Cytochrome_c1_heme_protein_mitochondrial_putative /GeneDB:LmjF.07.0060

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c1, heme protein, mitochondrial, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPP0_LEIDO

TriTrypDb:

LdBPK_070210.1 , LdCL_070005600 , LDHU3_07.0100

Length:

258

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c1, Complex III heme , mitochondrial

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005750	mitochondrial respiratory chain complex III	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045275	respiratory chain complex III	4	1
GO:0070069	cytochrome complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WPP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPP0

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009055	electron transfer activity	3	12
GO:0016491	oxidoreductase activity	2	12
GO:0020037	heme binding	4	12
GO:0046906	tetrapyrrole binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.227
CLV_NRD_NRD_1	215	217	PF00675	0.224
CLV_NRD_NRD_1	33	35	PF00675	0.257
CLV_NRD_NRD_1	88	90	PF00675	0.367
CLV_PCSK_KEX2_1	10	12	PF00082	0.374
CLV_PCSK_KEX2_1	215	217	PF00082	0.224
CLV_PCSK_KEX2_1	33	35	PF00082	0.239
CLV_PCSK_KEX2_1	88	90	PF00082	0.367
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.374
CLV_PCSK_SKI1_1	216	220	PF00082	0.225
CLV_PCSK_SKI1_1	221	225	PF00082	0.225
DOC_CKS1_1	97	102	PF01111	0.300
DOC_PP1_RVXF_1	213	220	PF00149	0.224
DOC_PP2B_LxvP_1	172	175	PF13499	0.239
DOC_PP4_FxxP_1	162	165	PF00568	0.224
DOC_PP4_MxPP_1	174	177	PF00568	0.224
DOC_SPAK_OSR1_1	20	24	PF12202	0.258
DOC_USP7_MATH_1	45	49	PF00917	0.367
DOC_WW_Pin1_4	186	191	PF00397	0.263
DOC_WW_Pin1_4	96	101	PF00397	0.300
LIG_14-3-3_CanoR_1	205	212	PF00244	0.224
LIG_14-3-3_CanoR_1	248	252	PF00244	0.358
LIG_14-3-3_CanoR_1	36	45	PF00244	0.224
LIG_14-3-3_CanoR_1	51	61	PF00244	0.224
LIG_Actin_WH2_2	143	160	PF00022	0.260
LIG_Actin_WH2_2	189	207	PF00022	0.258
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BIR_III_4	81	85	PF00653	0.258
LIG_deltaCOP1_diTrp_1	12	21	PF00928	0.345
LIG_deltaCOP1_diTrp_1	22	29	PF00928	0.224
LIG_FHA_1	223	229	PF00498	0.224
LIG_FHA_1	92	98	PF00498	0.224
LIG_FHA_2	60	66	PF00498	0.224
LIG_IBAR_NPY_1	164	166	PF08397	0.224
LIG_LIR_Gen_1	131	140	PF02991	0.224
LIG_LIR_Gen_1	22	32	PF02991	0.263
LIG_LIR_Gen_1	53	61	PF02991	0.224
LIG_LIR_Gen_1	71	80	PF02991	0.264
LIG_LIR_Nem_3	131	137	PF02991	0.224
LIG_LIR_Nem_3	22	27	PF02991	0.263
LIG_LIR_Nem_3	241	246	PF02991	0.404
LIG_LIR_Nem_3	28	32	PF02991	0.263
LIG_LIR_Nem_3	53	57	PF02991	0.224
LIG_LIR_Nem_3	71	76	PF02991	0.264
LIG_MYND_1	155	159	PF01753	0.235
LIG_Pex14_1	163	167	PF04695	0.224
LIG_PTB_Apo_2	161	168	PF02174	0.224
LIG_SH2_GRB2like	14	17	PF00017	0.336
LIG_SH2_NCK_1	39	43	PF00017	0.239
LIG_SH2_NCK_1	73	77	PF00017	0.224
LIG_SH2_SRC	185	188	PF00017	0.224
LIG_SH2_STAP1	39	43	PF00017	0.239
LIG_SH2_STAT3	101	104	PF00017	0.318
LIG_SH2_STAT5	132	135	PF00017	0.224
LIG_SH2_STAT5	166	169	PF00017	0.224
LIG_SH2_STAT5	39	42	PF00017	0.239
LIG_SH3_3	149	155	PF00018	0.226
LIG_SH3_3	39	45	PF00018	0.224
LIG_SH3_3	87	93	PF00018	0.230
LIG_TRAF2_1	62	65	PF00917	0.224
MOD_CK1_1	135	141	PF00069	0.239
MOD_CK1_1	207	213	PF00069	0.228
MOD_CK2_1	59	65	PF00069	0.224
MOD_CK2_1	68	74	PF00069	0.224
MOD_Cter_Amidation	2	5	PF01082	0.415
MOD_GlcNHglycan	206	209	PF01048	0.224
MOD_NEK2_1	52	57	PF00069	0.249
MOD_NEK2_2	247	252	PF00069	0.361
MOD_PIKK_1	191	197	PF00454	0.224
MOD_PIKK_1	68	74	PF00454	0.224
MOD_PKA_2	204	210	PF00069	0.224
MOD_PKA_2	247	253	PF00069	0.366
MOD_PKA_2	50	56	PF00069	0.239
MOD_ProDKin_1	186	192	PF00069	0.263
MOD_ProDKin_1	96	102	PF00069	0.300
MOD_SUMO_rev_2	64	69	PF00179	0.203
TRG_DiLeu_BaEn_4	64	70	PF01217	0.224
TRG_ENDOCYTIC_2	39	42	PF00928	0.239
TRG_ENDOCYTIC_2	73	76	PF00928	0.263
TRG_ER_diArg_1	215	217	PF00400	0.224
TRG_ER_diArg_1	32	34	PF00400	0.262
TRG_ER_diArg_1	88	90	PF00400	0.367
TRG_ER_diLys_1	255	258	PF00400	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF2	Leptomonas seymouri	96%	100%
A0A0S4IRH2	Bodo saltans	83%	100%
A0A1X0NKV6	Trypanosomatidae	90%	100%
A0A422NTC0	Trypanosoma rangeli	90%	100%
A4H4U9	Leishmania braziliensis	97%	100%
A4HT63	Leishmania infantum	100%	100%
C9ZUW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	91%	85%
D5ANZ4	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	29%	92%
E9AL16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O59680	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	84%
P00125	Bos taurus	45%	79%
P07142	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	78%
P07143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	83%
P08574	Homo sapiens	45%	79%
P0CY49	Rhodobacter capsulatus	29%	92%
P20114	Euglena gracilis	42%	100%
P23135	Rhodospirillum rubrum	38%	95%
P25076	Solanum tuberosum	42%	81%
P29610	Solanum tuberosum	41%	99%
P81379	Blastochloris viridis	33%	91%
Q00988	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	46%	88%
Q02760	Cereibacter sphaeroides	28%	91%
Q4QIT8	Leishmania major	100%	100%
Q54D07	Dictyostelium discoideum	43%	94%
Q9D0M3	Mus musculus	43%	79%
Q9FKS5	Arabidopsis thaliana	42%	84%
Q9LK29	Arabidopsis thaliana	39%	84%
V5D9C0	Trypanosoma cruzi	91%	100%