Coproporphyrinogen oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coproporphyrinogen III oxidase

Species:

Leishmania donovani

UniProt:

A0A3S7WPP3_LEIDO

TriTrypDb:

LdBPK_061330.1 , LdCL_060018600 , LDHU3_06.1490

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WPP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPP3

PDB structure(s): 1vju_A , 1vju_B , 2qt8_A , 2qt8_B , 3dwr_A , 3dwr_B , 3dws_A , 3dws_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006778	porphyrin-containing compound metabolic process	5	6
GO:0006779	porphyrin-containing compound biosynthetic process	6	6
GO:0006782	protoporphyrinogen IX biosynthetic process	7	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004109	coproporphyrinogen oxidase activity	5	6
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0016491	oxidoreductase activity	2	6
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	6
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	6
GO:0042802	identical protein binding	3	1
GO:0042803	protein homodimerization activity	4	1
GO:0046983	protein dimerization activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.498
CLV_NRD_NRD_1	237	239	PF00675	0.286
CLV_PCSK_KEX2_1	220	222	PF00082	0.498
CLV_PCSK_KEX2_1	237	239	PF00082	0.286
CLV_PCSK_KEX2_1	297	299	PF00082	0.415
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.415
CLV_PCSK_SKI1_1	9	13	PF00082	0.498
DEG_CRL4_CDT2_1	288	299	PF00400	0.698
DEG_CRL4_CDT2_2	288	299	PF00400	0.698
DEG_SPOP_SBC_1	72	76	PF00917	0.698

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0KEX7	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	66%	100%
A0KR67	Shewanella sp. (strain ANA-3)	63%	100%
A0Q6H6	Francisella tularensis subsp. novicida (strain U112)	51%	98%
A1ADV0	Escherichia coli O1:K1 / APEC	63%	100%
A1JL37	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	60%	98%
A1RDY8	Shewanella sp. (strain W3-18-1)	61%	100%
A1S1K6	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	62%	99%
A1V2G0	Burkholderia mallei (strain SAVP1)	54%	98%
A1VN15	Polaromonas naphthalenivorans (strain CJ2)	53%	98%
A2BTG1	Prochlorococcus marinus (strain AS9601)	45%	88%

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