Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WPN2_LEIDO

TriTrypDb:

LdBPK_061260.1 , LdCL_060017800 , LDHU3_06.1410

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.635
CLV_NRD_NRD_1	125	127	PF00675	0.590
CLV_NRD_NRD_1	380	382	PF00675	0.562
CLV_NRD_NRD_1	389	391	PF00675	0.546
CLV_NRD_NRD_1	481	483	PF00675	0.576
CLV_PCSK_FUR_1	479	483	PF00082	0.577
CLV_PCSK_KEX2_1	125	127	PF00082	0.590
CLV_PCSK_KEX2_1	377	379	PF00082	0.509
CLV_PCSK_KEX2_1	389	391	PF00082	0.523
CLV_PCSK_KEX2_1	457	459	PF00082	0.558
CLV_PCSK_KEX2_1	481	483	PF00082	0.576
CLV_PCSK_KEX2_1	575	577	PF00082	0.637
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.490
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.514
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.600
CLV_PCSK_SKI1_1	152	156	PF00082	0.431
CLV_PCSK_SKI1_1	181	185	PF00082	0.346
CLV_PCSK_SKI1_1	392	396	PF00082	0.584
CLV_PCSK_SKI1_1	544	548	PF00082	0.627
CLV_PCSK_SKI1_1	572	576	PF00082	0.596
CLV_PCSK_SKI1_1	74	78	PF00082	0.639
CLV_Separin_Metazoa	160	164	PF03568	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_SPOP_SBC_1	164	168	PF00917	0.532
DEG_SPOP_SBC_1	37	41	PF00917	0.663
DOC_CDC14_PxL_1	563	571	PF14671	0.592
DOC_CKS1_1	348	353	PF01111	0.596
DOC_MAPK_gen_1	239	248	PF00069	0.542
DOC_MAPK_gen_1	502	509	PF00069	0.551
DOC_MAPK_MEF2A_6	192	199	PF00069	0.365
DOC_MAPK_MEF2A_6	239	248	PF00069	0.542
DOC_PP1_RVXF_1	55	61	PF00149	0.651
DOC_USP7_MATH_1	165	169	PF00917	0.645
DOC_USP7_MATH_1	290	294	PF00917	0.587
DOC_USP7_MATH_1	344	348	PF00917	0.574
DOC_USP7_MATH_1	425	429	PF00917	0.611
DOC_USP7_MATH_1	65	69	PF00917	0.542
DOC_USP7_UBL2_3	245	249	PF12436	0.430
DOC_WW_Pin1_4	347	352	PF00397	0.545
DOC_WW_Pin1_4	38	43	PF00397	0.630
LIG_14-3-3_CanoR_1	163	173	PF00244	0.562
LIG_14-3-3_CanoR_1	291	299	PF00244	0.588
LIG_14-3-3_CanoR_1	406	416	PF00244	0.626
LIG_14-3-3_CanoR_1	429	435	PF00244	0.547
LIG_14-3-3_CanoR_1	468	474	PF00244	0.658
LIG_14-3-3_CanoR_1	57	65	PF00244	0.643
LIG_14-3-3_CanoR_1	576	584	PF00244	0.623
LIG_APCC_ABBA_1	155	160	PF00400	0.415
LIG_APCC_ABBA_1	217	222	PF00400	0.447
LIG_APCC_ABBAyCdc20_2	325	331	PF00400	0.504
LIG_BIR_III_4	302	306	PF00653	0.602
LIG_BIR_III_4	319	323	PF00653	0.470
LIG_BRCT_BRCA1_1	363	367	PF00533	0.491
LIG_BRCT_BRCA1_1	536	540	PF00533	0.640
LIG_CaM_NSCaTE_8	283	290	PF13499	0.444
LIG_Clathr_ClatBox_1	105	109	PF01394	0.683
LIG_FAT_LD_1	334	342	PF03623	0.458
LIG_FHA_1	302	308	PF00498	0.688
LIG_FHA_1	371	377	PF00498	0.637
LIG_FHA_1	38	44	PF00498	0.623
LIG_FHA_1	433	439	PF00498	0.559
LIG_FHA_1	552	558	PF00498	0.713
LIG_FHA_1	568	574	PF00498	0.492
LIG_FHA_1	82	88	PF00498	0.633
LIG_FHA_2	204	210	PF00498	0.460
LIG_LIR_Apic_2	144	150	PF02991	0.545
LIG_LIR_Gen_1	251	261	PF02991	0.412
LIG_LIR_Gen_1	537	546	PF02991	0.642
LIG_LIR_LC3C_4	274	279	PF02991	0.385
LIG_LIR_Nem_3	172	178	PF02991	0.531
LIG_LIR_Nem_3	218	223	PF02991	0.492
LIG_LIR_Nem_3	251	257	PF02991	0.418
LIG_LIR_Nem_3	537	543	PF02991	0.641
LIG_LIR_Nem_3	560	566	PF02991	0.592
LIG_LYPXL_yS_3	566	569	PF13949	0.596
LIG_MLH1_MIPbox_1	363	367	PF16413	0.491
LIG_NRBOX	333	339	PF00104	0.453
LIG_PCNA_yPIPBox_3	192	203	PF02747	0.404
LIG_PCNA_yPIPBox_3	389	398	PF02747	0.556
LIG_Pex14_2	203	207	PF04695	0.494
LIG_SH2_CRK	147	151	PF00017	0.606
LIG_SH2_CRK	404	408	PF00017	0.559
LIG_SH2_NCK_1	329	333	PF00017	0.488
LIG_SH2_SRC	329	332	PF00017	0.483
LIG_SH2_STAP1	215	219	PF00017	0.481
LIG_SH2_STAP1	329	333	PF00017	0.477
LIG_SH2_STAT3	107	110	PF00017	0.623
LIG_SH2_STAT5	107	110	PF00017	0.683
LIG_SH2_STAT5	223	226	PF00017	0.544
LIG_SH2_STAT5	260	263	PF00017	0.466
LIG_SH2_STAT5	59	62	PF00017	0.578
LIG_SH2_STAT5	75	78	PF00017	0.602
LIG_SH3_3	199	205	PF00018	0.407
LIG_SH3_3	40	46	PF00018	0.536
LIG_SH3_3	468	474	PF00018	0.683
LIG_SH3_3	504	510	PF00018	0.568
LIG_SH3_3	92	98	PF00018	0.587
LIG_UBA3_1	539	547	PF00899	0.626
LIG_WRC_WIRS_1	204	209	PF05994	0.528
MOD_CDK_SPxK_1	347	353	PF00069	0.549
MOD_CK1_1	119	125	PF00069	0.620
MOD_CK1_1	168	174	PF00069	0.519
MOD_CK1_1	285	291	PF00069	0.579
MOD_CK1_1	293	299	PF00069	0.553
MOD_CK1_1	347	353	PF00069	0.643
MOD_CK1_1	36	42	PF00069	0.774
MOD_CK1_1	405	411	PF00069	0.679
MOD_CK1_1	464	470	PF00069	0.595
MOD_CK1_1	495	501	PF00069	0.544
MOD_CK1_1	524	530	PF00069	0.612
MOD_CK1_1	550	556	PF00069	0.546
MOD_CK1_1	580	586	PF00069	0.639
MOD_CK2_1	23	29	PF00069	0.547
MOD_CK2_1	430	436	PF00069	0.499
MOD_CK2_1	542	548	PF00069	0.585
MOD_Cter_Amidation	123	126	PF01082	0.603
MOD_GlcNHglycan	133	136	PF01048	0.595
MOD_GlcNHglycan	167	170	PF01048	0.619
MOD_GlcNHglycan	287	290	PF01048	0.589
MOD_GlcNHglycan	35	38	PF01048	0.686
MOD_GlcNHglycan	363	366	PF01048	0.446
MOD_GlcNHglycan	412	415	PF01048	0.588
MOD_GlcNHglycan	446	449	PF01048	0.528
MOD_GlcNHglycan	463	466	PF01048	0.640
MOD_GlcNHglycan	471	474	PF01048	0.670
MOD_GlcNHglycan	486	489	PF01048	0.501
MOD_GlcNHglycan	494	497	PF01048	0.562
MOD_GlcNHglycan	536	539	PF01048	0.546
MOD_GlcNHglycan	65	68	PF01048	0.519
MOD_GSK3_1	131	138	PF00069	0.613
MOD_GSK3_1	164	171	PF00069	0.600
MOD_GSK3_1	203	210	PF00069	0.417
MOD_GSK3_1	281	288	PF00069	0.473
MOD_GSK3_1	29	36	PF00069	0.795
MOD_GSK3_1	37	44	PF00069	0.613
MOD_GSK3_1	405	412	PF00069	0.584
MOD_GSK3_1	519	526	PF00069	0.641
MOD_GSK3_1	547	554	PF00069	0.622
MOD_N-GLC_1	551	556	PF02516	0.581
MOD_NEK2_1	207	212	PF00069	0.417
MOD_NEK2_1	272	277	PF00069	0.450
MOD_NEK2_1	33	38	PF00069	0.584
MOD_NEK2_1	372	377	PF00069	0.514
MOD_NEK2_1	407	412	PF00069	0.611
MOD_NEK2_1	444	449	PF00069	0.609
MOD_NEK2_1	456	461	PF00069	0.502
MOD_NEK2_1	525	530	PF00069	0.617
MOD_NEK2_1	534	539	PF00069	0.550
MOD_NEK2_1	551	556	PF00069	0.509
MOD_NEK2_1	577	582	PF00069	0.622
MOD_PIKK_1	109	115	PF00454	0.567
MOD_PIKK_1	119	125	PF00454	0.542
MOD_PIKK_1	135	141	PF00454	0.493
MOD_PIKK_1	207	213	PF00454	0.410
MOD_PIKK_1	260	266	PF00454	0.418
MOD_PIKK_1	293	299	PF00454	0.609
MOD_PIKK_1	525	531	PF00454	0.593
MOD_PIKK_1	577	583	PF00454	0.556
MOD_PKA_2	285	291	PF00069	0.528
MOD_PKA_2	405	411	PF00069	0.612
MOD_PKA_2	461	467	PF00069	0.669
MOD_PKA_2	529	535	PF00069	0.656
MOD_Plk_1	339	345	PF00069	0.475
MOD_Plk_1	547	553	PF00069	0.562
MOD_Plk_2-3	23	29	PF00069	0.547
MOD_Plk_4	529	535	PF00069	0.582
MOD_Plk_4	552	558	PF00069	0.582
MOD_ProDKin_1	347	353	PF00069	0.546
MOD_ProDKin_1	38	44	PF00069	0.627
MOD_SUMO_for_1	76	79	PF00179	0.571
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.434
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.637
TRG_ENDOCYTIC_2	404	407	PF00928	0.556
TRG_ENDOCYTIC_2	566	569	PF00928	0.596
TRG_ENDOCYTIC_2	75	78	PF00928	0.602
TRG_ER_diArg_1	388	390	PF00400	0.588
TRG_ER_diArg_1	478	481	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF5	Leptomonas seymouri	32%	100%
A4H4T3	Leishmania braziliensis	69%	99%
A4HT12	Leishmania infantum	99%	100%
E9AL00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QIV5	Leishmania major	90%	100%