SET domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPJ6_LEIDO

TriTrypDb:

LdBPK_061040.1 , LdCL_060015500 , LDHU3_06.1180

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WPJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0042799	histone H4K20 methyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.471
CLV_NRD_NRD_1	170	172	PF00675	0.493
CLV_NRD_NRD_1	234	236	PF00675	0.197
CLV_NRD_NRD_1	442	444	PF00675	0.239
CLV_NRD_NRD_1	480	482	PF00675	0.362
CLV_NRD_NRD_1	499	501	PF00675	0.373
CLV_NRD_NRD_1	83	85	PF00675	0.453
CLV_PCSK_KEX2_1	134	136	PF00082	0.579
CLV_PCSK_KEX2_1	170	172	PF00082	0.487
CLV_PCSK_KEX2_1	234	236	PF00082	0.197
CLV_PCSK_KEX2_1	31	33	PF00082	0.504
CLV_PCSK_KEX2_1	442	444	PF00082	0.258
CLV_PCSK_KEX2_1	499	501	PF00082	0.446
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.372
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.330
CLV_PCSK_SKI1_1	175	179	PF00082	0.507
CLV_PCSK_SKI1_1	295	299	PF00082	0.309
CLV_PCSK_SKI1_1	323	327	PF00082	0.204
CLV_PCSK_SKI1_1	481	485	PF00082	0.281
DEG_APCC_DBOX_1	322	330	PF00400	0.414
DOC_MAPK_gen_1	456	466	PF00069	0.404
DOC_PP2B_LxvP_1	346	349	PF13499	0.426
DOC_USP7_MATH_1	112	116	PF00917	0.506
DOC_USP7_MATH_1	187	191	PF00917	0.409
DOC_USP7_MATH_1	204	208	PF00917	0.552
DOC_USP7_MATH_1	247	251	PF00917	0.417
DOC_USP7_MATH_1	426	430	PF00917	0.468
DOC_WW_Pin1_4	175	180	PF00397	0.405
DOC_WW_Pin1_4	209	214	PF00397	0.479
DOC_WW_Pin1_4	430	435	PF00397	0.545
LIG_14-3-3_CanoR_1	323	331	PF00244	0.515
LIG_14-3-3_CanoR_1	442	452	PF00244	0.473
LIG_14-3-3_CanoR_1	63	71	PF00244	0.415
LIG_Actin_WH2_2	162	177	PF00022	0.373
LIG_CtBP_PxDLS_1	105	109	PF00389	0.441
LIG_EH1_1	410	418	PF00400	0.468
LIG_FHA_1	144	150	PF00498	0.701
LIG_FHA_1	176	182	PF00498	0.353
LIG_FHA_1	197	203	PF00498	0.437
LIG_FHA_1	471	477	PF00498	0.382
LIG_FHA_1	50	56	PF00498	0.345
LIG_FHA_1	89	95	PF00498	0.353
LIG_FHA_2	472	478	PF00498	0.323
LIG_FHA_2	63	69	PF00498	0.387
LIG_GBD_Chelix_1	372	380	PF00786	0.204
LIG_LIR_Gen_1	392	402	PF02991	0.422
LIG_LIR_Nem_3	269	275	PF02991	0.444
LIG_LIR_Nem_3	392	397	PF02991	0.433
LIG_LIR_Nem_3	462	468	PF02991	0.400
LIG_NRBOX	392	398	PF00104	0.511
LIG_PCNA_PIPBox_1	387	396	PF02747	0.407
LIG_SH2_CRK	411	415	PF00017	0.421
LIG_SH2_NCK_1	34	38	PF00017	0.300
LIG_SH2_NCK_1	360	364	PF00017	0.443
LIG_SH2_SRC	360	363	PF00017	0.509
LIG_SH2_STAP1	34	38	PF00017	0.276
LIG_SH2_STAT3	12	15	PF00017	0.513
LIG_SH2_STAT3	20	23	PF00017	0.260
LIG_SH2_STAT3	64	67	PF00017	0.313
LIG_SH2_STAT5	155	158	PF00017	0.371
LIG_SH2_STAT5	20	23	PF00017	0.368
LIG_SH2_STAT5	262	265	PF00017	0.443
LIG_SH2_STAT5	40	43	PF00017	0.319
LIG_SH2_STAT5	493	496	PF00017	0.449
LIG_SH2_STAT5	64	67	PF00017	0.313
LIG_SH3_3	249	255	PF00018	0.459
LIG_TRAF2_1	13	16	PF00917	0.359
LIG_TRAF2_1	77	80	PF00917	0.430
MOD_CK1_1	107	113	PF00069	0.663
MOD_CK1_1	237	243	PF00069	0.366
MOD_CK1_1	279	285	PF00069	0.458
MOD_CK1_1	307	313	PF00069	0.352
MOD_CK1_1	327	333	PF00069	0.253
MOD_CK1_1	412	418	PF00069	0.378
MOD_CK1_1	66	72	PF00069	0.546
MOD_CK2_1	315	321	PF00069	0.379
MOD_CK2_1	443	449	PF00069	0.265
MOD_CK2_1	86	92	PF00069	0.419
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.379
MOD_GlcNHglycan	112	115	PF01048	0.545
MOD_GlcNHglycan	120	123	PF01048	0.406
MOD_GlcNHglycan	175	178	PF01048	0.483
MOD_GlcNHglycan	231	234	PF01048	0.309
MOD_GlcNHglycan	249	252	PF01048	0.293
MOD_GlcNHglycan	306	309	PF01048	0.306
MOD_GlcNHglycan	317	320	PF01048	0.357
MOD_GlcNHglycan	376	379	PF01048	0.382
MOD_GlcNHglycan	405	408	PF01048	0.245
MOD_GlcNHglycan	428	431	PF01048	0.328
MOD_GlcNHglycan	445	448	PF01048	0.282
MOD_GlcNHglycan	59	63	PF01048	0.282
MOD_GSK3_1	104	111	PF00069	0.491
MOD_GSK3_1	114	121	PF00069	0.627
MOD_GSK3_1	139	146	PF00069	0.502
MOD_GSK3_1	169	176	PF00069	0.492
MOD_GSK3_1	235	242	PF00069	0.332
MOD_GSK3_1	426	433	PF00069	0.378
MOD_GSK3_1	58	65	PF00069	0.352
MOD_N-GLC_1	417	422	PF02516	0.285
MOD_NEK2_1	108	113	PF00069	0.730
MOD_NEK2_1	196	201	PF00069	0.288
MOD_NEK2_1	403	408	PF00069	0.334
MOD_NEK2_1	78	83	PF00069	0.416
MOD_NEK2_2	26	31	PF00069	0.322
MOD_PIKK_1	114	120	PF00454	0.459
MOD_PIKK_1	63	69	PF00454	0.422
MOD_PK_1	235	241	PF00069	0.220
MOD_PKA_1	234	240	PF00069	0.220
MOD_PKA_2	139	145	PF00069	0.492
MOD_PKA_2	169	175	PF00069	0.386
MOD_PKA_2	204	210	PF00069	0.345
MOD_PKA_2	234	240	PF00069	0.280
MOD_PKA_2	62	68	PF00069	0.352
MOD_Plk_4	150	156	PF00069	0.374
MOD_Plk_4	16	22	PF00069	0.330
MOD_Plk_4	204	210	PF00069	0.363
MOD_Plk_4	389	395	PF00069	0.236
MOD_Plk_4	409	415	PF00069	0.138
MOD_Plk_4	66	72	PF00069	0.423
MOD_Plk_4	94	100	PF00069	0.496
MOD_ProDKin_1	175	181	PF00069	0.398
MOD_ProDKin_1	209	215	PF00069	0.336
MOD_ProDKin_1	430	436	PF00069	0.428
MOD_SUMO_for_1	133	136	PF00179	0.386
MOD_SUMO_for_1	149	152	PF00179	0.542
MOD_SUMO_rev_2	220	225	PF00179	0.349
MOD_SUMO_rev_2	477	484	PF00179	0.311
TRG_DiLeu_BaEn_1	211	216	PF01217	0.378
TRG_DiLeu_BaEn_4	479	485	PF01217	0.305
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.265
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.298
TRG_ENDOCYTIC_2	411	414	PF00928	0.238
TRG_ER_diArg_1	169	171	PF00400	0.492
TRG_ER_diArg_1	2	5	PF00400	0.431
TRG_ER_diArg_1	21	24	PF00400	0.281
TRG_ER_diArg_1	498	500	PF00400	0.324
TRG_NES_CRM1_1	389	401	PF08389	0.235
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P571	Leptomonas seymouri	66%	100%
A0A0S4JRV8	Bodo saltans	39%	100%
A0A1X0NL17	Trypanosomatidae	47%	100%
A0A3R7KQ99	Trypanosoma rangeli	46%	100%
A0A3S7WYH0	Leishmania donovani	24%	100%
A4H4R3	Leishmania braziliensis	80%	100%
A4HDM9	Leishmania braziliensis	27%	100%
A4HSZ2	Leishmania infantum	100%	100%
C9ZTM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AH76	Leishmania infantum	24%	100%
E9AKX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
E9AX14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAG2	Leishmania major	26%	100%
Q4QIX6	Leishmania major	94%	100%
Q5ZIZ2	Gallus gallus	24%	100%
V5BT58	Trypanosoma cruzi	45%	100%