Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-tRNA hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPI5_LEIDO

TriTrypDb:

LdBPK_060940.1 , LdCL_060014500 , LDHU3_06.1080

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7WPI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPI5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0004045	aminoacyl-tRNA hydrolase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016788	hydrolase activity, acting on ester bonds	3	18
GO:0052689	carboxylic ester hydrolase activity	4	18
GO:0140098	catalytic activity, acting on RNA	3	18
GO:0140101	catalytic activity, acting on a tRNA	4	18
GO:0140640	catalytic activity, acting on a nucleic acid	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	38	40	PF00675	0.561
CLV_NRD_NRD_1	70	72	PF00675	0.485
CLV_NRD_NRD_1	95	97	PF00675	0.254
CLV_PCSK_KEX2_1	70	72	PF00082	0.455
CLV_PCSK_SKI1_1	133	137	PF00082	0.193
CLV_PCSK_SKI1_1	157	161	PF00082	0.246
CLV_PCSK_SKI1_1	62	66	PF00082	0.393
CLV_PCSK_SKI1_1	90	94	PF00082	0.288
CLV_PCSK_SKI1_1	97	101	PF00082	0.264
DEG_Nend_UBRbox_2	1	3	PF02207	0.412
DOC_PP4_FxxP_1	69	72	PF00568	0.608
DOC_USP7_MATH_1	123	127	PF00917	0.558
DOC_USP7_MATH_1	152	156	PF00917	0.393
DOC_USP7_MATH_1	31	35	PF00917	0.390
DOC_USP7_MATH_1	78	82	PF00917	0.662
DOC_WW_Pin1_4	128	133	PF00397	0.596
DOC_WW_Pin1_4	9	14	PF00397	0.494
LIG_14-3-3_CanoR_1	77	83	PF00244	0.604
LIG_14-3-3_CanoR_1	9	13	PF00244	0.398
LIG_Actin_WH2_2	86	102	PF00022	0.426
LIG_BRCT_BRCA1_1	46	50	PF00533	0.458
LIG_FHA_1	213	219	PF00498	0.502
LIG_LIR_Apic_2	67	72	PF02991	0.597
LIG_LIR_Gen_1	14	23	PF02991	0.548
LIG_LIR_Nem_3	14	19	PF02991	0.546
LIG_OCRL_FandH_1	15	27	PF00620	0.373
LIG_Pex14_1	143	147	PF04695	0.487
LIG_Pex14_2	42	46	PF04695	0.259
LIG_Pex14_2	50	54	PF04695	0.304
LIG_SH2_STAP1	3	7	PF00017	0.426
LIG_SH2_STAT5	183	186	PF00017	0.515
LIG_SH3_3	35	41	PF00018	0.417
LIG_UBA3_1	168	173	PF00899	0.513
MOD_CDK_SPK_2	128	133	PF00069	0.433
MOD_CK1_1	11	17	PF00069	0.499
MOD_CK1_1	126	132	PF00069	0.471
MOD_CK1_1	153	159	PF00069	0.517
MOD_CK2_1	24	30	PF00069	0.406
MOD_CMANNOS	143	146	PF00535	0.283
MOD_GlcNHglycan	133	136	PF01048	0.376
MOD_GlcNHglycan	139	142	PF01048	0.397
MOD_GlcNHglycan	152	155	PF01048	0.279
MOD_GlcNHglycan	33	36	PF01048	0.694
MOD_GSK3_1	123	130	PF00069	0.499
MOD_GSK3_1	78	85	PF00069	0.662
MOD_N-GLC_1	150	155	PF02516	0.176
MOD_NEK2_1	124	129	PF00069	0.512
MOD_NEK2_1	50	55	PF00069	0.294
MOD_NEK2_1	64	69	PF00069	0.671
MOD_NEK2_1	99	104	PF00069	0.546
MOD_PIKK_1	188	194	PF00454	0.439
MOD_PKA_2	8	14	PF00069	0.487
MOD_Plk_4	11	17	PF00069	0.409
MOD_Plk_4	196	202	PF00069	0.457
MOD_Plk_4	206	212	PF00069	0.468
MOD_Plk_4	64	70	PF00069	0.669
MOD_ProDKin_1	128	134	PF00069	0.596
MOD_ProDKin_1	9	15	PF00069	0.495
TRG_ER_diArg_1	69	71	PF00400	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P574	Leptomonas seymouri	60%	100%
A0A0N1IHT0	Leptomonas seymouri	33%	92%
A0A0S4JH35	Bodo saltans	48%	91%
A0A1X0NKN2	Trypanosomatidae	54%	100%
A0A1X0P1N6	Trypanosomatidae	27%	85%
A0A3Q8IED2	Leishmania donovani	31%	100%
A0A3R7N0D9	Trypanosoma rangeli	49%	100%
A4H4Q4	Leishmania braziliensis	78%	100%
A4HIH3	Leishmania braziliensis	28%	100%
A4I5S0	Leishmania infantum	31%	100%
C9ZR39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZTL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AKW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B115	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q751	Leishmania major	31%	100%
Q4QIY6	Leishmania major	90%	100%