Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPJ7_LEIDO

TriTrypDb:

LdBPK_060920.1 , LdCL_060014300 , LDHU3_06.1060

Length:

778

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.560
CLV_C14_Caspase3-7	22	26	PF00656	0.576
CLV_C14_Caspase3-7	35	39	PF00656	0.528
CLV_NRD_NRD_1	218	220	PF00675	0.542
CLV_NRD_NRD_1	234	236	PF00675	0.589
CLV_NRD_NRD_1	303	305	PF00675	0.688
CLV_NRD_NRD_1	401	403	PF00675	0.604
CLV_NRD_NRD_1	439	441	PF00675	0.627
CLV_NRD_NRD_1	515	517	PF00675	0.610
CLV_NRD_NRD_1	529	531	PF00675	0.496
CLV_NRD_NRD_1	56	58	PF00675	0.621
CLV_NRD_NRD_1	712	714	PF00675	0.576
CLV_PCSK_KEX2_1	218	220	PF00082	0.542
CLV_PCSK_KEX2_1	234	236	PF00082	0.589
CLV_PCSK_KEX2_1	303	305	PF00082	0.647
CLV_PCSK_KEX2_1	401	403	PF00082	0.604
CLV_PCSK_KEX2_1	439	441	PF00082	0.627
CLV_PCSK_KEX2_1	514	516	PF00082	0.511
CLV_PCSK_KEX2_1	529	531	PF00082	0.556
CLV_PCSK_KEX2_1	714	716	PF00082	0.670
CLV_PCSK_KEX2_1	726	728	PF00082	0.528
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.670
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.528
CLV_PCSK_PC7_1	397	403	PF00082	0.611
CLV_PCSK_PC7_1	510	516	PF00082	0.487
CLV_PCSK_SKI1_1	11	15	PF00082	0.560
CLV_PCSK_SKI1_1	203	207	PF00082	0.455
CLV_PCSK_SKI1_1	221	225	PF00082	0.620
CLV_PCSK_SKI1_1	245	249	PF00082	0.553
CLV_PCSK_SKI1_1	304	308	PF00082	0.641
CLV_PCSK_SKI1_1	454	458	PF00082	0.616
CLV_PCSK_SKI1_1	515	519	PF00082	0.508
CLV_PCSK_SKI1_1	530	534	PF00082	0.551
CLV_PCSK_SKI1_1	544	548	PF00082	0.518
CLV_PCSK_SKI1_1	58	62	PF00082	0.588
CLV_PCSK_SKI1_1	703	707	PF00082	0.640
DEG_APCC_DBOX_1	237	245	PF00400	0.499
DEG_COP1_1	330	340	PF00400	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.581
DEG_SCF_TRCP1_1	588	593	PF00400	0.640
DEG_SCF_TRCP1_1	673	678	PF00400	0.632
DEG_SPOP_SBC_1	599	603	PF00917	0.567
DOC_CDC14_PxL_1	764	772	PF14671	0.498
DOC_CKS1_1	332	337	PF01111	0.594
DOC_CKS1_1	351	356	PF01111	0.528
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	765	771	PF00134	0.474
DOC_MAPK_FxFP_2	14	17	PF00069	0.487
DOC_MAPK_gen_1	234	243	PF00069	0.532
DOC_MAPK_gen_1	401	407	PF00069	0.582
DOC_PP1_RVXF_1	342	348	PF00149	0.523
DOC_PP1_RVXF_1	505	512	PF00149	0.516
DOC_PP2B_LxvP_1	147	150	PF13499	0.546
DOC_PP2B_LxvP_1	177	180	PF13499	0.484
DOC_PP2B_LxvP_1	366	369	PF13499	0.612
DOC_PP2B_LxvP_1	74	77	PF13499	0.583
DOC_PP2B_LxvP_1	765	768	PF13499	0.468
DOC_PP4_FxxP_1	14	17	PF00568	0.556
DOC_USP7_MATH_1	29	33	PF00917	0.675
DOC_USP7_MATH_1	296	300	PF00917	0.731
DOC_USP7_MATH_1	306	310	PF00917	0.636
DOC_USP7_MATH_1	39	43	PF00917	0.570
DOC_USP7_MATH_1	396	400	PF00917	0.602
DOC_USP7_MATH_1	449	453	PF00917	0.672
DOC_USP7_MATH_1	458	462	PF00917	0.593
DOC_USP7_MATH_1	46	50	PF00917	0.497
DOC_USP7_MATH_1	482	486	PF00917	0.648
DOC_USP7_MATH_1	599	603	PF00917	0.650
DOC_USP7_MATH_1	664	668	PF00917	0.621
DOC_USP7_MATH_1	720	724	PF00917	0.589
DOC_USP7_MATH_1	91	95	PF00917	0.614
DOC_USP7_MATH_1	98	102	PF00917	0.584
DOC_USP7_UBL2_3	275	279	PF12436	0.504
DOC_WW_Pin1_4	104	109	PF00397	0.607
DOC_WW_Pin1_4	142	147	PF00397	0.530
DOC_WW_Pin1_4	30	35	PF00397	0.623
DOC_WW_Pin1_4	331	336	PF00397	0.808
DOC_WW_Pin1_4	350	355	PF00397	0.524
DOC_WW_Pin1_4	498	503	PF00397	0.550
DOC_WW_Pin1_4	544	549	PF00397	0.649
DOC_WW_Pin1_4	588	593	PF00397	0.618
DOC_WW_Pin1_4	668	673	PF00397	0.587
DOC_WW_Pin1_4	76	81	PF00397	0.581
LIG_14-3-3_CanoR_1	11	17	PF00244	0.572
LIG_14-3-3_CanoR_1	121	127	PF00244	0.654
LIG_14-3-3_CanoR_1	203	210	PF00244	0.571
LIG_14-3-3_CanoR_1	363	367	PF00244	0.655
LIG_14-3-3_CanoR_1	397	401	PF00244	0.599
LIG_14-3-3_CanoR_1	402	406	PF00244	0.521
LIG_14-3-3_CanoR_1	529	539	PF00244	0.538
LIG_14-3-3_CanoR_1	600	609	PF00244	0.553
LIG_14-3-3_CanoR_1	642	651	PF00244	0.673
LIG_14-3-3_CanoR_1	676	685	PF00244	0.546
LIG_14-3-3_CanoR_1	747	756	PF00244	0.571
LIG_BIR_III_2	499	503	PF00653	0.608
LIG_BIR_III_4	391	395	PF00653	0.629
LIG_CaM_IQ_9	60	75	PF13499	0.587
LIG_deltaCOP1_diTrp_1	414	418	PF00928	0.572
LIG_Dynein_DLC8_1	59	65	PF01221	0.611
LIG_FHA_1	211	217	PF00498	0.483
LIG_FHA_1	269	275	PF00498	0.542
LIG_FHA_1	332	338	PF00498	0.611
LIG_FHA_1	589	595	PF00498	0.623
LIG_FHA_1	638	644	PF00498	0.578
LIG_FHA_1	737	743	PF00498	0.539
LIG_FHA_1	771	777	PF00498	0.552
LIG_FHA_1	79	85	PF00498	0.597
LIG_GBD_Chelix_1	571	579	PF00786	0.559
LIG_Integrin_RGD_1	118	120	PF01839	0.631
LIG_Integrin_RGD_1	136	138	PF01839	0.512
LIG_Integrin_RGD_1	408	410	PF01839	0.539
LIG_LIR_Apic_2	187	192	PF02991	0.497
LIG_LIR_Gen_1	353	364	PF02991	0.631
LIG_LIR_Gen_1	87	98	PF02991	0.562
LIG_LIR_Nem_3	15	19	PF02991	0.536
LIG_LIR_Nem_3	353	359	PF02991	0.545
LIG_LIR_Nem_3	414	419	PF02991	0.571
LIG_LIR_Nem_3	87	93	PF02991	0.561
LIG_MYND_1	464	468	PF01753	0.556
LIG_NRBOX	536	542	PF00104	0.607
LIG_PDZ_Class_2	773	778	PF00595	0.589
LIG_Pex14_1	415	419	PF04695	0.499
LIG_Pex14_2	12	16	PF04695	0.479
LIG_SH2_CRK	189	193	PF00017	0.625
LIG_SH2_CRK	90	94	PF00017	0.562
LIG_SH2_NCK_1	497	501	PF00017	0.623
LIG_SH2_SRC	20	23	PF00017	0.629
LIG_SH2_STAT5	195	198	PF00017	0.490
LIG_SH2_STAT5	419	422	PF00017	0.505
LIG_SH2_STAT5	497	500	PF00017	0.618
LIG_SH3_2	595	600	PF14604	0.628
LIG_SH3_3	123	129	PF00018	0.656
LIG_SH3_3	28	34	PF00018	0.623
LIG_SH3_3	329	335	PF00018	0.604
LIG_SH3_3	348	354	PF00018	0.515
LIG_SH3_3	545	551	PF00018	0.575
LIG_SH3_3	563	569	PF00018	0.558
LIG_SH3_3	579	585	PF00018	0.544
LIG_SH3_3	589	595	PF00018	0.639
LIG_SH3_3	633	639	PF00018	0.660
LIG_SH3_3	645	651	PF00018	0.627
LIG_SH3_3	658	664	PF00018	0.539
LIG_SH3_3	74	80	PF00018	0.693
LIG_SUMO_SIM_anti_2	239	245	PF11976	0.549
LIG_SUMO_SIM_par_1	327	334	PF11976	0.588
LIG_TRAF2_1	237	240	PF00917	0.503
LIG_WRC_WIRS_1	523	528	PF05994	0.541
MOD_CDK_SPK_2	350	355	PF00069	0.524
MOD_CDK_SPxxK_3	76	83	PF00069	0.621
MOD_CK1_1	100	106	PF00069	0.634
MOD_CK1_1	309	315	PF00069	0.595
MOD_CK1_1	485	491	PF00069	0.626
MOD_CK1_1	56	62	PF00069	0.615
MOD_CK1_1	69	75	PF00069	0.632
MOD_CK2_1	29	35	PF00069	0.623
MOD_CK2_1	76	82	PF00069	0.634
MOD_CMANNOS	415	418	PF00535	0.500
MOD_Cter_Amidation	301	304	PF01082	0.643
MOD_GlcNHglycan	198	201	PF01048	0.514
MOD_GlcNHglycan	338	341	PF01048	0.586
MOD_GlcNHglycan	370	373	PF01048	0.650
MOD_GlcNHglycan	380	383	PF01048	0.595
MOD_GlcNHglycan	433	437	PF01048	0.680
MOD_GlcNHglycan	445	448	PF01048	0.585
MOD_GlcNHglycan	460	463	PF01048	0.581
MOD_GlcNHglycan	470	473	PF01048	0.566
MOD_GlcNHglycan	48	51	PF01048	0.640
MOD_GlcNHglycan	558	561	PF01048	0.732
MOD_GlcNHglycan	588	591	PF01048	0.604
MOD_GlcNHglycan	603	606	PF01048	0.660
MOD_GlcNHglycan	611	615	PF01048	0.679
MOD_GlcNHglycan	644	647	PF01048	0.579
MOD_GlcNHglycan	673	676	PF01048	0.673
MOD_GlcNHglycan	679	682	PF01048	0.648
MOD_GlcNHglycan	689	692	PF01048	0.492
MOD_GlcNHglycan	722	725	PF01048	0.623
MOD_GSK3_1	166	173	PF00069	0.539
MOD_GSK3_1	206	213	PF00069	0.487
MOD_GSK3_1	292	299	PF00069	0.607
MOD_GSK3_1	327	334	PF00069	0.694
MOD_GSK3_1	468	475	PF00069	0.710
MOD_GSK3_1	481	488	PF00069	0.663
MOD_GSK3_1	56	63	PF00069	0.755
MOD_GSK3_1	586	593	PF00069	0.642
MOD_GSK3_1	637	644	PF00069	0.762
MOD_GSK3_1	664	671	PF00069	0.651
MOD_GSK3_1	98	105	PF00069	0.556
MOD_N-GLC_1	122	127	PF02516	0.632
MOD_N-GLC_1	458	463	PF02516	0.513
MOD_N-GLC_1	485	490	PF02516	0.616
MOD_NEK2_1	12	17	PF00069	0.569
MOD_NEK2_1	184	189	PF00069	0.480
MOD_NEK2_1	248	253	PF00069	0.692
MOD_NEK2_1	307	312	PF00069	0.704
MOD_NEK2_1	362	367	PF00069	0.628
MOD_NEK2_1	586	591	PF00069	0.558
MOD_NEK2_1	618	623	PF00069	0.516
MOD_NEK2_1	84	89	PF00069	0.598
MOD_NEK2_2	396	401	PF00069	0.602
MOD_NEK2_2	632	637	PF00069	0.627
MOD_PIKK_1	296	302	PF00454	0.574
MOD_PIKK_1	530	536	PF00454	0.543
MOD_PIKK_1	60	66	PF00454	0.664
MOD_PK_1	401	407	PF00069	0.604
MOD_PKA_1	401	407	PF00069	0.582
MOD_PKA_2	165	171	PF00069	0.559
MOD_PKA_2	362	368	PF00069	0.563
MOD_PKA_2	396	402	PF00069	0.599
MOD_PKA_2	482	488	PF00069	0.606
MOD_PKA_2	56	62	PF00069	0.599
MOD_PKA_2	599	605	PF00069	0.560
MOD_PKA_2	641	647	PF00069	0.630
MOD_PKA_2	675	681	PF00069	0.584
MOD_Plk_1	122	128	PF00069	0.631
MOD_Plk_1	248	254	PF00069	0.531
MOD_Plk_1	619	625	PF00069	0.561
MOD_Plk_4	15	21	PF00069	0.552
MOD_Plk_4	327	333	PF00069	0.604
MOD_Plk_4	362	368	PF00069	0.600
MOD_Plk_4	4	10	PF00069	0.557
MOD_Plk_4	619	625	PF00069	0.492
MOD_Plk_4	650	656	PF00069	0.588
MOD_ProDKin_1	104	110	PF00069	0.608
MOD_ProDKin_1	142	148	PF00069	0.524
MOD_ProDKin_1	30	36	PF00069	0.621
MOD_ProDKin_1	331	337	PF00069	0.805
MOD_ProDKin_1	350	356	PF00069	0.525
MOD_ProDKin_1	498	504	PF00069	0.545
MOD_ProDKin_1	544	550	PF00069	0.655
MOD_ProDKin_1	588	594	PF00069	0.620
MOD_ProDKin_1	668	674	PF00069	0.586
MOD_ProDKin_1	76	82	PF00069	0.577
MOD_SUMO_for_1	274	277	PF00179	0.578
TRG_DiLeu_BaEn_1	239	244	PF01217	0.508
TRG_ENDOCYTIC_2	419	422	PF00928	0.689
TRG_ENDOCYTIC_2	90	93	PF00928	0.562
TRG_ER_diArg_1	218	221	PF00400	0.511
TRG_ER_diArg_1	233	235	PF00400	0.544
TRG_ER_diArg_1	400	402	PF00400	0.607
TRG_ER_diArg_1	514	516	PF00400	0.609
TRG_ER_diArg_1	528	530	PF00400	0.494
TRG_NLS_MonoExtN_4	710	717	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	516	521	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4D6	Leptomonas seymouri	35%	100%
A4H4Q1	Leishmania braziliensis	62%	95%
A4HSY1	Leishmania infantum	99%	100%
E9AKW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
Q4QIY8	Leishmania major	87%	100%