260	PF00514	0.723
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV3	Leptomonas seymouri	54%	100%
A0A1X0NP77	Trypanosomatidae	30%	99%
A0A3R7K8M9	Trypanosoma rangeli	33%	100%
A4H4X6	Leishmania braziliensis	79%	100%
A4HT49	Leishmania infantum	100%	100%
C9ZUS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AL41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIR3	Leishmania major	95%	100%
V5ASS7	Trypanosoma cruzi	32%	100%