Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPL3_LEIDO

TriTrypDb:

LdBPK_061070.1 , LdCL_060015800 , LDHU3_06.1210

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	3
GO:0005875	microtubule associated complex	2	3
GO:0032991	protein-containing complex	1	3
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3
GO:0110165	cellular anatomical entity	1	4
GO:0035869	ciliary transition zone	2	1

Expansion

Sequence features

A0A3S7WPL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPL3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	17
GO:0007018	microtubule-based movement	3	17
GO:0009987	cellular process	1	17
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0051231	spindle elongation	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003774	cytoskeletal motor activity	1	17
GO:0003777	microtubule motor activity	2	17
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	17
GO:0005515	protein binding	2	17
GO:0005524	ATP binding	5	17
GO:0008017	microtubule binding	5	17
GO:0008092	cytoskeletal protein binding	3	17
GO:0015631	tubulin binding	4	17
GO:0016787	hydrolase activity	2	13
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140657	ATP-dependent activity	1	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.263
CLV_C14_Caspase3-7	557	561	PF00656	0.606
CLV_C14_Caspase3-7	567	571	PF00656	0.526
CLV_C14_Caspase3-7	629	633	PF00656	0.615
CLV_C14_Caspase3-7	724	728	PF00656	0.584
CLV_NRD_NRD_1	231	233	PF00675	0.314
CLV_NRD_NRD_1	390	392	PF00675	0.517
CLV_NRD_NRD_1	398	400	PF00675	0.538
CLV_NRD_NRD_1	485	487	PF00675	0.435
CLV_NRD_NRD_1	506	508	PF00675	0.634
CLV_NRD_NRD_1	511	513	PF00675	0.555
CLV_NRD_NRD_1	748	750	PF00675	0.599
CLV_NRD_NRD_1	794	796	PF00675	0.521
CLV_NRD_NRD_1	825	827	PF00675	0.562
CLV_PCSK_FUR_1	388	392	PF00082	0.491
CLV_PCSK_KEX2_1	231	233	PF00082	0.266
CLV_PCSK_KEX2_1	390	392	PF00082	0.511
CLV_PCSK_KEX2_1	398	400	PF00082	0.538
CLV_PCSK_KEX2_1	510	512	PF00082	0.518
CLV_PCSK_KEX2_1	794	796	PF00082	0.525
CLV_PCSK_KEX2_1	825	827	PF00082	0.562
CLV_PCSK_PC7_1	227	233	PF00082	0.285
CLV_PCSK_PC7_1	507	513	PF00082	0.444
CLV_PCSK_PC7_1	821	827	PF00082	0.541
CLV_PCSK_SKI1_1	144	148	PF00082	0.330
CLV_PCSK_SKI1_1	166	170	PF00082	0.285
CLV_PCSK_SKI1_1	231	235	PF00082	0.279
CLV_PCSK_SKI1_1	40	44	PF00082	0.290
CLV_PCSK_SKI1_1	477	481	PF00082	0.428
CLV_PCSK_SKI1_1	512	516	PF00082	0.498
CLV_PCSK_SKI1_1	566	570	PF00082	0.617
CLV_PCSK_SKI1_1	573	577	PF00082	0.575
CLV_PCSK_SKI1_1	705	709	PF00082	0.544
CLV_PCSK_SKI1_1	845	849	PF00082	0.414
CLV_PCSK_SKI1_1	87	91	PF00082	0.306
CLV_PCSK_SKI1_1	886	890	PF00082	0.446
CLV_Separin_Metazoa	846	850	PF03568	0.469
DEG_APCC_DBOX_1	509	517	PF00400	0.447
DEG_APCC_DBOX_1	878	886	PF00400	0.418
DEG_SPOP_SBC_1	118	122	PF00917	0.252
DEG_SPOP_SBC_1	519	523	PF00917	0.532
DOC_CYCLIN_RxL_1	437	448	PF00134	0.452
DOC_CYCLIN_RxL_1	570	580	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.274
DOC_MAPK_gen_1	271	280	PF00069	0.292
DOC_MAPK_gen_1	871	880	PF00069	0.410
DOC_MAPK_MEF2A_6	273	282	PF00069	0.311
DOC_MAPK_MEF2A_6	4	11	PF00069	0.372
DOC_MAPK_MEF2A_6	586	593	PF00069	0.589
DOC_MAPK_MEF2A_6	873	882	PF00069	0.404
DOC_PP4_FxxP_1	517	520	PF00568	0.497
DOC_USP7_MATH_1	118	122	PF00917	0.263
DOC_USP7_MATH_1	154	158	PF00917	0.282
DOC_USP7_MATH_1	233	237	PF00917	0.263
DOC_USP7_MATH_1	241	245	PF00917	0.237
DOC_USP7_MATH_1	329	333	PF00917	0.313
DOC_USP7_MATH_1	449	453	PF00917	0.431
DOC_USP7_MATH_1	595	599	PF00917	0.674
DOC_USP7_MATH_1	624	628	PF00917	0.562
DOC_USP7_MATH_1	699	703	PF00917	0.551
DOC_USP7_MATH_1	740	744	PF00917	0.689
DOC_USP7_MATH_1	752	756	PF00917	0.526
DOC_USP7_MATH_1	764	768	PF00917	0.557
DOC_USP7_MATH_1	771	775	PF00917	0.569
DOC_WW_Pin1_4	176	181	PF00397	0.267
DOC_WW_Pin1_4	187	192	PF00397	0.384
DOC_WW_Pin1_4	197	202	PF00397	0.252
DOC_WW_Pin1_4	391	396	PF00397	0.517
DOC_WW_Pin1_4	398	403	PF00397	0.562
DOC_WW_Pin1_4	406	411	PF00397	0.582
DOC_WW_Pin1_4	620	625	PF00397	0.615
DOC_WW_Pin1_4	664	669	PF00397	0.623
DOC_WW_Pin1_4	684	689	PF00397	0.531
DOC_WW_Pin1_4	692	697	PF00397	0.603
LIG_14-3-3_CanoR_1	166	173	PF00244	0.262
LIG_14-3-3_CanoR_1	176	180	PF00244	0.272
LIG_14-3-3_CanoR_1	586	592	PF00244	0.637
LIG_14-3-3_CanoR_1	602	608	PF00244	0.602
LIG_14-3-3_CanoR_1	616	624	PF00244	0.690
LIG_14-3-3_CanoR_1	71	80	PF00244	0.225
LIG_14-3-3_CanoR_1	749	756	PF00244	0.581
LIG_14-3-3_CanoR_1	798	804	PF00244	0.560
LIG_Actin_WH2_2	95	111	PF00022	0.273
LIG_APCC_ABBA_1	136	141	PF00400	0.342
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_BIR_III_4	582	586	PF00653	0.572
LIG_BRCT_BRCA1_1	795	799	PF00533	0.522
LIG_Clathr_ClatBox_1	877	881	PF01394	0.426
LIG_CtBP_PxDLS_1	410	414	PF00389	0.568
LIG_EH1_1	88	96	PF00400	0.266
LIG_FHA_1	24	30	PF00498	0.467
LIG_FHA_1	273	279	PF00498	0.418
LIG_FHA_1	288	294	PF00498	0.221
LIG_FHA_1	334	340	PF00498	0.347
LIG_FHA_1	347	353	PF00498	0.348
LIG_FHA_1	491	497	PF00498	0.440
LIG_FHA_1	52	58	PF00498	0.289
LIG_FHA_1	567	573	PF00498	0.603
LIG_FHA_1	636	642	PF00498	0.576
LIG_FHA_1	73	79	PF00498	0.284
LIG_FHA_1	86	92	PF00498	0.424
LIG_FHA_2	140	146	PF00498	0.250
LIG_FHA_2	471	477	PF00498	0.423
LIG_FHA_2	553	559	PF00498	0.603
LIG_FHA_2	693	699	PF00498	0.574
LIG_FHA_2	851	857	PF00498	0.419
LIG_LIR_Gen_1	368	379	PF02991	0.276
LIG_LIR_Gen_1	448	457	PF02991	0.428
LIG_LIR_Nem_3	368	374	PF02991	0.277
LIG_LIR_Nem_3	448	453	PF02991	0.435
LIG_LIR_Nem_3	638	643	PF02991	0.759
LIG_LIR_Nem_3	702	706	PF02991	0.599
LIG_NRBOX	334	340	PF00104	0.340
LIG_Pex14_2	69	73	PF04695	0.266
LIG_Pex14_2	799	803	PF04695	0.514
LIG_SH2_CRK	371	375	PF00017	0.266
LIG_SH2_CRK	450	454	PF00017	0.426
LIG_SH2_PTP2	135	138	PF00017	0.279
LIG_SH2_PTP2	640	643	PF00017	0.548
LIG_SH2_SRC	135	138	PF00017	0.266
LIG_SH2_SRC	58	61	PF00017	0.258
LIG_SH2_STAP1	257	261	PF00017	0.266
LIG_SH2_STAP1	418	422	PF00017	0.512
LIG_SH2_STAP1	457	461	PF00017	0.436
LIG_SH2_STAP1	58	62	PF00017	0.279
LIG_SH2_STAT3	457	460	PF00017	0.417
LIG_SH2_STAT5	132	135	PF00017	0.296
LIG_SH2_STAT5	371	374	PF00017	0.271
LIG_SH2_STAT5	418	421	PF00017	0.511
LIG_SH2_STAT5	640	643	PF00017	0.548
LIG_SH2_STAT5	706	709	PF00017	0.658
LIG_SH3_3	25	31	PF00018	0.409
LIG_SH3_3	513	519	PF00018	0.496
LIG_SH3_3	665	671	PF00018	0.616
LIG_SH3_3	693	699	PF00018	0.575
LIG_SUMO_SIM_anti_2	836	844	PF11976	0.469
LIG_SUMO_SIM_par_1	25	30	PF11976	0.376
LIG_SUMO_SIM_par_1	409	415	PF11976	0.588
LIG_SUMO_SIM_par_1	442	448	PF11976	0.429
LIG_SUMO_SIM_par_1	95	101	PF11976	0.285
LIG_TRAF2_1	498	501	PF00917	0.428
LIG_TRAF2_1	642	645	PF00917	0.579
LIG_TRAF2_1	779	782	PF00917	0.541
LIG_TYR_ITIM	133	138	PF00017	0.279
LIG_TYR_ITIM	369	374	PF00017	0.266
LIG_UBA3_1	98	106	PF00899	0.263
MOD_CDC14_SPxK_1	623	626	PF00782	0.594
MOD_CDK_SPxK_1	620	626	PF00069	0.593
MOD_CDK_SPxxK_3	391	398	PF00069	0.524
MOD_CK1_1	179	185	PF00069	0.236
MOD_CK1_1	243	249	PF00069	0.341
MOD_CK1_1	333	339	PF00069	0.359
MOD_CK1_1	409	415	PF00069	0.577
MOD_CK1_1	470	476	PF00069	0.465
MOD_CK1_1	554	560	PF00069	0.575
MOD_CK1_1	620	626	PF00069	0.613
MOD_CK1_1	743	749	PF00069	0.544
MOD_CK1_1	751	757	PF00069	0.560
MOD_CK1_1	767	773	PF00069	0.542
MOD_CK1_1	793	799	PF00069	0.541
MOD_CK2_1	154	160	PF00069	0.225
MOD_CK2_1	266	272	PF00069	0.325
MOD_CK2_1	409	415	PF00069	0.647
MOD_CK2_1	470	476	PF00069	0.428
MOD_CK2_1	552	558	PF00069	0.578
MOD_CK2_1	692	698	PF00069	0.584
MOD_CK2_1	809	815	PF00069	0.608
MOD_CK2_1	850	856	PF00069	0.479
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.260
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.513
MOD_GlcNHglycan	109	112	PF01048	0.391
MOD_GlcNHglycan	346	349	PF01048	0.286
MOD_GlcNHglycan	402	405	PF01048	0.558
MOD_GlcNHglycan	447	450	PF01048	0.479
MOD_GlcNHglycan	605	608	PF01048	0.710
MOD_GlcNHglycan	619	622	PF01048	0.626
MOD_GlcNHglycan	750	753	PF01048	0.553
MOD_GlcNHglycan	795	798	PF01048	0.517
MOD_GlcNHglycan	836	840	PF01048	0.469
MOD_GSK3_1	118	125	PF00069	0.404
MOD_GSK3_1	175	182	PF00069	0.247
MOD_GSK3_1	227	234	PF00069	0.368
MOD_GSK3_1	329	336	PF00069	0.341
MOD_GSK3_1	414	421	PF00069	0.565
MOD_GSK3_1	445	452	PF00069	0.467
MOD_GSK3_1	467	474	PF00069	0.432
MOD_GSK3_1	519	526	PF00069	0.593
MOD_GSK3_1	552	559	PF00069	0.668
MOD_GSK3_1	620	627	PF00069	0.605
MOD_GSK3_1	739	746	PF00069	0.561
MOD_GSK3_1	748	755	PF00069	0.538
MOD_GSK3_1	766	773	PF00069	0.532
MOD_N-GLC_1	524	529	PF02516	0.539
MOD_N-GLC_1	73	78	PF02516	0.270
MOD_N-GLC_2	466	468	PF02516	0.381
MOD_NEK2_1	167	172	PF00069	0.273
MOD_NEK2_1	282	287	PF00069	0.266
MOD_NEK2_1	339	344	PF00069	0.345
MOD_NEK2_1	467	472	PF00069	0.426
MOD_NEK2_1	587	592	PF00069	0.635
MOD_NEK2_1	73	78	PF00069	0.276
MOD_NEK2_1	744	749	PF00069	0.551
MOD_NEK2_1	799	804	PF00069	0.552
MOD_NEK2_1	835	840	PF00069	0.430
MOD_NEK2_2	139	144	PF00069	0.276
MOD_NEK2_2	248	253	PF00069	0.276
MOD_PIKK_1	436	442	PF00454	0.541
MOD_PIKK_1	490	496	PF00454	0.474
MOD_PIKK_1	595	601	PF00454	0.633
MOD_PIKK_1	624	630	PF00454	0.583
MOD_PIKK_1	635	641	PF00454	0.570
MOD_PKA_1	231	237	PF00069	0.266
MOD_PKA_2	175	181	PF00069	0.235
MOD_PKA_2	231	237	PF00069	0.337
MOD_PKA_2	330	336	PF00069	0.361
MOD_PKA_2	427	433	PF00069	0.564
MOD_PKA_2	748	754	PF00069	0.563
MOD_PKA_2	793	799	PF00069	0.556
MOD_Plk_1	362	368	PF00069	0.287
MOD_Plk_1	73	79	PF00069	0.266
MOD_Plk_1	814	820	PF00069	0.553
MOD_Plk_1	835	841	PF00069	0.432
MOD_Plk_2-3	815	821	PF00069	0.535
MOD_Plk_4	208	214	PF00069	0.263
MOD_Plk_4	23	29	PF00069	0.452
MOD_Plk_4	248	254	PF00069	0.277
MOD_Plk_4	346	352	PF00069	0.344
MOD_Plk_4	699	705	PF00069	0.542
MOD_Plk_4	73	79	PF00069	0.299
MOD_Plk_4	783	789	PF00069	0.491
MOD_Plk_4	90	96	PF00069	0.295
MOD_ProDKin_1	176	182	PF00069	0.267
MOD_ProDKin_1	187	193	PF00069	0.384
MOD_ProDKin_1	197	203	PF00069	0.252
MOD_ProDKin_1	391	397	PF00069	0.519
MOD_ProDKin_1	398	404	PF00069	0.563
MOD_ProDKin_1	406	412	PF00069	0.581
MOD_ProDKin_1	620	626	PF00069	0.620
MOD_ProDKin_1	664	670	PF00069	0.625
MOD_ProDKin_1	684	690	PF00069	0.532
MOD_ProDKin_1	692	698	PF00069	0.600
MOD_SUMO_rev_2	269	275	PF00179	0.300
MOD_SUMO_rev_2	429	439	PF00179	0.524
MOD_SUMO_rev_2	881	888	PF00179	0.404
TRG_DiLeu_BaEn_1	23	28	PF01217	0.403
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.294
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.334
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.285
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.266
TRG_ENDOCYTIC_2	135	138	PF00928	0.279
TRG_ENDOCYTIC_2	371	374	PF00928	0.266
TRG_ENDOCYTIC_2	386	389	PF00928	0.538
TRG_ENDOCYTIC_2	450	453	PF00928	0.427
TRG_ENDOCYTIC_2	640	643	PF00928	0.679
TRG_ER_diArg_1	388	391	PF00400	0.563
TRG_ER_diArg_1	509	512	PF00400	0.468
TRG_ER_diArg_1	9	12	PF00400	0.386
TRG_NES_CRM1_1	567	580	PF08389	0.520
TRG_NLS_MonoExtC_3	506	511	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	44%	100%
A0A3Q8IEL2	Leishmania donovani	29%	100%
A0A3Q8IHG6	Leishmania donovani	29%	100%
A4H4R6	Leishmania braziliensis	74%	99%
A4H7S0	Leishmania braziliensis	27%	83%
A4HHY2	Leishmania braziliensis	26%	100%
A4HSZ5	Leishmania infantum	99%	100%
A4I4V2	Leishmania infantum	29%	100%
A4I4V3	Leishmania infantum	29%	100%
E9AEA0	Leishmania major	30%	100%
E9AEA1	Leishmania major	30%	100%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4QIX3	Leishmania major	91%	99%