Qb-SNARE protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPJ4_LEIDO

TriTrypDb:

LdBPK_060850.1 , LdCL_060013600 , LDHU3_06.0980

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A0A3S7WPJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPJ4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.559
CLV_C14_Caspase3-7	97	101	PF00656	0.666
CLV_NRD_NRD_1	114	116	PF00675	0.570
CLV_NRD_NRD_1	143	145	PF00675	0.392
CLV_NRD_NRD_1	36	38	PF00675	0.425
CLV_NRD_NRD_1	376	378	PF00675	0.373
CLV_NRD_NRD_1	379	381	PF00675	0.344
CLV_NRD_NRD_1	83	85	PF00675	0.404
CLV_PCSK_FUR_1	377	381	PF00082	0.416
CLV_PCSK_KEX2_1	114	116	PF00082	0.570
CLV_PCSK_KEX2_1	143	145	PF00082	0.415
CLV_PCSK_KEX2_1	2	4	PF00082	0.492
CLV_PCSK_KEX2_1	36	38	PF00082	0.424
CLV_PCSK_KEX2_1	376	378	PF00082	0.399
CLV_PCSK_KEX2_1	379	381	PF00082	0.370
CLV_PCSK_KEX2_1	45	47	PF00082	0.347
CLV_PCSK_KEX2_1	83	85	PF00082	0.406
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.492
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.409
CLV_PCSK_PC7_1	139	145	PF00082	0.414
CLV_PCSK_SKI1_1	209	213	PF00082	0.444
CLV_PCSK_SKI1_1	312	316	PF00082	0.414
CLV_PCSK_SKI1_1	46	50	PF00082	0.482
CLV_PCSK_SKI1_1	68	72	PF00082	0.364
DEG_APCC_DBOX_1	67	75	PF00400	0.543
DEG_Nend_UBRbox_1	1	4	PF02207	0.701
DEG_SPOP_SBC_1	122	126	PF00917	0.560
DEG_SPOP_SBC_1	169	173	PF00917	0.677
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.724
DOC_MAPK_gen_1	2	13	PF00069	0.671
DOC_MAPK_MEF2A_6	6	15	PF00069	0.600
DOC_USP7_MATH_1	122	126	PF00917	0.713
DOC_USP7_MATH_1	169	173	PF00917	0.713
DOC_USP7_MATH_1	180	184	PF00917	0.737
DOC_USP7_MATH_1	233	237	PF00917	0.736
DOC_USP7_MATH_1	249	253	PF00917	0.743
DOC_USP7_MATH_1	258	262	PF00917	0.766
DOC_USP7_MATH_1	268	272	PF00917	0.714
DOC_USP7_MATH_1	291	295	PF00917	0.719
DOC_USP7_MATH_1	360	364	PF00917	0.544
DOC_WW_Pin1_4	276	281	PF00397	0.611
DOC_WW_Pin1_4	294	299	PF00397	0.690
DOC_WW_Pin1_4	48	53	PF00397	0.608
LIG_14-3-3_CanoR_1	215	221	PF00244	0.676
LIG_14-3-3_CanoR_1	28	34	PF00244	0.705
LIG_14-3-3_CanoR_1	3	9	PF00244	0.637
LIG_14-3-3_CanoR_1	331	339	PF00244	0.572
LIG_14-3-3_CanoR_1	46	51	PF00244	0.646
LIG_14-3-3_CanoR_1	83	89	PF00244	0.616
LIG_14-3-3_CterR_2	409	412	PF00244	0.363
LIG_Actin_WH2_2	1	16	PF00022	0.588
LIG_Actin_WH2_2	393	411	PF00022	0.339
LIG_Actin_WH2_2	57	74	PF00022	0.550
LIG_CaM_IQ_9	369	385	PF13499	0.610
LIG_EH1_1	392	400	PF00400	0.422
LIG_eIF4E_1	393	399	PF01652	0.422
LIG_FHA_1	108	114	PF00498	0.639
LIG_FHA_1	126	132	PF00498	0.638
LIG_FHA_2	29	35	PF00498	0.658
LIG_GBD_Chelix_1	394	402	PF00786	0.452
LIG_LIR_Gen_1	313	320	PF02991	0.559
LIG_LIR_Nem_3	308	314	PF02991	0.541
LIG_LIR_Nem_3	57	61	PF02991	0.546
LIG_MAD2	215	223	PF02301	0.635
LIG_NRBOX	396	402	PF00104	0.422
LIG_NRBOX	403	409	PF00104	0.423
LIG_Pex14_2	311	315	PF04695	0.598
LIG_SH2_STAT5	393	396	PF00017	0.339
LIG_SH3_3	227	233	PF00018	0.782
LIG_SUMO_SIM_par_1	297	304	PF11976	0.620
LIG_TRAF2_1	279	282	PF00917	0.667
LIG_TRAF2_1	351	354	PF00917	0.608
LIG_TRAF2_1	92	95	PF00917	0.742
LIG_Vh1_VBS_1	392	410	PF01044	0.368
MOD_CDK_SPxK_1	48	54	PF00069	0.562
MOD_CK1_1	123	129	PF00069	0.621
MOD_CK1_1	183	189	PF00069	0.552
MOD_CK1_1	236	242	PF00069	0.687
MOD_CK1_1	252	258	PF00069	0.635
MOD_CK1_1	26	32	PF00069	0.711
MOD_CK1_1	261	267	PF00069	0.608
MOD_CK1_1	294	300	PF00069	0.616
MOD_CK1_1	4	10	PF00069	0.529
MOD_CK2_1	121	127	PF00069	0.564
MOD_CK2_1	276	282	PF00069	0.770
MOD_CK2_1	28	34	PF00069	0.629
MOD_CK2_1	301	307	PF00069	0.477
MOD_CK2_1	89	95	PF00069	0.726
MOD_Cter_Amidation	81	84	PF01082	0.471
MOD_GlcNHglycan	172	175	PF01048	0.700
MOD_GlcNHglycan	181	185	PF01048	0.650
MOD_GlcNHglycan	235	238	PF01048	0.705
MOD_GlcNHglycan	264	267	PF01048	0.708
MOD_GlcNHglycan	272	275	PF01048	0.730
MOD_GlcNHglycan	303	306	PF01048	0.653
MOD_GlcNHglycan	361	365	PF01048	0.541
MOD_GlcNHglycan	85	88	PF01048	0.549
MOD_GSK3_1	121	128	PF00069	0.601
MOD_GSK3_1	14	21	PF00069	0.647
MOD_GSK3_1	24	31	PF00069	0.752
MOD_GSK3_1	258	265	PF00069	0.612
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	135	140	PF00069	0.472
MOD_NEK2_1	262	267	PF00069	0.501
MOD_NEK2_1	301	306	PF00069	0.517
MOD_NEK2_1	314	319	PF00069	0.516
MOD_NEK2_1	385	390	PF00069	0.442
MOD_PIKK_1	369	375	PF00454	0.479
MOD_PKA_1	83	89	PF00069	0.522
MOD_PKA_2	13	19	PF00069	0.630
MOD_PKA_2	268	274	PF00069	0.724
MOD_PKA_2	330	336	PF00069	0.456
MOD_PKA_2	82	88	PF00069	0.510
MOD_Plk_1	107	113	PF00069	0.547
MOD_Plk_1	385	391	PF00069	0.523
MOD_ProDKin_1	276	282	PF00069	0.515
MOD_ProDKin_1	294	300	PF00069	0.626
MOD_ProDKin_1	48	54	PF00069	0.507
TRG_DiLeu_BaEn_1	108	113	PF01217	0.678
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.646
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.514
TRG_DiLeu_LyEn_5	108	113	PF01217	0.594
TRG_ENDOCYTIC_2	208	211	PF00928	0.539
TRG_ENDOCYTIC_2	58	61	PF00928	0.421
TRG_ER_diArg_1	113	115	PF00400	0.619
TRG_ER_diArg_1	376	379	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P557	Leptomonas seymouri	47%	92%
A0A0S4JA95	Bodo saltans	25%	100%
A0A1X0NMF9	Trypanosomatidae	28%	100%
A0A422NZG0	Trypanosoma rangeli	30%	100%
A4H4P4	Leishmania braziliensis	76%	100%
A4HSX4	Leishmania infantum	100%	100%
E9AKW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QIZ5	Leishmania major	87%	100%
V5BT43	Trypanosoma cruzi	31%	94%