FAD binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPP5_LEIDO

TriTrypDb:

LdBPK_061290.1 , LdCL_060018100 , LDHU3_06.1440

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WPP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPP5

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	9
GO:0004497	monooxygenase activity	3	9
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	5
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.306
CLV_NRD_NRD_1	153	155	PF00675	0.519
CLV_NRD_NRD_1	3	5	PF00675	0.636
CLV_NRD_NRD_1	324	326	PF00675	0.362
CLV_PCSK_KEX2_1	3	5	PF00082	0.636
CLV_PCSK_KEX2_1	324	326	PF00082	0.304
CLV_PCSK_KEX2_1	67	69	PF00082	0.473
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.453
CLV_PCSK_SKI1_1	242	246	PF00082	0.265
CLV_PCSK_SKI1_1	308	312	PF00082	0.384
CLV_PCSK_SKI1_1	371	375	PF00082	0.244
CLV_PCSK_SKI1_1	443	447	PF00082	0.514
CLV_PCSK_SKI1_1	59	63	PF00082	0.319
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SCF_FBW7_1	83	90	PF00400	0.302
DEG_SPOP_SBC_1	299	303	PF00917	0.322
DEG_SPOP_SBC_1	341	345	PF00917	0.306
DOC_CKS1_1	182	187	PF01111	0.353
DOC_CKS1_1	245	250	PF01111	0.377
DOC_CYCLIN_RxL_1	305	314	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.333
DOC_MAPK_gen_1	154	162	PF00069	0.367
DOC_MAPK_HePTP_8	138	150	PF00069	0.460
DOC_MAPK_MEF2A_6	141	150	PF00069	0.442
DOC_PP1_RVXF_1	153	160	PF00149	0.343
DOC_PP2B_LxvP_1	6	9	PF13499	0.405
DOC_USP7_MATH_1	353	357	PF00917	0.318
DOC_USP7_MATH_1	378	382	PF00917	0.231
DOC_USP7_MATH_1	399	403	PF00917	0.293
DOC_USP7_MATH_1	407	411	PF00917	0.230
DOC_USP7_MATH_1	459	463	PF00917	0.467
DOC_USP7_MATH_1	464	468	PF00917	0.447
DOC_USP7_MATH_1	52	56	PF00917	0.403
DOC_USP7_MATH_1	87	91	PF00917	0.332
DOC_WW_Pin1_4	117	122	PF00397	0.435
DOC_WW_Pin1_4	181	186	PF00397	0.353
DOC_WW_Pin1_4	244	249	PF00397	0.404
DOC_WW_Pin1_4	311	316	PF00397	0.333
DOC_WW_Pin1_4	342	347	PF00397	0.263
DOC_WW_Pin1_4	446	451	PF00397	0.554
DOC_WW_Pin1_4	83	88	PF00397	0.307
DOC_WW_Pin1_4	9	14	PF00397	0.580
LIG_14-3-3_CanoR_1	128	133	PF00244	0.531
LIG_14-3-3_CanoR_1	141	148	PF00244	0.452
LIG_14-3-3_CanoR_1	237	242	PF00244	0.443
LIG_14-3-3_CanoR_1	3	7	PF00244	0.558
LIG_14-3-3_CanoR_1	324	330	PF00244	0.295
LIG_14-3-3_CanoR_1	458	464	PF00244	0.417
LIG_14-3-3_CanoR_1	46	53	PF00244	0.575
LIG_BRCT_BRCA1_1	128	132	PF00533	0.532
LIG_BRCT_BRCA1_1	461	465	PF00533	0.625
LIG_Clathr_ClatBox_1	60	64	PF01394	0.342
LIG_CtBP_PxDLS_1	315	319	PF00389	0.189
LIG_FHA_1	133	139	PF00498	0.641
LIG_FHA_1	245	251	PF00498	0.284
LIG_FHA_1	255	261	PF00498	0.221
LIG_FHA_1	293	299	PF00498	0.270
LIG_FHA_1	399	405	PF00498	0.322
LIG_FHA_1	430	436	PF00498	0.526
LIG_FHA_1	447	453	PF00498	0.405
LIG_FHA_1	80	86	PF00498	0.313
LIG_FHA_2	140	146	PF00498	0.562
LIG_FHA_2	193	199	PF00498	0.284
LIG_FHA_2	220	226	PF00498	0.388
LIG_FHA_2	289	295	PF00498	0.273
LIG_FHA_2	312	318	PF00498	0.352
LIG_FHA_2	342	348	PF00498	0.242
LIG_FHA_2	435	441	PF00498	0.361
LIG_GBD_Chelix_1	318	326	PF00786	0.234
LIG_GBD_Chelix_1	53	61	PF00786	0.387
LIG_LIR_Gen_1	149	157	PF02991	0.363
LIG_LIR_Gen_1	275	280	PF02991	0.303
LIG_LIR_Nem_3	149	153	PF02991	0.397
LIG_LIR_Nem_3	225	231	PF02991	0.290
LIG_LIR_Nem_3	275	279	PF02991	0.303
LIG_MLH1_MIPbox_1	129	133	PF16413	0.643
LIG_PCNA_yPIPBox_3	167	179	PF02747	0.272
LIG_Pex14_2	276	280	PF04695	0.244
LIG_REV1ctd_RIR_1	277	285	PF16727	0.377
LIG_SH2_NCK_1	71	75	PF00017	0.501
LIG_SH2_STAP1	254	258	PF00017	0.262
LIG_SH2_STAP1	395	399	PF00017	0.244
LIG_SH3_3	179	185	PF00018	0.346
LIG_SH3_3	197	203	PF00018	0.392
LIG_SH3_3	364	370	PF00018	0.252
LIG_SUMO_SIM_par_1	81	86	PF11976	0.293
LIG_UBA3_1	435	444	PF00899	0.465
LIG_WRC_WIRS_1	273	278	PF05994	0.357
LIG_WRC_WIRS_1	326	331	PF05994	0.263
MOD_CDK_SPxxK_3	342	349	PF00069	0.263
MOD_CK1_1	204	210	PF00069	0.498
MOD_CK1_1	211	217	PF00069	0.439
MOD_CK1_1	219	225	PF00069	0.372
MOD_CK1_1	246	252	PF00069	0.303
MOD_CK1_1	292	298	PF00069	0.224
MOD_CK2_1	139	145	PF00069	0.612
MOD_CK2_1	192	198	PF00069	0.380
MOD_CK2_1	310	316	PF00069	0.349
MOD_CK2_1	399	405	PF00069	0.377
MOD_CK2_1	434	440	PF00069	0.356
MOD_Cter_Amidation	65	68	PF01082	0.410
MOD_GlcNHglycan	213	216	PF01048	0.411
MOD_GlcNHglycan	218	221	PF01048	0.381
MOD_GlcNHglycan	23	26	PF01048	0.311
MOD_GlcNHglycan	409	412	PF01048	0.357
MOD_GlcNHglycan	47	50	PF01048	0.637
MOD_GlcNHglycan	478	481	PF01048	0.311
MOD_GlcNHglycan	64	67	PF01048	0.405
MOD_GSK3_1	128	135	PF00069	0.547
MOD_GSK3_1	204	211	PF00069	0.469
MOD_GSK3_1	216	223	PF00069	0.441
MOD_GSK3_1	288	295	PF00069	0.290
MOD_GSK3_1	79	86	PF00069	0.327
MOD_N-GLC_1	139	144	PF02516	0.607
MOD_N-GLC_2	167	169	PF02516	0.398
MOD_N-GLC_2	272	274	PF02516	0.244
MOD_NEK2_1	132	137	PF00069	0.595
MOD_NEK2_1	2	7	PF00069	0.575
MOD_NEK2_1	208	213	PF00069	0.473
MOD_NEK2_1	259	264	PF00069	0.338
MOD_NEK2_1	300	305	PF00069	0.274
MOD_NEK2_1	310	315	PF00069	0.271
MOD_NEK2_1	33	38	PF00069	0.333
MOD_NEK2_1	429	434	PF00069	0.318
MOD_NEK2_1	44	49	PF00069	0.407
MOD_NEK2_1	465	470	PF00069	0.480
MOD_NEK2_1	475	480	PF00069	0.359
MOD_NEK2_1	62	67	PF00069	0.366
MOD_NEK2_1	76	81	PF00069	0.426
MOD_NEK2_2	378	383	PF00069	0.231
MOD_PIKK_1	201	207	PF00454	0.494
MOD_PIKK_1	300	306	PF00454	0.313
MOD_PK_1	81	87	PF00069	0.430
MOD_PKA_1	443	449	PF00069	0.531
MOD_PKA_2	127	133	PF00069	0.645
MOD_PKA_2	140	146	PF00069	0.590
MOD_PKA_2	2	8	PF00069	0.555
MOD_PKA_2	236	242	PF00069	0.443
MOD_PKA_2	45	51	PF00069	0.454
MOD_Plk_4	128	134	PF00069	0.539
MOD_Plk_4	399	405	PF00069	0.358
MOD_ProDKin_1	117	123	PF00069	0.443
MOD_ProDKin_1	181	187	PF00069	0.342
MOD_ProDKin_1	244	250	PF00069	0.404
MOD_ProDKin_1	311	317	PF00069	0.333
MOD_ProDKin_1	342	348	PF00069	0.263
MOD_ProDKin_1	446	452	PF00069	0.557
MOD_ProDKin_1	83	89	PF00069	0.303
MOD_ProDKin_1	9	15	PF00069	0.572
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.436
TRG_ENDOCYTIC_2	108	111	PF00928	0.384
TRG_ER_diArg_1	2	4	PF00400	0.593
TRG_ER_diArg_1	324	326	PF00400	0.360
TRG_ER_diArg_1	335	338	PF00400	0.343
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M2	Leptomonas seymouri	74%	97%
A0A1X0NI75	Trypanosomatidae	57%	96%
A0A3R7KEW4	Trypanosoma rangeli	56%	99%
A4H4T6	Leishmania braziliensis	83%	100%
A4HT15	Leishmania infantum	99%	100%
C9ZTQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	96%
E9AL03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
F1RAX8	Danio rerio	28%	100%
O01884	Caenorhabditis elegans	26%	100%
P25535	Escherichia coli (strain K12)	27%	100%
P75728	Escherichia coli (strain K12)	24%	100%
Q2KIL4	Bos taurus	25%	100%
Q4QIV2	Leishmania major	96%	100%
Q68FU7	Rattus norvegicus	26%	100%
Q6DF46	Xenopus tropicalis	29%	100%
Q8R1S0	Mus musculus	27%	100%
Q9Y2Z9	Homo sapiens	26%	100%
Q9Y7Z9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5B825	Trypanosoma cruzi	55%	99%