Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPS2_LEIDO

TriTrypDb:

LdBPK_070390.1 , LdCL_070007400 , LDHU3_07.0300

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	12
GO:0031970	organelle envelope lumen	5	12
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7WPS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPS2

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0051537	2 iron, 2 sulfur cluster binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.455
CLV_NRD_NRD_1	46	48	PF00675	0.373
CLV_NRD_NRD_1	60	62	PF00675	0.377
CLV_PCSK_KEX2_1	45	47	PF00082	0.402
CLV_PCSK_SKI1_1	31	35	PF00082	0.456
DOC_PP2B_LxvP_1	68	71	PF13499	0.582
DOC_USP7_UBL2_3	34	38	PF12436	0.482
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_FHA_2	25	31	PF00498	0.443
LIG_FHA_2	35	41	PF00498	0.475
LIG_PDZ_Class_3	108	113	PF00595	0.451
MOD_CK1_1	12	18	PF00069	0.479
MOD_CK1_1	3	9	PF00069	0.484
MOD_CK2_1	34	40	PF00069	0.480
MOD_GlcNHglycan	3	6	PF01048	0.549
MOD_GSK3_1	1	8	PF00069	0.527
MOD_N-GLC_1	107	112	PF02516	0.494
MOD_N-GLC_1	76	81	PF02516	0.293
MOD_NEK2_1	1	6	PF00069	0.461
MOD_PIKK_1	5	11	PF00454	0.484
MOD_SUMO_rev_2	58	63	PF00179	0.476
MOD_SUMO_rev_2	98	105	PF00179	0.414
TRG_DiLeu_BaEn_4	28	34	PF01217	0.569
TRG_ER_diArg_1	45	47	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W2	Leptomonas seymouri	85%	96%
A0A0S4JP81	Bodo saltans	62%	99%
A0A1X0ND50	Trypanosomatidae	75%	97%
A0A3S5IRT3	Trypanosoma rangeli	77%	98%
A4H4W7	Leishmania braziliensis	87%	100%
A4HT41	Leishmania infantum	95%	100%
C9ZUU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	91%
E9AL33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4D3B7	Trypanosoma cruzi (strain CL Brener)	78%	98%
Q4DER6	Trypanosoma cruzi (strain CL Brener)	77%	98%
Q4QIS1	Leishmania major	96%	100%
Q582A7	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	70%	91%
Q8SWE5	Encephalitozoon cuniculi (strain GB-M1)	34%	100%
V5BDG5	Trypanosoma cruzi	77%	98%