LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WPM3_LEIDO
TriTrypDb:
LdBPK_061160.1 * , LdCL_060016700 , LDHU3_06.1310
Length:
469

Annotations

LeishMANIAdb annotations

A short well-folded TM protein, possibly with GPI anchor. Structurally weakly similar to PBN1, a GPI anchor biogenesis protein.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S7WPM3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPM3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 344 348 PF00656 0.281
CLV_NRD_NRD_1 396 398 PF00675 0.464
CLV_NRD_NRD_1 42 44 PF00675 0.413
CLV_NRD_NRD_1 77 79 PF00675 0.425
CLV_PCSK_KEX2_1 396 398 PF00082 0.464
CLV_PCSK_KEX2_1 41 43 PF00082 0.409
CLV_PCSK_KEX2_1 77 79 PF00082 0.425
CLV_PCSK_PC7_1 73 79 PF00082 0.415
CLV_PCSK_SKI1_1 264 268 PF00082 0.431
CLV_PCSK_SKI1_1 311 315 PF00082 0.468
CLV_PCSK_SKI1_1 386 390 PF00082 0.500
CLV_PCSK_SKI1_1 397 401 PF00082 0.458
CLV_PCSK_SKI1_1 411 415 PF00082 0.491
CLV_PCSK_SKI1_1 49 53 PF00082 0.413
DEG_APCC_DBOX_1 395 403 PF00400 0.253
DEG_Nend_UBRbox_1 1 4 PF02207 0.593
DEG_SCF_FBW7_1 124 130 PF00400 0.601
DOC_CKS1_1 124 129 PF01111 0.600
DOC_CYCLIN_yCln2_LP_2 117 123 PF00134 0.603
DOC_CYCLIN_yCln2_LP_2 247 253 PF00134 0.222
DOC_CYCLIN_yCln2_LP_2 436 442 PF00134 0.262
DOC_MAPK_DCC_7 94 103 PF00069 0.581
DOC_MAPK_gen_1 362 369 PF00069 0.221
DOC_MAPK_gen_1 396 404 PF00069 0.250
DOC_MAPK_gen_1 92 101 PF00069 0.585
DOC_MAPK_HePTP_8 91 103 PF00069 0.584
DOC_MAPK_MEF2A_6 199 207 PF00069 0.400
DOC_MAPK_MEF2A_6 362 369 PF00069 0.221
DOC_MAPK_MEF2A_6 433 442 PF00069 0.259
DOC_MAPK_MEF2A_6 94 103 PF00069 0.581
DOC_MAPK_NFAT4_5 433 441 PF00069 0.256
DOC_PP1_RVXF_1 255 261 PF00149 0.231
DOC_PP2B_LxvP_1 117 120 PF13499 0.603
DOC_PP2B_LxvP_1 365 368 PF13499 0.214
DOC_PP2B_LxvP_1 436 439 PF13499 0.252
DOC_PP4_FxxP_1 121 124 PF00568 0.600
DOC_PP4_FxxP_1 190 193 PF00568 0.543
DOC_PP4_FxxP_1 260 263 PF00568 0.235
DOC_USP7_MATH_1 169 173 PF00917 0.591
DOC_USP7_MATH_1 177 181 PF00917 0.569
DOC_USP7_MATH_1 219 223 PF00917 0.287
DOC_USP7_MATH_1 368 372 PF00917 0.224
DOC_USP7_MATH_1 416 420 PF00917 0.272
DOC_USP7_MATH_1 47 51 PF00917 0.621
DOC_USP7_MATH_1 65 69 PF00917 0.588
DOC_USP7_UBL2_3 425 429 PF12436 0.331
DOC_WW_Pin1_4 115 120 PF00397 0.601
DOC_WW_Pin1_4 123 128 PF00397 0.599
DOC_WW_Pin1_4 13 18 PF00397 0.604
DOC_WW_Pin1_4 134 139 PF00397 0.586
DOC_WW_Pin1_4 165 170 PF00397 0.587
DOC_WW_Pin1_4 21 26 PF00397 0.606
DOC_WW_Pin1_4 227 232 PF00397 0.254
DOC_WW_Pin1_4 301 306 PF00397 0.241
DOC_WW_Pin1_4 377 382 PF00397 0.307
LIG_14-3-3_CanoR_1 139 145 PF00244 0.584
LIG_14-3-3_CanoR_1 182 191 PF00244 0.557
LIG_14-3-3_CanoR_1 2 10 PF00244 0.592
LIG_14-3-3_CanoR_1 257 261 PF00244 0.233
LIG_14-3-3_CanoR_1 307 314 PF00244 0.257
LIG_14-3-3_CanoR_1 41 47 PF00244 0.616
LIG_14-3-3_CanoR_1 418 424 PF00244 0.285
LIG_14-3-3_CanoR_1 85 89 PF00244 0.615
LIG_Actin_WH2_2 292 309 PF00022 0.253
LIG_BRCT_BRCA1_1 117 121 PF00533 0.604
LIG_BRCT_BRCA1_1 223 227 PF00533 0.250
LIG_BRCT_BRCA1_1 232 236 PF00533 0.220
LIG_deltaCOP1_diTrp_1 158 166 PF00928 0.601
LIG_eIF4E_1 448 454 PF01652 0.199
LIG_FHA_1 289 295 PF00498 0.265
LIG_FHA_1 325 331 PF00498 0.254
LIG_FHA_1 7 13 PF00498 0.600
LIG_FHA_2 398 404 PF00498 0.243
LIG_LIR_Apic_2 118 124 PF02991 0.601
LIG_LIR_Apic_2 163 169 PF02991 0.589
LIG_LIR_Apic_2 189 193 PF02991 0.545
LIG_LIR_Apic_2 23 29 PF02991 0.608
LIG_LIR_Apic_2 248 252 PF02991 0.224
LIG_LIR_Apic_2 259 263 PF02991 0.233
LIG_LIR_Gen_1 233 241 PF02991 0.241
LIG_LIR_Gen_1 331 342 PF02991 0.291
LIG_LIR_Gen_1 371 381 PF02991 0.281
LIG_LIR_Nem_3 233 237 PF02991 0.220
LIG_LIR_Nem_3 300 306 PF02991 0.240
LIG_LIR_Nem_3 331 337 PF02991 0.257
LIG_LIR_Nem_3 371 376 PF02991 0.258
LIG_LIR_Nem_3 380 385 PF02991 0.304
LIG_NRBOX 452 458 PF00104 0.199
LIG_RPA_C_Fungi 194 206 PF08784 0.199
LIG_SH2_CRK 234 238 PF00017 0.244
LIG_SH2_CRK 303 307 PF00017 0.255
LIG_SH2_CRK 450 454 PF00017 0.199
LIG_SH2_NCK_1 26 30 PF00017 0.496
LIG_SH2_SRC 448 451 PF00017 0.199
LIG_SH2_STAP1 113 117 PF00017 0.470
LIG_SH2_STAP1 312 316 PF00017 0.290
LIG_SH2_STAT5 102 105 PF00017 0.447
LIG_SH2_STAT5 234 237 PF00017 0.229
LIG_SH2_STAT5 26 29 PF00017 0.495
LIG_SH2_STAT5 325 328 PF00017 0.287
LIG_SH2_STAT5 349 352 PF00017 0.328
LIG_SH2_STAT5 394 397 PF00017 0.296
LIG_SH2_STAT5 448 451 PF00017 0.199
LIG_SH3_3 121 127 PF00018 0.478
LIG_SH3_3 178 184 PF00018 0.438
LIG_SH3_4 429 436 PF00018 0.296
LIG_SUMO_SIM_anti_2 198 204 PF11976 0.199
LIG_WW_1 231 234 PF00397 0.252
MOD_CDC14_SPxK_1 304 307 PF00782 0.261
MOD_CDK_SPK_2 134 139 PF00069 0.460
MOD_CDK_SPxK_1 13 19 PF00069 0.487
MOD_CDK_SPxK_1 301 307 PF00069 0.262
MOD_CK1_1 122 128 PF00069 0.479
MOD_CK1_1 134 140 PF00069 0.457
MOD_CK1_1 165 171 PF00069 0.464
MOD_CK1_1 186 192 PF00069 0.411
MOD_CK1_1 230 236 PF00069 0.247
MOD_CK1_1 419 425 PF00069 0.329
MOD_CK1_1 84 90 PF00069 0.502
MOD_CK2_1 152 158 PF00069 0.474
MOD_CK2_1 368 374 PF00069 0.257
MOD_CK2_1 47 53 PF00069 0.503
MOD_DYRK1A_RPxSP_1 301 305 PF00069 0.265
MOD_GlcNHglycan 154 157 PF01048 0.475
MOD_GlcNHglycan 185 188 PF01048 0.417
MOD_GlcNHglycan 221 224 PF01048 0.272
MOD_GlcNHglycan 282 285 PF01048 0.292
MOD_GlcNHglycan 343 346 PF01048 0.326
MOD_GlcNHglycan 419 422 PF01048 0.292
MOD_GlcNHglycan 48 52 PF01048 0.505
MOD_GSK3_1 115 122 PF00069 0.483
MOD_GSK3_1 123 130 PF00069 0.481
MOD_GSK3_1 148 155 PF00069 0.464
MOD_GSK3_1 165 172 PF00069 0.464
MOD_GSK3_1 191 198 PF00069 0.375
MOD_GSK3_1 2 9 PF00069 0.467
MOD_GSK3_1 215 222 PF00069 0.199
MOD_GSK3_1 226 233 PF00069 0.274
MOD_GSK3_1 297 304 PF00069 0.263
MOD_GSK3_1 407 414 PF00069 0.305
MOD_GSK3_1 419 426 PF00069 0.330
MOD_GSK3_1 61 68 PF00069 0.465
MOD_N-GLC_1 29 34 PF02516 0.491
MOD_N-GLC_1 323 328 PF02516 0.300
MOD_NEK2_1 1 6 PF00069 0.466
MOD_NEK2_1 148 153 PF00069 0.462
MOD_NEK2_1 195 200 PF00069 0.353
MOD_NEK2_1 205 210 PF00069 0.199
MOD_NEK2_1 215 220 PF00069 0.199
MOD_NEK2_1 306 311 PF00069 0.269
MOD_NEK2_1 63 68 PF00069 0.464
MOD_NEK2_1 72 77 PF00069 0.495
MOD_NEK2_2 177 182 PF00069 0.438
MOD_NEK2_2 65 70 PF00069 0.465
MOD_OFUCOSY 61 67 PF10250 0.467
MOD_PIKK_1 11 17 PF00454 0.485
MOD_PIKK_1 285 291 PF00454 0.301
MOD_PKA_1 42 48 PF00069 0.506
MOD_PKA_2 1 7 PF00069 0.466
MOD_PKA_2 191 197 PF00069 0.380
MOD_PKA_2 256 262 PF00069 0.241
MOD_PKA_2 306 312 PF00069 0.270
MOD_PKA_2 417 423 PF00069 0.297
MOD_PKA_2 42 48 PF00069 0.506
MOD_PKA_2 72 78 PF00069 0.499
MOD_PKA_2 84 90 PF00069 0.502
MOD_Plk_1 29 35 PF00069 0.492
MOD_Plk_1 330 336 PF00069 0.266
MOD_Plk_4 191 197 PF00069 0.380
MOD_Plk_4 232 238 PF00069 0.243
MOD_Plk_4 262 268 PF00069 0.245
MOD_ProDKin_1 115 121 PF00069 0.482
MOD_ProDKin_1 123 129 PF00069 0.479
MOD_ProDKin_1 13 19 PF00069 0.487
MOD_ProDKin_1 134 140 PF00069 0.457
MOD_ProDKin_1 165 171 PF00069 0.464
MOD_ProDKin_1 21 27 PF00069 0.489
MOD_ProDKin_1 227 233 PF00069 0.269
MOD_ProDKin_1 301 307 PF00069 0.262
MOD_ProDKin_1 377 383 PF00069 0.347
MOD_SUMO_for_1 424 427 PF00179 0.389
MOD_SUMO_rev_2 371 381 PF00179 0.313
MOD_SUMO_rev_2 426 430 PF00179 0.379
TRG_ENDOCYTIC_2 234 237 PF00928 0.229
TRG_ENDOCYTIC_2 303 306 PF00928 0.246
TRG_ENDOCYTIC_2 373 376 PF00928 0.299
TRG_ENDOCYTIC_2 450 453 PF00928 0.199
TRG_ER_diArg_1 361 364 PF00400 0.249
TRG_ER_diArg_1 395 397 PF00400 0.288
TRG_ER_diArg_1 40 43 PF00400 0.490
TRG_ER_diArg_1 91 94 PF00400 0.473

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS