Peptidase_dimerisation_domain_containing_protein_ putative/Pfam:PF07687

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPP6_LEIDO

TriTrypDb:

LdBPK_070040.1 , LdCL_070005300 , LDHU3_07.0070

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPP6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006520	amino acid metabolic process	3	16
GO:0006525	arginine metabolic process	6	16
GO:0006526	arginine biosynthetic process	7	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0008652	amino acid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009064	glutamine family amino acid metabolic process	5	16
GO:0009084	glutamine family amino acid biosynthetic process	6	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16
GO:1901605	alpha-amino acid metabolic process	4	16
GO:1901607	alpha-amino acid biosynthetic process	5	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004180	carboxypeptidase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	17
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0008777	acetylornithine deacetylase activity	4	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10
GO:0019213	deacetylase activity	3	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.464
CLV_NRD_NRD_1	270	272	PF00675	0.538
CLV_PCSK_KEX2_1	264	266	PF00082	0.568
CLV_PCSK_KEX2_1	72	74	PF00082	0.223
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.339
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.223
CLV_PCSK_SKI1_1	40	44	PF00082	0.531
CLV_PCSK_SKI1_1	95	99	PF00082	0.430
DOC_CDC14_PxL_1	188	196	PF14671	0.429
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.419
DOC_MAPK_gen_1	263	269	PF00069	0.526
DOC_PP1_RVXF_1	11	18	PF00149	0.344
DOC_PP1_RVXF_1	93	99	PF00149	0.223
DOC_PP2B_LxvP_1	189	192	PF13499	0.395
DOC_PP4_FxxP_1	148	151	PF00568	0.165
DOC_USP7_MATH_1	205	209	PF00917	0.448
DOC_USP7_UBL2_3	68	72	PF12436	0.367
LIG_BIR_II_1	1	5	PF00653	0.316
LIG_FHA_1	135	141	PF00498	0.341
LIG_FHA_1	64	70	PF00498	0.258
LIG_FHA_2	221	227	PF00498	0.556
LIG_FHA_2	51	57	PF00498	0.468
LIG_LIR_Apic_2	147	151	PF02991	0.165
LIG_LIR_Gen_1	226	236	PF02991	0.398
LIG_LIR_Nem_3	226	231	PF02991	0.406
LIG_Pex14_2	144	148	PF04695	0.306
LIG_PTB_Apo_2	142	149	PF02174	0.187
LIG_SH2_CRK	228	232	PF00017	0.346
LIG_SH2_NCK_1	228	232	PF00017	0.477
LIG_SH2_STAT5	16	19	PF00017	0.378
LIG_SH2_STAT5	166	169	PF00017	0.535
LIG_SH3_3	234	240	PF00018	0.354
LIG_SUMO_SIM_par_1	186	193	PF11976	0.303
LIG_TRAF2_1	246	249	PF00917	0.517
LIG_UBA3_1	266	272	PF00899	0.377
LIG_WW_3	150	154	PF00397	0.165
MOD_CK1_1	118	124	PF00069	0.223
MOD_CK1_1	190	196	PF00069	0.349
MOD_CK1_1	208	214	PF00069	0.526
MOD_CK1_1	36	42	PF00069	0.589
MOD_CK2_1	50	56	PF00069	0.520
MOD_Cter_Amidation	261	264	PF01082	0.372
MOD_GlcNHglycan	117	120	PF01048	0.351
MOD_GlcNHglycan	177	181	PF01048	0.523
MOD_GlcNHglycan	203	206	PF01048	0.463
MOD_GlcNHglycan	207	210	PF01048	0.411
MOD_GlcNHglycan	78	81	PF01048	0.321
MOD_GSK3_1	115	122	PF00069	0.310
MOD_GSK3_1	172	179	PF00069	0.548
MOD_GSK3_1	201	208	PF00069	0.514
MOD_GSK3_1	76	83	PF00069	0.305
MOD_N-GLC_1	267	272	PF02516	0.379
MOD_N-GLC_2	259	261	PF02516	0.325
MOD_N-GLC_2	85	87	PF02516	0.187
MOD_NEK2_1	117	122	PF00069	0.450
MOD_NEK2_1	124	129	PF00069	0.472
MOD_NEK2_1	267	272	PF00069	0.475
MOD_NEK2_1	63	68	PF00069	0.187
MOD_PIKK_1	156	162	PF00454	0.522
MOD_Plk_4	119	125	PF00069	0.330
MOD_SUMO_rev_2	193	203	PF00179	0.465
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.275
TRG_ENDOCYTIC_2	228	231	PF00928	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V6	Leptomonas seymouri	52%	72%
A0A0N1I646	Leptomonas seymouri	26%	70%
A0A0N1IHL3	Leptomonas seymouri	29%	66%
A0A3Q8IRE4	Leishmania donovani	28%	71%
A0A3S5H5X0	Leishmania donovani	27%	72%
A4H4X2	Leishmania braziliensis	25%	72%
A4HHG9	Leishmania braziliensis	27%	71%
A4HT25	Leishmania infantum	99%	100%
A4HT45	Leishmania infantum	27%	72%
A4I4L8	Leishmania infantum	28%	100%
C9ZUW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	72%
E9AE16	Leishmania major	27%	71%
E9AL37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	72%
E9ALR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
O68873	Myxococcus xanthus	25%	75%
Q4QIR7	Leishmania major	26%	72%
Q4QIU1	Leishmania major	76%	100%
V5D8Q5	Trypanosoma cruzi	26%	72%
V5D9A3	Trypanosoma cruzi	36%	72%