2OG-Fe(II) oxygenase superfamily, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPM5_LEIDO

TriTrypDb:

LdBPK_061100.1 , LdCL_060016100 , LDHU3_06.1250

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.581
CLV_C14_Caspase3-7	291	295	PF00656	0.681
CLV_NRD_NRD_1	236	238	PF00675	0.392
CLV_NRD_NRD_1	312	314	PF00675	0.733
CLV_PCSK_FUR_1	309	313	PF00082	0.627
CLV_PCSK_KEX2_1	235	237	PF00082	0.389
CLV_PCSK_KEX2_1	308	310	PF00082	0.703
CLV_PCSK_KEX2_1	311	313	PF00082	0.703
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.749
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.750
CLV_PCSK_SKI1_1	180	184	PF00082	0.264
CLV_PCSK_SKI1_1	305	309	PF00082	0.737
DOC_CKS1_1	220	225	PF01111	0.450
DOC_CYCLIN_RxL_1	177	187	PF00134	0.450
DOC_MAPK_FxFP_2	193	196	PF00069	0.439
DOC_MAPK_gen_1	164	174	PF00069	0.436
DOC_MAPK_MEF2A_6	167	176	PF00069	0.439
DOC_PP1_RVXF_1	178	185	PF00149	0.439
DOC_PP1_SILK_1	59	64	PF00149	0.462
DOC_PP4_FxxP_1	112	115	PF00568	0.413
DOC_PP4_FxxP_1	193	196	PF00568	0.439
DOC_PP4_MxPP_1	286	289	PF00568	0.579
DOC_SPAK_OSR1_1	227	231	PF12202	0.481
DOC_USP7_MATH_1	178	182	PF00917	0.477
DOC_USP7_MATH_1	27	31	PF00917	0.527
DOC_USP7_MATH_1	289	293	PF00917	0.670
DOC_WW_Pin1_4	219	224	PF00397	0.450
LIG_14-3-3_CanoR_1	235	240	PF00244	0.404
LIG_14-3-3_CanoR_1	80	86	PF00244	0.498
LIG_BRCT_BRCA1_1	118	122	PF00533	0.335
LIG_BRCT_BRCA1_1	180	184	PF00533	0.464
LIG_deltaCOP1_diTrp_1	105	112	PF00928	0.452
LIG_FHA_1	169	175	PF00498	0.439
LIG_FHA_1	177	183	PF00498	0.439
LIG_FHA_1	204	210	PF00498	0.439
LIG_FHA_1	212	218	PF00498	0.480
LIG_FHA_2	119	125	PF00498	0.411
LIG_FHA_2	236	242	PF00498	0.455
LIG_FHA_2	259	265	PF00498	0.421
LIG_FHA_2	289	295	PF00498	0.707
LIG_FHA_2	8	14	PF00498	0.588
LIG_LIR_Apic_2	192	196	PF02991	0.541
LIG_LIR_Gen_1	119	130	PF02991	0.312
LIG_LIR_Gen_1	226	232	PF02991	0.483
LIG_LIR_Gen_1	56	66	PF02991	0.449
LIG_LIR_Nem_3	119	125	PF02991	0.317
LIG_LIR_Nem_3	131	135	PF02991	0.277
LIG_LIR_Nem_3	192	198	PF02991	0.529
LIG_LIR_Nem_3	226	231	PF02991	0.483
LIG_LIR_Nem_3	30	34	PF02991	0.548
LIG_LIR_Nem_3	56	61	PF02991	0.397
LIG_PTB_Apo_2	111	118	PF02174	0.343
LIG_PTB_Phospho_1	111	117	PF10480	0.345
LIG_SH2_CRK	82	86	PF00017	0.372
LIG_SH2_STAP1	138	142	PF00017	0.450
LIG_SH2_STAT3	117	120	PF00017	0.320
LIG_SH2_STAT5	117	120	PF00017	0.453
LIG_SH2_STAT5	132	135	PF00017	0.421
LIG_SH2_STAT5	68	71	PF00017	0.312
LIG_SH3_3	217	223	PF00018	0.455
LIG_SH3_3	3	9	PF00018	0.644
MOD_CK1_1	116	122	PF00069	0.386
MOD_CK2_1	235	241	PF00069	0.425
MOD_CK2_1	81	87	PF00069	0.465
MOD_Cter_Amidation	233	236	PF01082	0.363
MOD_DYRK1A_RPxSP_1	219	223	PF00069	0.434
MOD_GlcNHglycan	248	251	PF01048	0.658
MOD_GlcNHglycan	291	294	PF01048	0.721
MOD_GlcNHglycan	46	49	PF01048	0.397
MOD_GlcNHglycan	99	102	PF01048	0.604
MOD_GSK3_1	168	175	PF00069	0.456
MOD_GSK3_1	289	296	PF00069	0.715
MOD_NEK2_1	15	20	PF00069	0.479
MOD_NEK2_1	176	181	PF00069	0.450
MOD_NEK2_1	81	86	PF00069	0.504
MOD_NEK2_1	97	102	PF00069	0.523
MOD_NEK2_2	27	32	PF00069	0.371
MOD_PIKK_1	116	122	PF00454	0.508
MOD_PIKK_1	146	152	PF00454	0.543
MOD_PIKK_1	186	192	PF00454	0.557
MOD_PKA_1	235	241	PF00069	0.406
MOD_PKA_2	226	232	PF00069	0.488
MOD_PKA_2	235	241	PF00069	0.412
MOD_Plk_1	168	174	PF00069	0.445
MOD_Plk_1	56	62	PF00069	0.407
MOD_Plk_4	113	119	PF00069	0.472
MOD_Plk_4	16	22	PF00069	0.425
MOD_Plk_4	57	63	PF00069	0.450
MOD_ProDKin_1	219	225	PF00069	0.450
MOD_SUMO_for_1	85	88	PF00179	0.369
TRG_ENDOCYTIC_2	132	135	PF00928	0.450
TRG_ENDOCYTIC_2	82	85	PF00928	0.352
TRG_ER_diArg_1	21	24	PF00400	0.549
TRG_ER_diArg_1	235	237	PF00400	0.437
TRG_ER_diArg_1	312	314	PF00400	0.632
TRG_NES_CRM1_1	124	136	PF08389	0.329
TRG_NLS_MonoExtC_3	307	312	PF00514	0.596
TRG_NLS_MonoExtN_4	305	312	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD0	Leptomonas seymouri	75%	85%
A0A0S4JRX9	Bodo saltans	46%	100%
A0A1X0NKP4	Trypanosomatidae	65%	100%
A0A3R7KF49	Trypanosoma rangeli	56%	93%
A4H4R9	Leishmania braziliensis	83%	100%
A4HSZ8	Leishmania infantum	100%	100%
C9ZTN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AKY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIX0	Leishmania major	94%	100%
V5BXY4	Trypanosoma cruzi	58%	99%