Eukaryotic_membrane_protein_family_putative/Pfam: PF05346

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic membrane protein family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPS5_LEIDO

TriTrypDb:

LdBPK_070310.1 , LdCL_070006500 , LDHU3_07.0200

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WPS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPS5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0032507	maintenance of protein location in cell	3	1
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	1
GO:0045185	maintenance of protein location	3	1
GO:0051179	localization	1	1
GO:0051235	maintenance of location	2	1
GO:0051651	maintenance of location in cell	2	1
GO:0072595	maintenance of protein localization in organelle	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.510
CLV_NRD_NRD_1	162	164	PF00675	0.230
CLV_NRD_NRD_1	209	211	PF00675	0.299
CLV_NRD_NRD_1	532	534	PF00675	0.439
CLV_NRD_NRD_1	69	71	PF00675	0.508
CLV_NRD_NRD_1	79	81	PF00675	0.401
CLV_NRD_NRD_1	9	11	PF00675	0.468
CLV_PCSK_KEX2_1	123	125	PF00082	0.525
CLV_PCSK_KEX2_1	162	164	PF00082	0.230
CLV_PCSK_KEX2_1	208	210	PF00082	0.299
CLV_PCSK_KEX2_1	222	224	PF00082	0.314
CLV_PCSK_KEX2_1	437	439	PF00082	0.220
CLV_PCSK_KEX2_1	532	534	PF00082	0.426
CLV_PCSK_KEX2_1	614	616	PF00082	0.464
CLV_PCSK_KEX2_1	69	71	PF00082	0.503
CLV_PCSK_KEX2_1	9	11	PF00082	0.510
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.353
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.277
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.464
CLV_PCSK_PC7_1	205	211	PF00082	0.276
CLV_PCSK_SKI1_1	117	121	PF00082	0.572
CLV_PCSK_SKI1_1	223	227	PF00082	0.249
CLV_PCSK_SKI1_1	249	253	PF00082	0.271
CLV_PCSK_SKI1_1	365	369	PF00082	0.230
CLV_PCSK_SKI1_1	434	438	PF00082	0.298
CLV_PCSK_SKI1_1	480	484	PF00082	0.386
DEG_APCC_DBOX_1	123	131	PF00400	0.271
DEG_APCC_DBOX_1	492	500	PF00400	0.581
DEG_APCC_DBOX_1	9	17	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DEG_SCF_FBW7_1	553	560	PF00400	0.720
DEG_SPOP_SBC_1	572	576	PF00917	0.633
DOC_CDC14_PxL_1	397	405	PF14671	0.471
DOC_CKS1_1	243	248	PF01111	0.506
DOC_CKS1_1	424	429	PF01111	0.471
DOC_CKS1_1	554	559	PF01111	0.640
DOC_CYCLIN_RxL_1	244	255	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.387
DOC_MAPK_DCC_7	588	598	PF00069	0.509
DOC_MAPK_gen_1	162	169	PF00069	0.459
DOC_MAPK_gen_1	9	15	PF00069	0.669
DOC_MAPK_MEF2A_6	128	135	PF00069	0.220
DOC_MAPK_MEF2A_6	162	171	PF00069	0.445
DOC_MAPK_MEF2A_6	592	600	PF00069	0.514
DOC_MAPK_MEF2A_6	85	93	PF00069	0.473
DOC_MAPK_NFAT4_5	128	136	PF00069	0.271
DOC_PP2B_LxvP_1	112	115	PF13499	0.273
DOC_USP7_MATH_1	225	229	PF00917	0.480
DOC_USP7_MATH_1	51	55	PF00917	0.675
DOC_USP7_MATH_1	510	514	PF00917	0.726
DOC_USP7_MATH_1	572	576	PF00917	0.640
DOC_USP7_MATH_1	58	62	PF00917	0.623
DOC_WW_Pin1_4	216	221	PF00397	0.553
DOC_WW_Pin1_4	242	247	PF00397	0.514
DOC_WW_Pin1_4	306	311	PF00397	0.332
DOC_WW_Pin1_4	423	428	PF00397	0.500
DOC_WW_Pin1_4	499	504	PF00397	0.618
DOC_WW_Pin1_4	549	554	PF00397	0.640
DOC_WW_Pin1_4	557	562	PF00397	0.679
DOC_WW_Pin1_4	580	585	PF00397	0.651
DOC_WW_Pin1_4	591	596	PF00397	0.609
LIG_14-3-3_CanoR_1	162	167	PF00244	0.430
LIG_14-3-3_CanoR_1	342	348	PF00244	0.271
LIG_14-3-3_CanoR_1	381	389	PF00244	0.448
LIG_14-3-3_CanoR_1	493	497	PF00244	0.617
LIG_14-3-3_CanoR_1	532	538	PF00244	0.649
LIG_14-3-3_CanoR_1	9	14	PF00244	0.587
LIG_Actin_WH2_2	112	130	PF00022	0.465
LIG_Actin_WH2_2	285	303	PF00022	0.311
LIG_DLG_GKlike_1	533	541	PF00625	0.610
LIG_EH1_1	106	114	PF00400	0.330
LIG_eIF4E_1	383	389	PF01652	0.511
LIG_EVH1_1	506	510	PF00568	0.576
LIG_EVH1_2	376	380	PF00568	0.437
LIG_FHA_1	10	16	PF00498	0.617
LIG_FHA_1	130	136	PF00498	0.384
LIG_FHA_1	148	154	PF00498	0.172
LIG_FHA_1	162	168	PF00498	0.379
LIG_FHA_1	274	280	PF00498	0.241
LIG_FHA_1	496	502	PF00498	0.600
LIG_FHA_1	536	542	PF00498	0.731
LIG_FHA_1	592	598	PF00498	0.532
LIG_FHA_2	414	420	PF00498	0.535
LIG_GBD_Chelix_1	178	186	PF00786	0.189
LIG_HCF-1_HBM_1	73	76	PF13415	0.562
LIG_LIR_Gen_1	151	161	PF02991	0.455
LIG_LIR_Gen_1	164	173	PF02991	0.409
LIG_LIR_Gen_1	192	203	PF02991	0.471
LIG_LIR_Gen_1	341	351	PF02991	0.248
LIG_LIR_Gen_1	38	48	PF02991	0.627
LIG_LIR_Gen_1	73	83	PF02991	0.567
LIG_LIR_Gen_1	88	98	PF02991	0.412
LIG_LIR_LC3C_4	498	501	PF02991	0.544
LIG_LIR_Nem_3	151	157	PF02991	0.473
LIG_LIR_Nem_3	164	169	PF02991	0.426
LIG_LIR_Nem_3	192	198	PF02991	0.511
LIG_LIR_Nem_3	341	346	PF02991	0.230
LIG_LIR_Nem_3	350	355	PF02991	0.325
LIG_LIR_Nem_3	378	383	PF02991	0.462
LIG_LIR_Nem_3	4	8	PF02991	0.651
LIG_LIR_Nem_3	505	509	PF02991	0.616
LIG_LIR_Nem_3	73	79	PF02991	0.585
LIG_LIR_Nem_3	88	93	PF02991	0.465
LIG_LIR_Nem_3	94	99	PF02991	0.350
LIG_MYND_3	400	404	PF01753	0.471
LIG_NRBOX	107	113	PF00104	0.275
LIG_NRBOX	267	273	PF00104	0.330
LIG_NRBOX	287	293	PF00104	0.358
LIG_NRBOX	596	602	PF00104	0.519
LIG_Pex14_2	368	372	PF04695	0.417
LIG_Rb_LxCxE_1	350	362	PF01857	0.330
LIG_SH2_CRK	154	158	PF00017	0.456
LIG_SH2_CRK	383	387	PF00017	0.430
LIG_SH2_CRK	446	450	PF00017	0.298
LIG_SH2_CRK	76	80	PF00017	0.594
LIG_SH2_NCK_1	195	199	PF00017	0.471
LIG_SH2_SRC	156	159	PF00017	0.430
LIG_SH2_STAP1	154	158	PF00017	0.421
LIG_SH2_STAP1	37	41	PF00017	0.623
LIG_SH2_STAP1	383	387	PF00017	0.473
LIG_SH2_STAP1	446	450	PF00017	0.298
LIG_SH2_STAT5	156	159	PF00017	0.478
LIG_SH2_STAT5	327	330	PF00017	0.345
LIG_SH2_STAT5	460	463	PF00017	0.329
LIG_SH2_STAT5	96	99	PF00017	0.361
LIG_SH3_3	497	503	PF00018	0.637
LIG_SH3_3	504	510	PF00018	0.606
LIG_SH3_3	512	518	PF00018	0.583
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.628
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.352
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.448
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.386
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.311
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.448
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.448
LIG_SUMO_SIM_par_1	131	137	PF11976	0.303
LIG_SUMO_SIM_par_1	168	174	PF11976	0.434
LIG_SUMO_SIM_par_1	387	392	PF11976	0.519
LIG_SUMO_SIM_par_1	497	502	PF11976	0.588
LIG_TYR_ITIM	193	198	PF00017	0.471
LIG_TYR_ITIM	444	449	PF00017	0.273
LIG_UBA3_1	111	117	PF00899	0.284
LIG_UBA3_1	172	181	PF00899	0.471
LIG_UBA3_1	471	480	PF00899	0.400
LIG_UBA3_1	596	602	PF00899	0.542
LIG_WW_2	507	510	PF00397	0.582
MOD_CDK_SPK_2	553	558	PF00069	0.718
MOD_CDK_SPxK_1	216	222	PF00069	0.445
MOD_CDK_SPxxK_3	216	223	PF00069	0.454
MOD_CDK_SPxxK_3	242	249	PF00069	0.471
MOD_CK1_1	184	190	PF00069	0.419
MOD_CK1_1	264	270	PF00069	0.343
MOD_CK1_1	312	318	PF00069	0.364
MOD_CK1_1	502	508	PF00069	0.645
MOD_CK1_1	513	519	PF00069	0.646
MOD_CK1_1	527	533	PF00069	0.694
MOD_CK1_1	536	542	PF00069	0.667
MOD_CK1_1	54	60	PF00069	0.740
MOD_CK1_1	552	558	PF00069	0.665
MOD_CK1_1	571	577	PF00069	0.568
MOD_CK1_1	580	586	PF00069	0.725
MOD_CK2_1	305	311	PF00069	0.319
MOD_CK2_1	413	419	PF00069	0.521
MOD_CK2_1	520	526	PF00069	0.703
MOD_Cter_Amidation	67	70	PF01082	0.414
MOD_GlcNHglycan	227	230	PF01048	0.351
MOD_GlcNHglycan	237	240	PF01048	0.292
MOD_GlcNHglycan	254	257	PF01048	0.308
MOD_GlcNHglycan	407	410	PF01048	0.314
MOD_GlcNHglycan	411	414	PF01048	0.270
MOD_GlcNHglycan	43	46	PF01048	0.487
MOD_GlcNHglycan	512	515	PF01048	0.540
MOD_GlcNHglycan	526	529	PF01048	0.569
MOD_GlcNHglycan	53	56	PF01048	0.559
MOD_GlcNHglycan	533	536	PF01048	0.531
MOD_GlcNHglycan	564	567	PF01048	0.458
MOD_GlcNHglycan	570	573	PF01048	0.449
MOD_GlcNHglycan	60	63	PF01048	0.431
MOD_GSK3_1	148	155	PF00069	0.296
MOD_GSK3_1	260	267	PF00069	0.338
MOD_GSK3_1	273	280	PF00069	0.195
MOD_GSK3_1	295	302	PF00069	0.271
MOD_GSK3_1	305	312	PF00069	0.326
MOD_GSK3_1	405	412	PF00069	0.528
MOD_GSK3_1	495	502	PF00069	0.601
MOD_GSK3_1	520	527	PF00069	0.735
MOD_GSK3_1	531	538	PF00069	0.691
MOD_GSK3_1	54	61	PF00069	0.715
MOD_GSK3_1	549	556	PF00069	0.613
MOD_GSK3_1	568	575	PF00069	0.643
MOD_N-GLC_1	277	282	PF02516	0.557
MOD_N-GLC_1	295	300	PF02516	0.412
MOD_NEK2_1	134	139	PF00069	0.370
MOD_NEK2_1	148	153	PF00069	0.197
MOD_NEK2_1	171	176	PF00069	0.564
MOD_NEK2_1	252	257	PF00069	0.337
MOD_NEK2_1	277	282	PF00069	0.245
MOD_NEK2_1	305	310	PF00069	0.249
MOD_NEK2_1	41	46	PF00069	0.625
MOD_NEK2_1	481	486	PF00069	0.325
MOD_NEK2_1	537	542	PF00069	0.683
MOD_NEK2_1	97	102	PF00069	0.273
MOD_NEK2_2	492	497	PF00069	0.528
MOD_OFUCOSY	260	265	PF10250	0.330
MOD_PIKK_1	117	123	PF00454	0.308
MOD_PIKK_1	148	154	PF00454	0.333
MOD_PIKK_1	184	190	PF00454	0.448
MOD_PIKK_1	25	31	PF00454	0.699
MOD_PIKK_1	381	387	PF00454	0.448
MOD_PIKK_1	527	533	PF00454	0.759
MOD_PKA_1	162	168	PF00069	0.430
MOD_PKA_1	209	215	PF00069	0.376
MOD_PKA_1	9	15	PF00069	0.571
MOD_PKA_2	161	167	PF00069	0.430
MOD_PKA_2	204	210	PF00069	0.458
MOD_PKA_2	341	347	PF00069	0.271
MOD_PKA_2	492	498	PF00069	0.618
MOD_PKA_2	531	537	PF00069	0.732
MOD_PKA_2	9	15	PF00069	0.640
MOD_Plk_1	277	283	PF00069	0.194
MOD_Plk_4	139	145	PF00069	0.275
MOD_Plk_4	152	158	PF00069	0.418
MOD_Plk_4	162	168	PF00069	0.497
MOD_Plk_4	266	272	PF00069	0.283
MOD_Plk_4	284	290	PF00069	0.148
MOD_Plk_4	299	305	PF00069	0.179
MOD_Plk_4	375	381	PF00069	0.415
MOD_Plk_4	482	488	PF00069	0.403
MOD_Plk_4	537	543	PF00069	0.577
MOD_ProDKin_1	216	222	PF00069	0.553
MOD_ProDKin_1	242	248	PF00069	0.514
MOD_ProDKin_1	306	312	PF00069	0.332
MOD_ProDKin_1	423	429	PF00069	0.500
MOD_ProDKin_1	499	505	PF00069	0.628
MOD_ProDKin_1	549	555	PF00069	0.642
MOD_ProDKin_1	557	563	PF00069	0.679
MOD_ProDKin_1	580	586	PF00069	0.646
MOD_ProDKin_1	591	597	PF00069	0.604
MOD_SUMO_rev_2	28	36	PF00179	0.610
TRG_DiLeu_BaEn_1	284	289	PF01217	0.230
TRG_DiLeu_BaEn_1	420	425	PF01217	0.471
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.553
TRG_ENDOCYTIC_2	154	157	PF00928	0.457
TRG_ENDOCYTIC_2	158	161	PF00928	0.473
TRG_ENDOCYTIC_2	195	198	PF00928	0.471
TRG_ENDOCYTIC_2	327	330	PF00928	0.356
TRG_ENDOCYTIC_2	37	40	PF00928	0.626
TRG_ENDOCYTIC_2	383	386	PF00928	0.419
TRG_ENDOCYTIC_2	446	449	PF00928	0.258
TRG_ENDOCYTIC_2	76	79	PF00928	0.596
TRG_ENDOCYTIC_2	96	99	PF00928	0.252
TRG_ER_diArg_1	122	124	PF00400	0.364
TRG_ER_diArg_1	161	163	PF00400	0.430
TRG_ER_diArg_1	208	210	PF00400	0.496
TRG_ER_diArg_1	69	72	PF00400	0.701
TRG_ER_diArg_1	8	10	PF00400	0.575
TRG_ER_diLys_1	612	617	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBJ3	Bodo saltans	33%	100%
A0A1X0NLV9	Trypanosomatidae	39%	100%
A0A422NTF0	Trypanosoma rangeli	41%	100%
A4H4V9	Leishmania braziliensis	78%	99%
A4HT53	Leishmania infantum	100%	100%
C9ZUV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9AL25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4QIS9	Leishmania major	93%	100%
Q4VBD2	Mus musculus	25%	100%
Q5EAY8	Xenopus laevis	25%	100%
V5D9E0	Trypanosoma cruzi	36%	100%