Transcription and mRNA export factor ENY2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcription factor e(y)2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPN6_LEIDO

TriTrypDb:

LdBPK_061300.1 , LdCL_060018200 , LDHU3_06.1450

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	10
GO:0000124	SAGA complex	4	10
GO:0005643	nuclear pore	3	10
GO:0031248	protein acetyltransferase complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0070390	transcription export complex 2	3	6
GO:0070461	SAGA-type complex	5	10
GO:0071819	DUBm complex	3	6
GO:0140513	nuclear protein-containing complex	2	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902493	acetyltransferase complex	4	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1990234	transferase complex	3	10

Expansion

Sequence features

A0A3S7WPN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPN6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006325	chromatin organization	4	6
GO:0006354	DNA-templated transcription elongation	6	6
GO:0006368	transcription elongation by RNA polymerase II	7	6
GO:0006405	RNA export from nucleus	5	10
GO:0006406	mRNA export from nucleus	6	10
GO:0006508	proteolysis	4	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006810	transport	3	10
GO:0006913	nucleocytoplasmic transport	5	10
GO:0008104	protein localization	4	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009059	macromolecule biosynthetic process	4	6
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	6
GO:0015931	nucleobase-containing compound transport	5	10
GO:0016043	cellular component organization	3	6
GO:0016070	RNA metabolic process	5	6
GO:0016570	histone modification	5	6
GO:0016578	histone deubiquitination	6	6
GO:0016579	protein deubiquitination	6	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0019538	protein metabolic process	3	6
GO:0032774	RNA biosynthetic process	5	6
GO:0033036	macromolecule localization	2	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0045184	establishment of protein localization	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0046907	intracellular transport	3	10
GO:0050657	nucleic acid transport	6	10
GO:0050658	RNA transport	4	10
GO:0051028	mRNA transport	5	10
GO:0051168	nuclear export	6	10
GO:0051169	nuclear transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051236	establishment of RNA localization	3	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070646	protein modification by small protein removal	5	6
GO:0070647	protein modification by small protein conjugation or removal	5	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	10
GO:0071704	organic substance metabolic process	2	6
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	10
GO:0003713	transcription coactivator activity	3	10
GO:0140110	transcription regulator activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.467
CLV_NRD_NRD_1	67	69	PF00675	0.593
CLV_NRD_NRD_1	80	82	PF00675	0.402
CLV_PCSK_KEX2_1	115	117	PF00082	0.479
CLV_PCSK_KEX2_1	67	69	PF00082	0.589
CLV_PCSK_KEX2_1	80	82	PF00082	0.405
CLV_PCSK_SKI1_1	115	119	PF00082	0.542
DOC_MAPK_gen_1	115	123	PF00069	0.495
DOC_WW_Pin1_4	3	8	PF00397	0.687
LIG_14-3-3_CanoR_1	115	123	PF00244	0.465
LIG_14-3-3_CanoR_1	67	74	PF00244	0.599
LIG_FHA_1	116	122	PF00498	0.531
LIG_FHA_2	14	20	PF00498	0.577
LIG_FHA_2	27	33	PF00498	0.477
LIG_LIR_Nem_3	111	117	PF02991	0.483
LIG_PDZ_Class_2	118	123	PF00595	0.529
LIG_SH2_SRC	23	26	PF00017	0.483
LIG_SH2_STAP1	23	27	PF00017	0.648
LIG_TYR_ITIM	36	41	PF00017	0.603
MOD_CDK_SPxK_1	3	9	PF00069	0.611
MOD_CK2_1	13	19	PF00069	0.639
MOD_CK2_1	26	32	PF00069	0.640
MOD_GlcNHglycan	102	105	PF01048	0.500
MOD_GlcNHglycan	29	32	PF01048	0.530
MOD_GlcNHglycan	83	86	PF01048	0.506
MOD_GSK3_1	57	64	PF00069	0.555
MOD_NEK2_1	57	62	PF00069	0.660
MOD_PIKK_1	61	67	PF00454	0.614
MOD_PKA_1	115	121	PF00069	0.482
MOD_PKA_1	67	73	PF00069	0.601
MOD_PKA_2	115	121	PF00069	0.496
MOD_PKA_2	67	73	PF00069	0.601
MOD_ProDKin_1	3	9	PF00069	0.688
TRG_ENDOCYTIC_2	38	41	PF00928	0.458
TRG_ER_diArg_1	114	116	PF00400	0.486
TRG_ER_diArg_1	66	68	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR1	Leptomonas seymouri	57%	100%
A0A0S4J9F0	Bodo saltans	33%	90%
A0A1X0NHA4	Trypanosomatidae	44%	100%
A0A3R7MII2	Trypanosoma rangeli	39%	100%
A4HT16	Leishmania infantum	100%	100%
C9ZTQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AL04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIV1	Leishmania major	93%	100%