NTF2-related export protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA transport regulator MTR2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPM6_LEIDO

TriTrypDb:

LdBPK_061210.1 , LdCL_060017200 , LDHU3_06.1360

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0044613	nuclear pore central transport channel	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7WPM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPM6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0009987	cellular process	1	11
GO:0046907	intracellular transport	3	11
GO:0051169	nuclear transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.247
CLV_C14_Caspase3-7	82	86	PF00656	0.247
CLV_NRD_NRD_1	104	106	PF00675	0.273
CLV_NRD_NRD_1	114	116	PF00675	0.229
CLV_PCSK_KEX2_1	104	106	PF00082	0.247
CLV_PCSK_KEX2_1	114	116	PF00082	0.267
CLV_PCSK_PC7_1	110	116	PF00082	0.379
CLV_PCSK_SKI1_1	11	15	PF00082	0.265
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DOC_PP1_RVXF_1	10	17	PF00149	0.265
DOC_PP2B_LxvP_1	36	39	PF13499	0.265
DOC_USP7_MATH_1	66	70	PF00917	0.302
LIG_BIR_III_2	76	80	PF00653	0.247
LIG_FHA_2	52	58	PF00498	0.355
LIG_FHA_2	96	102	PF00498	0.265
LIG_LIR_Gen_1	106	116	PF02991	0.261
LIG_LIR_Nem_3	117	123	PF02991	0.335
LIG_LIR_Nem_3	125	130	PF02991	0.271
LIG_PTB_Apo_2	121	128	PF02174	0.247
LIG_PTB_Apo_2	15	22	PF02174	0.379
LIG_PTB_Phospho_1	121	127	PF10480	0.247
LIG_PTB_Phospho_1	15	21	PF10480	0.379
LIG_SH2_STAT5	121	124	PF00017	0.247
LIG_SH2_STAT5	61	64	PF00017	0.275
LIG_SH3_3	36	42	PF00018	0.250
MOD_GlcNHglycan	62	65	PF01048	0.302
MOD_GSK3_1	85	92	PF00069	0.288
MOD_NEK2_1	89	94	PF00069	0.293
MOD_Plk_4	85	91	PF00069	0.247
TRG_ENDOCYTIC_2	108	111	PF00928	0.337
TRG_ENDOCYTIC_2	120	123	PF00928	0.176
TRG_ENDOCYTIC_2	127	130	PF00928	0.237
TRG_ENDOCYTIC_2	20	23	PF00928	0.294
TRG_ER_diArg_1	113	115	PF00400	0.386
TRG_ER_diArg_1	16	19	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC6	Leptomonas seymouri	89%	100%
A0A0S4J9D4	Bodo saltans	52%	97%
A0A1X0NHB6	Trypanosomatidae	61%	100%
A0A3R7KHF2	Trypanosoma rangeli	63%	100%
A4H4S8	Leishmania braziliensis	96%	100%
A4HT08	Leishmania infantum	100%	100%
C9ZTP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AKZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q2KIW0	Bos taurus	28%	96%
Q4QIV9	Leishmania major	99%	100%
Q9NPJ8	Homo sapiens	27%	95%
Q9QZV9	Mus musculus	28%	96%
Q9U757	Caenorhabditis elegans	29%	99%
Q9V3H8	Drosophila melanogaster	26%	100%