Leucine-rich repeat-containing protein 51

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPS7_LEIDO

TriTrypDb:

LdBPK_070460.1 , LdCL_070008100 , LDHU3_07.0380

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S7WPS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.750
CLV_C14_Caspase3-7	500	504	PF00656	0.719
CLV_C14_Caspase3-7	758	762	PF00656	0.566
CLV_NRD_NRD_1	10	12	PF00675	0.509
CLV_NRD_NRD_1	120	122	PF00675	0.678
CLV_NRD_NRD_1	143	145	PF00675	0.656
CLV_NRD_NRD_1	349	351	PF00675	0.539
CLV_NRD_NRD_1	417	419	PF00675	0.553
CLV_NRD_NRD_1	472	474	PF00675	0.768
CLV_NRD_NRD_1	657	659	PF00675	0.492
CLV_PCSK_KEX2_1	10	12	PF00082	0.509
CLV_PCSK_KEX2_1	119	121	PF00082	0.689
CLV_PCSK_KEX2_1	292	294	PF00082	0.772
CLV_PCSK_KEX2_1	417	419	PF00082	0.553
CLV_PCSK_KEX2_1	474	476	PF00082	0.787
CLV_PCSK_KEX2_1	657	659	PF00082	0.492
CLV_PCSK_KEX2_1	768	770	PF00082	0.592
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.689
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.772
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.754
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.598
CLV_PCSK_PC7_1	116	122	PF00082	0.785
CLV_PCSK_SKI1_1	11	15	PF00082	0.506
CLV_PCSK_SKI1_1	123	127	PF00082	0.681
CLV_PCSK_SKI1_1	351	355	PF00082	0.591
CLV_PCSK_SKI1_1	404	408	PF00082	0.529
CLV_PCSK_SKI1_1	417	421	PF00082	0.419
CLV_PCSK_SKI1_1	753	757	PF00082	0.773
CLV_PCSK_SKI1_1	768	772	PF00082	0.478
DEG_Nend_UBRbox_2	1	3	PF02207	0.571
DEG_ODPH_VHL_1	708	719	PF01847	0.472
DEG_SPOP_SBC_1	432	436	PF00917	0.595
DEG_SPOP_SBC_1	832	836	PF00917	0.620
DOC_CDC14_PxL_1	677	685	PF14671	0.521
DOC_CDC14_PxL_1	708	716	PF14671	0.475
DOC_CYCLIN_RxL_1	119	130	PF00134	0.674
DOC_MAPK_DCC_7	707	716	PF00069	0.534
DOC_MAPK_FxFP_2	39	42	PF00069	0.532
DOC_MAPK_gen_1	768	775	PF00069	0.534
DOC_MAPK_HePTP_8	704	716	PF00069	0.538
DOC_MAPK_MEF2A_6	707	716	PF00069	0.534
DOC_MAPK_MEF2A_6	768	775	PF00069	0.519
DOC_MAPK_NFAT4_5	768	776	PF00069	0.540
DOC_MAPK_RevD_3	338	351	PF00069	0.538
DOC_PP1_RVXF_1	402	408	PF00149	0.355
DOC_PP1_RVXF_1	783	790	PF00149	0.578
DOC_PP2B_LxvP_1	258	261	PF13499	0.762
DOC_PP2B_LxvP_1	360	363	PF13499	0.566
DOC_PP2B_LxvP_1	420	423	PF13499	0.477
DOC_PP4_FxxP_1	39	42	PF00568	0.532
DOC_USP7_MATH_1	182	186	PF00917	0.720
DOC_USP7_MATH_1	40	44	PF00917	0.581
DOC_USP7_MATH_1	431	435	PF00917	0.690
DOC_USP7_MATH_1	481	485	PF00917	0.668
DOC_USP7_MATH_1	564	568	PF00917	0.693
DOC_USP7_MATH_1	687	691	PF00917	0.590
DOC_USP7_MATH_1	734	738	PF00917	0.706
DOC_USP7_MATH_1	755	759	PF00917	0.704
DOC_USP7_MATH_1	78	82	PF00917	0.724
DOC_USP7_MATH_1	832	836	PF00917	0.702
DOC_USP7_UBL2_3	575	579	PF12436	0.617
DOC_WW_Pin1_4	27	32	PF00397	0.523
DOC_WW_Pin1_4	433	438	PF00397	0.786
DOC_WW_Pin1_4	447	452	PF00397	0.593
DOC_WW_Pin1_4	526	531	PF00397	0.576
DOC_WW_Pin1_4	774	779	PF00397	0.497
LIG_14-3-3_CanoR_1	10	18	PF00244	0.485
LIG_14-3-3_CanoR_1	133	140	PF00244	0.731
LIG_14-3-3_CanoR_1	212	218	PF00244	0.627
LIG_14-3-3_CanoR_1	264	271	PF00244	0.712
LIG_14-3-3_CanoR_1	417	423	PF00244	0.580
LIG_14-3-3_CanoR_1	548	555	PF00244	0.704
LIG_14-3-3_CanoR_1	592	598	PF00244	0.580
LIG_BRCT_BRCA1_1	266	270	PF00533	0.661
LIG_BRCT_BRCA1_1	316	320	PF00533	0.556
LIG_DLG_GKlike_1	139	146	PF00625	0.675
LIG_eIF4E_1	318	324	PF01652	0.564
LIG_EVH1_1	443	447	PF00568	0.720
LIG_FHA_1	12	18	PF00498	0.496
LIG_FHA_1	394	400	PF00498	0.518
LIG_FHA_1	667	673	PF00498	0.514
LIG_FHA_1	809	815	PF00498	0.584
LIG_FHA_2	204	210	PF00498	0.826
LIG_FHA_2	306	312	PF00498	0.572
LIG_FHA_2	366	372	PF00498	0.602
LIG_FHA_2	419	425	PF00498	0.612
LIG_FHA_2	437	443	PF00498	0.768
LIG_FHA_2	498	504	PF00498	0.728
LIG_FHA_2	726	732	PF00498	0.709
LIG_FHA_2	791	797	PF00498	0.578
LIG_LIR_Apic_2	37	42	PF02991	0.516
LIG_LIR_Gen_1	2	8	PF02991	0.527
LIG_LIR_Gen_1	24	34	PF02991	0.515
LIG_LIR_Gen_1	371	380	PF02991	0.567
LIG_LIR_Gen_1	485	495	PF02991	0.651
LIG_LIR_Gen_1	506	517	PF02991	0.537
LIG_LIR_Gen_1	788	797	PF02991	0.582
LIG_LIR_Nem_3	141	146	PF02991	0.663
LIG_LIR_Nem_3	2	6	PF02991	0.532
LIG_LIR_Nem_3	24	29	PF02991	0.509
LIG_LIR_Nem_3	317	323	PF02991	0.451
LIG_LIR_Nem_3	371	376	PF02991	0.588
LIG_LIR_Nem_3	485	491	PF02991	0.655
LIG_LIR_Nem_3	506	512	PF02991	0.521
LIG_LIR_Nem_3	513	517	PF02991	0.485
LIG_LIR_Nem_3	700	704	PF02991	0.462
LIG_LIR_Nem_3	764	770	PF02991	0.544
LIG_LIR_Nem_3	788	792	PF02991	0.601
LIG_MAD2	702	710	PF02301	0.508
LIG_NRBOX	769	775	PF00104	0.530
LIG_PCNA_PIPBox_1	32	41	PF02747	0.603
LIG_PCNA_yPIPBox_3	639	653	PF02747	0.514
LIG_SH2_CRK	26	30	PF00017	0.605
LIG_SH2_CRK	373	377	PF00017	0.686
LIG_SH2_NCK_1	3	7	PF00017	0.523
LIG_SH2_NCK_1	797	801	PF00017	0.581
LIG_SH2_SRC	303	306	PF00017	0.722
LIG_SH2_SRC	598	601	PF00017	0.782
LIG_SH2_STAP1	303	307	PF00017	0.705
LIG_SH2_STAT3	586	589	PF00017	0.658
LIG_SH2_STAT5	713	716	PF00017	0.554
LIG_SH3_1	193	199	PF00018	0.751
LIG_SH3_1	441	447	PF00018	0.736
LIG_SH3_3	193	199	PF00018	0.812
LIG_SH3_3	25	31	PF00018	0.404
LIG_SH3_3	356	362	PF00018	0.631
LIG_SH3_3	441	447	PF00018	0.664
LIG_SH3_3	558	564	PF00018	0.753
LIG_SUMO_SIM_anti_2	682	687	PF11976	0.558
LIG_SUMO_SIM_par_1	32	37	PF11976	0.490
LIG_SUMO_SIM_par_1	341	346	PF11976	0.625
LIG_SUMO_SIM_par_1	418	424	PF11976	0.458
LIG_SUMO_SIM_par_1	663	669	PF11976	0.507
LIG_TRAF2_1	368	371	PF00917	0.709
LIG_TYR_ITIM	711	716	PF00017	0.495
LIG_WRC_WIRS_1	140	145	PF05994	0.731
MOD_CDC14_SPxK_1	777	780	PF00782	0.536
MOD_CDK_SPK_2	433	438	PF00069	0.644
MOD_CDK_SPxK_1	774	780	PF00069	0.473
MOD_CDK_SPxxK_3	447	454	PF00069	0.723
MOD_CK1_1	114	120	PF00069	0.670
MOD_CK1_1	273	279	PF00069	0.692
MOD_CK1_1	436	442	PF00069	0.725
MOD_CK1_1	45	51	PF00069	0.603
MOD_CK1_1	450	456	PF00069	0.677
MOD_CK1_1	460	466	PF00069	0.616
MOD_CK1_1	567	573	PF00069	0.682
MOD_CK1_1	737	743	PF00069	0.676
MOD_CK1_1	835	841	PF00069	0.747
MOD_CK2_1	305	311	PF00069	0.590
MOD_CK2_1	365	371	PF00069	0.563
MOD_CK2_1	418	424	PF00069	0.510
MOD_CK2_1	436	442	PF00069	0.765
MOD_CK2_1	593	599	PF00069	0.664
MOD_CK2_1	725	731	PF00069	0.693
MOD_Cter_Amidation	8	11	PF01082	0.486
MOD_GlcNHglycan	113	116	PF01048	0.545
MOD_GlcNHglycan	221	224	PF01048	0.754
MOD_GlcNHglycan	232	235	PF01048	0.660
MOD_GlcNHglycan	274	278	PF01048	0.799
MOD_GlcNHglycan	42	45	PF01048	0.684
MOD_GlcNHglycan	459	462	PF01048	0.743
MOD_GlcNHglycan	479	482	PF01048	0.598
MOD_GlcNHglycan	531	534	PF01048	0.638
MOD_GlcNHglycan	566	569	PF01048	0.675
MOD_GlcNHglycan	599	604	PF01048	0.741
MOD_GlcNHglycan	640	643	PF01048	0.474
MOD_GlcNHglycan	71	74	PF01048	0.671
MOD_GlcNHglycan	81	84	PF01048	0.482
MOD_GlcNHglycan	839	842	PF01048	0.808
MOD_GlcNHglycan	99	102	PF01048	0.506
MOD_GSK3_1	262	269	PF00069	0.748
MOD_GSK3_1	327	334	PF00069	0.656
MOD_GSK3_1	385	392	PF00069	0.532
MOD_GSK3_1	432	439	PF00069	0.782
MOD_GSK3_1	446	453	PF00069	0.600
MOD_GSK3_1	477	484	PF00069	0.639
MOD_GSK3_1	666	673	PF00069	0.478
MOD_GSK3_1	804	811	PF00069	0.574
MOD_GSK3_1	816	823	PF00069	0.585
MOD_GSK3_1	830	837	PF00069	0.685
MOD_LATS_1	416	422	PF00433	0.585
MOD_N-GLC_1	675	680	PF02516	0.558
MOD_N-GLC_1	735	740	PF02516	0.700
MOD_NEK2_1	149	154	PF00069	0.673
MOD_NEK2_1	213	218	PF00069	0.687
MOD_NEK2_1	314	319	PF00069	0.432
MOD_NEK2_1	34	39	PF00069	0.483
MOD_NEK2_1	411	416	PF00069	0.451
MOD_NEK2_1	497	502	PF00069	0.549
MOD_NEK2_1	512	517	PF00069	0.531
MOD_NEK2_1	670	675	PF00069	0.482
MOD_NEK2_1	820	825	PF00069	0.743
MOD_NEK2_2	663	668	PF00069	0.612
MOD_NEK2_2	687	692	PF00069	0.594
MOD_NEK2_2	715	720	PF00069	0.535
MOD_PIKK_1	114	120	PF00454	0.784
MOD_PIKK_1	132	138	PF00454	0.432
MOD_PIKK_1	16	22	PF00454	0.617
MOD_PIKK_1	371	377	PF00454	0.646
MOD_PIKK_1	547	553	PF00454	0.710
MOD_PIKK_1	587	593	PF00454	0.713
MOD_PIKK_1	670	676	PF00454	0.491
MOD_PIKK_1	822	828	PF00454	0.768
MOD_PKA_2	132	138	PF00069	0.728
MOD_PKA_2	265	271	PF00069	0.724
MOD_PKA_2	453	459	PF00069	0.758
MOD_PKA_2	547	553	PF00069	0.720
MOD_PKA_2	638	644	PF00069	0.499
MOD_PKA_2	87	93	PF00069	0.693
MOD_PKB_1	264	272	PF00069	0.741
MOD_Plk_1	273	279	PF00069	0.583
MOD_Plk_1	512	518	PF00069	0.538
MOD_Plk_1	633	639	PF00069	0.510
MOD_Plk_1	675	681	PF00069	0.615
MOD_Plk_2-3	305	311	PF00069	0.590
MOD_Plk_4	266	272	PF00069	0.759
MOD_Plk_4	520	526	PF00069	0.602
MOD_Plk_4	681	687	PF00069	0.553
MOD_ProDKin_1	27	33	PF00069	0.516
MOD_ProDKin_1	433	439	PF00069	0.789
MOD_ProDKin_1	447	453	PF00069	0.593
MOD_ProDKin_1	526	532	PF00069	0.577
MOD_ProDKin_1	774	780	PF00069	0.492
MOD_SUMO_rev_2	305	315	PF00179	0.633
MOD_SUMO_rev_2	329	335	PF00179	0.629
MOD_SUMO_rev_2	397	406	PF00179	0.507
TRG_DiLeu_BaEn_1	311	316	PF01217	0.499
TRG_DiLeu_BaEn_1	521	526	PF01217	0.460
TRG_DiLeu_BaLyEn_6	766	771	PF01217	0.642
TRG_ENDOCYTIC_2	140	143	PF00928	0.630
TRG_ENDOCYTIC_2	25	28	PF00928	0.530
TRG_ENDOCYTIC_2	3	6	PF00928	0.532
TRG_ENDOCYTIC_2	318	321	PF00928	0.458
TRG_ENDOCYTIC_2	373	376	PF00928	0.590
TRG_ENDOCYTIC_2	488	491	PF00928	0.651
TRG_ENDOCYTIC_2	713	716	PF00928	0.500
TRG_ENDOCYTIC_2	803	806	PF00928	0.666
TRG_ER_diArg_1	10	12	PF00400	0.509
TRG_ER_diArg_1	120	123	PF00400	0.776
TRG_ER_diArg_1	417	419	PF00400	0.560
TRG_ER_diArg_1	656	658	PF00400	0.492
TRG_NLS_MonoExtC_3	118	123	PF00514	0.682
TRG_NLS_MonoExtN_4	116	123	PF00514	0.785
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.707
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.770
TRG_Pf-PMV_PEXEL_1	620	625	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I156	Leptomonas seymouri	48%	100%
A4H4X5	Leishmania braziliensis	70%	99%
A4HT48	Leishmania infantum	97%	100%
E9AL40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIR4	Leishmania major	93%	100%