Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPM1_LEIDO

TriTrypDb:

LdBPK_061150.1 , LdCL_060016600 , LDHU3_06.1300

Length:

1107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.640
CLV_NRD_NRD_1	1100	1102	PF00675	0.650
CLV_NRD_NRD_1	240	242	PF00675	0.683
CLV_NRD_NRD_1	448	450	PF00675	0.682
CLV_NRD_NRD_1	469	471	PF00675	0.515
CLV_NRD_NRD_1	536	538	PF00675	0.538
CLV_NRD_NRD_1	547	549	PF00675	0.538
CLV_NRD_NRD_1	579	581	PF00675	0.647
CLV_NRD_NRD_1	612	614	PF00675	0.575
CLV_NRD_NRD_1	697	699	PF00675	0.683
CLV_NRD_NRD_1	754	756	PF00675	0.577
CLV_NRD_NRD_1	898	900	PF00675	0.580
CLV_PCSK_KEX2_1	240	242	PF00082	0.683
CLV_PCSK_KEX2_1	469	471	PF00082	0.515
CLV_PCSK_KEX2_1	536	538	PF00082	0.538
CLV_PCSK_KEX2_1	547	549	PF00082	0.538
CLV_PCSK_KEX2_1	579	581	PF00082	0.674
CLV_PCSK_KEX2_1	754	756	PF00082	0.546
CLV_PCSK_KEX2_1	838	840	PF00082	0.573
CLV_PCSK_KEX2_1	891	893	PF00082	0.437
CLV_PCSK_PC1ET2_1	838	840	PF00082	0.524
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.413
CLV_PCSK_SKI1_1	1059	1063	PF00082	0.648
CLV_PCSK_SKI1_1	182	186	PF00082	0.601
CLV_PCSK_SKI1_1	536	540	PF00082	0.562
CLV_PCSK_SKI1_1	687	691	PF00082	0.664
CLV_Separin_Metazoa	1081	1085	PF03568	0.438
DEG_ODPH_VHL_1	269	280	PF01847	0.642
DEG_SPOP_SBC_1	567	571	PF00917	0.740
DOC_MAPK_gen_1	316	326	PF00069	0.622
DOC_MAPK_gen_1	454	463	PF00069	0.531
DOC_MAPK_gen_1	513	522	PF00069	0.621
DOC_MAPK_gen_1	899	909	PF00069	0.639
DOC_PP1_RVXF_1	65	72	PF00149	0.640
DOC_PP2B_LxvP_1	177	180	PF13499	0.606
DOC_PP2B_LxvP_1	278	281	PF13499	0.634
DOC_PP4_FxxP_1	853	856	PF00568	0.562
DOC_USP7_MATH_1	1012	1016	PF00917	0.719
DOC_USP7_MATH_1	1053	1057	PF00917	0.596
DOC_USP7_MATH_1	128	132	PF00917	0.634
DOC_USP7_MATH_1	2	6	PF00917	0.599
DOC_USP7_MATH_1	259	263	PF00917	0.619
DOC_USP7_MATH_1	288	292	PF00917	0.630
DOC_USP7_MATH_1	352	356	PF00917	0.670
DOC_USP7_MATH_1	386	390	PF00917	0.657
DOC_USP7_MATH_1	410	414	PF00917	0.574
DOC_USP7_MATH_1	490	494	PF00917	0.609
DOC_USP7_MATH_1	559	563	PF00917	0.573
DOC_USP7_MATH_1	586	590	PF00917	0.640
DOC_USP7_MATH_1	705	709	PF00917	0.599
DOC_USP7_MATH_1	841	845	PF00917	0.663
DOC_USP7_UBL2_3	1098	1102	PF12436	0.605
DOC_WW_Pin1_4	1001	1006	PF00397	0.691
DOC_WW_Pin1_4	1014	1019	PF00397	0.612
DOC_WW_Pin1_4	1091	1096	PF00397	0.568
DOC_WW_Pin1_4	209	214	PF00397	0.672
DOC_WW_Pin1_4	241	246	PF00397	0.597
DOC_WW_Pin1_4	263	268	PF00397	0.655
DOC_WW_Pin1_4	354	359	PF00397	0.719
DOC_WW_Pin1_4	374	379	PF00397	0.521
DOC_WW_Pin1_4	45	50	PF00397	0.624
DOC_WW_Pin1_4	578	583	PF00397	0.644
DOC_WW_Pin1_4	707	712	PF00397	0.638
DOC_WW_Pin1_4	871	876	PF00397	0.738
DOC_WW_Pin1_4	955	960	PF00397	0.766
LIG_14-3-3_CanoR_1	1019	1027	PF00244	0.764
LIG_14-3-3_CanoR_1	1042	1049	PF00244	0.628
LIG_14-3-3_CanoR_1	196	201	PF00244	0.597
LIG_14-3-3_CanoR_1	260	267	PF00244	0.646
LIG_14-3-3_CanoR_1	319	324	PF00244	0.549
LIG_14-3-3_CanoR_1	343	347	PF00244	0.681
LIG_14-3-3_CanoR_1	380	387	PF00244	0.684
LIG_14-3-3_CanoR_1	405	414	PF00244	0.551
LIG_14-3-3_CanoR_1	509	517	PF00244	0.621
LIG_14-3-3_CanoR_1	67	72	PF00244	0.647
LIG_14-3-3_CanoR_1	727	733	PF00244	0.710
LIG_14-3-3_CanoR_1	754	760	PF00244	0.545
LIG_14-3-3_CanoR_1	843	851	PF00244	0.654
LIG_APCC_ABBA_1	459	464	PF00400	0.512
LIG_BIR_III_4	981	985	PF00653	0.554
LIG_BRCT_BRCA1_1	634	638	PF00533	0.615
LIG_BRCT_BRCA1_1	69	73	PF00533	0.641
LIG_BRCT_BRCA1_1	992	996	PF00533	0.570
LIG_deltaCOP1_diTrp_1	246	254	PF00928	0.568
LIG_FHA_1	1046	1052	PF00498	0.634
LIG_FHA_1	509	515	PF00498	0.578
LIG_FHA_1	547	553	PF00498	0.582
LIG_FHA_1	6	12	PF00498	0.602
LIG_FHA_1	600	606	PF00498	0.584
LIG_FHA_1	801	807	PF00498	0.566
LIG_FHA_2	210	216	PF00498	0.601
LIG_FHA_2	227	233	PF00498	0.573
LIG_LIR_Gen_1	164	173	PF02991	0.648
LIG_LIR_Gen_1	606	615	PF02991	0.553
LIG_LIR_Nem_3	1085	1089	PF02991	0.489
LIG_LIR_Nem_3	164	168	PF02991	0.650
LIG_LIR_Nem_3	246	252	PF02991	0.565
LIG_LIR_Nem_3	322	326	PF02991	0.534
LIG_LIR_Nem_3	606	611	PF02991	0.553
LIG_LIR_Nem_3	957	963	PF02991	0.633
LIG_LIR_Nem_3	995	1000	PF02991	0.622
LIG_MYND_1	267	271	PF01753	0.644
LIG_PCNA_PIPBox_1	757	766	PF02747	0.592
LIG_PCNA_yPIPBox_3	122	133	PF02747	0.573
LIG_Rb_LxCxE_1	357	377	PF01857	0.582
LIG_SH2_CRK	1009	1013	PF00017	0.651
LIG_SH2_CRK	165	169	PF00017	0.649
LIG_SH2_STAP1	1035	1039	PF00017	0.488
LIG_SH2_STAP1	526	530	PF00017	0.643
LIG_SH2_STAT3	890	893	PF00017	0.470
LIG_SH2_STAT5	1039	1042	PF00017	0.486
LIG_SH2_STAT5	888	891	PF00017	0.421
LIG_SH2_STAT5	945	948	PF00017	0.727
LIG_SH2_STAT5	979	982	PF00017	0.613
LIG_SH3_1	848	854	PF00018	0.663
LIG_SH3_3	1008	1014	PF00018	0.636
LIG_SH3_3	1062	1068	PF00018	0.606
LIG_SH3_3	210	216	PF00018	0.661
LIG_SH3_3	356	362	PF00018	0.649
LIG_SH3_3	43	49	PF00018	0.638
LIG_SH3_3	50	56	PF00018	0.664
LIG_SH3_3	795	801	PF00018	0.615
LIG_SH3_3	848	854	PF00018	0.663
LIG_SH3_3	944	950	PF00018	0.522
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.549
LIG_SUMO_SIM_par_1	601	609	PF11976	0.593
LIG_TRAF2_1	1078	1081	PF00917	0.510
LIG_TRAF2_1	16	19	PF00917	0.571
LIG_TRAF2_1	229	232	PF00917	0.650
LIG_TRAF2_1	591	594	PF00917	0.604
LIG_TRAF2_1	786	789	PF00917	0.643
LIG_TRAF2_1	856	859	PF00917	0.667
LIG_TRAF2_1	912	915	PF00917	0.500
LIG_WRC_WIRS_1	129	134	PF05994	0.608
LIG_WRC_WIRS_1	320	325	PF05994	0.538
LIG_WRC_WIRS_1	938	943	PF05994	0.576
MOD_CDC14_SPxK_1	217	220	PF00782	0.665
MOD_CDC14_SPxK_1	357	360	PF00782	0.625
MOD_CDC14_SPxK_1	377	380	PF00782	0.538
MOD_CDK_SPK_2	1014	1019	PF00069	0.564
MOD_CDK_SPK_2	707	712	PF00069	0.664
MOD_CDK_SPxK_1	214	220	PF00069	0.663
MOD_CDK_SPxK_1	354	360	PF00069	0.679
MOD_CDK_SPxK_1	374	380	PF00069	0.545
MOD_CDK_SPxK_1	955	961	PF00069	0.541
MOD_CDK_SPxxK_3	1014	1021	PF00069	0.562
MOD_CDK_SPxxK_3	1091	1098	PF00069	0.564
MOD_CDK_SPxxK_3	241	248	PF00069	0.562
MOD_CK1_1	1001	1007	PF00069	0.547
MOD_CK1_1	131	137	PF00069	0.628
MOD_CK1_1	186	192	PF00069	0.558
MOD_CK1_1	420	426	PF00069	0.657
MOD_CK1_1	5	11	PF00069	0.690
MOD_CK1_1	568	574	PF00069	0.615
MOD_CK1_1	632	638	PF00069	0.711
MOD_CK1_1	710	716	PF00069	0.702
MOD_CK1_1	917	923	PF00069	0.603
MOD_CK1_1	990	996	PF00069	0.666
MOD_CK2_1	1075	1081	PF00069	0.556
MOD_CK2_1	209	215	PF00069	0.604
MOD_CK2_1	226	232	PF00069	0.573
MOD_CK2_1	369	375	PF00069	0.696
MOD_CK2_1	603	609	PF00069	0.615
MOD_CK2_1	753	759	PF00069	0.535
MOD_CK2_1	77	83	PF00069	0.636
MOD_DYRK1A_RPxSP_1	241	245	PF00069	0.558
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.598
MOD_DYRK1A_RPxSP_1	45	49	PF00069	0.622
MOD_GlcNHglycan	101	104	PF01048	0.641
MOD_GlcNHglycan	1021	1024	PF01048	0.620
MOD_GlcNHglycan	1068	1071	PF01048	0.691
MOD_GlcNHglycan	261	264	PF01048	0.617
MOD_GlcNHglycan	354	357	PF01048	0.640
MOD_GlcNHglycan	388	391	PF01048	0.674
MOD_GlcNHglycan	408	411	PF01048	0.469
MOD_GlcNHglycan	419	422	PF01048	0.657
MOD_GlcNHglycan	427	430	PF01048	0.631
MOD_GlcNHglycan	445	448	PF01048	0.802
MOD_GlcNHglycan	451	454	PF01048	0.591
MOD_GlcNHglycan	49	52	PF01048	0.606
MOD_GlcNHglycan	492	495	PF01048	0.628
MOD_GlcNHglycan	570	573	PF01048	0.688
MOD_GlcNHglycan	588	591	PF01048	0.635
MOD_GlcNHglycan	707	710	PF01048	0.719
MOD_GlcNHglycan	724	727	PF01048	0.560
MOD_GlcNHglycan	728	731	PF01048	0.630
MOD_GlcNHglycan	739	742	PF01048	0.553
MOD_GlcNHglycan	79	82	PF01048	0.623
MOD_GlcNHglycan	843	846	PF01048	0.644
MOD_GlcNHglycan	85	88	PF01048	0.658
MOD_GlcNHglycan	992	995	PF01048	0.753
MOD_GSK3_1	1041	1048	PF00069	0.648
MOD_GSK3_1	183	190	PF00069	0.596
MOD_GSK3_1	259	266	PF00069	0.725
MOD_GSK3_1	350	357	PF00069	0.659
MOD_GSK3_1	406	413	PF00069	0.590
MOD_GSK3_1	41	48	PF00069	0.632
MOD_GSK3_1	416	423	PF00069	0.624
MOD_GSK3_1	495	502	PF00069	0.828
MOD_GSK3_1	567	574	PF00069	0.793
MOD_GSK3_1	599	606	PF00069	0.591
MOD_GSK3_1	63	70	PF00069	0.706
MOD_GSK3_1	7	14	PF00069	0.828
MOD_GSK3_1	722	729	PF00069	0.631
MOD_GSK3_1	733	740	PF00069	0.643
MOD_GSK3_1	79	86	PF00069	0.557
MOD_GSK3_1	879	886	PF00069	0.514
MOD_GSK3_1	983	990	PF00069	0.663
MOD_LATS_1	348	354	PF00433	0.648
MOD_LATS_1	39	45	PF00433	0.654
MOD_N-GLC_1	186	191	PF02516	0.539
MOD_N-GLC_1	369	374	PF02516	0.589
MOD_N-GLC_1	67	72	PF02516	0.772
MOD_N-GLC_1	733	738	PF02516	0.633
MOD_NEK2_1	11	16	PF00069	0.653
MOD_NEK2_1	136	141	PF00069	0.626
MOD_NEK2_1	298	303	PF00069	0.592
MOD_NEK2_1	987	992	PF00069	0.654
MOD_PIKK_1	2	8	PF00454	0.658
MOD_PIKK_1	420	426	PF00454	0.631
MOD_PIKK_1	713	719	PF00454	0.573
MOD_PIKK_1	753	759	PF00454	0.584
MOD_PIKK_1	843	849	PF00454	0.606
MOD_PK_1	515	521	PF00069	0.572
MOD_PK_1	969	975	PF00069	0.611
MOD_PKA_1	449	455	PF00069	0.660
MOD_PKA_2	1041	1047	PF00069	0.608
MOD_PKA_2	259	265	PF00069	0.692
MOD_PKA_2	342	348	PF00069	0.653
MOD_PKA_2	508	514	PF00069	0.576
MOD_PKA_2	546	552	PF00069	0.625
MOD_PKA_2	559	565	PF00069	0.568
MOD_PKA_2	609	615	PF00069	0.546
MOD_PKA_2	669	675	PF00069	0.663
MOD_PKA_2	726	732	PF00069	0.712
MOD_PKA_2	753	759	PF00069	0.560
MOD_PKA_2	77	83	PF00069	0.685
MOD_PKA_2	87	93	PF00069	0.605
MOD_PKB_1	513	521	PF00069	0.580
MOD_PKB_1	55	63	PF00069	0.584
MOD_PKB_1	563	571	PF00069	0.683
MOD_Plk_1	1044	1050	PF00069	0.655
MOD_Plk_1	1059	1065	PF00069	0.554
MOD_Plk_1	18	24	PF00069	0.627
MOD_Plk_1	186	192	PF00069	0.537
MOD_Plk_1	67	73	PF00069	0.696
MOD_Plk_1	917	923	PF00069	0.527
MOD_Plk_4	128	134	PF00069	0.571
MOD_Plk_4	196	202	PF00069	0.603
MOD_Plk_4	515	521	PF00069	0.587
MOD_Plk_4	603	609	PF00069	0.556
MOD_Plk_4	983	989	PF00069	0.667
MOD_Plk_4	992	998	PF00069	0.573
MOD_ProDKin_1	1001	1007	PF00069	0.693
MOD_ProDKin_1	1014	1020	PF00069	0.608
MOD_ProDKin_1	1091	1097	PF00069	0.573
MOD_ProDKin_1	209	215	PF00069	0.672
MOD_ProDKin_1	241	247	PF00069	0.597
MOD_ProDKin_1	263	269	PF00069	0.655
MOD_ProDKin_1	354	360	PF00069	0.720
MOD_ProDKin_1	374	380	PF00069	0.521
MOD_ProDKin_1	45	51	PF00069	0.626
MOD_ProDKin_1	578	584	PF00069	0.641
MOD_ProDKin_1	707	713	PF00069	0.637
MOD_ProDKin_1	871	877	PF00069	0.735
MOD_ProDKin_1	955	961	PF00069	0.764
MOD_SUMO_for_1	776	779	PF00179	0.517
MOD_SUMO_rev_2	1080	1089	PF00179	0.482
MOD_SUMO_rev_2	244	250	PF00179	0.555
MOD_SUMO_rev_2	308	318	PF00179	0.574
MOD_SUMO_rev_2	446	452	PF00179	0.635
TRG_ENDOCYTIC_2	165	168	PF00928	0.650
TRG_ER_diArg_1	1018	1021	PF00400	0.643
TRG_ER_diArg_1	176	179	PF00400	0.635
TRG_ER_diArg_1	22	25	PF00400	0.560
TRG_ER_diArg_1	513	516	PF00400	0.626
TRG_ER_diArg_1	55	58	PF00400	0.725
TRG_ER_diArg_1	563	566	PF00400	0.598
TRG_ER_diArg_1	578	580	PF00400	0.624
TRG_ER_diArg_1	811	814	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	1077	1081	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	902	906	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J9	Leptomonas seymouri	33%	100%
A4H4S2	Leishmania braziliensis	49%	100%
A4HT03	Leishmania infantum	100%	100%
E9AKZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QIW5	Leishmania major	83%	100%