C2_domain/Ankyrin_repeats_(3_copies)/Ankyrin_repe at_putative/Pfam:PF00168/Pfam:PF12796/Pfam:PF00023

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2 domain/Ankyrin repeats (3 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPJ8_LEIDO

TriTrypDb:

LdBPK_060730.1 , LdCL_060012400 , LDHU3_06.0850

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.724
CLV_NRD_NRD_1	497	499	PF00675	0.732
CLV_NRD_NRD_1	529	531	PF00675	0.683
CLV_NRD_NRD_1	575	577	PF00675	0.781
CLV_NRD_NRD_1	618	620	PF00675	0.393
CLV_PCSK_KEX2_1	497	499	PF00082	0.732
CLV_PCSK_KEX2_1	529	531	PF00082	0.683
CLV_PCSK_KEX2_1	574	576	PF00082	0.796
CLV_PCSK_KEX2_1	618	620	PF00082	0.435
CLV_PCSK_SKI1_1	557	561	PF00082	0.659
CLV_PCSK_SKI1_1	640	644	PF00082	0.478
CLV_PCSK_SKI1_1	716	720	PF00082	0.492
DEG_SCF_FBW7_1	318	325	PF00400	0.788
DEG_SPOP_SBC_1	317	321	PF00917	0.717
DEG_SPOP_SBC_1	477	481	PF00917	0.665
DEG_SPOP_SBC_1	95	99	PF00917	0.595
DOC_CKS1_1	247	252	PF01111	0.714
DOC_CKS1_1	38	43	PF01111	0.477
DOC_MAPK_gen_1	497	504	PF00069	0.690
DOC_PP1_RVXF_1	71	77	PF00149	0.451
DOC_PP2B_LxvP_1	248	251	PF13499	0.761
DOC_PP2B_LxvP_1	301	304	PF13499	0.752
DOC_PP2B_LxvP_1	409	412	PF13499	0.698
DOC_PP2B_LxvP_1	735	738	PF13499	0.505
DOC_USP7_MATH_1	176	180	PF00917	0.741
DOC_USP7_MATH_1	231	235	PF00917	0.737
DOC_USP7_MATH_1	322	326	PF00917	0.705
DOC_USP7_MATH_1	387	391	PF00917	0.830
DOC_USP7_MATH_1	401	405	PF00917	0.780
DOC_USP7_MATH_1	477	481	PF00917	0.689
DOC_USP7_MATH_1	491	495	PF00917	0.782
DOC_USP7_MATH_1	516	520	PF00917	0.771
DOC_USP7_MATH_1	550	554	PF00917	0.817
DOC_USP7_MATH_1	562	566	PF00917	0.843
DOC_USP7_MATH_1	586	590	PF00917	0.832
DOC_USP7_MATH_1	675	679	PF00917	0.397
DOC_WW_Pin1_4	238	243	PF00397	0.765
DOC_WW_Pin1_4	246	251	PF00397	0.683
DOC_WW_Pin1_4	272	277	PF00397	0.739
DOC_WW_Pin1_4	318	323	PF00397	0.781
DOC_WW_Pin1_4	37	42	PF00397	0.477
DOC_WW_Pin1_4	417	422	PF00397	0.690
DOC_WW_Pin1_4	472	477	PF00397	0.813
DOC_WW_Pin1_4	486	491	PF00397	0.728
DOC_WW_Pin1_4	504	509	PF00397	0.735
DOC_WW_Pin1_4	569	574	PF00397	0.728
LIG_14-3-3_CanoR_1	366	371	PF00244	0.699
LIG_14-3-3_CanoR_1	497	503	PF00244	0.779
LIG_14-3-3_CanoR_1	557	562	PF00244	0.701
LIG_14-3-3_CanoR_1	576	584	PF00244	0.805
LIG_14-3-3_CanoR_1	699	703	PF00244	0.545
LIG_14-3-3_CanoR_1	716	725	PF00244	0.487
LIG_BRCT_BRCA1_1	24	28	PF00533	0.477
LIG_BRCT_BRCA1_1	363	367	PF00533	0.747
LIG_BRCT_BRCA1_1	450	454	PF00533	0.714
LIG_CtBP_PxDLS_1	250	254	PF00389	0.761
LIG_DLG_GKlike_1	366	374	PF00625	0.697
LIG_EH_1	25	29	PF12763	0.477
LIG_eIF4E_1	637	643	PF01652	0.397
LIG_EVH1_1	301	305	PF00568	0.724
LIG_FHA_1	124	130	PF00498	0.515
LIG_FHA_1	212	218	PF00498	0.739
LIG_FHA_1	261	267	PF00498	0.711
LIG_FHA_1	28	34	PF00498	0.408
LIG_FHA_1	352	358	PF00498	0.610
LIG_FHA_1	37	43	PF00498	0.408
LIG_FHA_1	481	487	PF00498	0.900
LIG_FHA_1	5	11	PF00498	0.426
LIG_FHA_1	536	542	PF00498	0.688
LIG_FHA_1	83	89	PF00498	0.413
LIG_FHA_1	96	102	PF00498	0.521
LIG_FHA_2	319	325	PF00498	0.726
LIG_FHA_2	608	614	PF00498	0.547
LIG_FHA_2	717	723	PF00498	0.480
LIG_FHA_2	87	93	PF00498	0.408
LIG_LIR_Apic_2	263	267	PF02991	0.752
LIG_LIR_Apic_2	56	61	PF02991	0.467
LIG_LIR_Gen_1	234	242	PF02991	0.703
LIG_LIR_Gen_1	364	372	PF02991	0.743
LIG_LIR_Nem_3	234	238	PF02991	0.771
LIG_LIR_Nem_3	288	294	PF02991	0.753
LIG_LIR_Nem_3	364	370	PF02991	0.743
LIG_LIR_Nem_3	53	58	PF02991	0.454
LIG_LIR_Nem_3	615	620	PF02991	0.400
LIG_LIR_Nem_3	726	732	PF02991	0.495
LIG_MAD2	653	661	PF02301	0.397
LIG_MYND_1	251	255	PF01753	0.714
LIG_NRBOX	654	660	PF00104	0.397
LIG_PCNA_yPIPBox_3	691	699	PF02747	0.397
LIG_Pex14_2	51	55	PF04695	0.410
LIG_PTB_Apo_2	23	30	PF02174	0.477
LIG_PTB_Apo_2	45	52	PF02174	0.408
LIG_SH2_CRK	58	62	PF00017	0.451
LIG_SH2_GRB2like	327	330	PF00017	0.723
LIG_SH2_NCK_1	127	131	PF00017	0.573
LIG_SH2_NCK_1	393	397	PF00017	0.700
LIG_SH2_NCK_1	561	565	PF00017	0.735
LIG_SH2_NCK_1	700	704	PF00017	0.551
LIG_SH2_STAP1	291	295	PF00017	0.718
LIG_SH2_STAP1	393	397	PF00017	0.700
LIG_SH2_STAT3	294	297	PF00017	0.772
LIG_SH2_STAT5	264	267	PF00017	0.835
LIG_SH2_STAT5	393	396	PF00017	0.703
LIG_SH2_STAT5	603	606	PF00017	0.539
LIG_SH3_1	300	306	PF00018	0.750
LIG_SH3_3	252	258	PF00018	0.701
LIG_SH3_3	266	272	PF00018	0.696
LIG_SH3_3	299	305	PF00018	0.726
LIG_SH3_3	35	41	PF00018	0.477
LIG_SH3_3	353	359	PF00018	0.663
LIG_SH3_3	407	413	PF00018	0.694
LIG_SH3_3	470	476	PF00018	0.742
LIG_SH3_3	512	518	PF00018	0.734
LIG_SH3_3	660	666	PF00018	0.397
LIG_SUMO_SIM_anti_2	7	12	PF11976	0.451
LIG_SUMO_SIM_par_1	4	9	PF11976	0.477
LIG_SUMO_SIM_par_1	665	672	PF11976	0.397
LIG_SUMO_SIM_par_1	706	711	PF11976	0.518
LIG_SUMO_SIM_par_1	85	92	PF11976	0.408
LIG_TRAF2_1	133	136	PF00917	0.688
LIG_TRAF2_1	369	372	PF00917	0.696
LIG_TRFH_1	91	95	PF08558	0.346
LIG_UBA3_1	65	73	PF00899	0.425
MOD_CDC14_SPxK_1	254	257	PF00782	0.651
MOD_CDC14_SPxK_1	572	575	PF00782	0.741
MOD_CDK_SPK_2	569	574	PF00069	0.728
MOD_CDK_SPxK_1	251	257	PF00069	0.709
MOD_CDK_SPxK_1	569	575	PF00069	0.731
MOD_CDK_SPxxK_3	238	245	PF00069	0.744
MOD_CDK_SPxxK_3	569	576	PF00069	0.735
MOD_CK1_1	146	152	PF00069	0.785
MOD_CK1_1	203	209	PF00069	0.777
MOD_CK1_1	246	252	PF00069	0.803
MOD_CK1_1	275	281	PF00069	0.765
MOD_CK1_1	282	288	PF00069	0.690
MOD_CK1_1	348	354	PF00069	0.678
MOD_CK1_1	37	43	PF00069	0.397
MOD_CK1_1	379	385	PF00069	0.797
MOD_CK1_1	388	394	PF00069	0.643
MOD_CK1_1	427	433	PF00069	0.763
MOD_CK1_1	480	486	PF00069	0.741
MOD_CK1_1	519	525	PF00069	0.750
MOD_CK1_1	565	571	PF00069	0.738
MOD_CK1_1	577	583	PF00069	0.687
MOD_CK1_1	589	595	PF00069	0.558
MOD_CK1_1	638	644	PF00069	0.492
MOD_CK1_1	678	684	PF00069	0.397
MOD_CK1_1	701	707	PF00069	0.541
MOD_CK2_1	318	324	PF00069	0.719
MOD_CK2_1	366	372	PF00069	0.700
MOD_CK2_1	577	583	PF00069	0.779
MOD_CK2_1	716	722	PF00069	0.491
MOD_GlcNHglycan	204	208	PF01048	0.870
MOD_GlcNHglycan	335	338	PF01048	0.703
MOD_GlcNHglycan	341	344	PF01048	0.680
MOD_GlcNHglycan	374	377	PF01048	0.824
MOD_GlcNHglycan	387	390	PF01048	0.603
MOD_GlcNHglycan	394	397	PF01048	0.725
MOD_GlcNHglycan	438	441	PF01048	0.817
MOD_GlcNHglycan	493	496	PF01048	0.803
MOD_GlcNHglycan	519	522	PF01048	0.871
MOD_GlcNHglycan	535	538	PF01048	0.730
MOD_GlcNHglycan	543	546	PF01048	0.795
MOD_GlcNHglycan	552	555	PF01048	0.585
MOD_GlcNHglycan	562	565	PF01048	0.707
MOD_GlcNHglycan	567	570	PF01048	0.814
MOD_GlcNHglycan	587	591	PF01048	0.563
MOD_GlcNHglycan	592	595	PF01048	0.579
MOD_GlcNHglycan	636	640	PF01048	0.397
MOD_GlcNHglycan	677	680	PF01048	0.429
MOD_GSK3_1	121	128	PF00069	0.561
MOD_GSK3_1	143	150	PF00069	0.742
MOD_GSK3_1	167	174	PF00069	0.697
MOD_GSK3_1	190	197	PF00069	0.793
MOD_GSK3_1	271	278	PF00069	0.742
MOD_GSK3_1	318	325	PF00069	0.834
MOD_GSK3_1	362	369	PF00069	0.825
MOD_GSK3_1	372	379	PF00069	0.677
MOD_GSK3_1	383	390	PF00069	0.786
MOD_GSK3_1	415	422	PF00069	0.747
MOD_GSK3_1	424	431	PF00069	0.698
MOD_GSK3_1	432	439	PF00069	0.699
MOD_GSK3_1	444	451	PF00069	0.724
MOD_GSK3_1	468	475	PF00069	0.757
MOD_GSK3_1	476	483	PF00069	0.749
MOD_GSK3_1	500	507	PF00069	0.862
MOD_GSK3_1	516	523	PF00069	0.630
MOD_GSK3_1	565	572	PF00069	0.734
MOD_GSK3_1	586	593	PF00069	0.702
MOD_GSK3_1	82	89	PF00069	0.408
MOD_N-GLC_1	328	333	PF02516	0.716
MOD_N-GLC_1	415	420	PF02516	0.660
MOD_N-GLC_1	51	56	PF02516	0.446
MOD_N-GLC_2	118	120	PF02516	0.506
MOD_NEK2_1	279	284	PF00069	0.715
MOD_NEK2_1	29	34	PF00069	0.477
MOD_NEK2_1	370	375	PF00069	0.732
MOD_NEK2_1	392	397	PF00069	0.701
MOD_NEK2_1	424	429	PF00069	0.764
MOD_NEK2_1	432	437	PF00069	0.749
MOD_NEK2_1	478	483	PF00069	0.726
MOD_NEK2_1	51	56	PF00069	0.413
MOD_NEK2_1	541	546	PF00069	0.733
MOD_NEK2_1	635	640	PF00069	0.451
MOD_NEK2_1	698	703	PF00069	0.550
MOD_NEK2_1	708	713	PF00069	0.547
MOD_NEK2_2	64	69	PF00069	0.463
MOD_NEK2_2	86	91	PF00069	0.408
MOD_PIKK_1	243	249	PF00454	0.736
MOD_PIKK_1	379	385	PF00454	0.747
MOD_PIKK_1	401	407	PF00454	0.769
MOD_PIKK_1	424	430	PF00454	0.730
MOD_PIKK_1	592	598	PF00454	0.518
MOD_PKA_2	698	704	PF00069	0.540
MOD_Plk_1	51	57	PF00069	0.446
MOD_Plk_1	586	592	PF00069	0.708
MOD_Plk_4	260	266	PF00069	0.721
MOD_Plk_4	322	328	PF00069	0.760
MOD_Plk_4	388	394	PF00069	0.705
MOD_Plk_4	419	425	PF00069	0.800
MOD_Plk_4	6	12	PF00069	0.419
MOD_Plk_4	678	684	PF00069	0.397
MOD_Plk_4	86	92	PF00069	0.423
MOD_ProDKin_1	238	244	PF00069	0.764
MOD_ProDKin_1	246	252	PF00069	0.684
MOD_ProDKin_1	272	278	PF00069	0.745
MOD_ProDKin_1	318	324	PF00069	0.785
MOD_ProDKin_1	37	43	PF00069	0.477
MOD_ProDKin_1	417	423	PF00069	0.690
MOD_ProDKin_1	472	478	PF00069	0.817
MOD_ProDKin_1	486	492	PF00069	0.727
MOD_ProDKin_1	504	510	PF00069	0.728
MOD_ProDKin_1	569	575	PF00069	0.731
MOD_SUMO_for_1	11	14	PF00179	0.397
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.670
TRG_DiLeu_BaLyEn_6	704	709	PF01217	0.530
TRG_DiLeu_BaLyEn_6	731	736	PF01217	0.477
TRG_ER_diArg_1	573	576	PF00400	0.746
TRG_ER_diArg_1	617	619	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C1	Leptomonas seymouri	56%	98%
A4H4U3	Leishmania braziliensis	70%	100%
A4HSW2	Leishmania infantum	100%	100%
E9AKV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QJ07	Leishmania major	93%	100%