TLD, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

TLD, putative

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPK2_LEIDO

TriTrypDb:

LdBPK_060970.1 , LdCL_060014800 , LDHU3_06.1110

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.472
CLV_C14_Caspase3-7	125	129	PF00656	0.509
CLV_C14_Caspase3-7	484	488	PF00656	0.794
CLV_C14_Caspase3-7	526	530	PF00656	0.671
CLV_NRD_NRD_1	122	124	PF00675	0.524
CLV_NRD_NRD_1	16	18	PF00675	0.649
CLV_NRD_NRD_1	195	197	PF00675	0.780
CLV_NRD_NRD_1	386	388	PF00675	0.709
CLV_NRD_NRD_1	417	419	PF00675	0.443
CLV_NRD_NRD_1	48	50	PF00675	0.659
CLV_PCSK_FUR_1	384	388	PF00082	0.635
CLV_PCSK_KEX2_1	122	124	PF00082	0.524
CLV_PCSK_KEX2_1	195	197	PF00082	0.780
CLV_PCSK_KEX2_1	386	388	PF00082	0.713
CLV_PCSK_KEX2_1	519	521	PF00082	0.578
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.679
CLV_PCSK_PC7_1	191	197	PF00082	0.622
CLV_PCSK_SKI1_1	300	304	PF00082	0.656
DEG_APCC_DBOX_1	84	92	PF00400	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DEG_SPOP_SBC_1	283	287	PF00917	0.740
DOC_CKS1_1	70	75	PF01111	0.524
DOC_CKS1_1	76	81	PF01111	0.471
DOC_CYCLIN_yClb1_LxF_4	103	108	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.715
DOC_MAPK_DCC_7	343	353	PF00069	0.587
DOC_MAPK_DCC_7	495	505	PF00069	0.700
DOC_MAPK_gen_1	519	527	PF00069	0.539
DOC_MAPK_MEF2A_6	373	380	PF00069	0.796
DOC_PP1_RVXF_1	103	109	PF00149	0.450
DOC_PP1_RVXF_1	133	140	PF00149	0.568
DOC_PP1_RVXF_1	507	514	PF00149	0.448
DOC_PP4_FxxP_1	228	231	PF00568	0.544
DOC_PP4_FxxP_1	457	460	PF00568	0.572
DOC_PP4_FxxP_1	584	587	PF00568	0.669
DOC_PP4_FxxP_1	70	73	PF00568	0.490
DOC_USP7_MATH_1	129	133	PF00917	0.530
DOC_USP7_MATH_1	160	164	PF00917	0.683
DOC_USP7_MATH_1	180	184	PF00917	0.607
DOC_USP7_MATH_1	189	193	PF00917	0.570
DOC_USP7_MATH_1	283	287	PF00917	0.813
DOC_USP7_MATH_1	314	318	PF00917	0.716
DOC_USP7_MATH_1	367	371	PF00917	0.579
DOC_USP7_MATH_1	474	478	PF00917	0.725
DOC_USP7_MATH_1	528	532	PF00917	0.663
DOC_USP7_MATH_1	54	58	PF00917	0.560
DOC_USP7_MATH_1	548	552	PF00917	0.700
DOC_USP7_MATH_1	561	565	PF00917	0.640
DOC_WW_Pin1_4	156	161	PF00397	0.712
DOC_WW_Pin1_4	173	178	PF00397	0.653
DOC_WW_Pin1_4	210	215	PF00397	0.418
DOC_WW_Pin1_4	227	232	PF00397	0.518
DOC_WW_Pin1_4	336	341	PF00397	0.685
DOC_WW_Pin1_4	351	356	PF00397	0.629
DOC_WW_Pin1_4	379	384	PF00397	0.698
DOC_WW_Pin1_4	470	475	PF00397	0.732
DOC_WW_Pin1_4	485	490	PF00397	0.688
DOC_WW_Pin1_4	563	568	PF00397	0.733
DOC_WW_Pin1_4	69	74	PF00397	0.521
DOC_WW_Pin1_4	75	80	PF00397	0.471
DOC_WW_Pin1_4	93	98	PF00397	0.284
LIG_14-3-3_CanoR_1	191	197	PF00244	0.627
LIG_14-3-3_CanoR_1	357	361	PF00244	0.634
LIG_14-3-3_CanoR_1	523	528	PF00244	0.719
LIG_14-3-3_CanoR_1	98	103	PF00244	0.484
LIG_Actin_WH2_2	328	345	PF00022	0.600
LIG_BRCT_BRCA1_1	111	115	PF00533	0.502
LIG_BRCT_BRCA1_1	182	186	PF00533	0.632
LIG_eIF4E_1	296	302	PF01652	0.581
LIG_FHA_1	211	217	PF00498	0.466
LIG_FHA_1	357	363	PF00498	0.681
LIG_FHA_1	551	557	PF00498	0.713
LIG_FHA_1	76	82	PF00498	0.534
LIG_FHA_2	108	114	PF00498	0.459
LIG_FHA_2	251	257	PF00498	0.555
LIG_FHA_2	450	456	PF00498	0.485
LIG_FHA_2	552	558	PF00498	0.802
LIG_FHA_2	70	76	PF00498	0.615
LIG_LIR_Apic_2	455	460	PF02991	0.469
LIG_LIR_Nem_3	136	142	PF02991	0.435
LIG_LIR_Nem_3	96	102	PF02991	0.571
LIG_LYPXL_SIV_4	295	303	PF13949	0.662
LIG_MYND_1	340	344	PF01753	0.675
LIG_Pex14_1	104	108	PF04695	0.454
LIG_Pex14_1	453	457	PF04695	0.464
LIG_Pex14_2	139	143	PF04695	0.433
LIG_PTB_Apo_2	421	428	PF02174	0.466
LIG_SH2_CRK	298	302	PF00017	0.787
LIG_SH2_NCK_1	545	549	PF00017	0.611
LIG_SH2_STAP1	298	302	PF00017	0.746
LIG_SH2_STAT5	227	230	PF00017	0.542
LIG_SH2_STAT5	440	443	PF00017	0.581
LIG_SH2_STAT5	482	485	PF00017	0.586
LIG_SH3_1	398	404	PF00018	0.686
LIG_SH3_2	393	398	PF14604	0.739
LIG_SH3_3	172	178	PF00018	0.615
LIG_SH3_3	211	217	PF00018	0.407
LIG_SH3_3	308	314	PF00018	0.671
LIG_SH3_3	377	383	PF00018	0.690
LIG_SH3_3	390	396	PF00018	0.738
LIG_SH3_3	398	404	PF00018	0.549
LIG_SH3_3	419	425	PF00018	0.430
LIG_SH3_3	564	570	PF00018	0.703
LIG_SH3_3	74	80	PF00018	0.523
LIG_SUMO_SIM_par_1	358	364	PF11976	0.573
LIG_SUMO_SIM_par_1	90	96	PF11976	0.485
LIG_WW_2	79	82	PF00397	0.519
MOD_CDC14_SPxK_1	354	357	PF00782	0.784
MOD_CDK_SPK_2	379	384	PF00069	0.693
MOD_CDK_SPK_2	485	490	PF00069	0.677
MOD_CDK_SPK_2	93	98	PF00069	0.506
MOD_CDK_SPxK_1	351	357	PF00069	0.790
MOD_CDK_SPxxK_3	336	343	PF00069	0.602
MOD_CDK_SPxxK_3	379	386	PF00069	0.775
MOD_CK1_1	116	122	PF00069	0.450
MOD_CK1_1	165	171	PF00069	0.696
MOD_CK1_1	230	236	PF00069	0.473
MOD_CK1_1	317	323	PF00069	0.800
MOD_CK1_1	324	330	PF00069	0.721
MOD_CK1_1	473	479	PF00069	0.750
MOD_CK1_1	481	487	PF00069	0.624
MOD_CK1_1	531	537	PF00069	0.649
MOD_CK1_1	546	552	PF00069	0.677
MOD_CK2_1	182	188	PF00069	0.796
MOD_CK2_1	250	256	PF00069	0.540
MOD_CK2_1	449	455	PF00069	0.487
MOD_CK2_1	511	517	PF00069	0.448
MOD_CK2_1	81	87	PF00069	0.502
MOD_Cter_Amidation	384	387	PF01082	0.637
MOD_GlcNHglycan	145	148	PF01048	0.440
MOD_GlcNHglycan	164	167	PF01048	0.628
MOD_GlcNHglycan	369	372	PF01048	0.566
MOD_GlcNHglycan	43	46	PF01048	0.737
MOD_GlcNHglycan	434	437	PF01048	0.423
MOD_GlcNHglycan	457	460	PF01048	0.465
MOD_GlcNHglycan	468	471	PF01048	0.751
MOD_GlcNHglycan	483	486	PF01048	0.694
MOD_GlcNHglycan	497	500	PF01048	0.684
MOD_GlcNHglycan	533	536	PF01048	0.650
MOD_GlcNHglycan	548	551	PF01048	0.558
MOD_GlcNHglycan	559	562	PF01048	0.695
MOD_GSK3_1	109	116	PF00069	0.480
MOD_GSK3_1	129	136	PF00069	0.284
MOD_GSK3_1	156	163	PF00069	0.740
MOD_GSK3_1	165	172	PF00069	0.577
MOD_GSK3_1	239	246	PF00069	0.668
MOD_GSK3_1	317	324	PF00069	0.748
MOD_GSK3_1	327	334	PF00069	0.637
MOD_GSK3_1	356	363	PF00069	0.671
MOD_GSK3_1	449	456	PF00069	0.535
MOD_GSK3_1	466	473	PF00069	0.522
MOD_GSK3_1	474	481	PF00069	0.621
MOD_GSK3_1	546	553	PF00069	0.727
MOD_GSK3_1	557	564	PF00069	0.706
MOD_N-GLC_1	169	174	PF02516	0.661
MOD_N-GLC_1	351	356	PF02516	0.664
MOD_NEK2_1	115	120	PF00069	0.472
MOD_NEK2_1	164	169	PF00069	0.674
MOD_NEK2_1	204	209	PF00069	0.538
MOD_NEK2_1	335	340	PF00069	0.711
MOD_NEK2_1	356	361	PF00069	0.578
MOD_NEK2_1	478	483	PF00069	0.670
MOD_NEK2_1	505	510	PF00069	0.459
MOD_NEK2_1	55	60	PF00069	0.669
MOD_OFUCOSY	540	547	PF10250	0.657
MOD_PIKK_1	129	135	PF00454	0.623
MOD_PK_1	523	529	PF00069	0.568
MOD_PKA_2	190	196	PF00069	0.689
MOD_PKA_2	317	323	PF00069	0.821
MOD_PKA_2	342	348	PF00069	0.626
MOD_PKA_2	356	362	PF00069	0.567
MOD_PKA_2	543	549	PF00069	0.687
MOD_Plk_1	169	175	PF00069	0.577
MOD_Plk_1	321	327	PF00069	0.698
MOD_Plk_1	331	337	PF00069	0.640
MOD_Plk_1	528	534	PF00069	0.662
MOD_Plk_4	116	122	PF00069	0.465
MOD_Plk_4	182	188	PF00069	0.621
MOD_Plk_4	204	210	PF00069	0.529
MOD_Plk_4	230	236	PF00069	0.467
MOD_Plk_4	331	337	PF00069	0.669
MOD_Plk_4	356	362	PF00069	0.670
MOD_Plk_4	474	480	PF00069	0.760
MOD_Plk_4	571	577	PF00069	0.776
MOD_ProDKin_1	156	162	PF00069	0.714
MOD_ProDKin_1	173	179	PF00069	0.655
MOD_ProDKin_1	210	216	PF00069	0.417
MOD_ProDKin_1	227	233	PF00069	0.508
MOD_ProDKin_1	336	342	PF00069	0.685
MOD_ProDKin_1	351	357	PF00069	0.630
MOD_ProDKin_1	379	385	PF00069	0.698
MOD_ProDKin_1	470	476	PF00069	0.730
MOD_ProDKin_1	485	491	PF00069	0.691
MOD_ProDKin_1	563	569	PF00069	0.726
MOD_ProDKin_1	69	75	PF00069	0.516
MOD_ProDKin_1	93	99	PF00069	0.462
MOD_SUMO_rev_2	125	132	PF00179	0.616
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.722
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.717
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.461
TRG_DiLeu_LyEn_5	346	351	PF01217	0.667
TRG_ENDOCYTIC_2	121	124	PF00928	0.493
TRG_ENDOCYTIC_2	298	301	PF00928	0.773
TRG_ER_diArg_1	121	123	PF00400	0.522
TRG_ER_diArg_1	195	197	PF00400	0.772
TRG_ER_diArg_1	383	386	PF00400	0.780
TRG_ER_diArg_1	387	390	PF00400	0.747
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P572	Leptomonas seymouri	43%	89%
A4H4Q7	Leishmania braziliensis	61%	100%
A4HSY6	Leishmania infantum	99%	100%
E9AKX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIY3	Leishmania major	87%	100%