Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPI2_LEIDO

TriTrypDb:

LdBPK_060770.1 , LdCL_060012800 , LDHU3_06.0900

Length:

1064

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.552
CLV_C14_Caspase3-7	507	511	PF00656	0.672
CLV_C14_Caspase3-7	580	584	PF00656	0.624
CLV_C14_Caspase3-7	7	11	PF00656	0.463
CLV_C14_Caspase3-7	812	816	PF00656	0.502
CLV_NRD_NRD_1	1044	1046	PF00675	0.559
CLV_NRD_NRD_1	319	321	PF00675	0.694
CLV_NRD_NRD_1	344	346	PF00675	0.689
CLV_NRD_NRD_1	356	358	PF00675	0.585
CLV_NRD_NRD_1	488	490	PF00675	0.665
CLV_NRD_NRD_1	556	558	PF00675	0.633
CLV_NRD_NRD_1	595	597	PF00675	0.670
CLV_NRD_NRD_1	614	616	PF00675	0.541
CLV_NRD_NRD_1	654	656	PF00675	0.558
CLV_NRD_NRD_1	740	742	PF00675	0.527
CLV_NRD_NRD_1	813	815	PF00675	0.543
CLV_NRD_NRD_1	837	839	PF00675	0.509
CLV_NRD_NRD_1	889	891	PF00675	0.504
CLV_PCSK_KEX2_1	1044	1046	PF00082	0.559
CLV_PCSK_KEX2_1	319	321	PF00082	0.694
CLV_PCSK_KEX2_1	343	345	PF00082	0.684
CLV_PCSK_KEX2_1	355	357	PF00082	0.597
CLV_PCSK_KEX2_1	488	490	PF00082	0.696
CLV_PCSK_KEX2_1	556	558	PF00082	0.633
CLV_PCSK_KEX2_1	577	579	PF00082	0.693
CLV_PCSK_KEX2_1	595	597	PF00082	0.524
CLV_PCSK_KEX2_1	614	616	PF00082	0.561
CLV_PCSK_KEX2_1	654	656	PF00082	0.562
CLV_PCSK_KEX2_1	740	742	PF00082	0.527
CLV_PCSK_KEX2_1	813	815	PF00082	0.543
CLV_PCSK_KEX2_1	836	838	PF00082	0.517
CLV_PCSK_KEX2_1	889	891	PF00082	0.504
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.667
CLV_PCSK_SKI1_1	1007	1011	PF00082	0.566
CLV_PCSK_SKI1_1	20	24	PF00082	0.466
CLV_PCSK_SKI1_1	678	682	PF00082	0.439
CLV_PCSK_SKI1_1	838	842	PF00082	0.502
DEG_APCC_DBOX_1	824	832	PF00400	0.584
DEG_APCC_DBOX_1	922	930	PF00400	0.494
DEG_Nend_UBRbox_4	1	3	PF02207	0.467
DEG_SCF_FBW7_1	1	7	PF00400	0.458
DEG_SCF_FBW7_1	567	573	PF00400	0.576
DEG_SCF_TRCP1_1	298	303	PF00400	0.655
DEG_SPOP_SBC_1	1013	1017	PF00917	0.664
DEG_SPOP_SBC_1	136	140	PF00917	0.579
DOC_ANK_TNKS_1	356	363	PF00023	0.636
DOC_CKS1_1	1	6	PF01111	0.460
DOC_CKS1_1	567	572	PF01111	0.575
DOC_CYCLIN_RxL_1	672	684	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	26	29	PF00134	0.445
DOC_MAPK_DCC_7	557	567	PF00069	0.630
DOC_MAPK_gen_1	921	928	PF00069	0.488
DOC_PP2B_LxvP_1	121	124	PF13499	0.496
DOC_PP2B_LxvP_1	26	29	PF13499	0.445
DOC_PP2B_LxvP_1	951	954	PF13499	0.616
DOC_SPAK_OSR1_1	699	703	PF12202	0.495
DOC_USP7_MATH_1	1013	1017	PF00917	0.664
DOC_USP7_MATH_1	109	113	PF00917	0.489
DOC_USP7_MATH_1	124	128	PF00917	0.514
DOC_USP7_MATH_1	136	140	PF00917	0.571
DOC_USP7_MATH_1	212	216	PF00917	0.653
DOC_USP7_MATH_1	286	290	PF00917	0.634
DOC_USP7_MATH_1	387	391	PF00917	0.633
DOC_USP7_MATH_1	53	57	PF00917	0.490
DOC_USP7_MATH_1	570	574	PF00917	0.669
DOC_USP7_MATH_1	605	609	PF00917	0.694
DOC_USP7_MATH_1	664	668	PF00917	0.423
DOC_USP7_MATH_1	752	756	PF00917	0.585
DOC_USP7_MATH_1	761	765	PF00917	0.555
DOC_USP7_MATH_1	907	911	PF00917	0.539
DOC_USP7_MATH_1	974	978	PF00917	0.552
DOC_USP7_UBL2_3	921	925	PF12436	0.485
DOC_WW_Pin1_4	151	156	PF00397	0.691
DOC_WW_Pin1_4	225	230	PF00397	0.680
DOC_WW_Pin1_4	320	325	PF00397	0.663
DOC_WW_Pin1_4	369	374	PF00397	0.675
DOC_WW_Pin1_4	453	458	PF00397	0.713
DOC_WW_Pin1_4	566	571	PF00397	0.578
DOC_WW_Pin1_4	748	753	PF00397	0.596
DOC_WW_Pin1_4	762	767	PF00397	0.536
DOC_WW_Pin1_4	768	773	PF00397	0.505
DOC_WW_Pin1_4	95	100	PF00397	0.535
LIG_14-3-3_CanoR_1	100	105	PF00244	0.537
LIG_14-3-3_CanoR_1	301	309	PF00244	0.750
LIG_14-3-3_CanoR_1	331	339	PF00244	0.594
LIG_14-3-3_CanoR_1	415	420	PF00244	0.600
LIG_14-3-3_CanoR_1	42	48	PF00244	0.457
LIG_14-3-3_CanoR_1	421	429	PF00244	0.551
LIG_14-3-3_CanoR_1	566	570	PF00244	0.605
LIG_14-3-3_CanoR_1	578	587	PF00244	0.542
LIG_14-3-3_CanoR_1	748	752	PF00244	0.528
LIG_14-3-3_CanoR_1	75	80	PF00244	0.478
LIG_14-3-3_CanoR_1	858	864	PF00244	0.514
LIG_AP2alpha_2	546	548	PF02296	0.589
LIG_APCC_ABBA_1	707	712	PF00400	0.480
LIG_BIR_III_4	403	407	PF00653	0.552
LIG_BIR_III_4	609	613	PF00653	0.669
LIG_BRCT_BRCA1_1	371	375	PF00533	0.590
LIG_Clathr_ClatBox_1	806	810	PF01394	0.508
LIG_Clathr_ClatBox_1	867	871	PF01394	0.377
LIG_eIF4E_1	79	85	PF01652	0.469
LIG_FHA_1	114	120	PF00498	0.522
LIG_FHA_1	325	331	PF00498	0.636
LIG_FHA_1	334	340	PF00498	0.596
LIG_FHA_1	453	459	PF00498	0.759
LIG_FHA_1	527	533	PF00498	0.662
LIG_FHA_1	635	641	PF00498	0.646
LIG_FHA_1	644	650	PF00498	0.558
LIG_FHA_1	675	681	PF00498	0.524
LIG_FHA_1	785	791	PF00498	0.593
LIG_FHA_1	953	959	PF00498	0.650
LIG_FHA_2	633	639	PF00498	0.696
LIG_FHA_2	646	652	PF00498	0.510
LIG_FHA_2	729	735	PF00498	0.435
LIG_FHA_2	955	961	PF00498	0.667
LIG_GBD_Chelix_1	868	876	PF00786	0.381
LIG_Integrin_RGD_1	492	494	PF01839	0.537
LIG_Integrin_RGD_1	998	1000	PF01839	0.621
LIG_LIR_Apic_2	142	148	PF02991	0.665
LIG_LIR_Gen_1	78	87	PF02991	0.490
LIG_LIR_Nem_3	30	34	PF02991	0.447
LIG_LIR_Nem_3	98	104	PF02991	0.553
LIG_MYND_1	95	99	PF01753	0.511
LIG_PTAP_UEV_1	357	362	PF05743	0.570
LIG_SH2_GRB2like	982	985	PF00017	0.589
LIG_SH2_NCK_1	982	986	PF00017	0.683
LIG_SH2_SRC	980	983	PF00017	0.624
LIG_SH2_STAP1	117	121	PF00017	0.515
LIG_SH2_STAT5	710	713	PF00017	0.477
LIG_SH3_1	181	187	PF00018	0.631
LIG_SH3_1	355	361	PF00018	0.661
LIG_SH3_2	772	777	PF14604	0.668
LIG_SH3_3	101	107	PF00018	0.531
LIG_SH3_3	149	155	PF00018	0.720
LIG_SH3_3	181	187	PF00018	0.695
LIG_SH3_3	192	198	PF00018	0.620
LIG_SH3_3	223	229	PF00018	0.621
LIG_SH3_3	230	236	PF00018	0.632
LIG_SH3_3	26	32	PF00018	0.469
LIG_SH3_3	318	324	PF00018	0.663
LIG_SH3_3	355	361	PF00018	0.661
LIG_SH3_3	367	373	PF00018	0.590
LIG_SH3_3	673	679	PF00018	0.564
LIG_SH3_3	769	775	PF00018	0.695
LIG_SH3_3	82	88	PF00018	0.490
LIG_SUMO_SIM_anti_2	787	792	PF11976	0.579
LIG_SUMO_SIM_anti_2	924	930	PF11976	0.495
LIG_SUMO_SIM_anti_2	955	960	PF11976	0.664
LIG_SUMO_SIM_par_1	784	792	PF11976	0.554
LIG_SUMO_SIM_par_1	865	871	PF11976	0.378
LIG_SUMO_SIM_par_1	954	960	PF11976	0.660
LIG_TRAF2_1	1049	1052	PF00917	0.620
LIG_TRAF2_1	205	208	PF00917	0.657
LIG_TRAF2_1	461	464	PF00917	0.653
LIG_TRAF2_1	542	545	PF00917	0.573
LIG_TRAF2_1	658	661	PF00917	0.540
LIG_TRAF2_1	731	734	PF00917	0.435
LIG_WRC_WIRS_1	685	690	PF05994	0.487
LIG_WW_2	184	187	PF00397	0.650
MOD_CDK_SPK_2	95	100	PF00069	0.491
MOD_CDK_SPxxK_3	453	460	PF00069	0.642
MOD_CK1_1	1016	1022	PF00069	0.625
MOD_CK1_1	127	133	PF00069	0.624
MOD_CK1_1	135	141	PF00069	0.684
MOD_CK1_1	274	280	PF00069	0.790
MOD_CK1_1	299	305	PF00069	0.680
MOD_CK1_1	314	320	PF00069	0.575
MOD_CK1_1	329	335	PF00069	0.567
MOD_CK1_1	374	380	PF00069	0.711
MOD_CK1_1	390	396	PF00069	0.579
MOD_CK1_1	447	453	PF00069	0.775
MOD_CK1_1	503	509	PF00069	0.719
MOD_CK1_1	518	524	PF00069	0.519
MOD_CK1_1	568	574	PF00069	0.771
MOD_CK1_1	58	64	PF00069	0.498
MOD_CK1_1	634	640	PF00069	0.686
MOD_CK1_1	784	790	PF00069	0.587
MOD_CK1_1	862	868	PF00069	0.466
MOD_CK1_1	924	930	PF00069	0.527
MOD_CK2_1	421	427	PF00069	0.560
MOD_CK2_1	458	464	PF00069	0.643
MOD_CK2_1	645	651	PF00069	0.553
MOD_CK2_1	728	734	PF00069	0.435
MOD_CK2_1	924	930	PF00069	0.527
MOD_Cter_Amidation	317	320	PF01082	0.608
MOD_DYRK1A_RPxSP_1	151	155	PF00069	0.690
MOD_DYRK1A_RPxSP_1	320	324	PF00069	0.662
MOD_DYRK1A_RPxSP_1	748	752	PF00069	0.552
MOD_GlcNHglycan	1018	1021	PF01048	0.647
MOD_GlcNHglycan	1030	1033	PF01048	0.573
MOD_GlcNHglycan	129	132	PF01048	0.620
MOD_GlcNHglycan	134	137	PF01048	0.639
MOD_GlcNHglycan	256	259	PF01048	0.838
MOD_GlcNHglycan	273	276	PF01048	0.575
MOD_GlcNHglycan	288	292	PF01048	0.668
MOD_GlcNHglycan	296	301	PF01048	0.655
MOD_GlcNHglycan	366	369	PF01048	0.679
MOD_GlcNHglycan	423	426	PF01048	0.617
MOD_GlcNHglycan	510	513	PF01048	0.726
MOD_GlcNHglycan	572	575	PF01048	0.710
MOD_GlcNHglycan	579	582	PF01048	0.655
MOD_GlcNHglycan	601	604	PF01048	0.652
MOD_GlcNHglycan	754	757	PF01048	0.591
MOD_GlcNHglycan	960	964	PF01048	0.679
MOD_GlcNHglycan	976	979	PF01048	0.513
MOD_GSK3_1	1012	1019	PF00069	0.663
MOD_GSK3_1	107	114	PF00069	0.518
MOD_GSK3_1	132	139	PF00069	0.657
MOD_GSK3_1	212	219	PF00069	0.696
MOD_GSK3_1	254	261	PF00069	0.730
MOD_GSK3_1	270	277	PF00069	0.730
MOD_GSK3_1	296	303	PF00069	0.681
MOD_GSK3_1	307	314	PF00069	0.623
MOD_GSK3_1	320	327	PF00069	0.618
MOD_GSK3_1	329	336	PF00069	0.680
MOD_GSK3_1	369	376	PF00069	0.754
MOD_GSK3_1	444	451	PF00069	0.683
MOD_GSK3_1	495	502	PF00069	0.751
MOD_GSK3_1	504	511	PF00069	0.625
MOD_GSK3_1	565	572	PF00069	0.705
MOD_GSK3_1	573	580	PF00069	0.663
MOD_GSK3_1	632	639	PF00069	0.636
MOD_GSK3_1	643	650	PF00069	0.595
MOD_GSK3_1	748	755	PF00069	0.603
MOD_GSK3_1	789	796	PF00069	0.547
MOD_N-GLC_1	983	988	PF02516	0.588
MOD_NEK2_1	1054	1059	PF00069	0.617
MOD_NEK2_1	119	124	PF00069	0.600
MOD_NEK2_1	132	137	PF00069	0.663
MOD_NEK2_1	309	314	PF00069	0.724
MOD_NEK2_1	375	380	PF00069	0.708
MOD_NEK2_1	469	474	PF00069	0.664
MOD_NEK2_1	499	504	PF00069	0.679
MOD_NEK2_1	565	570	PF00069	0.701
MOD_NEK2_1	89	94	PF00069	0.512
MOD_NEK2_2	11	16	PF00069	0.465
MOD_NEK2_2	495	500	PF00069	0.669
MOD_PIKK_1	500	506	PF00454	0.675
MOD_PIKK_1	632	638	PF00454	0.650
MOD_PIKK_1	702	708	PF00454	0.455
MOD_PIKK_1	778	784	PF00454	0.667
MOD_PIKK_1	907	913	PF00454	0.538
MOD_PIKK_1	998	1004	PF00454	0.598
MOD_PK_1	100	106	PF00069	0.510
MOD_PKA_1	356	362	PF00069	0.576
MOD_PKA_1	577	583	PF00069	0.673
MOD_PKA_2	1054	1060	PF00069	0.619
MOD_PKA_2	300	306	PF00069	0.690
MOD_PKA_2	330	336	PF00069	0.570
MOD_PKA_2	356	362	PF00069	0.587
MOD_PKA_2	444	450	PF00069	0.714
MOD_PKA_2	459	465	PF00069	0.600
MOD_PKA_2	565	571	PF00069	0.655
MOD_PKA_2	577	583	PF00069	0.590
MOD_PKA_2	629	635	PF00069	0.649
MOD_PKA_2	747	753	PF00069	0.532
MOD_PKA_2	859	865	PF00069	0.473
MOD_PKB_1	413	421	PF00069	0.666
MOD_Plk_1	277	283	PF00069	0.606
MOD_Plk_1	287	293	PF00069	0.619
MOD_Plk_1	334	340	PF00069	0.689
MOD_Plk_1	495	501	PF00069	0.670
MOD_Plk_1	515	521	PF00069	0.506
MOD_Plk_1	883	889	PF00069	0.525
MOD_Plk_2-3	684	690	PF00069	0.487
MOD_Plk_4	172	178	PF00069	0.690
MOD_Plk_4	789	795	PF00069	0.543
MOD_Plk_4	797	803	PF00069	0.437
MOD_Plk_4	924	930	PF00069	0.495
MOD_Plk_4	954	960	PF00069	0.660
MOD_ProDKin_1	151	157	PF00069	0.690
MOD_ProDKin_1	225	231	PF00069	0.683
MOD_ProDKin_1	320	326	PF00069	0.663
MOD_ProDKin_1	369	375	PF00069	0.674
MOD_ProDKin_1	453	459	PF00069	0.715
MOD_ProDKin_1	566	572	PF00069	0.576
MOD_ProDKin_1	748	754	PF00069	0.600
MOD_ProDKin_1	762	768	PF00069	0.540
MOD_ProDKin_1	95	101	PF00069	0.538
TRG_DiLeu_BaEn_4	651	657	PF01217	0.478
TRG_DiLeu_BaLyEn_6	560	565	PF01217	0.686
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.560
TRG_DiLeu_BaLyEn_6	824	829	PF01217	0.584
TRG_ENDOCYTIC_2	79	82	PF00928	0.465
TRG_ER_diArg_1	1044	1046	PF00400	0.559
TRG_ER_diArg_1	319	321	PF00400	0.694
TRG_ER_diArg_1	342	345	PF00400	0.682
TRG_ER_diArg_1	355	357	PF00400	0.590
TRG_ER_diArg_1	407	410	PF00400	0.667
TRG_ER_diArg_1	412	415	PF00400	0.661
TRG_ER_diArg_1	487	489	PF00400	0.658
TRG_ER_diArg_1	595	597	PF00400	0.670
TRG_ER_diArg_1	654	656	PF00400	0.562
TRG_ER_diArg_1	714	717	PF00400	0.524
TRG_ER_diArg_1	739	741	PF00400	0.442
TRG_ER_diArg_1	835	838	PF00400	0.491
TRG_ER_diArg_1	857	860	PF00400	0.524
TRG_NES_CRM1_1	917	932	PF08389	0.529
TRG_Pf-PMV_PEXEL_1	654	659	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	678	682	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	890	894	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H4N8	Leishmania braziliensis	62%	100%
A4HSW6	Leishmania infantum	100%	100%
E9AKV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	97%
Q4QJ03	Leishmania major	80%	100%