LeishMANIAdb
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Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase, putative
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WPQ0_LEIDO
TriTrypDb:
LdBPK_070320.1 , LdCL_070006600 , LDHU3_07.0220
Length:
848

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPQ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPQ0

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016310 phosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003824 catalytic activity 1 6
GO:0004672 protein kinase activity 3 6
GO:0005488 binding 1 6
GO:0005524 ATP binding 5 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 6
GO:0017076 purine nucleotide binding 4 6
GO:0030554 adenyl nucleotide binding 5 6
GO:0032553 ribonucleotide binding 3 6
GO:0032555 purine ribonucleotide binding 4 6
GO:0032559 adenyl ribonucleotide binding 5 6
GO:0035639 purine ribonucleoside triphosphate binding 4 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043168 anion binding 3 6
GO:0097159 organic cyclic compound binding 2 6
GO:0097367 carbohydrate derivative binding 2 6
GO:0140096 catalytic activity, acting on a protein 2 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 195 197 PF00675 0.371
CLV_NRD_NRD_1 326 328 PF00675 0.667
CLV_NRD_NRD_1 483 485 PF00675 0.713
CLV_NRD_NRD_1 490 492 PF00675 0.656
CLV_NRD_NRD_1 536 538 PF00675 0.646
CLV_NRD_NRD_1 653 655 PF00675 0.717
CLV_NRD_NRD_1 679 681 PF00675 0.782
CLV_NRD_NRD_1 818 820 PF00675 0.614
CLV_NRD_NRD_1 821 823 PF00675 0.571
CLV_PCSK_FUR_1 793 797 PF00082 0.605
CLV_PCSK_KEX2_1 34 36 PF00082 0.394
CLV_PCSK_KEX2_1 490 492 PF00082 0.720
CLV_PCSK_KEX2_1 536 538 PF00082 0.646
CLV_PCSK_KEX2_1 566 568 PF00082 0.653
CLV_PCSK_KEX2_1 653 655 PF00082 0.717
CLV_PCSK_KEX2_1 678 680 PF00082 0.787
CLV_PCSK_KEX2_1 795 797 PF00082 0.600
CLV_PCSK_KEX2_1 818 820 PF00082 0.673
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.394
CLV_PCSK_PC1ET2_1 490 492 PF00082 0.693
CLV_PCSK_PC1ET2_1 566 568 PF00082 0.705
CLV_PCSK_PC1ET2_1 795 797 PF00082 0.574
CLV_PCSK_PC1ET2_1 818 820 PF00082 0.601
CLV_PCSK_SKI1_1 123 127 PF00082 0.394
CLV_PCSK_SKI1_1 246 250 PF00082 0.523
CLV_PCSK_SKI1_1 253 257 PF00082 0.515
CLV_PCSK_SKI1_1 443 447 PF00082 0.634
CLV_PCSK_SKI1_1 566 570 PF00082 0.747
CLV_PCSK_SKI1_1 599 603 PF00082 0.629
DEG_SCF_FBW7_1 338 345 PF00400 0.635
DEG_SCF_FBW7_1 370 375 PF00400 0.719
DEG_SPOP_SBC_1 320 324 PF00917 0.608
DEG_SPOP_SBC_1 348 352 PF00917 0.625
DOC_CKS1_1 339 344 PF01111 0.639
DOC_CKS1_1 697 702 PF01111 0.739
DOC_CYCLIN_yCln2_LP_2 195 201 PF00134 0.394
DOC_MAPK_gen_1 123 132 PF00069 0.394
DOC_MAPK_gen_1 51 60 PF00069 0.394
DOC_MAPK_gen_1 772 779 PF00069 0.651
DOC_MAPK_gen_1 818 829 PF00069 0.646
DOC_MAPK_MEF2A_6 464 473 PF00069 0.648
DOC_MAPK_MEF2A_6 595 604 PF00069 0.623
DOC_MAPK_MEF2A_6 822 831 PF00069 0.649
DOC_PP2B_LxvP_1 463 466 PF13499 0.667
DOC_PP2B_LxvP_1 541 544 PF13499 0.650
DOC_PP2B_LxvP_1 602 605 PF13499 0.631
DOC_PP4_FxxP_1 199 202 PF00568 0.394
DOC_PP4_FxxP_1 478 481 PF00568 0.632
DOC_PP4_FxxP_1 686 689 PF00568 0.731
DOC_PP4_MxPP_1 424 427 PF00568 0.571
DOC_PP4_MxPP_1 698 701 PF00568 0.656
DOC_USP7_MATH_1 276 280 PF00917 0.670
DOC_USP7_MATH_1 313 317 PF00917 0.669
DOC_USP7_MATH_1 318 322 PF00917 0.632
DOC_USP7_MATH_1 340 344 PF00917 0.699
DOC_USP7_MATH_1 395 399 PF00917 0.722
DOC_USP7_MATH_1 610 614 PF00917 0.613
DOC_USP7_MATH_1 749 753 PF00917 0.667
DOC_USP7_MATH_1 775 779 PF00917 0.643
DOC_USP7_UBL2_3 486 490 PF12436 0.682
DOC_USP7_UBL2_3 553 557 PF12436 0.719
DOC_USP7_UBL2_3 595 599 PF12436 0.645
DOC_WW_Pin1_4 159 164 PF00397 0.394
DOC_WW_Pin1_4 214 219 PF00397 0.464
DOC_WW_Pin1_4 263 268 PF00397 0.608
DOC_WW_Pin1_4 287 292 PF00397 0.823
DOC_WW_Pin1_4 299 304 PF00397 0.655
DOC_WW_Pin1_4 321 326 PF00397 0.648
DOC_WW_Pin1_4 338 343 PF00397 0.569
DOC_WW_Pin1_4 368 373 PF00397 0.720
DOC_WW_Pin1_4 396 401 PF00397 0.723
DOC_WW_Pin1_4 407 412 PF00397 0.602
DOC_WW_Pin1_4 453 458 PF00397 0.645
DOC_WW_Pin1_4 513 518 PF00397 0.646
DOC_WW_Pin1_4 582 587 PF00397 0.717
DOC_WW_Pin1_4 662 667 PF00397 0.655
DOC_WW_Pin1_4 678 683 PF00397 0.763
DOC_WW_Pin1_4 685 690 PF00397 0.769
DOC_WW_Pin1_4 696 701 PF00397 0.606
DOC_WW_Pin1_4 730 735 PF00397 0.665
DOC_WW_Pin1_4 92 97 PF00397 0.381
LIG_14-3-3_CanoR_1 196 202 PF00244 0.371
LIG_14-3-3_CanoR_1 242 249 PF00244 0.394
LIG_14-3-3_CanoR_1 287 291 PF00244 0.658
LIG_14-3-3_CanoR_1 394 400 PF00244 0.668
LIG_14-3-3_CanoR_1 526 533 PF00244 0.667
LIG_14-3-3_CanoR_1 704 713 PF00244 0.669
LIG_14-3-3_CanoR_1 737 742 PF00244 0.689
LIG_14-3-3_CanoR_1 755 760 PF00244 0.779
LIG_14-3-3_CanoR_1 774 780 PF00244 0.571
LIG_14-3-3_CanoR_1 94 104 PF00244 0.342
LIG_BIR_III_2 614 618 PF00653 0.644
LIG_BRCT_BRCA1_1 759 763 PF00533 0.663
LIG_deltaCOP1_diTrp_1 181 189 PF00928 0.394
LIG_FHA_1 134 140 PF00498 0.394
LIG_FHA_1 150 156 PF00498 0.238
LIG_FHA_1 38 44 PF00498 0.394
LIG_FHA_1 528 534 PF00498 0.633
LIG_FHA_1 550 556 PF00498 0.703
LIG_FHA_1 96 102 PF00498 0.394
LIG_FHA_2 339 345 PF00498 0.667
LIG_FHA_2 350 356 PF00498 0.571
LIG_FHA_2 401 407 PF00498 0.609
LIG_FHA_2 444 450 PF00498 0.609
LIG_Integrin_isoDGR_2 764 766 PF01839 0.718
LIG_LIR_Apic_2 162 168 PF02991 0.394
LIG_LIR_Apic_2 475 481 PF02991 0.630
LIG_LIR_Apic_2 684 689 PF02991 0.725
LIG_LIR_Gen_1 203 211 PF02991 0.407
LIG_LIR_Gen_1 4 12 PF02991 0.501
LIG_LIR_Gen_1 69 76 PF02991 0.405
LIG_LIR_LC3C_4 28 32 PF02991 0.355
LIG_LIR_LC3C_4 355 360 PF02991 0.642
LIG_LIR_Nem_3 203 207 PF02991 0.407
LIG_LIR_Nem_3 212 216 PF02991 0.277
LIG_LIR_Nem_3 4 9 PF02991 0.496
LIG_LIR_Nem_3 83 89 PF02991 0.436
LIG_MAD2 553 561 PF02301 0.704
LIG_PALB2_WD40_1 100 108 PF16756 0.394
LIG_Pex14_2 60 64 PF04695 0.394
LIG_SH2_CRK 6 10 PF00017 0.498
LIG_SH2_NCK_1 190 194 PF00017 0.394
LIG_SH2_STAP1 178 182 PF00017 0.386
LIG_SH2_STAT3 635 638 PF00017 0.588
LIG_SH2_STAT3 741 744 PF00017 0.684
LIG_SH2_STAT3 88 91 PF00017 0.394
LIG_SH2_STAT5 114 117 PF00017 0.394
LIG_SH2_STAT5 140 143 PF00017 0.394
LIG_SH2_STAT5 6 9 PF00017 0.494
LIG_SH2_STAT5 635 638 PF00017 0.640
LIG_SH2_STAT5 741 744 PF00017 0.632
LIG_SH2_STAT5 88 91 PF00017 0.394
LIG_SH3_1 300 306 PF00018 0.679
LIG_SH3_3 157 163 PF00018 0.497
LIG_SH3_3 233 239 PF00018 0.394
LIG_SH3_3 266 272 PF00018 0.697
LIG_SH3_3 300 306 PF00018 0.707
LIG_SH3_3 307 313 PF00018 0.690
LIG_SH3_3 334 340 PF00018 0.663
LIG_SH3_3 350 356 PF00018 0.535
LIG_SH3_3 410 416 PF00018 0.631
LIG_SH3_3 433 439 PF00018 0.621
LIG_SH3_3 506 512 PF00018 0.633
LIG_SH3_3 576 582 PF00018 0.712
LIG_SH3_3 594 600 PF00018 0.520
LIG_SH3_3 602 608 PF00018 0.647
LIG_SH3_3 686 692 PF00018 0.705
LIG_SH3_3 694 700 PF00018 0.665
LIG_SH3_3 708 714 PF00018 0.739
LIG_SH3_4 599 606 PF00018 0.684
LIG_Sin3_3 428 435 PF02671 0.636
LIG_SUMO_SIM_anti_2 28 34 PF11976 0.355
LIG_SUMO_SIM_anti_2 354 363 PF11976 0.643
LIG_SUMO_SIM_par_1 233 238 PF11976 0.394
LIG_SUMO_SIM_par_1 354 363 PF11976 0.659
LIG_TRAF2_1 403 406 PF00917 0.569
LIG_TRAF2_1 778 781 PF00917 0.637
LIG_WRC_WIRS_1 61 66 PF05994 0.523
LIG_WW_3 284 288 PF00397 0.651
LIG_WW_3 324 328 PF00397 0.662
LIG_WW_3 577 581 PF00397 0.661
LIG_WW_3 699 703 PF00397 0.709
MOD_CDC14_SPxK_1 268 271 PF00782 0.650
MOD_CDC14_SPxK_1 585 588 PF00782 0.712
MOD_CDK_SPxK_1 265 271 PF00069 0.624
MOD_CDK_SPxK_1 321 327 PF00069 0.660
MOD_CDK_SPxK_1 582 588 PF00069 0.717
MOD_CDK_SPxK_1 696 702 PF00069 0.758
MOD_CDK_SPxxK_3 321 328 PF00069 0.663
MOD_CDK_SPxxK_3 662 669 PF00069 0.608
MOD_CDK_SPxxK_3 678 685 PF00069 0.666
MOD_CDK_SPxxK_3 730 737 PF00069 0.652
MOD_CK1_1 133 139 PF00069 0.400
MOD_CK1_1 146 152 PF00069 0.267
MOD_CK1_1 153 159 PF00069 0.199
MOD_CK1_1 200 206 PF00069 0.397
MOD_CK1_1 277 283 PF00069 0.695
MOD_CK1_1 316 322 PF00069 0.696
MOD_CK1_1 343 349 PF00069 0.690
MOD_CK1_1 351 357 PF00069 0.612
MOD_CK1_1 375 381 PF00069 0.720
MOD_CK1_1 399 405 PF00069 0.705
MOD_CK1_1 516 522 PF00069 0.657
MOD_CK1_1 529 535 PF00069 0.588
MOD_CK1_1 545 551 PF00069 0.692
MOD_CK1_1 681 687 PF00069 0.732
MOD_CK1_1 75 81 PF00069 0.456
MOD_CK1_1 754 760 PF00069 0.698
MOD_CK1_1 92 98 PF00069 0.248
MOD_CK2_1 287 293 PF00069 0.661
MOD_CK2_1 399 405 PF00069 0.660
MOD_CK2_1 775 781 PF00069 0.654
MOD_GlcNHglycan 145 148 PF01048 0.464
MOD_GlcNHglycan 199 202 PF01048 0.512
MOD_GlcNHglycan 279 282 PF01048 0.704
MOD_GlcNHglycan 318 321 PF01048 0.666
MOD_GlcNHglycan 377 380 PF01048 0.699
MOD_GlcNHglycan 548 551 PF01048 0.632
MOD_GlcNHglycan 662 665 PF01048 0.691
MOD_GlcNHglycan 77 80 PF01048 0.434
MOD_GlcNHglycan 807 810 PF01048 0.533
MOD_GlcNHglycan 842 845 PF01048 0.632
MOD_GSK3_1 146 153 PF00069 0.510
MOD_GSK3_1 155 162 PF00069 0.365
MOD_GSK3_1 226 233 PF00069 0.475
MOD_GSK3_1 276 283 PF00069 0.790
MOD_GSK3_1 304 311 PF00069 0.697
MOD_GSK3_1 312 319 PF00069 0.655
MOD_GSK3_1 338 345 PF00069 0.693
MOD_GSK3_1 347 354 PF00069 0.626
MOD_GSK3_1 368 375 PF00069 0.726
MOD_GSK3_1 395 402 PF00069 0.718
MOD_GSK3_1 405 412 PF00069 0.622
MOD_GSK3_1 472 479 PF00069 0.657
MOD_GSK3_1 512 519 PF00069 0.663
MOD_GSK3_1 527 534 PF00069 0.534
MOD_GSK3_1 542 549 PF00069 0.650
MOD_GSK3_1 681 688 PF00069 0.715
MOD_GSK3_1 751 758 PF00069 0.804
MOD_N-GLC_1 153 158 PF02516 0.394
MOD_N-GLC_1 46 51 PF02516 0.394
MOD_N-GLC_1 66 71 PF02516 0.199
MOD_NEK2_1 12 17 PF00069 0.572
MOD_NEK2_1 150 155 PF00069 0.440
MOD_NEK2_1 171 176 PF00069 0.396
MOD_NEK2_1 331 336 PF00069 0.661
MOD_NEK2_1 46 51 PF00069 0.394
MOD_NEK2_1 471 476 PF00069 0.656
MOD_NEK2_1 60 65 PF00069 0.258
MOD_NEK2_1 759 764 PF00069 0.661
MOD_NEK2_1 89 94 PF00069 0.355
MOD_NEK2_2 66 71 PF00069 0.394
MOD_PIKK_1 308 314 PF00454 0.666
MOD_PIKK_1 329 335 PF00454 0.661
MOD_PIKK_1 37 43 PF00454 0.458
MOD_PIKK_1 383 389 PF00454 0.668
MOD_PIKK_1 87 93 PF00454 0.394
MOD_PK_1 507 513 PF00069 0.660
MOD_PKA_2 241 247 PF00069 0.394
MOD_PKA_2 286 292 PF00069 0.708
MOD_PKA_2 545 551 PF00069 0.666
MOD_PKA_2 754 760 PF00069 0.786
MOD_PKA_2 775 781 PF00069 0.659
MOD_PKB_1 505 513 PF00069 0.704
MOD_PKB_1 702 710 PF00069 0.674
MOD_Plk_1 443 449 PF00069 0.608
MOD_Plk_1 46 52 PF00069 0.394
MOD_Plk_4 155 161 PF00069 0.382
MOD_Plk_4 230 236 PF00069 0.482
MOD_Plk_4 60 66 PF00069 0.523
MOD_Plk_4 737 743 PF00069 0.609
MOD_Plk_4 97 103 PF00069 0.517
MOD_ProDKin_1 159 165 PF00069 0.394
MOD_ProDKin_1 214 220 PF00069 0.464
MOD_ProDKin_1 263 269 PF00069 0.617
MOD_ProDKin_1 287 293 PF00069 0.827
MOD_ProDKin_1 299 305 PF00069 0.651
MOD_ProDKin_1 321 327 PF00069 0.672
MOD_ProDKin_1 338 344 PF00069 0.574
MOD_ProDKin_1 368 374 PF00069 0.722
MOD_ProDKin_1 396 402 PF00069 0.723
MOD_ProDKin_1 407 413 PF00069 0.599
MOD_ProDKin_1 453 459 PF00069 0.648
MOD_ProDKin_1 513 519 PF00069 0.648
MOD_ProDKin_1 582 588 PF00069 0.717
MOD_ProDKin_1 662 668 PF00069 0.657
MOD_ProDKin_1 678 684 PF00069 0.764
MOD_ProDKin_1 685 691 PF00069 0.770
MOD_ProDKin_1 696 702 PF00069 0.607
MOD_ProDKin_1 730 736 PF00069 0.661
MOD_ProDKin_1 92 98 PF00069 0.381
MOD_SUMO_for_1 441 444 PF00179 0.627
MOD_SUMO_for_1 783 786 PF00179 0.523
MOD_SUMO_rev_2 118 128 PF00179 0.326
MOD_SUMO_rev_2 133 139 PF00179 0.394
MOD_SUMO_rev_2 362 366 PF00179 0.681
MOD_SUMO_rev_2 642 647 PF00179 0.614
TRG_DiLeu_BaEn_2 519 525 PF01217 0.709
TRG_DiLeu_BaLyEn_6 353 358 PF01217 0.701
TRG_ENDOCYTIC_2 6 9 PF00928 0.494
TRG_ER_diArg_1 50 53 PF00400 0.400
TRG_ER_diArg_1 504 507 PF00400 0.708
TRG_ER_diArg_1 678 680 PF00400 0.650
TRG_ER_diArg_1 701 704 PF00400 0.764
TRG_ER_diArg_1 774 777 PF00400 0.663
TRG_ER_diArg_1 800 803 PF00400 0.646
TRG_NLS_MonoExtC_3 817 822 PF00514 0.605
TRG_NLS_MonoExtN_4 481 488 PF00514 0.653
TRG_NLS_MonoExtN_4 489 494 PF00514 0.652
TRG_NLS_MonoExtN_4 815 822 PF00514 0.580
TRG_Pf-PMV_PEXEL_1 526 531 PF00026 0.645
TRG_Pf-PMV_PEXEL_1 704 708 PF00026 0.721

Homologs

Protein Taxonomy Sequence identity Coverage
A4H4W0 Leishmania braziliensis 66% 96%
A4HT34 Leishmania infantum 100% 100%
E9AL26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QIS8 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS