Golgi/lysosome glycoprotein 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi/lysosome glycoprotein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPQ4_LEIDO

TriTrypDb:

LdBPK_070230.1 , LdCL_070005800 , LDHU3_07.0120

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005765	lysosomal membrane	7	1
GO:0005773	vacuole	5	1
GO:0005774	vacuolar membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098852	lytic vacuole membrane	6	1

Expansion

Sequence features

A0A3S7WPQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	320	322	PF00675	0.599
CLV_NRD_NRD_1	381	383	PF00675	0.564
CLV_NRD_NRD_1	465	467	PF00675	0.593
CLV_NRD_NRD_1	572	574	PF00675	0.484
CLV_PCSK_KEX2_1	31	33	PF00082	0.630
CLV_PCSK_KEX2_1	381	383	PF00082	0.549
CLV_PCSK_KEX2_1	465	467	PF00082	0.660
CLV_PCSK_KEX2_1	572	574	PF00082	0.484
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.630
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.549
CLV_PCSK_PC7_1	568	574	PF00082	0.470
CLV_PCSK_SKI1_1	157	161	PF00082	0.622
CLV_PCSK_SKI1_1	192	196	PF00082	0.524
CLV_PCSK_SKI1_1	253	257	PF00082	0.554
CLV_PCSK_SKI1_1	439	443	PF00082	0.537
CLV_PCSK_SKI1_1	466	470	PF00082	0.547
CLV_PCSK_SKI1_1	5	9	PF00082	0.603
DEG_Nend_Nbox_1	1	3	PF02207	0.574
DOC_CYCLIN_RxL_1	151	163	PF00134	0.379
DOC_MAPK_gen_1	3	12	PF00069	0.579
DOC_MAPK_gen_1	437	445	PF00069	0.393
DOC_MAPK_gen_1	572	579	PF00069	0.626
DOC_MAPK_MEF2A_6	3	11	PF00069	0.548
DOC_MAPK_MEF2A_6	481	488	PF00069	0.319
DOC_PP1_RVXF_1	251	258	PF00149	0.398
DOC_PP1_RVXF_1	326	333	PF00149	0.408
DOC_PP1_RVXF_1	479	486	PF00149	0.342
DOC_PP4_FxxP_1	257	260	PF00568	0.406
DOC_USP7_MATH_1	134	138	PF00917	0.386
DOC_USP7_MATH_1	18	22	PF00917	0.603
DOC_USP7_MATH_1	190	194	PF00917	0.408
DOC_USP7_MATH_1	269	273	PF00917	0.418
DOC_USP7_MATH_1	403	407	PF00917	0.458
DOC_USP7_UBL2_3	377	381	PF12436	0.280
DOC_WW_Pin1_4	171	176	PF00397	0.476
DOC_WW_Pin1_4	178	183	PF00397	0.421
DOC_WW_Pin1_4	411	416	PF00397	0.431
LIG_14-3-3_CanoR_1	136	142	PF00244	0.419
LIG_14-3-3_CanoR_1	157	163	PF00244	0.280
LIG_14-3-3_CanoR_1	247	253	PF00244	0.396
LIG_14-3-3_CanoR_1	268	278	PF00244	0.396
LIG_14-3-3_CanoR_1	3	8	PF00244	0.609
LIG_14-3-3_CanoR_1	465	469	PF00244	0.354
LIG_14-3-3_CanoR_1	60	65	PF00244	0.380
LIG_Actin_WH2_2	451	467	PF00022	0.349
LIG_BRCT_BRCA1_1	139	143	PF00533	0.275
LIG_deltaCOP1_diTrp_1	432	438	PF00928	0.402
LIG_DLG_GKlike_1	122	129	PF00625	0.326
LIG_DLG_GKlike_1	3	10	PF00625	0.541
LIG_FHA_1	172	178	PF00498	0.405
LIG_FHA_1	20	26	PF00498	0.645
LIG_FHA_1	206	212	PF00498	0.417
LIG_FHA_1	238	244	PF00498	0.408
LIG_FHA_1	260	266	PF00498	0.324
LIG_FHA_1	360	366	PF00498	0.350
LIG_FHA_1	426	432	PF00498	0.380
LIG_FHA_1	445	451	PF00498	0.256
LIG_FHA_1	49	55	PF00498	0.415
LIG_FHA_1	528	534	PF00498	0.447
LIG_FHA_1	59	65	PF00498	0.330
LIG_FHA_1	611	617	PF00498	0.589
LIG_FHA_2	254	260	PF00498	0.416
LIG_FHA_2	367	373	PF00498	0.416
LIG_FHA_2	418	424	PF00498	0.420
LIG_FHA_2	79	85	PF00498	0.367
LIG_GBD_Chelix_1	11	19	PF00786	0.516
LIG_LIR_Apic_2	256	260	PF02991	0.405
LIG_LIR_Gen_1	137	147	PF02991	0.336
LIG_LIR_Gen_1	232	241	PF02991	0.415
LIG_LIR_Gen_1	326	335	PF02991	0.376
LIG_LIR_Gen_1	432	443	PF02991	0.332
LIG_LIR_Gen_1	82	89	PF02991	0.448
LIG_LIR_Nem_3	140	146	PF02991	0.342
LIG_LIR_Nem_3	227	233	PF02991	0.389
LIG_LIR_Nem_3	310	316	PF02991	0.285
LIG_LIR_Nem_3	326	332	PF02991	0.369
LIG_LIR_Nem_3	432	438	PF02991	0.351
LIG_LIR_Nem_3	82	88	PF02991	0.404
LIG_NRBOX	457	463	PF00104	0.330
LIG_PCNA_yPIPBox_3	151	160	PF02747	0.380
LIG_Pex14_2	139	143	PF04695	0.331
LIG_PTB_Apo_2	284	291	PF02174	0.310
LIG_PTB_Phospho_1	284	290	PF10480	0.309
LIG_Rb_pABgroove_1	584	592	PF01858	0.674
LIG_SH2_CRK	291	295	PF00017	0.350
LIG_SH2_NCK_1	162	166	PF00017	0.316
LIG_SH2_NCK_1	291	295	PF00017	0.404
LIG_SH2_NCK_1	604	608	PF00017	0.728
LIG_SH2_NCK_1	71	75	PF00017	0.384
LIG_SH2_STAP1	186	190	PF00017	0.368
LIG_SH2_STAP1	590	594	PF00017	0.727
LIG_SH2_STAP1	96	100	PF00017	0.367
LIG_SH2_STAT3	267	270	PF00017	0.333
LIG_SH2_STAT5	104	107	PF00017	0.243
LIG_SH2_STAT5	233	236	PF00017	0.366
LIG_SH2_STAT5	473	476	PF00017	0.393
LIG_SH2_STAT5	509	512	PF00017	0.291
LIG_SH2_STAT5	85	88	PF00017	0.383
LIG_SH3_3	128	134	PF00018	0.306
LIG_SH3_3	412	418	PF00018	0.353
LIG_SH3_3	428	434	PF00018	0.328
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.322
LIG_SUMO_SIM_anti_2	207	215	PF11976	0.248
LIG_SUMO_SIM_par_1	176	181	PF11976	0.332
LIG_SUMO_SIM_par_1	193	198	PF11976	0.349
LIG_SUMO_SIM_par_1	207	215	PF11976	0.338
LIG_SUMO_SIM_par_1	618	624	PF11976	0.644
LIG_TRAF2_1	420	423	PF00917	0.424
LIG_TYR_ITIM	69	74	PF00017	0.383
LIG_UBA3_1	1	8	PF00899	0.554
LIG_UBA3_1	468	475	PF00899	0.328
LIG_WRC_WIRS_1	54	59	PF05994	0.329
MOD_CDK_SPK_2	178	183	PF00069	0.386
MOD_CK1_1	137	143	PF00069	0.306
MOD_CK1_1	181	187	PF00069	0.333
MOD_CK1_1	21	27	PF00069	0.568
MOD_CK1_1	217	223	PF00069	0.445
MOD_CK1_1	368	374	PF00069	0.364
MOD_CK1_1	45	51	PF00069	0.362
MOD_CK1_1	456	462	PF00069	0.364
MOD_CK1_1	467	473	PF00069	0.337
MOD_CK1_1	58	64	PF00069	0.260
MOD_CK2_1	122	128	PF00069	0.403
MOD_CK2_1	253	259	PF00069	0.403
MOD_CK2_1	366	372	PF00069	0.400
MOD_CK2_1	416	422	PF00069	0.396
MOD_CK2_1	499	505	PF00069	0.429
MOD_CK2_1	615	621	PF00069	0.713
MOD_Cter_Amidation	29	32	PF01082	0.615
MOD_GlcNHglycan	188	191	PF01048	0.601
MOD_GlcNHglycan	439	442	PF01048	0.523
MOD_GlcNHglycan	44	47	PF01048	0.586
MOD_GlcNHglycan	541	544	PF01048	0.726
MOD_GlcNHglycan	57	60	PF01048	0.611
MOD_GlcNHglycan	597	600	PF01048	0.530
MOD_GSK3_1	137	144	PF00069	0.401
MOD_GSK3_1	186	193	PF00069	0.414
MOD_GSK3_1	205	212	PF00069	0.428
MOD_GSK3_1	269	276	PF00069	0.374
MOD_GSK3_1	361	368	PF00069	0.375
MOD_GSK3_1	40	47	PF00069	0.382
MOD_GSK3_1	413	420	PF00069	0.430
MOD_GSK3_1	433	440	PF00069	0.298
MOD_GSK3_1	449	456	PF00069	0.326
MOD_GSK3_1	49	56	PF00069	0.329
MOD_GSK3_1	522	529	PF00069	0.367
MOD_GSK3_1	58	65	PF00069	0.247
MOD_N-GLC_1	114	119	PF02516	0.608
MOD_N-GLC_1	171	176	PF02516	0.573
MOD_N-GLC_1	359	364	PF02516	0.576
MOD_NEK2_1	19	24	PF00069	0.540
MOD_NEK2_1	365	370	PF00069	0.427
MOD_NEK2_1	454	459	PF00069	0.328
MOD_NEK2_1	464	469	PF00069	0.301
MOD_NEK2_1	551	556	PF00069	0.371
MOD_NEK2_1	64	69	PF00069	0.317
MOD_NEK2_2	248	253	PF00069	0.264
MOD_NEK2_2	279	284	PF00069	0.375
MOD_NEK2_2	522	527	PF00069	0.324
MOD_NEK2_2	96	101	PF00069	0.228
MOD_PIKK_1	134	140	PF00454	0.366
MOD_PIKK_1	214	220	PF00454	0.426
MOD_PIKK_1	273	279	PF00454	0.351
MOD_PIKK_1	45	51	PF00454	0.397
MOD_PK_1	114	120	PF00069	0.405
MOD_PKA_2	464	470	PF00069	0.312
MOD_Plk_1	114	120	PF00069	0.416
MOD_Plk_1	190	196	PF00069	0.327
MOD_Plk_1	307	313	PF00069	0.312
MOD_Plk_1	359	365	PF00069	0.374
MOD_Plk_1	499	505	PF00069	0.444
MOD_Plk_2-3	209	215	PF00069	0.343
MOD_Plk_2-3	500	506	PF00069	0.352
MOD_Plk_4	173	179	PF00069	0.326
MOD_Plk_4	209	215	PF00069	0.343
MOD_Plk_4	361	367	PF00069	0.305
MOD_Plk_4	457	463	PF00069	0.296
MOD_Plk_4	551	557	PF00069	0.298
MOD_Plk_4	615	621	PF00069	0.713
MOD_ProDKin_1	171	177	PF00069	0.469
MOD_ProDKin_1	178	184	PF00069	0.420
MOD_ProDKin_1	411	417	PF00069	0.426
MOD_SUMO_rev_2	125	132	PF00179	0.402
MOD_SUMO_rev_2	325	330	PF00179	0.337
MOD_SUMO_rev_2	478	483	PF00179	0.352
TRG_DiLeu_BaEn_1	83	88	PF01217	0.432
TRG_ENDOCYTIC_2	290	293	PF00928	0.301
TRG_ENDOCYTIC_2	71	74	PF00928	0.385
TRG_ENDOCYTIC_2	85	88	PF00928	0.323
TRG_ER_diArg_1	464	466	PF00400	0.426
TRG_ER_FFAT_2	227	239	PF00635	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P769	Leptomonas seymouri	50%	99%
A0A1X0NKD5	Trypanosomatidae	37%	100%
A0A3R7KSB6	Trypanosoma rangeli	37%	100%
A4H4V1	Leishmania braziliensis	74%	100%
A4HT61	Leishmania infantum	100%	100%
C9ZUW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AL18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIT6	Leishmania major	91%	100%
V5BDE1	Trypanosoma cruzi	36%	100%